Published in Proc Natl Acad Sci U S A on May 12, 2005
Digenic inheritance of an SMCHD1 mutation and an FSHD-permissive D4Z4 allele causes facioscapulohumeral muscular dystrophy type 2. Nat Genet (2012) 2.82
Intra- and interindividual epigenetic variation in human germ cells. Am J Hum Genet (2006) 2.79
Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity. Cell (2016) 2.75
Gene silencing in X-chromosome inactivation: advances in understanding facultative heterochromatin formation. Nat Rev Genet (2011) 2.39
Gender specific differences in levels of DNA methylation at selected loci from human total blood: a tendency toward higher methylation levels in males. Hum Genet (2007) 2.36
Child health, developmental plasticity, and epigenetic programming. Endocr Rev (2010) 2.15
Modifiers of epigenetic reprogramming show paternal effects in the mouse. Nat Genet (2007) 1.79
Transcriptional silencing and reactivation in transgenic zebrafish. Genetics (2009) 1.67
The case for transgenerational epigenetic inheritance in humans. Mamm Genome (2008) 1.54
Smchd1-dependent and -independent pathways determine developmental dynamics of CpG island methylation on the inactive X chromosome. Dev Cell (2012) 1.47
X chromosome regulation: diverse patterns in development, tissues and disease. Nat Rev Genet (2014) 1.36
A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development. Genome Biol (2008) 1.35
Constitutive heterochromatin formation and transcription in mammals. Epigenetics Chromatin (2015) 1.26
Epigenetics and phenotypic variation in mammals. Mamm Genome (2006) 1.26
The FSHD2 gene SMCHD1 is a modifier of disease severity in families affected by FSHD1. Am J Hum Genet (2013) 1.25
Intraclonal protein expression heterogeneity in recombinant CHO cells. PLoS One (2009) 1.14
Reduced levels of two modifiers of epigenetic gene silencing, Dnmt3a and Trim28, cause increased phenotypic noise. Genome Biol (2010) 1.10
Epigenetic functions of smchd1 repress gene clusters on the inactive X chromosome and on autosomes. Mol Cell Biol (2013) 1.07
Smchd1 regulates a subset of autosomal genes subject to monoallelic expression in addition to being critical for X inactivation. Epigenetics Chromatin (2013) 1.06
Modifier genes and the plasticity of genetic networks in mice. PLoS Genet (2012) 1.05
Digenic inheritance and Mendelian disease. Nat Genet (2012) 1.02
Mutations in mouse Ift144 model the craniofacial, limb and rib defects in skeletal ciliopathies. Hum Mol Genet (2012) 1.00
Mechanistic insights into chromosome-wide silencing in X inactivation. Hum Genet (2011) 1.00
An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse. Genome Biol (2013) 0.97
A missense mutation in the transcription factor Foxo3a causes teratomas and oocyte abnormalities in mice. Mamm Genome (2011) 0.94
Positional information resolves structural variations and uncovers an evolutionarily divergent genetic locus in accessions of Arabidopsis thaliana. Genome Biol Evol (2011) 0.91
Facioscapulohumeral muscular dystrophy as a model for epigenetic regulation and disease. Antioxid Redox Signal (2014) 0.86
Genome-wide binding and mechanistic analyses of Smchd1-mediated epigenetic regulation. Proc Natl Acad Sci U S A (2015) 0.84
The first mouse mutants of D14Abb1e (Fam208a) show that it is critical for early development. Mamm Genome (2014) 0.84
Mutations in DNMT3B Modify Epigenetic Repression of the D4Z4 Repeat and the Penetrance of Facioscapulohumeral Dystrophy. Am J Hum Genet (2016) 0.82
No evidence for cumulative effects in a Dnmt3b hypomorph across multiple generations. Mamm Genome (2013) 0.82
When the Lyon(ized chromosome) roars: ongoing expression from an inactive X chromosome. Philos Trans R Soc Lond B Biol Sci (2017) 0.81
Paternal nicotine exposure alters hepatic xenobiotic metabolism in offspring. Elife (2017) 0.81
Progress in understanding the molecular mechanism of Xist RNA function through genetics. Philos Trans R Soc Lond B Biol Sci (2017) 0.80
DICER/AGO-dependent epigenetic silencing of D4Z4 repeats enhanced by exogenous siRNA suggests mechanisms and therapies for FSHD. Hum Mol Genet (2015) 0.80
Trim33 Binds and Silences a Class of Young Endogenous Retroviruses in the Mouse Testis; a Novel Component of the Arms Race between Retrotransposons and the Host Genome. PLoS Genet (2015) 0.80
Reduced dosage of the modifiers of epigenetic reprogramming Dnmt1, Dnmt3L, SmcHD1 and Foxo3a has no detectable effect on mouse telomere length in vivo. Chromosoma (2011) 0.80
The use of mouse models to study epigenetics. Cold Spring Harb Perspect Biol (2013) 0.80
Impact of flanking chromosomal sequences on localization and silencing by the human non-coding RNA XIST. Genome Biol (2015) 0.80
The recently identified modifier of murine metastable epialleles, Rearranged L-Myc Fusion, is involved in maintaining epigenetic marks at CpG island shores and enhancers. BMC Biol (2015) 0.79
Double SMCHD1 variants in FSHD2: the synergistic effect of two SMCHD1 variants on D4Z4 hypomethylation and disease penetrance in FSHD2. Eur J Hum Genet (2015) 0.79
SMCHD1 accumulates at DNA damage sites and facilitates the repair of DNA double-strand breaks. J Cell Sci (2014) 0.78
The molecular basis of the organization of repetitive DNA-containing constitutive heterochromatin in mammals. Chromosome Res (2017) 0.77
High throughput sequencing approaches to mutation discovery in the mouse. Mamm Genome (2012) 0.76
Differential regulation of the α-globin locus by Krüppel-like Factor 3 in erythroid and non-erythroid cells. BMC Mol Biol (2014) 0.76
SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome. Nat Genet (2017) 0.76
Independent Mechanisms Target SMCHD1 to Trimethylated Histone H3 Lysine 9-Modified Chromatin and the Inactive X Chromosome. Mol Cell Biol (2015) 0.75
Modifier genes for mouse phosphatidylinositol transfer protein α (vibrator) that bypass juvenile lethality. Genetics (2011) 0.75
Hypomethylation of ERVs in the sperm of mice haploinsufficient for the histone methyltransferase Setdb1 correlates with a paternal effect on phenotype. Sci Rep (2016) 0.75
Leaving the past behind. PLoS Genet (2008) 0.75
Wiz binds active promoters and CTCF-binding sites and is required for normal behaviour in the mouse. Elife (2016) 0.75
Non-telomeric epigenetic and genetic changes are associated with the inheritance of shorter telomeres in mice. Chromosoma (2013) 0.75
Epigenetic reprogramming in mammalian development. Science (2001) 13.42
Epigenetic inheritance at the agouti locus in the mouse. Nat Genet (1999) 9.14
Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery. Science (2004) 6.35
Expansions of transgene repeats cause heterochromatin formation and gene silencing in Drosophila. Cell (1994) 4.83
Repeat-induced gene silencing in mammals. Nat Genet (1998) 4.74
Transgenerational inheritance of epigenetic states at the murine Axin(Fu) allele occurs after maternal and paternal transmission. Proc Natl Acad Sci U S A (2003) 4.70
Molecular characterization of the mouse agouti locus. Cell (1992) 4.55
Position effect variegation and chromatin proteins. Bioessays (1992) 4.24
Dosage-dependent modifiers of position effect variegation in Drosophila and a mass action model that explains their effect. Genetics (1988) 3.99
Neomorphic agouti mutations in obese yellow mice. Nat Genet (1994) 3.92
Position-effect variegation after 60 years. Trends Genet (1990) 3.57
Metastable epialleles in mammals. Trends Genet (2002) 3.36
Dependence of position-effect variegation in Drosophila on dose of a gene encoding an unusual zinc-finger protein. Nature (1990) 3.33
The enhancer of position-effect variegation of Drosophila, E(var)3-93D, codes for a chromatin protein containing a conserved domain common to several transcriptional regulators. Proc Natl Acad Sci U S A (1993) 2.57
Position-effect variegation and the genetic dissection of chromatin regulation in Drosophila. Semin Cell Dev Biol (2003) 2.37
Dose-repetition increases the mutagenic effectiveness of N-ethyl-N-nitrosourea in mouse spermatogonia. Proc Natl Acad Sci U S A (1985) 2.22
CpG island promoter region methylation patterns of the inactive-X-chromosome hypoxanthine phosphoribosyltransferase (Hprt) gene. Mol Cell Biol (1994) 2.15
Influence of maternal phenotype on metabolic differentiation of agouti locus mutants in the mouse. Genetics (1978) 1.94
Dnmt1 expression in pre- and postimplantation embryogenesis and the maintenance of IAP silencing. Mol Cell Biol (2004) 1.86
The vagaries of variegating transgenes. Bioessays (1996) 1.84
Epigenetic changes in the expression of the maize A1 gene in Petunia hybrida: role of numbers of integrated gene copies and state of methylation. Mol Gen Genet (1990) 1.82
The Lighten up (Lip) gene of Drosophila melanogaster, a modifier of retroelement expression, position effect variegation and white locus insertion alleles. Genetics (1994) 1.58
Rapid DNA extraction and PCR-sexing of mouse embryos. Mol Reprod Dev (2001) 1.53
The genetic basis of XX-XY differences present before gonadal sex differentiation in the mouse. Philos Trans R Soc Lond B Biol Sci (1995) 1.39
Increased number of cells and metabolic activity in male human preimplantation embryos following in vitro fertilization. J Reprod Fertil (1995) 1.35
Genetic factors required to maintain repression of a paramutagenic maize pl1 allele. Genetics (2001) 1.27
Parental control of position-effect variegation. II. Effect of sex of parent contributing white-mottled rearrangement in Drosophila melanogaster. Genetics (1961) 1.22
Efficient localization of mutations by interval haplotype analysis. Mamm Genome (1998) 1.14
Autosomal dominant mutations affecting X inactivation choice in the mouse. Science (2002) 1.12
Sensitive flow cytometric analysis reveals a novel type of parent-of-origin effect in the mouse genome. Curr Biol (2003) 1.04
Evidence for translational regulation of the imprinted Snurf-Snrpn locus in mice. Hum Mol Genet (2002) 0.92
Weakener of white (Wow), a gene that modifies the expression of the white eye color locus and that suppresses position effect variegation in Drosophila melanogaster. Genetics (1994) 0.92
Effective chemical mutagenesis in FVB/N mice requires low doses of ethylnitrosourea. Mamm Genome (1999) 0.84
Microsatellite DNA variants between the FVB/N and C3HeB/FeJLe and C57BL/6J mouse strains. Mamm Genome (1997) 0.80
Transgenerational inheritance of epigenetic states at the murine Axin(Fu) allele occurs after maternal and paternal transmission. Proc Natl Acad Sci U S A (2003) 4.70
Natural and experimental infection of Caenorhabditis nematodes by novel viruses related to nodaviruses. PLoS Biol (2011) 3.58
Metastable epialleles in mammals. Trends Genet (2002) 3.36
Transgenerational epigenetic effects. Annu Rev Genomics Hum Genet (2008) 3.16
Understanding transgenerational epigenetic inheritance via the gametes in mammals. Nat Rev Genet (2012) 2.93
SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation. Nat Genet (2008) 2.19
Disruption of scribble (Scrb1) causes severe neural tube defects in the circletail mouse. Hum Mol Genet (2003) 2.11
Dynamic reprogramming of DNA methylation at an epigenetically sensitive allele in mice. PLoS Genet (2006) 2.07
Maternal ethanol consumption alters the epigenotype and the phenotype of offspring in a mouse model. PLoS Genet (2010) 2.03
Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation. Development (2005) 1.90
Epigenetic germline inheritance. Curr Opin Genet Dev (2004) 1.85
Transgenerational epigenetic inheritance in health and disease. Curr Opin Genet Dev (2008) 1.81
Modifiers of epigenetic reprogramming show paternal effects in the mouse. Nat Genet (2007) 1.79
Complex patterns of transcription at the insertion site of a retrotransposon in the mouse. Nucleic Acids Res (2004) 1.75
Transgenerational epigenetic inheritance: more questions than answers. Genome Res (2010) 1.67
Loss of Atrx affects trophoblast development and the pattern of X-inactivation in extraembryonic tissues. PLoS Genet (2006) 1.64
Apc mice: models, modifiers and mutants. Pathol Res Pract (2008) 1.59
The case for transgenerational epigenetic inheritance in humans. Mamm Genome (2008) 1.54
The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking. J Cell Biol (2012) 1.54
Redistribution of H3K27me3 upon DNA hypomethylation results in de-repression of Polycomb target genes. Genome Biol (2013) 1.47
The culture of zygotes to the blastocyst stage changes the postnatal expression of an epigentically labile allele, agouti viable yellow, in mice. Biol Reprod (2008) 1.45
A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development. Genome Biol (2008) 1.35
Cited2 is required both for heart morphogenesis and establishment of the left-right axis in mouse development. Development (2005) 1.28
How lifetimes shape epigenotype within and across generations. Hum Mol Genet (2006) 1.27
Neural plate morphogenesis during mouse neurulation is regulated by antagonism of Bmp signalling. Development (2007) 1.27
Epigenetics and phenotypic variation in mammals. Mamm Genome (2006) 1.26
In vitro analysis of partial loss-of-function ZIC2 mutations in holoprosencephaly: alanine tract expansion modulates DNA binding and transactivation. Hum Mol Genet (2004) 1.16
Organization and evolution of a gene-rich region of the mouse genome: a 12.7-Mb region deleted in the Del(13)Svea36H mouse. Genome Res (2004) 1.12
BMP/SMAD1 signaling sets a threshold for the left/right pathway in lateral plate mesoderm and limits availability of SMAD4. Genes Dev (2008) 1.12
Zic2 is required for neural crest formation and hindbrain patterning during mouse development. Dev Biol (2003) 1.10
Reduced levels of two modifiers of epigenetic gene silencing, Dnmt3a and Trim28, cause increased phenotypic noise. Genome Biol (2010) 1.10
Transgenerational epigenetic inheritance. Curr Biol (2003) 1.06
Thermal stress responses in the bacterial biosphere of the Great Barrier Reef sponge, Rhopaloeides odorabile. Environ Microbiol (2012) 1.05
Sensitive flow cytometric analysis reveals a novel type of parent-of-origin effect in the mouse genome. Curr Biol (2003) 1.04
Heritable germline epimutation is not the same as transgenerational epigenetic inheritance. Nat Genet (2007) 1.04
Overlapping and distinct expression domains of Zic2 and Zic3 during mouse gastrulation. Gene Expr Patterns (2004) 1.04
Somatic point mutation calling in low cellularity tumors. PLoS One (2013) 1.03
Cited1 is required in trophoblasts for placental development and for embryo growth and survival. Mol Cell Biol (2004) 1.03
Mutations in mouse Ift144 model the craniofacial, limb and rib defects in skeletal ciliopathies. Hum Mol Genet (2012) 1.00
An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse. Genome Biol (2013) 0.97
Reintroducing domesticated wild mice to sociality induces adaptive transgenerational effects on MUP expression. Proc Natl Acad Sci U S A (2013) 0.96
Role of the transcription factor sox4 in insulin secretion and impaired glucose tolerance. Diabetes (2008) 0.95
A missense mutation in the transcription factor Foxo3a causes teratomas and oocyte abnormalities in mice. Mamm Genome (2011) 0.94
Flightless I regulates hemidesmosome formation and integrin-mediated cellular adhesion and migration during wound repair. J Invest Dermatol (2009) 0.93
DNA methylation: A source of random variation in natural populations. Epigenetics (2011) 0.90
Loss of Cited2 causes congenital heart disease by perturbing left-right patterning of the body axis. Hum Mol Genet (2010) 0.90
Tuning in to noise: epigenetics and intangible variation. Dev Cell (2010) 0.90
Stringent requirement of a proper level of canonical WNT signalling activity for head formation in mouse embryo. Development (2011) 0.90
Epigenetics: sins of the fathers, and their fathers. Eur J Hum Genet (2006) 0.90
New semidominant mutations that affect mouse development. Genesis (2004) 0.89
Endogenous retroviruses in mammals: an emerging picture of how ERVs modify expression of adjacent genes. Bioessays (2012) 0.88
Disputing Lamarckian epigenetic inheritance in mammals. Genome Biol (2015) 0.88
ENU mutagenesis identifies the first mouse mutants reproducing human β-thalassemia at the genomic level. Blood Cells Mol Dis (2012) 0.88
Competition between virus-derived and endogenous small RNAs regulates gene expression in Caenorhabditis elegans. Genome Res (2013) 0.88
Postnatal growth restriction and gene expression changes in a mouse model of fetal alcohol syndrome. Birth Defects Res A Clin Mol Teratol (2010) 0.87
The ZIC gene family encodes multi-functional proteins essential for patterning and morphogenesis. Cell Mol Life Sci (2013) 0.86
Epigenetic reprogramming: enforcer or enabler of developmental fate? Dev Growth Differ (2010) 0.86
Another role for RNA: a messenger across generations. Trends Genet (2006) 0.85
The first mouse mutants of D14Abb1e (Fam208a) show that it is critical for early development. Mamm Genome (2014) 0.84
The role of early embryonic environment on epigenotype and phenotype. Reprod Fertil Dev (2005) 0.83
The role of epigenetics in mediating environmental effects on phenotype. Nestle Nutr Workshop Ser Pediatr Program (2009) 0.82
The effects of acquired paternal obesity on the next generation. Asian J Androl (2010) 0.82
No evidence for cumulative effects in a Dnmt3b hypomorph across multiple generations. Mamm Genome (2013) 0.82
The use of mouse models to study epigenetics. Cold Spring Harb Perspect Biol (2013) 0.80
Reduced dosage of the modifiers of epigenetic reprogramming Dnmt1, Dnmt3L, SmcHD1 and Foxo3a has no detectable effect on mouse telomere length in vivo. Chromosoma (2011) 0.80
The influence of Flightless I on Toll-like-receptor-mediated inflammation in a murine model of diabetic wound healing. Biomed Res Int (2013) 0.79
How the mouse got its spots. Trends Genet (2004) 0.79
The recently identified modifier of murine metastable epialleles, Rearranged L-Myc Fusion, is involved in maintaining epigenetic marks at CpG island shores and enhancers. BMC Biol (2015) 0.79
The characterisation of piRNA-related 19mers in the mouse. BMC Genomics (2011) 0.78
DNMT3L is a regulator of X chromosome compaction and post-meiotic gene transcription. PLoS One (2011) 0.78
Commentary: Gärtner's 'third component': still an open question. Int J Epidemiol (2012) 0.78
Gene silencing is an ancient means of producing multiple phenotypes from the same genotype: common mechanisms and functions in epigenetic processes can be seen throughout all life forms. Bioessays (2011) 0.77
A forward genetic screen identifies eukaryotic translation initiation factor 3, subunit H (eIF3h), as an enhancer of variegation in the mouse. G3 (Bethesda) (2012) 0.77
Mammalian epigenetics in biology and medicine. Philos Trans R Soc Lond B Biol Sci (2013) 0.76
Differential regulation of the α-globin locus by Krüppel-like Factor 3 in erythroid and non-erythroid cells. BMC Mol Biol (2014) 0.76
Upregulation of PKD1L2 provokes a complex neuromuscular disease in the mouse. Hum Mol Genet (2009) 0.76
Leaving the past behind. PLoS Genet (2008) 0.75
Non-telomeric epigenetic and genetic changes are associated with the inheritance of shorter telomeres in mice. Chromosoma (2013) 0.75