Published in J Biol Chem on April 14, 2000
Acetylation: a regulatory modification to rival phosphorylation? EMBO J (2000) 7.35
Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB. EMBO J (2002) 4.91
Regulation of transcription factor YY1 by acetylation and deacetylation. Mol Cell Biol (2001) 2.72
E2F-dependent histone acetylation and recruitment of the Tip60 acetyltransferase complex to chromatin in late G1. Mol Cell Biol (2004) 1.85
Nonhistone protein acetylation as cancer therapy targets. Expert Rev Anticancer Ther (2010) 1.45
Acetylation of HIV-1 integrase by p300 regulates viral integration. EMBO J (2005) 1.39
Histone deacetylase inhibitors (HDACIs): multitargeted anticancer agents. Biologics (2013) 1.38
Acetylation by GCN5 regulates CDC6 phosphorylation in the S phase of the cell cycle. Nat Struct Mol Biol (2009) 1.36
Functional relevance of novel p300-mediated lysine 314 and 315 acetylation of RelA/p65. Nucleic Acids Res (2008) 1.32
Putting the 'HAT' back on survival signalling: the promises and challenges of HDAC inhibition in the treatment of neurological conditions. Expert Opin Investig Drugs (2009) 1.28
P/CAF-mediated acetylation regulates the function of the basic helix-loop-helix transcription factor TAL1/SCL. EMBO J (2000) 1.25
Inhibitors of histone deacetylase (HDAC) restore the p53 pathway in neuroblastoma cells. Br J Pharmacol (2007) 1.23
Apoptotic sensitivity of colon cancer cells to histone deacetylase inhibitors is mediated by an Sp1/Sp3-activated transcriptional program involving immediate-early gene induction. Cancer Res (2010) 1.22
The role of histone deacetylases in prostate cancer. Epigenetics (2008) 1.21
HPV31 E7 facilitates replication by activating E2F2 transcription through its interaction with HDACs. EMBO J (2005) 1.21
p300 (histone acetyltransferase) biomarker predicts prostate cancer biochemical recurrence and correlates with changes in epithelia nuclear size and shape. Prostate (2008) 1.19
Acetylation of the human DNA glycosylase NEIL2 and inhibition of its activity. Nucleic Acids Res (2004) 1.15
Generation of acetyllysine antibodies and affinity enrichment of acetylated peptides. Nat Protoc (2010) 1.13
Tripartite motif containing 28 (Trim28) can regulate cell proliferation by bridging HDAC1/E2F interactions. J Biol Chem (2012) 1.06
Modulation of antigen-presenting cells by HDAC inhibitors: implications in autoimmunity and cancer. Immunol Cell Biol (2011) 1.05
Exploring the yeast acetylome using functional genomics. Cell (2012) 1.05
DNA damage signals through differentially modified E2F1 molecules to induce apoptosis. Mol Cell Biol (2011) 1.03
Expression profile of histone deacetylases 1, 2 and 3 in ovarian cancer tissues. J Gynecol Oncol (2008) 0.99
Polydactyly in mice lacking HDAC9/HDRP. Exp Biol Med (Maywood) (2008) 0.99
Small molecule regulators of Rb-E2F pathway as modulators of transcription. Biochim Biophys Acta (2010) 0.97
Class IIA HDACs in the regulation of neurodegeneration. Front Biosci (2008) 0.94
GCN5-dependent acetylation of HIV-1 integrase enhances viral integration. Retrovirology (2010) 0.93
The functional genomic response of developing embryonic submandibular glands to NF-kappa B inhibition. BMC Dev Biol (2001) 0.93
Dual targeting of histone deacetylase and topoisomerase II with novel bifunctional inhibitors. J Med Chem (2012) 0.93
Histone deacetylases in viral infections. Clin Epigenetics (2010) 0.93
E2F1 coregulates cell cycle genes and chromatin components during the transition of oligodendrocyte progenitors from proliferation to differentiation. J Neurosci (2014) 0.92
Adeno-associated virus type 2 rep protein inhibits human papillomavirus type 16 E2 recruitment of the transcriptional coactivator p300. J Virol (2000) 0.90
Selectively targeting prostate cancer with antiandrogen equipped histone deacetylase inhibitors. ACS Chem Biol (2013) 0.90
Structure and mechanism of non-histone protein acetyltransferase enzymes. FEBS J (2013) 0.90
Investigation of the expression patterns and correlation of DNA methyltransferases and class I histone deacetylases in ovarian cancer tissues. Oncol Lett (2012) 0.88
Epigenetics and autosomal dominant polycystic kidney disease. Biochim Biophys Acta (2010) 0.88
Increased acetylation in the DNA-binding domain of TR4 nuclear receptor by the coregulator ARA55 leads to suppression of TR4 transactivation. J Biol Chem (2011) 0.87
Modulation of cell cycle regulators by HDACs. Front Biosci (Schol Ed) (2012) 0.86
Interaction of the retinoblastoma protein with Orc1 and its recruitment to human origins of DNA replication. PLoS One (2010) 0.86
A novel role for histone deacetylase 6 in the regulation of the tolerogenic STAT3/IL-10 pathway in APCs. J Immunol (2014) 0.86
Gatekeepers of chromatin: Small metabolites elicit big changes in gene expression. Trends Biochem Sci (2012) 0.83
E2F1 responds to ultraviolet radiation by directly stimulating DNA repair and suppressing carcinogenesis. Cancer Res (2014) 0.83
The promise and perils of HDAC inhibitors in neurodegeneration. Ann Clin Transl Neurol (2014) 0.81
Preclinical studies on histone deacetylase inhibitors as therapeutic reagents for endometrial and ovarian cancers. Future Oncol (2011) 0.81
Prediction of human protein-protein interaction by a mixed Bayesian model and its application to exploring underlying cancer-related pathway crosstalk. J R Soc Interface (2010) 0.81
The adenovirus E4-6/7 protein directs nuclear localization of E2F-4 via an arginine-rich motif. J Virol (2005) 0.81
Mechanisms of Histone Deacetylase Inhibitor-Regulated Gene Expression in Cancer Cells. Antioxid Redox Signal (2014) 0.80
The nuclear protein ALY binds to and modulates the activity of transcription factor E2F2. Mol Cell Proteomics (2013) 0.80
Epigenetics in NG2 glia cells. Brain Res (2015) 0.79
Two independent regions of simian virus 40 T antigen increase CBP/p300 levels, alter patterns of cellular histone acetylation, and immortalize primary cells. J Virol (2013) 0.79
Histone and Non-Histone Targets of Dietary Deacetylase Inhibitors. Curr Top Med Chem (2016) 0.77
Dual-acting histone deacetylase-topoisomerase I inhibitors. Bioorg Med Chem Lett (2013) 0.76
HDAC Inhibitors as Epigenetic Regulators of the Immune System: Impacts on Cancer Therapy and Inflammatory Diseases. Biomed Res Int (2016) 0.75
Dual Inhibitors Against Topoisomerases and Histone Deacetylases. J Cancer Prev (2015) 0.75
Post-translational Serine/Threonine Phosphorylation and Lysine Acetylation: A Novel Regulatory Aspect of the Global Nitrogen Response Regulator GlnR in S. coelicolor M145. Front Mol Biosci (2016) 0.75
E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis. Genes Dev (2001) 6.13
Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein. Genes Dev (1993) 5.54
A primary genetic map of markers of human chromosome 10. Genomics (1988) 4.23
The retinoblastoma protein binds to a family of E2F transcription factors. Mol Cell Biol (1993) 3.75
Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats. Nature (1991) 3.74
In vitro differentiation of endothelial cells from AC133-positive progenitor cells. Blood (2000) 3.57
A novel procedure for quantitative polymerase chain reaction by coamplification of competitive templates. Gene (1992) 3.48
Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures. Nature (1997) 3.16
Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization. EMBO J (1999) 3.05
Cyclin E-induced S phase without activation of the pRb/E2F pathway. Genes Dev (1997) 3.02
Internalization of HIV-1 tat requires cell surface heparan sulfate proteoglycans. J Biol Chem (2000) 2.98
Apaf-1 is a transcriptional target for E2F and p53. Nat Cell Biol (2001) 2.96
Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression. Nat Med (1997) 2.88
CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase. Mol Cell Biol (1999) 2.84
Start sites of bidirectional DNA synthesis at the human lamin B2 origin. Science (2000) 2.72
Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1. Genes Dev (2000) 2.58
Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site. Proc Natl Acad Sci U S A (1995) 2.48
Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression. Mol Cell Biol (1996) 2.44
The E2F transcription factors: key regulators of cell proliferation. Biochim Biophys Acta (2000) 2.34
Induction of S-phase entry by E2F transcription factors depends on their nuclear localization. Mol Cell Biol (1997) 2.27
Redefined nomenclature for members of the carcinoembryonic antigen family. Exp Cell Res (1999) 2.25
Characterization of the retinoblastoma binding proteins RBP1 and RBP2. Oncogene (1993) 2.20
Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint. EMBO J (2001) 2.13
HIV-1 tat transactivator recruits p300 and CREB-binding protein histone acetyltransferases to the viral promoter. Proc Natl Acad Sci U S A (1998) 2.12
E2F-6: a novel member of the E2F family is an inhibitor of E2F-dependent transcription. Oncogene (1998) 2.12
Cell cycle-regulated expression of mammalian CDC6 is dependent on E2F. Mol Cell Biol (1998) 2.07
Overexpression of the death-promoting gene bax-alpha which is downregulated in breast cancer restores sensitivity to different apoptotic stimuli and reduces tumor growth in SCID mice. J Clin Invest (1996) 2.00
The transport by hepatocytes of immunoglobulin A from blood to bile visualized by autoradiography and electron microscopy. Immunology (1979) 1.86
Transcriptional interference perturbs the binding of Sp1 to the HIV-1 promoter. Nucleic Acids Res (1998) 1.86
Absolute quantitation of viremia in human immunodeficiency virus infection by competitive reverse transcription and polymerase chain reaction. J Clin Microbiol (1992) 1.85
Molecular profile of human immunodeficiency virus type 1 infection in symptomless patients and in patients with AIDS. J Virol (1992) 1.80
Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1. J Virol (1993) 1.78
Specific detection of carcinoembryonic antigen-expressing tumor cells in bone marrow aspirates by polymerase chain reaction. J Clin Oncol (1994) 1.78
Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes. Mol Cell Biol (1993) 1.75
A human binding site for transcription factor USF/MLTF mimics the negative regulatory element of human immunodeficiency virus type 1. Virology (1992) 1.72
Familial dilated cardiomyopathy: evidence for genetic and phenotypic heterogeneity. Heart Muscle Disease Study Group. J Am Coll Cardiol (1999) 1.71
The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein. Mol Cell Biol (1998) 1.69
The gene for a novel human lamin maps at a highly transcribed locus of chromosome 19 which replicates at the onset of S-phase. Mol Cell Biol (1992) 1.66
Selective induction of mitochondrial chaperones in response to loss of the mitochondrial genome. Eur J Biochem (1996) 1.66
Biliary glycoprotein, a potential human cell adhesion molecule, is down-regulated in colorectal carcinomas. Proc Natl Acad Sci U S A (1993) 1.64
CEA-related cell adhesion molecule 1: a potent angiogenic factor and a major effector of vascular endothelial growth factor. Mol Cell (2000) 1.63
Induction of DNA synthesis and apoptosis are separable functions of E2F-1. Genes Dev (1997) 1.59
CD66a (BGP), an adhesion molecule of the carcinoembryonic antigen family, is expressed in epithelium, endothelium, and myeloid cells in a wide range of normal human tissues. J Histochem Cytochem (1996) 1.59
Nested polymerase chain reaction for high-sensitivity detection of enteroviral RNA in biological samples. J Clin Microbiol (1993) 1.48
Methods for detection of point mutations: performance and quality assessment. IFCC Scientific Division, Committee on Molecular Biology Techniques. Clin Chem (1997) 1.46
High-resolution mapping of the origin of DNA replication in the hamster dihydrofolate reductase gene domain by competitive PCR. Mol Cell Biol (1996) 1.44
Specificity of reverse transcriptase polymerase chain reaction assays designed for the detection of circulating cancer cells is influenced by cytokines in vivo and in vitro. Br J Cancer (1998) 1.42
In vivo footprinting analysis of constitutive and inducible protein-DNA interactions at the long terminal repeat of human immunodeficiency virus type 1. J Virol (1993) 1.39
Immunocytological detection of micrometastatic cells: comparative evaluation of findings in the peritoneal cavity and the bone marrow of gastric, colorectal and pancreatic cancer patients. Int J Cancer (1994) 1.39
p27KIP1 blocks cyclin E-dependent transactivation of cyclin A gene expression. Mol Cell Biol (1997) 1.37
Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator. IUBMB Life (2001) 1.37
Cell cycle modulation of protein-DNA interactions at a human replication origin. EMBO J (1998) 1.32
Interaction of HIV-1 Tat protein with heparin. Role of the backbone structure, sulfation, and size. J Biol Chem (1997) 1.32
Molecular cloning of a cDNA coding biliary glycoprotein I: primary structure of a glycoprotein immunologically crossreactive with carcinoembryonic antigen. Proc Natl Acad Sci U S A (1988) 1.32
Expression of the bcl-2 gene family in normal and malignant breast tissue: low bax-alpha expression in tumor cells correlates with resistance towards apoptosis. Int J Cancer (1995) 1.31
Dystrophin gene abnormalities in two patients with idiopathic dilated cardiomyopathy. Heart (1997) 1.30
Involvement of cellular double-stranded DNA break binding proteins in processing of the recombinant adeno-associated virus genome. J Virol (2001) 1.29
Binding of Escherichia coli and Salmonella strains to members of the carcinoembryonic antigen family: differential binding inhibition by aromatic alpha-glycosides of mannose. Infect Immun (1991) 1.28
Association of pp60c-src with biliary glycoprotein (CD66a), an adhesion molecule of the carcinoembryonic antigen family downregulated in colorectal carcinomas. Oncogene (1995) 1.28
In vivo protein-DNA interactions at human DNA replication origin. Proc Natl Acad Sci U S A (1996) 1.27
Detection of human immunodeficiency virus type 1 genomic RNA in plasma samples by reverse-transcription polymerase chain reaction. J Med Virol (1991) 1.26
C-C chemokines released by lipopolysaccharide (LPS)-stimulated human macrophages suppress HIV-1 infection in both macrophages and T cells. J Exp Med (1997) 1.24
APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death. J Cell Biol (2001) 1.24
Time course of complement activation and inhibitor expression after ischemic injury of rat myocardium. Am J Pathol (1994) 1.24
Detection of micrometastasis by cytokeratin 20 RT-PCR is limited due to stable background transcription in granulocytes. Br J Cancer (1999) 1.24
G1/S-regulated E2F-containing protein complexes bind to the mouse thymidine kinase gene promoter. J Biol Chem (1994) 1.23
Regulation of stem cell differentiation by histone methyltransferases and demethylases. Cold Spring Harb Symp Quant Biol (2008) 1.22
A point mutation in the 5' splice site of the dystrophin gene first intron responsible for X-linked dilated cardiomyopathy. Hum Mol Genet (1996) 1.21
Adeno-associated viral vector-mediated human vascular endothelial growth factor gene transfer stimulates angiogenesis and wound healing in the genetically diabetic mouse. Diabetologia (2003) 1.21
Dynamics of viral replication in infants with vertically acquired human immunodeficiency virus type 1 infection. J Clin Invest (1996) 1.20
A radioautographic study of the hepatic uptake of circulating carcinoembryonic antigen by the mouse. Biochem Soc Trans (1977) 1.20
E2F-1-induced p53-independent apoptosis in transgenic mice. Oncogene (1998) 1.20
A new locus for arrhythmogenic right ventricular dysplasia on the long arm of chromosome 14. Genomics (1996) 1.20
A human DNA replication origin: localization and transcriptional characterization. Chromosoma (1992) 1.19
Measuring c-erbB-2 oncogene amplification in fresh and paraffin-embedded tumors by competitive polymerase chain reaction. Clin Chem (1994) 1.16
Expression of CD66a (human C-CAM) and other members of the carcinoembryonic antigen gene family of adhesion molecules in human colorectal adenomas. Cancer Res (1997) 1.15
Replication origins of mammalian chromosomes: the happy few. Front Biosci (1999) 1.13
Multiple interactions of HIV-I Tat protein with size-defined heparin oligosaccharides. J Biol Chem (1999) 1.13
Epidemic free-base cocaine abuse. Case study from the Bahamas. Lancet (1986) 1.12
DcE2F, a functional plant E2F-like transcriptional activator from Daucus carota. J Biol Chem (2000) 1.12
High-throughput DNA sequencing on a capillary array electrophoresis system. J Capillary Electrophor (1998) 1.12
Long-term VEGF-A expression promotes aberrant angiogenesis and fibrosis in skeletal muscle. Gene Ther (2011) 1.12
Differential expression of CD66a (BGP), a cell adhesion molecule of the carcinoembryonic antigen family, in benign, premalignant, and malignant lesions of the human mammary gland. J Histochem Cytochem (1997) 1.11
Inhibition of in vitro myogenic differentiation by cellular transcription factor E2F1. Cell Growth Differ (1995) 1.11
Visualization of in vivo direct interaction between HIV-1 TAT and human cyclin T1 in specific subcellular compartments by fluorescence resonance energy transfer. J Biol Chem (2001) 1.10
Activation of transcription factor NF-kappaB by the Tat protein of human immunodeficiency virus type 1. J Virol (1996) 1.10
E2F-HDAC complexes negatively regulate the tumor suppressor gene ARHI in breast cancer. Oncogene (2006) 1.09
Deaths among humanitarian workers. BMJ (2000) 1.09
Linkage of familial dilated cardiomyopathy to chromosome 9. Heart Muscle Disease Study Group. Am J Hum Genet (1995) 1.09
The H3K27me3 demethylase, KDM6B, is induced by Epstein-Barr virus and over-expressed in Hodgkin's Lymphoma. Oncogene (2011) 1.09
Diagnosis of micrometastases by the amplification of tissue-specific genes. Gene (1995) 1.09
Expression of biliary glycoprotein (CD66a) in normal and malignant breast epithelial cells. Anticancer Res (1998) 1.07
Characterization of human DNA sequences synthesized at the onset of S-phase. Nucleic Acids Res (1987) 1.07