Insights into microbial cryptic gene activation and strain improvement: principle, application and technical aspects.

PubWeight™: 0.80‹?›

🔗 View Article (PMID 27381522)

Published in J Antibiot (Tokyo) on July 06, 2016

Authors

Kozo Ochi1

Author Affiliations

1: Department of Life Sciences, Hiroshima Institute of Technology, Saeki-ku, Hiroshima, Japan.

Articles cited by this

(truncated to the top 100)

Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). Nature (2002) 19.35

DNA methylation landscapes: provocative insights from epigenomics. Nat Rev Genet (2008) 15.45

Histone acetylation in chromatin structure and transcription. Nature (1997) 14.64

Quorum sensing in bacteria. Annu Rev Microbiol (2001) 14.41

Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics. Nature (2000) 11.30

Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis. Nat Biotechnol (2003) 7.84

The Role of Spontaneous Variants in the Acquisition of Streptomycin Resistance by the Shigellae. J Bacteriol (1946) 6.97

Structural insights into translational fidelity. Annu Rev Biochem (2005) 4.97

Comparative analysis of the complete genome sequence of the plant growth-promoting bacterium Bacillus amyloliquefaciens FZB42. Nat Biotechnol (2007) 4.66

Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350. J Bacteriol (2008) 4.59

LaeA, a regulator of secondary metabolism in Aspergillus spp. Eukaryot Cell (2004) 3.72

A functional pseudoknot in 16S ribosomal RNA. EMBO J (1991) 3.59

S-Adenosylmethionine and methylation. FASEB J (1996) 3.48

Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338. Nat Biotechnol (2007) 3.45

Regulation of secondary metabolism in streptomycetes. Curr Opin Microbiol (2005) 3.45

Salmonella typhimurium recognizes a chemically distinct form of the bacterial quorum-sensing signal AI-2. Mol Cell (2004) 3.36

Autoinducer 2 controls biofilm formation in Escherichia coli through a novel motility quorum-sensing regulator (MqsR, B3022). J Bacteriol (2006) 3.14

Big effects from small changes: possible ways to explore nature's chemical diversity. Chembiochem (2002) 2.93

The world of subinhibitory antibiotic concentrations. Curr Opin Microbiol (2006) 2.89

Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans. Proc Natl Acad Sci U S A (2009) 2.86

Epigenetic gene regulation in the bacterial world. Microbiol Mol Biol Rev (2006) 2.66

Structural basis for transcription regulation by alarmone ppGpp. Cell (2004) 2.60

Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters. Cell (2014) 2.59

A radically different mechanism for S-adenosylmethionine-dependent methyltransferases. Science (2011) 2.55

Initiation of Bacillus subtilis sporulation by the stringent response to partial amino acid deprivation. J Biol Chem (1981) 2.54

Chromatin-level regulation of biosynthetic gene clusters. Nat Chem Biol (2009) 2.50

Fungal secondary metabolites - strategies to activate silent gene clusters. Fungal Genet Biol (2010) 2.49

Streptomycin resistance in mycobacteria. Antimicrob Agents Chemother (1994) 2.40

Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism. Proc Natl Acad Sci U S A (2010) 2.29

Stationary-phase production of the antibiotic actinorhodin in Streptomyces coelicolor A3(2) is transcriptionally regulated. Mol Microbiol (1993) 2.19

Loss of a conserved 7-methylguanosine modification in 16S rRNA confers low-level streptomycin resistance in bacteria. Mol Microbiol (2007) 2.13

Feast or famine: the global regulator DasR links nutrient stress to antibiotic production by Streptomyces. EMBO Rep (2008) 2.07

Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens. Proc Natl Acad Sci U S A (2011) 2.05

Induction of actinorhodin production by rpsL (encoding ribosomal protein S12) mutations that confer streptomycin resistance in Streptomyces lividans and Streptomyces coelicolor A3(2). J Bacteriol (1996) 2.03

CodY is required for nutritional repression of Bacillus subtilis genetic competence. J Bacteriol (1996) 2.02

Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters. Microb Biotechnol (2010) 2.02

New horizons for (p)ppGpp in bacterial and plant physiology. Trends Microbiol (2005) 2.00

Epigenetic remodeling of the fungal secondary metabolome. Org Biomol Chem (2008) 2.00

New developments in microbial interspecies signaling. Curr Opin Microbiol (2009) 2.00

E. coli ribosomes with a C912 to U base change in the 16S rRNA are streptomycin resistant. EMBO J (1986) 1.98

An alternative strategy for bacterial ribosome synthesis: Bacillus subtilis rRNA transcription regulation. EMBO J (2004) 1.96

Bacterial DNA methylation: a cell cycle regulator? J Bacteriol (1999) 1.84

Metabolic initiation of differentiation and secondary metabolism by Streptomyces griseus: significance of the stringent response (ppGpp) and GTP content in relation to A factor. J Bacteriol (1987) 1.83

The magic spot: a ppGpp binding site on E. coli RNA polymerase responsible for regulation of transcription initiation. Mol Cell (2013) 1.80

AdpA, a central transcriptional regulator in the A-factor regulatory cascade that leads to morphological development and secondary metabolism in Streptomyces griseus. Biosci Biotechnol Biochem (2005) 1.80

Chemical perturbation of secondary metabolism demonstrates important links to primary metabolism. Chem Biol (2012) 1.79

Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A. Proc Natl Acad Sci U S A (2014) 1.78

The mechanism of E. coli RNA polymerase regulation by ppGpp is suggested by the structure of their complex. Mol Cell (2013) 1.73

Guanine nucleotides guanosine 5'-diphosphate 3'-diphosphate and GTP co-operatively regulate the production of an antibiotic bacilysin in Bacillus subtilis. J Biol Chem (2002) 1.71

Antibacterial discovery in actinomycetes strains with mutations in RNA polymerase or ribosomal protein S12. Nat Biotechnol (2009) 1.68

Epigenetic phase variation of the pap operon in Escherichia coli. Trends Microbiol (1996) 1.63

Epigenome manipulation as a pathway to new natural product scaffolds and their congeners. Nat Prod Rep (2009) 1.63

Reinvigorating natural product combinatorial biosynthesis with synthetic biology. Nat Chem Biol (2015) 1.60

Methylthioadenosine/S-adenosylhomocysteine nucleosidase, a critical enzyme for bacterial metabolism. Mol Microbiol (2010) 1.56

Activation of antibiotic biosynthesis by specified mutations in the rpoB gene (encoding the RNA polymerase beta subunit) of Streptomyces lividans. J Bacteriol (2002) 1.55

New strategies for drug discovery: activation of silent or weakly expressed microbial gene clusters. Appl Microbiol Biotechnol (2012) 1.50

Mycolic acid-containing bacteria induce natural-product biosynthesis in Streptomyces species. Appl Environ Microbiol (2010) 1.48

Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering. Metab Eng (2008) 1.48

Recent advances in awakening silent biosynthetic gene clusters and linking orphan clusters to natural products in microorganisms. Curr Opin Chem Biol (2010) 1.43

Arabidopsis RelA/SpoT homologs implicate (p)ppGpp in plant signaling. Proc Natl Acad Sci U S A (2000) 1.42

Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation. Proc Natl Acad Sci U S A (2011) 1.41

Mutations in rsmG, encoding a 16S rRNA methyltransferase, result in low-level streptomycin resistance and antibiotic overproduction in Streptomyces coelicolor A3(2). J Bacteriol (2007) 1.39

Dramatic activation of antibiotic production in Streptomyces coelicolor by cumulative drug resistance mutations. Appl Environ Microbiol (2008) 1.38

From microbial differentiation to ribosome engineering. Biosci Biotechnol Biochem (2007) 1.38

Acquisition of certain streptomycin-resistant (str) mutations enhances antibiotic production in bacteria. Antimicrob Agents Chemother (1998) 1.37

RelA protein is involved in induction of genetic competence in certain Bacillus subtilis strains by moderating the level of intracellular GTP. J Bacteriol (2002) 1.37

RNA polymerase mutation activates the production of a dormant antibiotic 3,3'-neotrehalosadiamine via an autoinduction mechanism in Bacillus subtilis. J Biol Chem (2003) 1.37

Direct regulation of GTP homeostasis by (p)ppGpp: a critical component of viability and stress resistance. Mol Cell (2012) 1.37

Insight into the polar reactivity of the onium chalcogen analogues of S-adenosyl-L-methionine. Biochemistry (2004) 1.36

Activation of fungal silent gene clusters: a new avenue to drug discovery. Prog Drug Res (2008) 1.36

The 5' proximal helix of 16S rRNA is involved in the binding of streptomycin to the ribosome. FASEB J (1993) 1.34

Cloning and characterization of the metE gene encoding S-adenosylmethionine synthetase from Bacillus subtilis. J Bacteriol (1996) 1.31

Chemical induction of silent biosynthetic pathway transcription in Aspergillus niger. J Ind Microbiol Biotechnol (2009) 1.30

Studies on the role of the metK gene product of Escherichia coli K-12. Mol Microbiol (2002) 1.30

Streptomyces and Saccharopolyspora hosts for heterologous expression of secondary metabolite gene clusters. J Ind Microbiol Biotechnol (2010) 1.28

Increased expression of ribosome recycling factor is responsible for the enhanced protein synthesis during the late growth phase in an antibiotic-overproducing Streptomyces coelicolor ribosomal rpsL mutant. Mol Microbiol (2006) 1.28

Enhanced expression of S-adenosylmethionine synthetase causes overproduction of actinorhodin in Streptomyces coelicolor A3(2). J Bacteriol (2003) 1.26

Innovative approach for improvement of an antibiotic-overproducing industrial strain of Streptomyces albus. Appl Environ Microbiol (2003) 1.22

The regulator of streptomycin gene expression, StrR, of Streptomyces griseus is a DNA binding activator protein with multiple recognition sites. Mol Microbiol (1995) 1.21

High-throughput platform for the discovery of elicitors of silent bacterial gene clusters. Proc Natl Acad Sci U S A (2014) 1.20

Metabolic engineering of antibiotic factories: new tools for antibiotic production in actinomycetes. Trends Biotechnol (2014) 1.19

Identification of the bacterial alarmone guanosine 5'-diphosphate 3'-diphosphate (ppGpp) in plants. Proc Natl Acad Sci U S A (2004) 1.18

Effects of subinhibitory concentrations of antibiotics on SOS and DNA repair gene expression in Staphylococcus aureus. Antimicrob Agents Chemother (2008) 1.17

Insights into naturally minimised Streptomyces albus J1074 genome. BMC Genomics (2014) 1.15

Triggers and cues that activate antibiotic production by actinomycetes. J Ind Microbiol Biotechnol (2013) 1.14

Conversion of methionine to cysteine in Bacillus subtilis and its regulation. J Bacteriol (2006) 1.14

Metabolite induction via microorganism co-culture: a potential way to enhance chemical diversity for drug discovery. Biotechnol Adv (2014) 1.14

Inducible expression, enzymatic activity, and origin of higher plant homologues of bacterial RelA/SpoT stress proteins in Nicotiana tabacum. J Biol Chem (2003) 1.13

Novel mutation in 16S rRNA associated with streptomycin dependence in Mycobacterium tuberculosis. Antimicrob Agents Chemother (1995) 1.13

The novel mutation K87E in ribosomal protein S12 enhances protein synthesis activity during the late growth phase in Escherichia coli. Mol Genet Genomics (2004) 1.12

A rifampicin resistance mutation in the rpoB gene confers ppGpp-independent antibiotic production in Streptomyces coelicolor A3(2). Mol Genet Genomics (2002) 1.11

A novel method for improving Streptomyces coelicolor A3(2) for production of actinorhodin by introduction of rpsL (encoding ribosomal protein S12) mutations conferring resistance to streptomycin. J Antibiot (Tokyo) (1997) 1.10

Heterologous expression of natural product biosynthetic gene clusters in Streptomyces coelicolor: from genome mining to manipulation of biosynthetic pathways. J Ind Microbiol Biotechnol (2013) 1.09

Activation of dormant bacterial genes by Nonomuraea sp. strain ATCC 39727 mutant-type RNA polymerase. J Bacteriol (2008) 1.09

Phenotypes and gene expression profiles of Saccharopolyspora erythraea rifampicin-resistant (rif) mutants affected in erythromycin production. Microb Cell Fact (2009) 1.09

Accumulation of S-adenosyl-L-methionine enhances production of actinorhodin but inhibits sporulation in Streptomyces lividans TK23. J Bacteriol (2003) 1.09

Towards a new science of secondary metabolism. J Antibiot (Tokyo) (2013) 1.09

Impact of interspecific interactions on antimicrobial activity among soil bacteria. Front Microbiol (2014) 1.08

Strain improvement in actinomycetes in the postgenomic era. J Ind Microbiol Biotechnol (2011) 1.07

Antimicrobial drug resistance affects broad changes in metabolomic phenotype in addition to secondary metabolism. Proc Natl Acad Sci U S A (2013) 1.07