Published in J Biol Chem on April 04, 2005
Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice. J Clin Invest (2009) 2.66
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Rationale behind targeting fibroblast activation protein-expressing carcinoma-associated fibroblasts as a novel chemotherapeutic strategy. Mol Cancer Ther (2012) 1.48
Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia. J Exp Med (2013) 1.40
Intestinal myofibroblasts: targets for stem cell therapy. Am J Physiol Gastrointest Liver Physiol (2011) 1.33
Targeting the cancer stroma with a fibroblast activation protein-activated promelittin protoxin. Mol Cancer Ther (2009) 1.20
Fibroblast activation protein is expressed by rheumatoid myofibroblast-like synoviocytes. Arthritis Res Ther (2006) 1.17
Effect of fibroblast activation protein and alpha2-antiplasmin cleaving enzyme on collagen types I, III, and IV. Arch Biochem Biophys (2006) 1.09
Targeting fibroblast activation protein in tumor stroma with chimeric antigen receptor T cells can inhibit tumor growth and augment host immunity without severe toxicity. Cancer Immunol Res (2013) 1.07
Dipeptidyl peptidases as survival factors in Ewing sarcoma family of tumors: implications for tumor biology and therapy. J Biol Chem (2011) 1.00
Fibroblast activation protein-α promotes tumor growth and invasion of breast cancer cells through non-enzymatic functions. Clin Exp Metastasis (2011) 0.97
Fibroblast activation protein is induced by inflammation and degrades type I collagen in thin-cap fibroatheromata. Eur Heart J (2011) 0.97
Fibroblast activation protein alpha is expressed by chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthritis. Arthritis Res Ther (2006) 0.97
The in vivo expression of dipeptidyl peptidases 8 and 9. J Histochem Cytochem (2009) 0.93
Induced-fit mechanism for prolyl endopeptidase. J Biol Chem (2010) 0.92
Activatable near-infrared fluorescent probe for in vivo imaging of fibroblast activation protein-alpha. Bioconjug Chem (2012) 0.91
Dipeptidyl peptidases 8 and 9: specificity and molecular characterization compared with dipeptidyl peptidase IV. Biochem J (2006) 0.90
Selective fluorescence probes for dipeptidyl peptidase activity-fibroblast activation protein and dipeptidyl peptidase IV. Bioconjug Chem (2007) 0.90
Activation of EDTA-resistant gelatinases in malignant human tumors. Cancer Res (2006) 0.88
The expanding diversity of serine hydrolases. Curr Opin Struct Biol (2007) 0.88
Using substrate specificity of antiplasmin-cleaving enzyme for fibroblast activation protein inhibitor design. Biochemistry (2009) 0.86
Elevation of seprase expression and promotion of an invasive phenotype by collagenous matrices in ovarian tumor cells. Int J Cancer (2009) 0.85
Fibroblast activation protein (FAP) is essential for the migration of bone marrow mesenchymal stem cells through RhoA activation. PLoS One (2014) 0.84
A novel SUMO1-specific interacting motif in dipeptidyl peptidase 9 (DPP9) that is important for enzymatic regulation. J Biol Chem (2012) 0.84
Structures of human DPP7 reveal the molecular basis of specific inhibition and the architectural diversity of proline-specific peptidases. PLoS One (2012) 0.84
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Downregulation of Signaling-active IGF-1 by Dipeptidyl Peptidase IV (DPP-IV). Int J Biomed Sci (2010) 0.75
Fibroblast activation protein is dispensable in the anti-influenza immune response in mice. PLoS One (2017) 0.75
The expression of proline-specific enzymes in the human lung. Ann Transl Med (2017) 0.75
Targeting of cancer‑associated fibroblasts enhances the efficacy of cancer chemotherapy by regulating the tumor microenvironment. Mol Med Rep (2016) 0.75
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Selective Inhibitors of Fibroblast Activation Protein (FAP) with a (4-Quinolinoyl)-glycyl-2-cyanopyrrolidine Scaffold. ACS Med Chem Lett (2013) 0.75
Immunotherapy of tumor with vaccine based on basic fibroblast growth factor-activated fibroblasts. J Cancer Res Clin Oncol (2013) 0.75
3,4-Dihydroxyphenylalanine Peptides as Nonperturbative Quantum Dot Sensors of Aminopeptidase. ACS Nano (2016) 0.75
Selective Homogeneous Assay for Circulating Endopeptidase Fibroblast Activation Protein (FAP). Sci Rep (2017) 0.75
Co-expression of the homologous proteases fibroblast activation protein and dipeptidyl peptidase-IV in the adult human Langerhans islets. Histochem Cell Biol (2014) 0.75
[MMP- and FAP-mediated non-inflammation-related destruction of cartilage and bone in rheumatoid arthritis]. Z Rheumatol (2009) 0.75
Pericyte-targeting prodrug overcomes tumor resistance to vascular disrupting agents. J Clin Invest (2017) 0.75
Structural basis for the autoinhibition and STI-571 inhibition of c-Kit tyrosine kinase. J Biol Chem (2004) 3.79
Distinct microRNA expression profiles in acute myeloid leukemia with common translocations. Proc Natl Acad Sci U S A (2008) 3.13
MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia. Proc Natl Acad Sci U S A (2007) 3.00
Crystal structure of human cytochrome P450 2D6. J Biol Chem (2005) 2.34
Molecular basis of box C/D RNA-protein interactions; cocrystal structure of archaeal L7Ae and a box C/D RNA. Structure (2004) 2.08
Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis. J Biol Chem (2003) 2.06
Structure and thermodynamic characterization of the EphB4/Ephrin-B2 antagonist peptide complex reveals the determinants for receptor specificity. Structure (2006) 1.97
Structure of a c-kit product complex reveals the basis for kinase transactivation. J Biol Chem (2003) 1.95
Pomalidomide is active in the treatment of anemia associated with myelofibrosis. J Clin Oncol (2009) 1.88
Discovery of alogliptin: a potent, selective, bioavailable, and efficacious inhibitor of dipeptidyl peptidase IV. J Med Chem (2007) 1.73
Structural analysis of the mechanism of inhibition and allosteric activation of the kinase domain of HER2 protein. J Biol Chem (2011) 1.61
Will a peripheral blood (PB) sample yield the same diagnostic and prognostic cytogenetic data as the concomitant bone marrow (BM) in myelodysplasia? Leuk Res (2012) 1.44
Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic β-type globin promoters in differentiated adult erythroid cells. Mol Cell Biol (2011) 1.42
Structural and biophysical characterization of the EphB4*ephrinB2 protein-protein interaction and receptor specificity. J Biol Chem (2006) 1.40
Porcine small intestinal epithelial cell line (IPEC-J2) of rotavirus infection as a new model for the study of innate immune responses to rotaviruses and probiotics. Viral Immunol (2010) 1.37
Consistent deregulation of gene expression between human and murine MLL rearrangement leukemias. Cancer Res (2009) 1.35
Structural basis for the inhibition of RNase H activity of HIV-1 reverse transcriptase by RNase H active site-directed inhibitors. J Virol (2010) 1.32
Crystal structure of human dipeptidyl peptidase IV in complex with a decapeptide reveals details on substrate specificity and tetrahedral intermediate formation. Protein Sci (2004) 1.23
Discovery of TAK-733, a potent and selective MEK allosteric site inhibitor for the treatment of cancer. Bioorg Med Chem Lett (2011) 1.20
Identification of a 24-gene prognostic signature that improves the European LeukemiaNet risk classification of acute myeloid leukemia: an international collaborative study. J Clin Oncol (2013) 1.15
Scanning the human genome at kilobase resolution. Genome Res (2008) 1.13
MiR-495 is a tumor-suppressor microRNA down-regulated in MLL-rearranged leukemia. Proc Natl Acad Sci U S A (2012) 1.09
(E)-1-(2,2-Dimeth-oxy-eth-yl)-2-(nitro-methyl-idene)imidazolidine. Acta Crystallogr Sect E Struct Rep Online (2010) 1.08
PTTG1 promotes migration and invasion of human non-small cell lung cancer cells and is modulated by miR-186. Carcinogenesis (2013) 1.08
Pharmacokinetic, pharmacodynamic, and efficacy profiles of alogliptin, a novel inhibitor of dipeptidyl peptidase-4, in rats, dogs, and monkeys. Eur J Pharmacol (2008) 1.07
Suppression of Tak1 promotes prostate tumorigenesis. Cancer Res (2012) 1.04
Forced TR2/TR4 expression in sickle cell disease mice confers enhanced fetal hemoglobin synthesis and alleviated disease phenotypes. Proc Natl Acad Sci U S A (2011) 1.04
The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors. Bioorg Med Chem Lett (2008) 1.03
Alternative conformations of the archaeal Nop56/58-fibrillarin complex imply flexibility in box C/D RNPs. J Mol Biol (2007) 1.02
Mechanism of shortened bones in mucopolysaccharidosis VII. Mol Genet Metab (2009) 1.02
Design and synthesis of pyrimidinone and pyrimidinedione inhibitors of dipeptidyl peptidase IV. J Med Chem (2010) 1.02
Genome-wide binding of the orphan nuclear receptor TR4 suggests its general role in fundamental biological processes. BMC Genomics (2010) 1.01
Conformational flexibility in crystal structures of human 11beta-hydroxysteroid dehydrogenase type I provide insights into glucocorticoid interconversion and enzyme regulation. J Biol Chem (2004) 0.99
Common chromatin structures at breakpoint cluster regions may lead to chromosomal translocations found in chronic and acute leukemias. Hum Genet (2006) 0.99
Drug information specialists. Am J Health Syst Pharm (2006) 0.97
Structure-based engineering of internal cavities in coiled-coil peptides. Biochemistry (2005) 0.97
Identification of candidate tumor-suppressor genes in 6q27 by combined deletion mapping and electronic expression profiling in lymphoid neoplasms. Genes Chromosomes Cancer (2003) 0.96
X-ray crystal structures of monomeric and dimeric peptide inhibitors in complex with the human neonatal Fc receptor, FcRn. J Biol Chem (2010) 0.95
Polyunsaturated fatty acids affect the localization and signaling of PIP3/AKT in prostate cancer cells. Carcinogenesis (2013) 0.94
Amperometric glucose biosensor based on single-walled carbon nanohorns. Biosens Bioelectron (2008) 0.94
Histone deacetylase inhibitor romidepsin has differential activity in core binding factor acute myeloid leukemia. Clin Cancer Res (2008) 0.94
Nir1 promotes invasion of breast cancer cells by binding to chemokine (C-C motif) ligand 18 through the PI3K/Akt/GSK3β/Snail signalling pathway. Eur J Cancer (2013) 0.92
N-linked glycosylation of dipeptidyl peptidase IV (CD26): effects on enzyme activity, homodimer formation, and adenosine deaminase binding. Protein Sci (2004) 0.92
A phase I and pharmacokinetic study of XK469R (NSC 698215), a quinoxaline phenoxypropionic acid derivative, in patients with refractory acute leukemia. Invest New Drugs (2008) 0.91
Structural comparison of yeast snoRNP and spliceosomal protein Snu13p with its homologs. Biochem Biophys Res Commun (2005) 0.90
A modified enrichment method to construct microsatellite library from plateau pika genome (Ochotona curzoniae). Genomics Proteomics Bioinformatics (2010) 0.88
Azotobacter vinelandii ferredoxin I: a sequence and structure comparison approach to alteration of [4Fe-4S]2+/+ reduction potential. J Biol Chem (2001) 0.86
PARP-1 inhibitor, DPQ, attenuates LPS-induced acute lung injury through inhibiting NF-κB-mediated inflammatory response. PLoS One (2013) 0.86
Detection and differentiation of classical swine fever virus strains C and Shimen by high-resolution melt analysis. J Virol Methods (2013) 0.84
Fragment-based screening for inhibitors of PDE4A using enthalpy arrays and X-ray crystallography. J Biomol Screen (2012) 0.84
The structure of LpxD from Pseudomonas aeruginosa at 1.3 Å resolution. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.84
HSV-1 activates NF-kappaB in mouse astrocytes and increases TNF-alpha and IL-6 expression via Toll-like receptor 3. Neurol Res (2013) 0.83
A new class of non-thiazolidinedione, non-carboxylic-acid-based highly selective peroxisome proliferator-activated receptor (PPAR) γ agonists: design and synthesis of benzylpyrazole acylsulfonamides. Bioorg Med Chem (2011) 0.83
Disruption of the Hbs1l-Myb locus causes hereditary persistence of fetal hemoglobin in a mouse model. Mol Cell Biol (2013) 0.83
PGC-1 coactivator activity is required for murine erythropoiesis. Mol Cell Biol (2014) 0.82
IL-1β and TLR4 signaling are involved in the aggravated murine acute graft-versus-host disease caused by delayed bortezomib administration. J Immunol (2013) 0.82
ARK5 promotes glioma cell invasion, and its elevated expression is correlated with poor clinical outcome. Eur J Cancer (2012) 0.82
Autocrine IL-8 promotes F-actin polymerization and mediate mesenchymal transition via ELMO1-NF-κB-Snail signaling in glioma. Cancer Biol Ther (2015) 0.81
Design, synthesis and SAR of novel glucokinase activators. Bioorg Med Chem Lett (2013) 0.81
Placental mesenchymal dysplasia without fetal development in a twin gestation: a case report and review of the spectrum of androgenetic biparental mosaicism. Pediatr Dev Pathol (2015) 0.81
Design, synthesis and structure-activity relationships of 1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta. Bioorg Med Chem (2009) 0.81
Lead, cadmium, arsenic, mercury and copper levels in Chinese Yunnan Pu'er tea. Food Addit Contam Part B Surveill (2011) 0.80
Screening of cellular proteins that interact with the classical swine fever virus non-structural protein 5A by yeast two-hybrid analysis. J Biosci (2014) 0.80
Structure-based design and synthesis of benzimidazole derivatives as dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett (2008) 0.80
Increasing the dose of aclarubicin in low-dose cytarabine and aclarubicin in combination with granulocyte colony-stimulating factor (CAG regimen) can safely and effectively treat relapsed or refractory acute myeloid leukemia. Int J Hematol (2014) 0.80
Mitomycin C induces apoptosis in rheumatoid arthritis fibroblast-like synoviocytes via a mitochondrial-mediated pathway. Cell Physiol Biochem (2015) 0.80
Biological characterization of TAK-901, an investigational, novel, multitargeted Aurora B kinase inhibitor. Mol Cancer Ther (2013) 0.80
Classical swine fever virus NS2 protein promotes interleukin-8 expression and inhibits MG132-induced apoptosis. Virus Genes (2011) 0.80
Environmentally friendly and highly sensitive ruthenium(II) tris(2,2'-bipyridyl) electrochemiluminescent system using 2-(dibutylamino)ethanol as co-reactant. Angew Chem Int Ed Engl (2007) 0.80
2-{3-[4-(Alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta with good brain permeability. J Med Chem (2009) 0.79
Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors. Bioorg Med Chem Lett (2010) 0.79
Comparative structural analysis of a novel glutathioneS-transferase (ATU5508) from Agrobacterium tumefaciens at 2.0 A resolution. Proteins (2006) 0.79
The role of topoisomerase II beta on breakage and proximity of RUNX1 to partner alleles RUNX1T1 and EVI1. Genes Chromosomes Cancer (2013) 0.78
Evidences showing wide presence of small genomic aberrations in chronic lymphocytic leukemia. BMC Res Notes (2010) 0.78
Retroviral-vector-mediated gene therapy to mucopolysaccharidosis I mice improves sensorimotor impairments and other behavioral deficits. J Inherit Metab Dis (2012) 0.78
Discovery of novel benzo[b][1,4]oxazin-3(4H)-ones as poly(ADP-ribose)polymerase inhibitors. Bioorg Med Chem Lett (2013) 0.78
Photo-assisted proton exchange and chemical etching on Fe-doped lithium niobate crystals. Opt Express (2015) 0.78
Structure determination of LpxD from the lipopolysaccharide-synthesis pathway of Acinetobacter baumannii. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 0.78
Identification and effect decomposition of risk factors for Brucella contamination of raw whole milk in china. PLoS One (2013) 0.78
Serotypes, virulence factors, and antimicrobial susceptibilities of vaginal and fecal isolates of Escherichia coli from giant pandas. Appl Environ Microbiol (2013) 0.78
Effectiveness of 10 polymorphic microsatellite markers for parentage and pedigree analysis in plateau pika (Ochotona curzoniae). BMC Genet (2010) 0.78
Crystal structures of transhydrogenase domain I with and without bound NADH. Biochemistry (2002) 0.78
Genome Sequence of Klebsiella oxytoca SA2, an Endophytic Nitrogen-Fixing Bacterium Isolated from the Pioneer Grass Psammochloa villosa. Genome Announc (2013) 0.78
Successful autologous stem cell collection in patients with chronic myeloid leukemia in complete cytogenetic response, with quantitative measurement of BCR-ABL expression in blood, marrow, and apheresis products. Leuk Lymphoma (2008) 0.78
A role for interleukin-1 alpha in the 1,25 dihydroxyvitamin D3 response in mammary epithelial cells. PLoS One (2013) 0.78
Antimicrobial susceptibility testing and genotypic characterization of Staphylococcus aureus from food and food animals. Foodborne Pathog Dis (2011) 0.78
The classic swine fever virus (CSFV) core protein can enhance de novo-initiated RNA synthesis by the CSFV polymerase NS5B. Virus Genes (2014) 0.77
Analysis of the bacterial diversity existing on animal hide and wool: development of a preliminary PCR-restriction fragment length polymorphism fingerprint database for identifying isolates. J AOAC Int (2013) 0.77
Sero-epidemiological survey of human cytomegalovirus-infected children in Weifang (Eastern China) between 2009 and 2012. Virol J (2013) 0.77
Design and synthesis of potent inhibitor of apoptosis (IAP) proteins antagonists bearing an octahydropyrrolo[1,2-a]pyrazine scaffold as a novel proline mimetic. J Med Chem (2013) 0.77
Behavioral mechanisms of male sterilization on plateau pika in the Qinghai-Tibet plateau. Behav Processes (2011) 0.77
Characterization of Staphylococcus aureus isolated from powdered infant formula milk and infant rice cereal in China. Int J Food Microbiol (2011) 0.77
Effects of quinestrol and levonorgestrel on populations of plateau pikas, Ochotona curzoniae, in the Qinghai-Tibetan Plateau. Pest Manag Sci (2012) 0.76