Published in J Immunol on May 01, 2005
Pulmonary fibrosis: pathogenesis, etiology and regulation. Mucosal Immunol (2009) 3.13
IL-9 governs allergen-induced mast cell numbers in the lung and chronic remodeling of the airways. Am J Respir Crit Care Med (2010) 2.36
The tumor necrosis factor family member LIGHT is a target for asthmatic airway remodeling. Nat Med (2011) 2.12
Osteopontin has a crucial role in allergic airway disease through regulation of dendritic cell subsets. Nat Med (2007) 2.08
Regulatory T cells in asthma. Immunity (2009) 2.00
Allergen-induced peribronchial fibrosis and mucus production mediated by IkappaB kinase beta-dependent genes in airway epithelium. Proc Natl Acad Sci U S A (2005) 1.87
Immunologic and inflammatory mechanisms that drive asthma progression to remodeling. J Allergy Clin Immunol (2008) 1.71
Transforming growth factor-beta1 suppresses airway hyperresponsiveness in allergic airway disease. Am J Respir Crit Care Med (2007) 1.63
Airway smooth muscle in the pathophysiology and treatment of asthma. J Appl Physiol (1985) (2013) 1.56
CD4+CD25+ regulatory T cells reverse established allergic airway inflammation and prevent airway remodeling. J Allergy Clin Immunol (2008) 1.51
Resolvin D1 and aspirin-triggered resolvin D1 promote resolution of allergic airways responses. J Immunol (2012) 1.48
Anti-Siglec-F antibody reduces allergen-induced eosinophilic inflammation and airway remodeling. J Immunol (2009) 1.43
Dishing the dirt on asthma: What we can learn from poor hygiene. Biologics (2007) 1.40
Pin1 regulates TGF-beta1 production by activated human and murine eosinophils and contributes to allergic lung fibrosis. J Clin Invest (2008) 1.28
Eosinophils in the pathogenesis of allergic airways disease. Cell Mol Life Sci (2007) 1.26
c-Jun N-terminal kinase 1 is required for the development of pulmonary fibrosis. Am J Respir Cell Mol Biol (2008) 1.26
TGF-beta1 increases proliferation of airway smooth muscle cells by phosphorylation of map kinases. Respir Res (2006) 1.26
IL-25 drives remodelling in allergic airways disease induced by house dust mite. Thorax (2012) 1.26
Chronic OVA allergen challenged Siglec-F deficient mice have increased mucus, remodeling, and epithelial Siglec-F ligands which are up-regulated by IL-4 and IL-13. Respir Res (2010) 1.24
Chronic inflammation and asthma. Mutat Res (2009) 1.22
Th17 responses in chronic allergic airway inflammation abrogate regulatory T-cell-mediated tolerance and contribute to airway remodeling. Mucosal Immunol (2012) 1.22
Chronic respiratory aeroallergen exposure in mice induces epithelial-mesenchymal transition in the large airways. PLoS One (2011) 1.17
Human TH17 cells express a functional IL-13 receptor and IL-13 attenuates IL-17A production. J Allergy Clin Immunol (2011) 1.16
Expression and activation of TGF-beta isoforms in acute allergen-induced remodelling in asthma. Thorax (2007) 1.14
Overexpression of Smad2 drives house dust mite-mediated airway remodeling and airway hyperresponsiveness via activin and IL-25. Am J Respir Crit Care Med (2010) 1.14
PI3K gamma-deficient mice have reduced levels of allergen-induced eosinophilic inflammation and airway remodeling. Am J Physiol Lung Cell Mol Physiol (2008) 1.12
Integrin αvβ5-mediated TGF-β activation by airway smooth muscle cells in asthma. J Immunol (2011) 1.11
Mechanisms of induction of airway smooth muscle hyperplasia by transforming growth factor-beta. Am J Physiol Lung Cell Mol Physiol (2007) 1.09
CD4+ cells are required for chronic eosinophilic lung inflammation but not airway remodeling. Am J Physiol Lung Cell Mol Physiol (2008) 1.07
Tgf-Beta isoform specific regulation of airway inflammation and remodelling in a murine model of asthma. PLoS One (2010) 1.07
Pathophysiological features of asthma develop in parallel in house dust mite-exposed neonatal mice. Am J Respir Cell Mol Biol (2009) 1.06
Regulatory T cells and immune regulation of allergic diseases: roles of IL-10 and TGF-β. Genes Immun (2014) 1.05
Neutralization of TSLP inhibits airway remodeling in a murine model of allergic asthma induced by chronic exposure to house dust mite. PLoS One (2013) 1.04
ORMDL3 transgenic mice have increased airway remodeling and airway responsiveness characteristic of asthma. J Immunol (2014) 1.04
Tenascin-C deficiency attenuates TGF-ß-mediated fibrosis following murine lung injury. Am J Physiol Lung Cell Mol Physiol (2010) 1.03
Immunomodulation of allergic disease. Annu Rev Med (2009) 1.02
IL-33 induces IL-9 production in human CD4+ T cells and basophils. PLoS One (2011) 1.02
Airway smooth muscle hyperplasia and hypertrophy correlate with glycogen synthase kinase-3(beta) phosphorylation in a mouse model of asthma. Am J Physiol Lung Cell Mol Physiol (2008) 1.01
Bone morphogenetic protein (BMP)-4 and BMP-7 regulate differentially transforming growth factor (TGF)-beta1 in normal human lung fibroblasts (NHLF). Respir Res (2010) 1.01
Allergen-induced airway remodelling. Eur Respir J (2007) 0.98
Are mouse models of asthma appropriate for investigating the pathogenesis of airway hyper-responsiveness? Front Physiol (2012) 0.98
Systems biology approaches to understanding Epithelial Mesenchymal Transition (EMT) in mucosal remodeling and signaling in asthma. World Allergy Organ J (2014) 0.97
Attenuation of chronic pulmonary inflammation in A2B adenosine receptor knockout mice. Am J Respir Cell Mol Biol (2009) 0.97
Asthma and pulmonary arterial hypertension: do they share a key mechanism of pathogenesis? Eur Respir J (2010) 0.95
Controversy surrounding the increased expression of TGF beta 1 in asthma. Respir Res (2007) 0.92
Chronic OVA allergen challenged TNF p55/p75 receptor deficient mice have reduced airway remodeling. Int Immunopharmacol (2011) 0.90
Transforming growth factor-β-induced differentiation of airway smooth muscle cells is inhibited by fibroblast growth factor-2. Am J Respir Cell Mol Biol (2012) 0.90
Smad3-deficient mice have reduced esophageal fibrosis and angiogenesis in a model of egg-induced eosinophilic esophagitis. J Pediatr Gastroenterol Nutr (2014) 0.90
Recent advances in mechanisms and treatments of airway remodeling in asthma: a message from the bench side to the clinic. Korean J Intern Med (2011) 0.90
Airway epithelium interactions with aeroallergens: role of secreted cytokines and chemokines in innate immunity. Front Immunol (2015) 0.88
Toxoplasma gondii infection blocks the development of allergic airway inflammation in BALB/c mice. Clin Exp Immunol (2008) 0.88
Building better mouse models of asthma. Curr Allergy Asthma Rep (2007) 0.87
Eosinophils in fungus-associated allergic pulmonary disease. Front Pharmacol (2013) 0.87
In vivo disruption of TGF-beta signaling by Smad7 in airway epithelium alleviates allergic asthma but aggravates lung carcinogenesis in mouse. PLoS One (2010) 0.87
Lyn mitigates mouse airway remodeling by downregulating the TGF-β3 isoform in house dust mite models. J Immunol (2013) 0.86
Airway Remodeling in Chronic Obstructive Pulmonary Disease and Asthma: the Role of Matrix Metalloproteinase-9. Arch Immunol Ther Exp (Warsz) (2015) 0.86
Intestinal GUCY2C prevents TGF-β secretion coordinating desmoplasia and hyperproliferation in colorectal cancer. Cancer Res (2013) 0.86
Respiratory syncytial virus infection provokes airway remodelling in allergen-exposed mice in absence of prior allergen sensitization. Clin Exp Allergy (2008) 0.86
TGF-beta can leave you breathless. Curr Opin Pharmacol (2009) 0.85
HSP70/CD80 DNA vaccine inhibits airway remodeling by regulating the transcription factors T-bet and GATA-3 in a murine model of chronic asthma. Arch Med Sci (2013) 0.84
Epistatic interactions between Tgfb1 and genetic loci, Tgfbm2 and Tgfbm3, determine susceptibility to an asthmatic stimulus. Proc Natl Acad Sci U S A (2012) 0.84
Influenza promotes collagen deposition via αvβ6 integrin-mediated transforming growth factor β activation. J Biol Chem (2014) 0.83
Functional effects of TGF-β1 on mesenchymal stem cell mobilization in cockroach allergen-induced asthma. J Immunol (2014) 0.83
Allergen-induced coexpression of bFGF and TGF-β1 by macrophages in a mouse model of airway remodeling: bFGF induces macrophage TGF-β1 expression in vitro. Int Arch Allergy Immunol (2010) 0.83
Animal models of chronic experimental asthma - strategies for the identification of new therapeutic targets. J Occup Med Toxicol (2008) 0.83
Absence of c-Jun NH2-terminal kinase 1 protects against house dust mite-induced pulmonary remodeling but not airway hyperresponsiveness and inflammation. Am J Physiol Lung Cell Mol Physiol (2014) 0.82
Cigarette smoke exacerbates mouse allergic asthma through Smad proteins expressed in mast cells. Respir Res (2011) 0.82
Origin, Localization, and Immunoregulatory Properties of Pulmonary Phagocytes in Allergic Asthma. Front Immunol (2016) 0.82
Environmental tobacco smoke exposure does not prevent corticosteroids reducing inflammation, remodeling, and airway hyperreactivity in mice exposed to allergen. Am J Physiol Lung Cell Mol Physiol (2009) 0.81
Transforming Growth Factor-β: Master Regulator of the Respiratory System in Health and Disease. Am J Respir Cell Mol Biol (2016) 0.81
The immunoregulatory and fibrotic roles of activin A in allergic asthma. Clin Exp Allergy (2015) 0.80
Toll-like receptor-9 agonist inhibits airway inflammation, remodeling and hyperreactivity in mice exposed to chronic environmental tobacco smoke and allergen. Int Arch Allergy Immunol (2009) 0.80
Vehicular exhaust particles promote allergic airway inflammation through an aryl hydrocarbon receptor-notch signaling cascade. J Allergy Clin Immunol (2015) 0.80
A mast cell-ILC2-Th9 pathway promotes lung inflammation in cystic fibrosis. Nat Commun (2017) 0.79
The Chinese Herbal Medicine Formula Sheng-Fei-Yu-Chuan-Tang Suppresses Th2 Responses and Increases IFN γ in Dermatophagoides pteronyssinus Induced Chronic Asthmatic Mice. Evid Based Complement Alternat Med (2013) 0.79
Prolonged ovalbumin challenge facilitates Th17 polarization in sensitized mice. Inflamm Res (2010) 0.78
Airway hyperresponsiveness is associated with airway remodeling but not inflammation in aging Cav1-/- mice. Respir Res (2013) 0.78
ADAM metallopeptidase domain 33 (ADAM33): a promising target for asthma. Mediators Inflamm (2014) 0.78
Surfactant protein D attenuates sub-epithelial fibrosis in allergic airways disease through TGF-β. Respir Res (2014) 0.78
CTGF upregulation correlates with MMP-9 level in airway remodeling in a murine model of asthma. Arch Med Sci (2016) 0.77
Pulmonary Epithelial Cell-Derived Cytokine TGF-β1 Is a Critical Cofactor for Enhanced Innate Lymphoid Cell Function. Immunity (2015) 0.77
Aryl hydrocarbon receptor (AhR) modulates cockroach allergen-induced immune responses through active TGFβ1 release. Mediators Inflamm (2014) 0.76
The NR3C1 Glucocorticoid Receptor Gene Polymorphisms May Modulate the TGF-beta mRNA Expression in Asthma Patients. Inflammation (2015) 0.76
Genetic variants in TNFα, TGFB1, PTGS1 and PTGS2 genes are associated with diisocyanate-induced asthma. J Immunotoxicol (2015) 0.76
Immunization against TGF-β1 reduces collagen deposition but increases sustained inflammation in a murine asthma model. Hum Vaccin Immunother (2016) 0.75
γδT cells regulate chronic airway inflammation and development of airway remodelling. Clin Exp Allergy (2014) 0.75
Effect of tumor necrosis factor family member LIGHT (TNFSF14) on the activation of basophils and eosinophils interacting with bronchial epithelial cells. Mediators Inflamm (2014) 0.75
Heterozygous Vangl2(Looptail) mice reveal novel roles for the planar cell polarity pathway in adult lung homeostasis and repair. Dis Model Mech (2017) 0.75
Synthetic double-stranded RNA enhances airway inflammation and remodelling in a rat model of asthma. Immunology (2011) 0.75
The Biology of Eosinophils and Their Role in Asthma. Front Med (Lausanne) (2017) 0.75
A critical role for eosinophils in allergic airways remodeling. Science (2004) 5.53
Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4+CD25+ regulatory T cells is interleukin 10 dependent. J Exp Med (2005) 3.48
The Th17 pathway in cystic fibrosis lung disease. Am J Respir Crit Care Med (2011) 2.87
Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation. Nat Med (2008) 2.44
IL-9 governs allergen-induced mast cell numbers in the lung and chronic remodeling of the airways. Am J Respir Crit Care Med (2010) 2.36
Osteopontin has a crucial role in allergic airway disease through regulation of dendritic cell subsets. Nat Med (2007) 2.08
Activin A and TGF-β promote T(H)9 cell-mediated pulmonary allergic pathology. J Allergy Clin Immunol (2012) 1.98
Of flies, mice and men: a systematic approach to understanding the early life origins of chronic lung disease. Thorax (2012) 1.88
Orchestrating house dust mite-associated allergy in the lung. Trends Immunol (2011) 1.86
Peptide immunotherapy in allergic asthma generates IL-10-dependent immunological tolerance associated with linked epitope suppression. J Exp Med (2009) 1.73
Resolution of allergic inflammation and airway hyperreactivity is dependent upon disruption of the T1/ST2-IL-33 pathway. Am J Respir Crit Care Med (2009) 1.72
The absence of interleukin 9 does not affect the development of allergen-induced pulmonary inflammation nor airway hyperreactivity. J Exp Med (2002) 1.62
CD4+CD25+ regulatory T cells reverse established allergic airway inflammation and prevent airway remodeling. J Allergy Clin Immunol (2008) 1.51
Matrix metalloproteinase-9 deficiency results in enhanced allergen-induced airway inflammation. J Immunol (2004) 1.49
Pediatric severe asthma is characterized by eosinophilia and remodeling without T(H)2 cytokines. J Allergy Clin Immunol (2012) 1.45
IL-25 drives remodelling in allergic airways disease induced by house dust mite. Thorax (2012) 1.26
Chronic inflammation and asthma. Mutat Res (2009) 1.22
Phosphatidylethanolamine-esterified eicosanoids in the mouse: tissue localization and inflammation-dependent formation in Th-2 disease. J Biol Chem (2009) 1.18
CXCL4-induced migration of activated T lymphocytes is mediated by the chemokine receptor CXCR3. J Leukoc Biol (2008) 1.16
Resolution of allergic airway inflammation and airway hyperreactivity is mediated by IL-17-producing {gamma}{delta}T cells. Am J Respir Crit Care Med (2010) 1.15
Overexpression of Smad2 drives house dust mite-mediated airway remodeling and airway hyperresponsiveness via activin and IL-25. Am J Respir Crit Care Med (2010) 1.14
IL-33 promotes airway remodeling in pediatric patients with severe steroid-resistant asthma. J Allergy Clin Immunol (2013) 1.14
Th2-driven, allergen-induced airway inflammation is reduced after treatment with anti-Tim-3 antibody in vivo. J Exp Med (2007) 1.08
Activin and transforming growth factor-beta signaling pathways are activated after allergen challenge in mild asthma. J Allergy Clin Immunol (2009) 1.07
Pathophysiological features of asthma develop in parallel in house dust mite-exposed neonatal mice. Am J Respir Cell Mol Biol (2009) 1.06
Activin-A induces regulatory T cells that suppress T helper cell immune responses and protect from allergic airway disease. J Exp Med (2009) 1.06
CXCR2 mediates the recruitment of endothelial progenitor cells during allergic airways remodeling. Stem Cells (2009) 1.05
CC chemokine ligand 1 promotes recruitment of eosinophils but not Th2 cells during the development of allergic airways disease. J Immunol (2003) 1.04
Bone morphogenetic protein (BMP)-4 and BMP-7 regulate differentially transforming growth factor (TGF)-beta1 in normal human lung fibroblasts (NHLF). Respir Res (2010) 1.01
Osteopontin deficiency protects against airway remodeling and hyperresponsiveness in chronic asthma. Am J Respir Crit Care Med (2009) 1.01
CCR4 in human allergen-induced late responses in the skin and lung. Eur J Immunol (2002) 0.99
Nonredundant role of CCRL2 in lung dendritic cell trafficking. Blood (2010) 0.98
CCR4 blockade does not inhibit allergic airways inflammation. J Leukoc Biol (2003) 0.97
Asthma: T-bet--a master controller? Curr Biol (2002) 0.96
Alanine scanning mutagenesis of CCR3 reveals that the three intracellular loops are essential for functional receptor expression. Eur J Immunol (2002) 0.95
Basal expression of bone morphogenetic protein receptor is reduced in mild asthma. Am J Respir Crit Care Med (2008) 0.94
Regulation of adverse remodelling by osteopontin in a genetic heart failure model. Eur Heart J (2011) 0.92
Novel keto-phospholipids are generated by monocytes and macrophages, detected in cystic fibrosis, and activate peroxisome proliferator-activated receptor-γ. J Biol Chem (2012) 0.92
Distinct roles of TLR4 and CD14 in LPS-induced inflammatory responses of neonates. Pediatr Res (2009) 0.91
Adenoid-derived TH2 cells reactive to allergen and recall antigen express CC chemokine receptor 4. J Allergy Clin Immunol (2003) 0.88
Inflammatory chemokine expression in the peripheral blood of neonates with perinatal asphyxia and perinatal or nosocomial infections. Acta Paediatr (2005) 0.85
The carboxyl terminus of the chemokine receptor CCR3 contains distinct domains which regulate chemotactic signaling and receptor down-regulation in a ligand-dependent manner. Eur J Immunol (2005) 0.83
CXCR1+CD4+ T cells in human allergic disease. J Immunol (2004) 0.83
Eosinophils in the pathogenesis of paediatric severe asthma. Curr Opin Allergy Clin Immunol (2014) 0.82
Innate responsiveness of CD8 memory T-cell populations nonspecifically inhibits allergic sensitization. J Allergy Clin Immunol (2008) 0.81
Dust mites' dirty dealings in the lung. Nat Med (2009) 0.79
Osteopontin is increased in the bronchoalveolar lavage fluid and bronchial tissue of smoking asthmatics. Cytokine (2013) 0.79
Neurohormonal activity and vascular properties late after aortic coarctation repair. Int J Cardiol (2011) 0.78
Lung macrophages contribute to house dust mite driven airway remodeling via HIF-1α. PLoS One (2013) 0.78