Published in EMBO J on April 28, 2005
Human papillomavirus oncoproteins: pathways to transformation. Nat Rev Cancer (2010) 4.99
Fundamental differences in cell cycle deregulation in human papillomavirus-positive and human papillomavirus-negative head/neck and cervical cancers. Cancer Res (2007) 2.93
The human papillomavirus E7 oncoprotein. Virology (2008) 2.32
Human papillomaviruses activate the ATM DNA damage pathway for viral genome amplification upon differentiation. PLoS Pathog (2009) 2.21
Human papillomaviruses modulate expression of microRNA 203 upon epithelial differentiation to control levels of p63 proteins. J Virol (2010) 1.45
Molecular mechanisms of human papillomavirus-induced carcinogenesis. Public Health Genomics (2009) 1.45
The papillomavirus E7 proteins. Virology (2013) 1.28
Human papillomavirus E7 enhances hypoxia-inducible factor 1-mediated transcription by inhibiting binding of histone deacetylases. Cancer Res (2010) 1.23
Human cytomegalovirus UL29/28 protein interacts with components of the NuRD complex which promote accumulation of immediate-early RNA. PLoS Pathog (2010) 1.16
Combination of proteasome and HDAC inhibitors for uterine cervical cancer treatment. Clin Cancer Res (2009) 1.14
Regulation of human papillomavirus type 31 gene expression during the differentiation-dependent life cycle through histone modifications and transcription factor binding. Virology (2008) 1.10
The role of human papillomavirus in the pathogenesis of head & neck squamous cell carcinoma: an overview. Infect Agent Cancer (2011) 1.04
Small molecule inhibitors of human papillomavirus protein - protein interactions. Open Virol J (2011) 0.97
Histone deacetylases in viral infections. Clin Epigenetics (2010) 0.93
Towards incorporating epigenetic mechanisms into carcinogen identification and evaluation. Carcinogenesis (2013) 0.92
Recurrent respiratory papillomatosis. Otolaryngol Clin North Am (2012) 0.92
Human papillomaviruses and the interferon response. J Interferon Cytokine Res (2009) 0.91
The E7 open reading frame acts in cis and in trans to mediate differentiation-dependent activities in the human papillomavirus type 16 life cycle. J Virol (2011) 0.90
Manipulation of cellular DNA damage repair machinery facilitates propagation of human papillomaviruses. Semin Cancer Biol (2014) 0.90
Epigenetic mechanisms in virus-induced tumorigenesis. Clin Epigenetics (2011) 0.88
Regulation of the life cycle of HPVs by differentiation and the DNA damage response. Future Microbiol (2013) 0.87
Functional mapping of the human papillomavirus type 16 E1 cistron. J Virol (2008) 0.86
Multistep model of cervical cancer: participation of miRNAs and coding genes. Int J Mol Sci (2014) 0.84
Combined effects of E2F1 and E2F2 polymorphisms on risk and early onset of squamous cell carcinoma of the head and neck. Mol Carcinog (2012) 0.84
The Deacetylase Sirtuin 1 Regulates Human Papillomavirus Replication by Modulating Histone Acetylation and Recruitment of DNA Damage Factors NBS1 and Rad51 to Viral Genomes. PLoS Pathog (2015) 0.82
The Rb binding domain of HPV31 E7 is required to maintain high levels of DNA repair factors in infected cells. Virology (2016) 0.79
Recent advances in the search for antiviral agents against human papillomaviruses. Antivir Ther (2007) 0.79
Disrupted ectodermal organ morphogenesis in mice with a conditional histone deacetylase 1, 2 deletion in the epidermis. J Invest Dermatol (2013) 0.78
The human papillomavirus E7 oncoprotein as a regulator of transcription. Virus Res (2016) 0.76
Impact of the DNA Damage Response on Human Papillomavirus Chromatin. PLoS Pathog (2016) 0.76
DNA damage response is hijacked by human papillomaviruses to complete their life cycle. J Zhejiang Univ Sci B (2017) 0.75
Manipulation of the innate immune response by human papillomaviruses. Virus Res (2016) 0.75
Role of WDHD1 in Human Papillomavirus-Mediated Oncogenesis Identified by Transcriptional Profiling of E7-Expressing Cells. J Virol (2016) 0.75
LSD1 binds to HPV16 E7 and promotes the epithelial-mesenchymal transition in cervical cancer by demethylating histones at the Vimentin promoter. Oncotarget (2016) 0.75
Epigenetic Alterations in Human Papillomavirus-Associated Cancers. Viruses (2017) 0.75
Mechanisms by which HPV Induces a Replication Competent Environment in Differentiating Keratinocytes. Viruses (2017) 0.75
Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol (1999) 40.46
The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science (1989) 16.54
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell (2003) 11.40
Histone deacetylases (HDACs): characterization of the classical HDAC family. Biochem J (2003) 11.27
E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints. Genes Dev (2002) 10.06
The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes. J Virol (1989) 8.68
Histone deacetylase activity is required for full transcriptional repression by mSin3A. Cell (1997) 6.27
Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression. Genes Dev (2000) 6.07
The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3. Mol Cell Biol (2001) 4.92
The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells. J Virol (1991) 4.18
A point mutational analysis of human papillomavirus type 16 E7 protein. J Virol (1989) 3.00
Differentiation-induced and constitutive transcription of human papillomavirus type 31b in cell lines containing viral episomes. J Virol (1992) 2.99
Mre11 complex and DNA replication: linkage to E2F and sites of DNA synthesis. Mol Cell Biol (2001) 2.85
Differentiation-dependent up-regulation of the human papillomavirus E7 gene reactivates cellular DNA replication in suprabasal differentiated keratinocytes. Genes Dev (1995) 2.76
The E7 oncoprotein associates with Mi2 and histone deacetylase activity to promote cell growth. EMBO J (1999) 2.23
Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics. Genes Dev (2004) 1.97
E2F family members are differentially regulated by reversible acetylation. J Biol Chem (2000) 1.77
Human papillomavirus DNA replication compartments in a transient DNA replication system. J Virol (1999) 1.76
Destabilization of the retinoblastoma tumor suppressor by human papillomavirus type 16 E7 is not sufficient to overcome cell cycle arrest in human keratinocytes. J Virol (2001) 1.66
Human papillomavirus type 31 E5 protein supports cell cycle progression and activates late viral functions upon epithelial differentiation. J Virol (2003) 1.62
Inactivation of interferon regulatory factor-1 tumor suppressor protein by HPV E7 oncoprotein. Implication for the E7-mediated immune evasion mechanism in cervical carcinogenesis. J Biol Chem (2000) 1.52
The binding of histone deacetylases and the integrity of zinc finger-like motifs of the E7 protein are essential for the life cycle of human papillomavirus type 31. J Virol (2004) 1.43
Human papillomavirus 16 E7 protein is associated with the nuclear matrix. Proc Natl Acad Sci U S A (1991) 1.35
Human papillomavirus oncoproteins alter differentiation-dependent cell cycle exit on suspension in semisolid medium. Virology (1998) 1.30
The development of diabetes in E2f1/E2f2 mutant mice reveals important roles for bone marrow-derived cells in preventing islet cell loss. Proc Natl Acad Sci U S A (2003) 1.27
Functional studies of E7 proteins from different HPV types. Oncogene (1994) 1.22
Human papillomavirus type 31 life cycle: methods for study using tissue culture models. Methods Mol Biol (2005) 1.03
The Rb-family protein p107 inhibits translation by a PDK1-dependent mechanism. Oncogene (2002) 0.85
E2F3-a novel repressor of the ARF/p53 pathway. Dev Cell (2004) 0.81
Human papillomavirus oncoproteins: pathways to transformation. Nat Rev Cancer (2010) 4.99
Pathogenesis of human papillomaviruses in differentiating epithelia. Microbiol Mol Biol Rev (2004) 3.52
SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis. Antimicrob Agents Chemother (2012) 2.41
Human papillomaviruses: basic mechanisms of pathogenesis and oncogenicity. Rev Med Virol (2006) 2.22
Human papillomaviruses activate the ATM DNA damage pathway for viral genome amplification upon differentiation. PLoS Pathog (2009) 2.21
Persistence of human papillomavirus infection: keys to malignant progression. Trends Microbiol (2010) 1.96
Human papillomavirus type 31 E5 protein supports cell cycle progression and activates late viral functions upon epithelial differentiation. J Virol (2003) 1.62
Human papillomaviruses: targeting differentiating epithelial cells for malignant transformation. Oncogene (2003) 1.59
Amino acid substitutions that specifically impair the transcriptional activity of papillomavirus E2 affect binding to the long isoform of Brd4. Virology (2006) 1.47
Human papillomaviruses modulate expression of microRNA 203 upon epithelial differentiation to control levels of p63 proteins. J Virol (2010) 1.45
The binding of histone deacetylases and the integrity of zinc finger-like motifs of the E7 protein are essential for the life cycle of human papillomavirus type 31. J Virol (2004) 1.43
Human papillomaviruses recruit cellular DNA repair and homologous recombination factors to viral replication centers. J Virol (2012) 1.37
Role of the PDZ domain-binding motif of the oncoprotein E6 in the pathogenesis of human papillomavirus type 31. J Virol (2004) 1.35
Human papillomaviruses activate caspases upon epithelial differentiation to induce viral genome amplification. Proc Natl Acad Sci U S A (2007) 1.33
Nuclear accumulation of the papillomavirus E1 helicase blocks S-phase progression and triggers an ATM-dependent DNA damage response. J Virol (2011) 1.33
Human papillomavirus genotype 31 does not express detectable microRNA levels during latent or productive virus replication. J Virol (2006) 1.27
Human papillomavirus type 31 replication modes during the early phases of the viral life cycle depend on transcriptional and posttranscriptional regulation of E1 and E2 expression. J Virol (2002) 1.23
Human papillomavirus E7 enhances hypoxia-inducible factor 1-mediated transcription by inhibiting binding of histone deacetylases. Cancer Res (2010) 1.23
Hypoxia-specific stabilization of HIF-1alpha by human papillomaviruses. Virology (2009) 1.18
Differentiation of HPV-containing cells using organotypic "raft" culture or methylcellulose. Methods Mol Med (2005) 1.17
Human papillomaviruses target the double-stranded RNA protein kinase pathway. J Gen Virol (2006) 1.16
Role of the E1--E4 protein in the differentiation-dependent life cycle of human papillomavirus type 31. J Virol (2005) 1.16
Roles of the E6 and E7 proteins in the life cycle of low-risk human papillomavirus type 11. J Virol (2004) 1.11
Regulation of human papillomavirus type 31 gene expression during the differentiation-dependent life cycle through histone modifications and transcription factor binding. Virology (2008) 1.10
Human papillomaviruses modulate microRNA 145 expression to directly control genome amplification. J Virol (2013) 1.09
Mechanisms regulating expression of the HPV 31 L1 and L2 capsid proteins and pseudovirion entry. Virol J (2007) 1.08
Induction of the human papillomavirus type 31 late promoter requires differentiation but not DNA amplification. J Virol (2005) 1.06
The role of human papillomaviruses in oncogenesis. Recent Results Cancer Res (2014) 1.06
Human papillomavirus E1 helicase interacts with the WD repeat protein p80 to promote maintenance of the viral genome in keratinocytes. J Virol (2007) 1.04
Human papillomavirus type 31 life cycle: methods for study using tissue culture models. Methods Mol Biol (2005) 1.03
Long-term effect of interferon on keratinocytes that maintain human papillomavirus type 31. J Virol (2002) 1.02
The fanconi anemia pathway limits human papillomavirus replication. J Virol (2012) 1.01
The full-length E1E4 protein of human papillomavirus type 18 modulates differentiation-dependent viral DNA amplification and late gene expression. Virology (2007) 1.01
Bap31 is a novel target of the human papillomavirus E5 protein. J Virol (2008) 1.00
Suppression of STAT-1 expression by human papillomaviruses is necessary for differentiation-dependent genome amplification and plasmid maintenance. J Virol (2011) 0.99
Nuclear export of human papillomavirus type 31 E1 is regulated by Cdk2 phosphorylation and required for viral genome maintenance. J Virol (2010) 0.98
p63 is necessary for the activation of human papillomavirus late viral functions upon epithelial differentiation. J Virol (2011) 0.96
Human papillomavirus E6 proteins mediate resistance to interferon-induced growth arrest through inhibition of p53 acetylation. J Virol (2007) 0.95
The JAK-STAT transcriptional regulator, STAT-5, activates the ATM DNA damage pathway to induce HPV 31 genome amplification upon epithelial differentiation. PLoS Pathog (2013) 0.95
An interaction between human papillomavirus 16 E2 and TopBP1 is required for optimum viral DNA replication and episomal genome establishment. J Virol (2012) 0.91
The E7 open reading frame acts in cis and in trans to mediate differentiation-dependent activities in the human papillomavirus type 16 life cycle. J Virol (2011) 0.90
Regulation of the life cycle of HPVs by differentiation and the DNA damage response. Future Microbiol (2013) 0.87
Analysis of the roles of E6 binding to E6TP1 and nuclear localization in the human papillomavirus type 31 life cycle. Virology (2006) 0.84
Viral transformation of epithelial cells. Methods Mol Biol (2013) 0.75