Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells.

PubWeight™: 7.66‹?› | Rank: Top 0.1%

🔗 View Article (PMID 15812508)

Published in Nat Med on April 01, 2005

Authors

Massimiliano Gnecchi, Huamei He, Olin D Liang, Luis G Melo, Fulvio Morello, Hui Mu, Nicolas Noiseux, Lunan Zhang, Richard E Pratt, Joanne S Ingwall, Victor J Dzau

Articles citing this

(truncated to the top 100)

Paracrine mechanisms in adult stem cell signaling and therapy. Circ Res (2008) 8.49

Bone marrow mesenchymal stem cells stimulate cardiac stem cell proliferation and differentiation. Circ Res (2010) 5.47

Mesenchymal stem cells: biology, pathophysiology, translational findings, and therapeutic implications for cardiac disease. Circ Res (2011) 4.75

Extracellular vesicles: biology and emerging therapeutic opportunities. Nat Rev Drug Discov (2013) 4.35

Allogeneic mesenchymal stem cells restore cardiac function in chronic ischemic cardiomyopathy via trilineage differentiating capacity. Proc Natl Acad Sci U S A (2009) 4.21

Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice. Circ Res (2010) 4.19

Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair. Proc Natl Acad Sci U S A (2007) 3.74

Production of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming. Cell Stem Cell (2012) 3.66

Cell therapy for heart failure: a comprehensive overview of experimental and clinical studies, current challenges, and future directions. Circ Res (2013) 3.56

Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease. Cell Stem Cell (2012) 3.33

Mitochondrial transfer between cells can rescue aerobic respiration. Proc Natl Acad Sci U S A (2006) 3.24

Hypoxic preconditioning results in increased motility and improved therapeutic potential of human mesenchymal stem cells. Stem Cells (2008) 3.12

Local activation or implantation of cardiac progenitor cells rescues scarred infarcted myocardium improving cardiac function. Circ Res (2008) 3.07

Transcriptional and functional profiling of human embryonic stem cell-derived cardiomyocytes. PLoS One (2008) 2.85

Mesenchymal stem cell-derived molecules reverse fulminant hepatic failure. PLoS One (2007) 2.80

Mesenchymal stem cell secretes microparticles enriched in pre-microRNAs. Nucleic Acids Res (2009) 2.66

Airway delivery of mesenchymal stem cells prevents arrested alveolar growth in neonatal lung injury in rats. Am J Respir Crit Care Med (2009) 2.60

Imaging survival and function of transplanted cardiac resident stem cells. J Am Coll Cardiol (2009) 2.58

Mesenchymal stem cells: Mechanisms of immunomodulation and homing. Cell Transplant (2010) 2.50

Tissue-engineered vascular grafts transform into mature blood vessels via an inflammation-mediated process of vascular remodeling. Proc Natl Acad Sci U S A (2010) 2.49

Multipotent human stromal cells improve cardiac function after myocardial infarction in mice without long-term engraftment. Biochem Biophys Res Commun (2007) 2.35

Changes in ventricular remodelling and clinical status during the year following a single administration of stromal cell-derived factor-1 non-viral gene therapy in chronic ischaemic heart failure patients: the STOP-HF randomized Phase II trial. Eur Heart J (2015) 2.32

Cardiac progenitor cells and biotinylated insulin-like growth factor-1 nanofibers improve endogenous and exogenous myocardial regeneration after infarction. Circulation (2009) 2.30

VEGF/SDF-1 promotes cardiac stem cell mobilization and myocardial repair in the infarcted heart. Cardiovasc Res (2011) 2.30

Autologous mesenchymal stem cells produce reverse remodelling in chronic ischaemic cardiomyopathy. Eur Heart J (2009) 2.29

Human stem/progenitor cells from bone marrow promote neurogenesis of endogenous neural stem cells in the hippocampus of mice. Proc Natl Acad Sci U S A (2005) 2.26

Role of host tissues for sustained humoral effects after endothelial progenitor cell transplantation into the ischemic heart. J Exp Med (2007) 2.25

Engraftment of engineered ES cell-derived cardiomyocytes but not BM cells restores contractile function to the infarcted myocardium. J Exp Med (2006) 2.23

Immunobiology of mesenchymal stem cells. Cell Death Differ (2013) 2.18

Strategies to promote donor cell survival: combining preconditioning approach with stem cell transplantation. J Mol Cell Cardiol (2008) 2.16

Follistatin-like 1 is an Akt-regulated cardioprotective factor that is secreted by the heart. Circulation (2008) 1.99

Stem cell paracrine actions and tissue regeneration. Regen Med (2010) 1.99

Paracrine mechanisms of stem cell reparative and regenerative actions in the heart. J Mol Cell Cardiol (2010) 1.95

How mesenchymal stem cells interact with tissue immune responses. Trends Immunol (2012) 1.92

Human peripheral blood-derived CD31+ cells have robust angiogenic and vasculogenic properties and are effective for treating ischemic vascular disease. J Am Coll Cardiol (2010) 1.92

Factors released from embryonic stem cells inhibit apoptosis of H9c2 cells. Am J Physiol Heart Circ Physiol (2007) 1.87

Cardiac stem cell therapy and the promise of heart regeneration. Cell Stem Cell (2013) 1.86

Genetic engineering of human stem cells for enhanced angiogenesis using biodegradable polymeric nanoparticles. Proc Natl Acad Sci U S A (2009) 1.83

In vitro and in vivo effects of bone marrow stem cells on cardiac structure and function. J Mol Cell Cardiol (2006) 1.81

Transplantation of human pericyte progenitor cells improves the repair of infarcted heart through activation of an angiogenic program involving micro-RNA-132. Circ Res (2011) 1.78

Myocardial AKT: the omnipresent nexus. Physiol Rev (2011) 1.76

Long-term functional improvement and gene expression changes after bone marrow-derived multipotent progenitor cell transplantation in myocardial infarction. Am J Physiol Heart Circ Physiol (2010) 1.73

Cell therapy for the treatment of coronary heart disease: a critical appraisal. Nat Rev Cardiol (2010) 1.69

VEGFR1/CXCR4-positive progenitor cells modulate local inflammation and augment tissue perfusion by a SDF-1-dependent mechanism. J Mol Med (Berl) (2008) 1.67

Malignant tumor formation after transplantation of short-term cultured bone marrow mesenchymal stem cells in experimental myocardial infarction and diabetic neuropathy. Circ Res (2011) 1.62

Cardiac cell repair therapy: a clinical perspective. Mayo Clin Proc (2009) 1.62

Perspectives on Trypanosoma cruzi-induced heart disease (Chagas disease). Prog Cardiovasc Dis (2009) 1.60

Genetic modification of mesenchymal stem cells overexpressing CCR1 increases cell viability, migration, engraftment, and capillary density in the injured myocardium. Circ Res (2010) 1.60

Use of mesenchymal stem cells for therapy of cardiac disease. Circ Res (2015) 1.57

Cardiogenic differentiation and transdifferentiation of progenitor cells. Circ Res (2008) 1.54

Immunomodulation of activated hepatic stellate cells by mesenchymal stem cells. Biochem Biophys Res Commun (2007) 1.52

Exogenously administered secreted frizzled related protein 2 (Sfrp2) reduces fibrosis and improves cardiac function in a rat model of myocardial infarction. Proc Natl Acad Sci U S A (2010) 1.51

Early beneficial effects of bone marrow-derived mesenchymal stem cells overexpressing Akt on cardiac metabolism after myocardial infarction. Stem Cells (2009) 1.50

An emerging consensus on cardiac regeneration. Nat Med (2014) 1.50

Mesenchymal stem cell-based therapy: a new paradigm in regenerative medicine. J Cell Mol Med (2009) 1.49

Injection of bone marrow cell extract into infarcted hearts results in functional improvement comparable to intact cell therapy. Mol Ther (2009) 1.45

Mononuclear cell secretome protects from experimental autoimmune myocarditis. Eur Heart J (2013) 1.45

Stem cell conditioned medium improves acute lung injury in mice: in vivo evidence for stem cell paracrine action. Am J Physiol Lung Cell Mol Physiol (2012) 1.44

Akt1 in the cardiovascular system: friend or foe? J Clin Invest (2005) 1.43

Therapeutic Potential of Stem Cells from Human Exfoliated Deciduous Teeth in Models of Acute Kidney Injury. PLoS One (2015) 1.42

Experimental myocardial infarction triggers canonical Wnt signaling and endothelial-to-mesenchymal transition. Dis Model Mech (2011) 1.40

Role of paracrine factors in stem and progenitor cell mediated cardiac repair and tissue fibrosis. Fibrogenesis Tissue Repair (2008) 1.37

Mesenchymal stem cells and cardiac repair. J Cell Mol Med (2008) 1.37

Cell-based therapies and imaging in cardiology. Eur J Nucl Med Mol Imaging (2005) 1.36

Secreted frizzled related protein 2 protects cells from apoptosis by blocking the effect of canonical Wnt3a. J Mol Cell Cardiol (2008) 1.35

Mesenchymal stem cells in tissue repair. Front Immunol (2013) 1.35

Bone marrow stem cell derived paracrine factors for regenerative medicine: current perspectives and therapeutic potential. Bone Marrow Res (2010) 1.34

Bioenergetic and functional consequences of cellular therapy: activation of endogenous cardiovascular progenitor cells. Circ Res (2012) 1.34

Bone-derived stem cells repair the heart after myocardial infarction through transdifferentiation and paracrine signaling mechanisms. Circ Res (2013) 1.33

Ischemic preconditioning potentiates the protective effect of stem cells through secretion of exosomes by targeting Mecp2 via miR-22. PLoS One (2014) 1.32

Natural history of mesenchymal stem cells, from vessel walls to culture vessels. Cell Mol Life Sci (2013) 1.31

Donor myocardial infarction impairs the therapeutic potential of bone marrow cells by an interleukin-1-mediated inflammatory response. Sci Transl Med (2011) 1.31

Analysis of allogenicity of mesenchymal stem cells in engraftment and wound healing in mice. PLoS One (2009) 1.31

Bioengineered myocardium derived from induced pluripotent stem cells improves cardiac function and attenuates cardiac remodeling following chronic myocardial infarction in rats. Stem Cells Transl Med (2012) 1.30

Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper. J Extracell Vesicles (2015) 1.30

Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs. J Transl Med (2011) 1.29

CD133 identifies a human bone marrow stem/progenitor cell sub-population with a repertoire of secreted factors that protect against stroke. Mol Ther (2009) 1.27

Stem cells for myocardial repair with use of a transarterial catheter. Circulation (2009) 1.26

Human CD34+ cells in experimental myocardial infarction: long-term survival, sustained functional improvement, and mechanism of action. Circ Res (2010) 1.26

Age-related changes in rat bone-marrow mesenchymal stem cell plasticity. BMC Cell Biol (2011) 1.25

Capturing the stem cell paracrine effect using heparin-presenting nanofibres to treat cardiovascular diseases. J Tissue Eng Regen Med (2010) 1.23

Protein signaling networks from single cell fluctuations and information theory profiling. Biophys J (2011) 1.21

Genetic engineering of mesenchymal stem cells and its application in human disease therapy. Hum Gene Ther (2010) 1.19

Mesenchymal stem cells as therapeutics and vehicles for gene and drug delivery. Adv Drug Deliv Rev (2010) 1.18

Myocardial injection with GSK-3β-overexpressing bone marrow-derived mesenchymal stem cells attenuates cardiac dysfunction after myocardial infarction. Circ Res (2011) 1.17

Rebuilding the damaged heart: the potential of cytokines and growth factors in the treatment of ischemic heart disease. J Am Coll Cardiol (2010) 1.17

Cardiac repair and regeneration: the Rubik's cube of cell therapy for heart disease. Dis Model Mech (2009) 1.16

Improved survival of mesenchymal stromal cell after hypoxia preconditioning: role of oxidative stress. Life Sci (2010) 1.14

Double knockdown of prolyl hydroxylase and factor-inhibiting hypoxia-inducible factor with nonviral minicircle gene therapy enhances stem cell mobilization and angiogenesis after myocardial infarction. Circulation (2011) 1.14

MicroRNA-155 prevents necrotic cell death in human cardiomyocyte progenitor cells via targeting RIP1. J Cell Mol Med (2010) 1.13

G-CSF/SCF reduces inducible arrhythmias in the infarcted heart potentially via increased connexin43 expression and arteriogenesis. J Exp Med (2006) 1.13

Gene therapy for ischemic heart disease. J Mol Cell Cardiol (2010) 1.11

Mesenchymal stem cells attenuate peritoneal injury through secretion of TSG-6. PLoS One (2012) 1.11

A review of therapeutic effects of mesenchymal stem cell secretions and induction of secretory modification by different culture methods. J Transl Med (2014) 1.10

Bone marrow stromal cells contribute to bone formation following infusion into femoral cavities of a mouse model of osteogenesis imperfecta. Bone (2010) 1.09

Strategies for cardiac regeneration and repair. Sci Transl Med (2014) 1.08

Sonic Hedgehog gene delivery to the rodent heart promotes angiogenesis via iNOS/netrin-1/PKC pathway. PLoS One (2010) 1.08

Cellular and extracellular programming of cell fate through engineered intracrine-, paracrine-, and endocrine-like mechanisms. Biomaterials (2011) 1.08

Murine bone marrow stromal progenitor cells elicit an in vivo cellular and humoral alloimmune response. Biol Blood Marrow Transplant (2007) 1.07

Defining human mesenchymal stem cell efficacy in vivo. J Inflamm (Lond) (2010) 1.06

Articles by these authors

Paracrine mechanisms in adult stem cell signaling and therapy. Circ Res (2008) 8.49

Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts. Nat Med (2003) 8.46

Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement. FASEB J (2006) 5.93

Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle. Cell Metab (2005) 4.65

Gait speed as an incremental predictor of mortality and major morbidity in elderly patients undergoing cardiac surgery. J Am Coll Cardiol (2010) 4.53

Off-pump or on-pump coronary-artery bypass grafting at 30 days. N Engl J Med (2012) 4.32

Effects of off-pump and on-pump coronary-artery bypass grafting at 1 year. N Engl J Med (2013) 4.27

Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair. Proc Natl Acad Sci U S A (2007) 3.74

MicroRNA-mediated in vitro and in vivo direct reprogramming of cardiac fibroblasts to cardiomyocytes. Circ Res (2012) 3.53

Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury. BMC Neurosci (2002) 3.21

Adult mouse epicardium modulates myocardial injury by secreting paracrine factors. J Clin Invest (2011) 2.99

Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiation. Mol Ther (2006) 2.85

Bone marrow stromal cells attenuate lung injury in a murine model of neonatal chronic lung disease. Am J Respir Crit Care Med (2009) 2.83

Osseous abnormalities and early osteoarthritis: the role of hip impingement. Clin Orthop Relat Res (2004) 2.76

Predictors of postoperative movement and resting pain following total knee replacement. Pain (2012) 2.36

Isolation and transplantation of autologous circulating endothelial cells into denuded vessels and prosthetic grafts: implications for cell-based vascular therapy. Circulation (2003) 2.27

Targeted migration of mesenchymal stem cells modified with CXCR4 gene to infarcted myocardium improves cardiac performance. Mol Ther (2008) 2.25

Preoperative anxiety as a predictor of mortality and major morbidity in patients aged >70 years undergoing cardiac surgery. Am J Cardiol (2013) 2.18

A novel composite coronary bypass graft strategy: the saphenous vein bridge--a pilot study. Eur J Cardiothorac Surg (2013) 2.03

Therapeutic potential of endothelial progenitor cells in cardiovascular diseases. Hypertension (2005) 2.03

Implantation of CD133+ stem cells in patients undergoing coronary bypass surgery: IMPACT-CABG pilot trial. Can J Cardiol (2012) 2.02

Mechanisms for increased glycolysis in the hypertrophied rat heart. Hypertension (2004) 1.99

An initiative in mentoring to promote residents' and faculty members' careers. Acad Med (2004) 1.95

Paracrine mechanisms of stem cell reparative and regenerative actions in the heart. J Mol Cell Cardiol (2010) 1.95

Local renin angiotensin expression regulates human mesenchymal stem cell differentiation to adipocytes. Hypertension (2006) 1.91

Atherosclerosis 2005: recent discoveries and novel hypotheses. Circulation (2005) 1.87

Ets-1 is a critical transcriptional regulator of reactive oxygen species and p47(phox) gene expression in response to angiotensin II. Circ Res (2007) 1.79

Mesenchymal stem cells use integrin beta1 not CXC chemokine receptor 4 for myocardial migration and engraftment. Mol Biol Cell (2007) 1.72

Gene therapy strategy for long-term myocardial protection using adeno-associated virus-mediated delivery of heme oxygenase gene. Circulation (2002) 1.67

Genetic modification of mesenchymal stem cells overexpressing CCR1 increases cell viability, migration, engraftment, and capillary density in the injured myocardium. Circ Res (2010) 1.60

Bone marrow-derived mesenchymal stem cells: isolation, expansion, characterization, viral transduction, and production of conditioned medium. Methods Mol Biol (2009) 1.60

Molecular genetics and genomics of heart failure. Nat Rev Genet (2004) 1.60

Microarray gene expression profiles in dilated and hypertrophic cardiomyopathic end-stage heart failure. Physiol Genomics (2002) 1.57

MRI detection of paramagnetic chemical exchange effects in mice kidneys in vivo. Magn Reson Med (2007) 1.57

Diagnostic and prognostic value of presepsin in the management of sepsis in the emergency department: a multicenter prospective study. Crit Care (2013) 1.55

Decreased energetics in murine hearts bearing the R92Q mutation in cardiac troponin T. J Clin Invest (2003) 1.55

Histidine button engineered into cardiac troponin I protects the ischemic and failing heart. Nat Med (2006) 1.53

Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ. Mol Cell (2011) 1.52

Exogenously administered secreted frizzled related protein 2 (Sfrp2) reduces fibrosis and improves cardiac function in a rat model of myocardial infarction. Proc Natl Acad Sci U S A (2010) 1.51

Cell cycle-dependent regulation of smooth muscle cell activation. Arterioscler Thromb Vasc Biol (2004) 1.51

Early beneficial effects of bone marrow-derived mesenchymal stem cells overexpressing Akt on cardiac metabolism after myocardial infarction. Stem Cells (2009) 1.50

Oncomodulin links inflammation to optic nerve regeneration. Proc Natl Acad Sci U S A (2009) 1.50

Angiogenesis and vasculogenesis in pregnancy. Eur J Obstet Gynecol Reprod Biol (2003) 1.48

Essential role of ICAM-1/CD18 in mediating EPC recruitment, angiogenesis, and repair to the infarcted myocardium. Circ Res (2006) 1.46

Cytokine-induced mobilization of circulating endothelial progenitor cells enhances repair of injured arteries. Circulation (2004) 1.46

Addition of frailty and disability to cardiac surgery risk scores identifies elderly patients at high risk of mortality or major morbidity. Circ Cardiovasc Qual Outcomes (2012) 1.41

Enhanced inhibition of neointimal hyperplasia by genetically engineered endothelial progenitor cells. Circulation (2004) 1.41

Aberrant activation of AMP-activated protein kinase remodels metabolic network in favor of cardiac glycogen storage. J Clin Invest (2007) 1.40

Late retrograde perfusion of donor lungs does not decrease the severity of primary graft dysfunction. Ann Thorac Surg (2008) 1.39

Global gene expression profiling of end-stage dilated cardiomyopathy using a human cardiovascular-based cDNA microarray. Am J Pathol (2002) 1.38