Strategies to promote donor cell survival: combining preconditioning approach with stem cell transplantation.

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Published in J Mol Cell Cardiol on May 10, 2008

Authors

Husnain Kh Haider1, Muhammad Ashraf

Author Affiliations

1: Department of Pathology and Laboratory Medicine, 231-Albert Sabin Way, University of Cincinnati, OH-45267-0529, USA.

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The detection of antibody against peste des petits ruminants virus in sheep, goats, cattle and buffaloes. Trop Anim Health Prod (2008) 0.95

Suicide gene reveals the myocardial neovascularization role of mesenchymal stem cells overexpressing CXCR4 (MSC(CXCR4)). PLoS One (2012) 0.95

Bone marrow cell transplantation in clinical perspective. J Mol Cell Cardiol (2005) 0.95

Interaction of Hepatitis C virus proteins with pattern recognition receptors. Virol J (2012) 0.93

Angiomyogenesis for myocardial repair. Antioxid Redox Signal (2009) 0.93

Mesenchymal stem cells overexpressing CXCR4 attenuate remodeling of postmyocardial infarction by releasing matrix metalloproteinase-9. Stem Cells Dev (2011) 0.92

Activation of diverse signaling pathways by ex-vivo delivery of multiple cytokines for myocardial repair. Stem Cells Dev (2012) 0.92

Impaired cardiac contractility in mice lacking both the AE3 Cl-/HCO3- exchanger and the NKCC1 Na+-K+-2Cl- cotransporter: effects on Ca2+ handling and protein phosphatases. J Biol Chem (2008) 0.92

Combining neuropeptide Y and mesenchymal stem cells reverses remodeling after myocardial infarction. Am J Physiol Heart Circ Physiol (2009) 0.92

The role of notch 1 activation in cardiosphere derived cell differentiation. Stem Cells Dev (2012) 0.92

Phytohormones and microRNAs as sensors and regulators of leaf senescence: assigning macro roles to small molecules. Biotechnol Adv (2013) 0.91

Heat shock improves Sca-1+ stem cell survival and directs ischemic cardiomyocytes toward a prosurvival phenotype via exosomal transfer: a critical role for HSF1/miR-34a/HSP70 pathway. Stem Cells (2014) 0.91

Pathogenesis and protection of ischemia and reperfusion injury in myocardium. J Nippon Med Sch (2003) 0.91

Paracrine effect of Wnt11-overexpressing mesenchymal stem cells on ischemic injury. Stem Cells Dev (2011) 0.90

Protein kinase G1 α overexpression increases stem cell survival and cardiac function after myocardial infarction. PLoS One (2013) 0.90

Cardiac progenitors derived from reprogrammed mesenchymal stem cells contribute to angiomyogenic repair of the infarcted heart. Basic Res Cardiol (2012) 0.90

Adenosine A(1) receptor mediates late preconditioning via activation of PKC-delta signaling pathway. Am J Physiol Heart Circ Physiol (2002) 0.89

Cardiac stem cells with electrical stimulation improve ischaemic heart function through regulation of connective tissue growth factor and miR-378. Cardiovasc Res (2013) 0.89

Transduction of Wnt11 promotes mesenchymal stem cell transdifferentiation into cardiac phenotypes. Stem Cells Dev (2011) 0.89

Concomitant activation of miR-107/PDCD10 and hypoxamir-210/Casp8ap2 and their role in cytoprotection during ischemic preconditioning of stem cells. Antioxid Redox Signal (2012) 0.89

Insulin-like growth factor-1 preconditioning accentuates intrinsic survival mechanism in stem cells to resist ischemic injury by orchestrating protein kinase cα-erk1/2 activation. Antioxid Redox Signal (2011) 0.88

Stem cell-based delivery of Hypoxamir-210 to the infarcted heart: implications on stem cell survival and preservation of infarcted heart function. J Mol Med (Berl) (2012) 0.88

MyoCell, a cell-based, autologous skeletal myoblast therapy for the treatment of cardiovascular diseases. Curr Opin Mol Ther (2008) 0.88

Cardiomyocyte protection by GATA-4 gene engineered mesenchymal stem cells is partially mediated by translocation of miR-221 in microvesicles. PLoS One (2013) 0.87

Molecular study of HCV detection, genotypes and their routes of transmission in North West Frontier Province, Pakistan. Asian Pac J Trop Biomed (2012) 0.87

Non-steroidal anti-inflammatory drugs, tumour immunity and immunotherapy. Pharmacol Res (2012) 0.87

Non-hypoxic stabilization of HIF-Iα during coordinated interaction between Akt and angiopoietin-1 enhances endothelial commitment of bone marrow stem cells. J Mol Med (Berl) (2012) 0.87

The contribution of left ventricular muscle bands to left ventricular rotation: assessment by a 2-dimensional speckle tracking method. J Am Soc Echocardiogr (2007) 0.86

Monitoring impacts of air pollution: PIXE analysis and histopathological modalities in evaluating relative risks of elemental contamination. Ecotoxicology (2014) 0.86

Three-dimensional speckle-tracking imaging for left ventricular rotation measurement: an in vitro validation study. J Ultrasound Med (2010) 0.86

Aspirin and immune system. Int Immunopharmacol (2011) 0.85

Variation in antioxidant attributes at three ripening stages of guava (Psidium guajava L.) fruit from different geographical regions of Pakistan. Molecules (2012) 0.85

Regional strain determination and myocardial infarction detection by three-dimensional echocardiography with varied temporal resolution. Echocardiography (2014) 0.85

Artemisinins and immune system. Eur J Pharmacol (2011) 0.84

Preconditioning approach in stem cell therapy for the treatment of infarcted heart. Prog Mol Biol Transl Sci (2012) 0.84