Published in Org Biomol Chem on April 18, 2005
A protocol for generating a high-quality genome-scale metabolic reconstruction. Nat Protoc (2010) 6.64
A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology. Nat Biotechnol (2008) 4.55
Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases. BMC Med Genomics (2009) 2.36
Towards a genome-scale kinetic model of cellular metabolism. BMC Syst Biol (2010) 1.34
Userscripts for the life sciences. BMC Bioinformatics (2007) 1.29
Chemistry in bioinformatics. BMC Bioinformatics (2005) 1.18
Basic primitives for molecular diagram sketching. J Cheminform (2010) 1.08
Linking the Resource Description Framework to cheminformatics and proteochemometrics. J Biomed Semantics (2011) 1.01
MEMOSys: Bioinformatics platform for genome-scale metabolic models. BMC Syst Biol (2011) 0.93
Can Invalid Bioactives Undermine Natural Product-Based Drug Discovery? J Med Chem (2015) 0.93
An analysis of a 'community-driven' reconstruction of the human metabolic network. Metabolomics (2013) 0.90
Functional group and substructure searching as a tool in metabolomics. PLoS One (2008) 0.89
Cheminformatics and the Semantic Web: adding value with linked data and enhanced provenance. Wiley Interdiscip Rev Comput Mol Sci (2013) 0.84
Reconstruction and validation of RefRec: a global model for the yeast molecular interaction network. PLoS One (2010) 0.81
The metabolome 18 years on: a concept comes of age. Metabolomics (2016) 0.79
New concepts for building vocabulary for cell image ontologies. BMC Bioinformatics (2011) 0.79
Applications of the InChI in cheminformatics with the CDK and Bioclipse. J Cheminform (2013) 0.76
Many InChIs and quite some feat. J Comput Aided Mol Des (2015) 0.75
Prediction-driven matched molecular pairs to interpret QSARs and aid the molecular optimization process. J Cheminform (2014) 0.75
Current Challenges in Development of a Database of Three-Dimensional Chemical Structures. Front Bioeng Biotechnol (2015) 0.75
A draft sequence of the rice genome (Oryza sativa L. ssp. indica). Science (2002) 42.78
Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting. Nucleic Acids Res (2011) 16.53
FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription. Cell (2008) 14.18
Bis[bis(methoxycarbimido)amine-kappa2N,N']bis(perchlorato-kappaO)copper(II) bis[bis(methoxycarbimido)amine-kappa2N,N']bis(methanol-kappaO)copper(II) bis(perchlorate) methanol disolvate. Acta Crystallogr C (2006) 14.17
WEGO: a web tool for plotting GO annotations. Nucleic Acids Res (2006) 13.06
Sequencing of 50 human exomes reveals adaptation to high altitude. Science (2010) 11.27
The BioPAX community standard for pathway data sharing. Nat Biotechnol (2010) 9.19
The genome of the cucumber, Cucumis sativus L. Nat Genet (2009) 8.19
An abundance of rare functional variants in 202 drug target genes sequenced in 14,002 people. Science (2012) 7.94
The Genomes of Oryza sativa: a history of duplications. PLoS Biol (2005) 7.67
Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer. Cell (2009) 7.09
A draft sequence for the genome of the domesticated silkworm (Bombyx mori). Science (2004) 6.62
Epidemiological serosurvey of hepatitis B in China--declining HBV prevalence due to hepatitis B vaccination. Vaccine (2009) 6.30
Nucleosome dynamics define transcriptional enhancers. Nat Genet (2010) 5.94
CPC: assess the protein-coding potential of transcripts using sequence features and support vector machine. Nucleic Acids Res (2007) 5.88
Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling. Nat Cell Biol (2002) 5.37
The oyster genome reveals stress adaptation and complexity of shell formation. Nature (2012) 5.30
A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms. Nature (2004) 5.24
The Blue Obelisk-interoperability in chemical informatics. J Chem Inf Model (2006) 4.88
PPARgamma and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale. Genes Dev (2008) 4.83
A mammalian organelle map by protein correlation profiling. Cell (2006) 4.54
RePS: a sequence assembler that masks exact repeats identified from the shotgun data. Genome Res (2002) 4.35
Cistrome: an integrative platform for transcriptional regulation studies. Genome Biol (2011) 4.13
Formation of ArF from LPdAr(F): catalytic conversion of aryl triflates to aryl fluorides. Science (2009) 4.13
Production of offspring from a germline stem cell line derived from neonatal ovaries. Nat Cell Biol (2009) 4.11
A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases. Cancer Cell (2010) 4.02
An emerging recombinant human enterovirus 71 responsible for the 2008 outbreak of hand foot and mouth disease in Fuyang city of China. Virol J (2010) 3.90
Identifying ChIP-seq enrichment using MACS. Nat Protoc (2012) 3.60
Deep RNA sequencing at single base-pair resolution reveals high complexity of the rice transcriptome. Genome Res (2010) 3.34
Decreased serum vitamin D levels in children with asthma are associated with increased corticosteroid use. J Allergy Clin Immunol (2010) 3.22
NONCODE: an integrated knowledge database of non-coding RNAs. Nucleic Acids Res (2005) 3.16
A promiscuous intermediate underlies the evolution of LEAFY DNA binding specificity. Science (2014) 3.11
New approach for earthquake/tsunami monitoring using dense GPS networks. Sci Rep (2013) 3.03
C-H...pi, pi-pi and C-H...Cl interactions in chloro-substituted Schiff bases and 4-chloro-N-[4-(dimethylamino)benzylidene]aniline. Acta Crystallogr C (2004) 2.97
The palladium-catalyzed trifluoromethylation of aryl chlorides. Science (2010) 2.85
Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer. Nat Struct Mol Biol (2013) 2.84
Upconversion fluorescence imaging of cells and small animals using lanthanide doped nanocrystals. Biomaterials (2007) 2.80
Chemical Markup, XML, and the World Wide Web. 7. CMLSpect, an XML vocabulary for spectral data. J Chem Inf Model (2007) 2.79
A new palladium precatalyst allows for the fast Suzuki-Miyaura coupling reactions of unstable polyfluorophenyl and 2-heteroaryl boronic acids. J Am Chem Soc (2010) 2.73
BGI-RIS: an integrated information resource and comparative analysis workbench for rice genomics. Nucleic Acids Res (2004) 2.69
Chromatin signature of embryonic pluripotency is established during genome activation. Nature (2010) 2.64
Evaluation of the impact of hepatitis B vaccination among children born during 1992-2005 in China. J Infect Dis (2009) 2.62
Identification and control of a poliomyelitis outbreak in Xinjiang, China. N Engl J Med (2013) 2.55
Downregulation of miR-133 and miR-590 contributes to nicotine-induced atrial remodelling in canines. Cardiovasc Res (2009) 2.54
Exome sequencing identifies ZNF644 mutations in high myopia. PLoS Genet (2011) 2.52
Catena-poly[[diisothiocyanatocadmium(II)]-bis[mu-1,3-bis(1,2,4-triazol-1-ylmethyl)benzene-kappa2N4:N4']]: a double-chain coordination polymer. Acta Crystallogr C (2006) 2.50
OSCAR4: a flexible architecture for chemical text-mining. J Cheminform (2011) 2.44
Horizontal transfer of an adaptive chimeric photoreceptor from bryophytes to ferns. Proc Natl Acad Sci U S A (2014) 2.42
Retracted Down-regulation of miR-1/miR-133 contributes to re-expression of pacemaker channel genes HCN2 and HCN4 in hypertrophic heart. J Biol Chem (2008) 2.41
Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Nat Biotechnol (2011) 2.37
Chemical markup, XML, and the World Wide Web. 4. CML schema. J Chem Inf Comput Sci (2003) 2.34
Systematic evaluation of factors influencing ChIP-seq fidelity. Nat Methods (2012) 2.31
Comparative analysis of bat genomes provides insight into the evolution of flight and immunity. Science (2012) 2.29
Strong influence of human leukocyte antigen (HLA)-DP gene variants on development of persistent chronic hepatitis B virus carriers in the Han Chinese population. Hepatology (2011) 2.24
GFOLD: a generalized fold change for ranking differentially expressed genes from RNA-seq data. Bioinformatics (2012) 2.21
An outbreak of poliomyelitis caused by type 1 vaccine-derived poliovirus in China. J Infect Dis (2006) 2.17
Chemical name to structure: OPSIN, an open source solution. J Chem Inf Model (2011) 2.15
In vivo photodynamic therapy using upconversion nanoparticles as remote-controlled nanotransducers. Nat Med (2012) 2.13
Vertebrate gene predictions and the problem of large genes. Nat Rev Genet (2003) 2.11
MicroRNA-328 contributes to adverse electrical remodeling in atrial fibrillation. Circulation (2010) 2.07
Beating the superparamagnetic limit with exchange bias. Nature (2003) 2.05
Nanoparticles in photodynamic therapy: an emerging paradigm. Adv Drug Deliv Rev (2008) 2.05
1-(4-Bromophenyl)-3-(4-methylphenyl)prop-2-en-1-one. Acta Crystallogr C (2004) 2.00
The nature of the fourth bond in the ground state of C2: the quadruple bond conundrum. Chemistry (2014) 1.97
Bioclipse: an open source workbench for chemo- and bioinformatics. BMC Bioinformatics (2007) 1.97
The persistent circulation of enterovirus 71 in People's Republic of China: causing emerging nationwide epidemics since 2008. PLoS One (2011) 1.96
One molecule, two atoms, three views, four bonds? Angew Chem Int Ed Engl (2013) 1.95
MicroRNA-148b is frequently down-regulated in gastric cancer and acts as a tumor suppressor by inhibiting cell proliferation. Mol Cancer (2011) 1.89
Survey of the transcriptome of Aspergillus oryzae via massively parallel mRNA sequencing. Nucleic Acids Res (2010) 1.87
Evaluating methods for isolating total RNA and predicting the success of sequencing phylogenetically diverse plant transcriptomes. PLoS One (2012) 1.82
A genome triplication associated with early diversification of the core eudicots. Genome Biol (2012) 1.80
Synthesis, reactivity, and structural characterization of sodium and ytterbium complexes containing new imidazolidine-bridged bis(phenolato) ligands. Inorg Chem (2007) 1.76
Penicillium marneffei infection: an emerging disease in mainland China. Mycopathologia (2012) 1.76
Retrospective seroepidemiology indicated that human enterovirus 71 and coxsackievirus A16 circulated wildly in central and southern China before large-scale outbreaks from 2008. Virol J (2010) 1.76
ChemicalTagger: A tool for semantic text-mining in chemistry. J Cheminform (2011) 1.75
Autophagy and the degradation of mitochondria. Mitochondrion (2010) 1.75
Genome-wide assessment of worldwide chicken SNP genetic diversity indicates significant absence of rare alleles in commercial breeds. Proc Natl Acad Sci U S A (2008) 1.75
SPD--a web-based secreted protein database. Nucleic Acids Res (2005) 1.75
Targeted deletion of autophagy-related 5 (atg5) impairs adipogenesis in a cellular model and in mice. Autophagy (2009) 1.72
A 4-gigabase physical map unlocks the structure and evolution of the complex genome of Aegilops tauschii, the wheat D-genome progenitor. Proc Natl Acad Sci U S A (2013) 1.70
Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC. Nat Genet (2010) 1.69
General gene movement off the X chromosome in the Drosophila genus. Genome Res (2009) 1.68
Targeting FGFR with dovitinib (TKI258): preclinical and clinical data in breast cancer. Clin Cancer Res (2013) 1.68
Outbreak of acute respiratory disease in China caused by B2 species of adenovirus type 11. J Clin Microbiol (2008) 1.67
A mixed-valence copper coordination polymer generated by hydrothermal metal/ligand redox reactions. Chem Commun (Camb) (2002) 1.65
Representation and use of chemistry in the global electronic age. Org Biomol Chem (2004) 1.65
Using MACS to identify peaks from ChIP-Seq data. Curr Protoc Bioinformatics (2011) 1.64
A comprehensive view of nuclear receptor cancer cistromes. Cancer Res (2011) 1.64
Quadruple bonding in C2 and analogous eight-valence electron species. Nat Chem (2012) 1.62
Overdiagnosis and breast cancer screening. Breast Cancer Res (2005) 1.59
Chemical markup, XML, and the world wide web. 6. CMLReact, an XML vocabulary for chemical reactions. J Chem Inf Model (2006) 1.58
Standardized evaluation methodology and reference database for evaluating coronary artery centerline extraction algorithms. Med Image Anal (2009) 1.58
Increasing frequencies of site-specific mutagenesis and gene targeting in Arabidopsis by manipulating DNA repair pathways. Genome Res (2013) 1.57
MACiE (Mechanism, Annotation and Classification in Enzymes): novel tools for searching catalytic mechanisms. Nucleic Acids Res (2006) 1.57
Rapid and efficient gene modification in rice and Brachypodium using TALENs. Mol Plant (2013) 1.56
Efficacy of cardiac autonomic denervation for atrial fibrillation: a meta-analysis. J Cardiovasc Electrophysiol (2012) 1.56
Efficacy of Salmonella typhimurium A1-R versus chemotherapy on a pancreatic cancer patient-derived orthotopic xenograft (PDOX). J Cell Biochem (2014) 1.55