Published in Proc Natl Acad Sci U S A on October 01, 1985
Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior. Science (1994) 7.83
Efficient recovery of ENU-induced mutations from the zebrafish germline. Genetics (1994) 3.24
AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations. Proc Natl Acad Sci U S A (2001) 2.84
Spectra of spontaneous and mutagen-induced mutations in the lacI gene in transgenic mice. Proc Natl Acad Sci U S A (1991) 2.29
Forward and reverse genetic approaches to behavior in the mouse. Science (1994) 2.20
A phenotype-based screen for embryonic lethal mutations in the mouse. Proc Natl Acad Sci U S A (1998) 2.18
A gene-driven ENU-based approach to generating an allelic series in any gene. Mamm Genome (2004) 1.82
Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling. Proc Natl Acad Sci U S A (2004) 1.81
Analysis of mouse embryonic patterning and morphogenesis by forward genetics. Proc Natl Acad Sci U S A (2005) 1.77
Phenotype-based identification of mouse chromosome instability mutants. Genetics (2003) 1.74
Mutation discovery in mice by whole exome sequencing. Genome Biol (2011) 1.69
The mouse genomic instability mutation chaos1 is an allele of Polq that exhibits genetic interaction with Atm. Mol Cell Biol (2004) 1.68
A strategy for fine-structure functional analysis of a 6- to 11-centimorgan region of mouse chromosome 7 by high-efficiency mutagenesis. Proc Natl Acad Sci U S A (1990) 1.59
Chlorambucil effectively induces deletion mutations in mouse germ cells. Proc Natl Acad Sci U S A (1989) 1.54
An N-ethyl-N-nitrosourea screen for genes involved in variegation in the mouse. Proc Natl Acad Sci U S A (2005) 1.51
Large-scale mutagenesis of the mouse to understand the genetic bases of nervous system structure and function. Brain Res Mol Brain Res (2004) 1.36
Random mutagenesis of proximal mouse chromosome 5 uncovers predominantly embryonic lethal mutations. Genome Res (2005) 1.30
Mouse model resources for vision research. J Ophthalmol (2010) 1.26
Estimating the number of coding mutations in genotypic- and phenotypic-driven N-ethyl-N-nitrosourea (ENU) screens. Mamm Genome (2006) 1.24
An Oak Ridge legacy: the specific locus test and its role in mouse mutagenesis. Genetics (1998) 1.14
Efficient and fast targeted production of murine models based on ENU mutagenesis. Mamm Genome (2005) 1.11
Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene. Proc Natl Acad Sci U S A (2006) 1.09
Single amino acid substitution in aquaporin 11 causes renal failure. J Am Soc Nephrol (2008) 1.09
Implementation of the modified-SHIRPA protocol for screening of dominant phenotypes in a large-scale ENU mutagenesis program. Mamm Genome (2005) 1.08
Dissecting the genetic complexity of human 6p deletion syndromes by using a region-specific, phenotype-driven mouse screen. Proc Natl Acad Sci U S A (2005) 1.07
The expanding role of mouse genetics for understanding human biology and disease. Dis Model Mech (2008) 1.05
The mouse genetics toolkit: revealing function and mechanism. Genome Biol (2011) 1.05
Analysis of an ethylnitrosourea-generated mouse mutation defines a cell intrinsic role of nuclear factor kappaB2 in regulating circulating B cell numbers. J Exp Med (2002) 1.04
Random mutagenesis of the mouse genome: a strategy for discovering gene function and the molecular basis of disease. Am J Physiol Gastrointest Liver Physiol (2010) 0.99
Genetics-squared: combining host and pathogen genetics in the analysis of innate immunity and bacterial virulence. Immunogenetics (2007) 0.96
Characterization of mutations induced by ethylnitrosourea in seminiferous tubule germ cells of transgenic B6C3F1 mice. Proc Natl Acad Sci U S A (1994) 0.96
A mutant mouse with a highly specific contextual fear-conditioning deficit found in an N-ethyl-N-nitrosourea (ENU) mutagenesis screen. Learn Mem (2006) 0.93
Comparative genetic analysis: the utility of mouse genetic systems for studying human monogenic disease. Mamm Genome (2007) 0.92
An ENU-mutagenesis screen in the mouse: identification of novel developmental gene functions. PLoS One (2011) 0.88
High frequency of mosaic mutants produced by N-ethyl-N-nitrosourea exposure of mouse zygotes. Proc Natl Acad Sci U S A (1988) 0.88
Genome-wide ENU mutagenesis in combination with high density SNP analysis and exome sequencing provides rapid identification of novel mouse models of developmental disease. PLoS One (2013) 0.85
Functional annotation of mouse mutations in embryonic stem cells by use of expression profiling. Mamm Genome (2004) 0.84
Second-generation high-throughput forward genetic screen in mice to isolate subtle behavioral mutants. Proc Natl Acad Sci U S A (2011) 0.84
The use of mouse models to study epigenetics. Cold Spring Harb Perspect Biol (2013) 0.80
ENU-induced missense mutation in the C-propeptide coding region of Col2a1 creates a mouse model of platyspondylic lethal skeletal dysplasia, Torrance type. Mamm Genome (2011) 0.79
Functional genomics approaches to neurodegenerative diseases. Mamm Genome (2008) 0.79
KDEL receptor 1 regulates T-cell homeostasis via PP1 that is a key phosphatase for ISR. Nat Commun (2015) 0.79
ENU mutagenesis screen to establish motor phenotypes in wild-type mice and modifiers of a pre-existing motor phenotype in tau mutant mice. J Biomed Biotechnol (2011) 0.78
ENU Mutagenesis in the Mouse. Curr Protoc Hum Genet (2014) 0.77
ENU-induced mutagenesis in grass carp (Ctenopharyngodon idellus) by treating mature sperm. PLoS One (2011) 0.76
Mouse ENU Mutagenesis to Understand Immunity to Infection: Methods, Selected Examples, and Perspectives. Genes (Basel) (2014) 0.76
Novel retinoblastoma mutation abrogating the interaction to E2F2/3, but not E2F1, led to selective suppression of thyroid tumors. Cancer Sci (2014) 0.75
Identification of Mouse Cytomegalovirus Resistance Loci by ENU Mutagenesis. Viruses (2009) 0.75
Signaling advances from immunogenetics to immunogenomics. Genome Biol (2003) 0.75
A mouse model of hereditary coproporphyria identified in an ENU mutagenesis screen. Dis Model Mech (2017) 0.75
rahu is a mutant allele of Dnmt3c, encoding a DNA methyltransferase homolog required for meiosis and transposon repression in the mouse male germline. PLoS Genet (2017) 0.75
X-ray-induced mutations in mice. Cold Spring Harb Symp Quant Biol (1951) 9.00
Specific-locus test shows ethylnitrosourea to be the most potent mutagen in the mouse. Proc Natl Acad Sci U S A (1979) 4.14
Procarbazine-induced specific-locus mutations in male mice. Mutat Res (1979) 2.06
Dose--response curve for ethylnitrosourea-induced specific-locus mutations in mouse spermatogonia. Proc Natl Acad Sci U S A (1982) 1.75
Non-breeding-test methods for dominant skeletal mutations shown by ethylnitrosourea to be easily applicable to offspring examined in specific-locus experiments. Mutat Res (1984) 1.14
Of man and mouse. Nature (1985) 1.05
Importance of hemodynamic factors in the prognosis of symptomatic carotid occlusion. JAMA (1998) 4.76
Specific-locus test shows ethylnitrosourea to be the most potent mutagen in the mouse. Proc Natl Acad Sci U S A (1979) 4.14
A Study of the Physiological Genetics of Coat Color in the Mouse by Means of the Dopa Reaction in Frozen Sections of Skin. Genetics (1948) 2.57
Dose--response curve for ethylnitrosourea-induced specific-locus mutations in mouse spermatogonia. Proc Natl Acad Sci U S A (1982) 1.75
Grey scale echography in the diagnosis of intrahepatic disease. J Clin Ultrasound (1973) 1.71
Ultrasound and scintigraphy in the differential diagnosis of obstructive jaundice. J Clin Ultrasound (1974) 1.70
Effects of ENU dosage on mouse strains. Mamm Genome (2000) 1.69
Effect of the interval between irradiation and conception on mutation frequency in female mice. Proc Natl Acad Sci U S A (1965) 1.61
A strategy for fine-structure functional analysis of a 6- to 11-centimorgan region of mouse chromosome 7 by high-efficiency mutagenesis. Proc Natl Acad Sci U S A (1990) 1.59
Mutation frequencies in male mice and the estimation of genetic hazards of radiation in men. Proc Natl Acad Sci U S A (1982) 1.58
Chlorambucil effectively induces deletion mutations in mouse germ cells. Proc Natl Acad Sci U S A (1989) 1.54
A Difference in Skeletal Type between Reciprocal Hybrids of Two Inbred Strains of Mice (C57 Blk and C3h). Genetics (1951) 1.53
Mutation frequencies in female mice and the estimation of genetic hazards of radiation in women. Proc Natl Acad Sci U S A (1977) 1.48
Ciromosomal control of reversion in transformed cells. Nature (1971) 1.48
Analysis of the albino-locus region of the mouse. I. Origin and viability. Genetics (1979) 1.44
Cost-effectiveness of preoperative localization studies in primary hyperparathyroid disease. Ann Surg (1994) 1.40
Radiation-induced mutations at mouse hemoglobin loci. Proc Natl Acad Sci U S A (1976) 1.30
N-ethyl-N-nitrosourea-induced prenatally lethal mutations define at least two complementation groups within the embryonic ectoderm development (eed) locus in mouse chromosome 7. Mamm Genome (1993) 1.29
Point mutations in the murine fumarylacetoacetate hydrolase gene: Animal models for the human genetic disorder hereditary tyrosinemia type 1. Proc Natl Acad Sci U S A (2001) 1.28
Effect of dose fractionation on the ethylnitrosourea induction of specific-locus mutations in mouse spermatogonia. Proc Natl Acad Sci U S A (1982) 1.28
Frequency and nature of specific-locus mutations induced in female mice by radiations and chemicals: a review. Mutat Res (1992) 1.23
Spontaneous mutations recovered as mosaics in the mouse specific-locus test. Proc Natl Acad Sci U S A (1996) 1.20
Compensatory mechanisms for chronic cerebral hypoperfusion in patients with carotid occlusion. Stroke (1999) 1.18
Gray scale ultrasound imaging. The anatomy and pathology of the liver. Radiology (1976) 1.15
Specific-locus mutation frequencies in mouse stem-cell spermatogonia at very low radiation dose rates. Proc Natl Acad Sci U S A (1982) 1.13
Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear. Mech Dev (1998) 1.13
Aortoiliac occlusive disease: factors influencing survival and function following reconstructive operation over a twenty-five-year period. Surgery (1981) 1.13
Hematopoietic deficiencies in c-mpl and TPO knockout mice. Stem Cells (1998) 1.06
Serum amylase and lipase in the evaluation of acute abdominal pain. Am Surg (1996) 1.06
Effects of dose on the induction of dominant-lethal mutations and heritable translocations with ethyl methanesulfonate in male mice. Genetics (1974) 1.05
Strain and sex variations in the sensitivity of mice to dominant-lethal induction with ethyl methanesulfonate. Mutat Res (1970) 1.05
Increased oxygen extraction fraction is associated with prior ischemic events in patients with carotid occlusion. Stroke (1998) 1.01
Deletion mapping of four loci defined by N-ethyl-N-nitrosourea-induced postimplantation-lethal mutations within the pid-Hbb region of mouse chromosome 7. Genetics (1993) 0.99
Chromosomal control of chemical carcinogenesis. Int J Cancer (1972) 0.98
Pleiotropy in microdeletion syndromes: neurologic and spermatogenic abnormalities in mice homozygous for the p6H deletion are likely due to dysfunction of a single gene. Proc Natl Acad Sci U S A (1995) 0.98
The mouse scurfy (sf) mutation is tightly linked to Gata1 and Tfe3 on the proximal X chromosome. Mamm Genome (1994) 0.95
Utilization and wide clinical implementation using the wick catheter for compartment pressure measurement. Surg Gynecol Obstet (1985) 0.95
Laparoscopic inguinal herniorrhaphy in a swine model. Third place winner of the Conrad Jobst Award in the Gold Medal paper competition. Am Surg (1993) 0.95
Prediction of long-term ventilatory support in trauma patients. Am Surg (1996) 0.93
Benign prognosis of never-symptomatic carotid occlusion. Neurology (2000) 0.92
Laparoscopic hernia repair: a preliminary report. Am Surg (1993) 0.91
Genetic and physical mapping of the fitness 1 (fit1) locus within the Fes-Hbb region of mouse chromosome 7. Mamm Genome (1995) 0.91
A fatality due to the intranasal abuse of methylphenidate (Ritalin). J Forensic Sci (1999) 0.91
Mutations in the murine fitness 1 gene result in defective hematopoiesis. Blood (1997) 0.90
Reverse genetics in the mouse and its application to the study of deafness. Ann N Y Acad Sci (1991) 0.87
Letter: Grey-scale ultrasonography in the investigation of obstructive jaundice. Lancet (1974) 0.85
Therapeutic substitution in the health maintenance organization outpatient environment. Drug Intell Clin Pharm (1988) 0.84
Gray scale ultrasonic investigation of focal defects on 99Tc sulphur colloid liver scanning. Radiology (1976) 0.83
The anatomy and pathology of the porta hepatis demonstrated by gray scale ultrasonography. J Clin Ultrasound (1975) 0.83
The role of ultrasonography and inferior vena cava filter placement in high-risk trauma patients. Am Surg (1997) 0.81
Confirmation of a computer-derived nomogram to predict gentamicin serum concentrations in postsurgical patients. Am J Hosp Pharm (1978) 0.80
Cimetidine-induced mental status changes: case report and literature review. Am J Hosp Pharm (1980) 0.80
Lifespan and autopsy findings in the first-generation offspring of X-irradiated male mice. Mutat Res (1993) 0.80
Results of tests for possible transmitted genetic effects of hycanthone in mammals. J Toxicol Environ Health (1975) 0.79
Cost of acid peptic disorders in a managed-care organization. Clin Ther (1997) 0.79
Stercoraceous ulcer. Am Surg (1976) 0.78
Comments on mutagenesis risk estimation. Genetics (1979) 0.78
Establishment of hybridomas secreting human monoclonal antibodies against tetanus toxin and hepatitis B virus surface antigen. Biochem Biophys Res Commun (1985) 0.78
Comparison of the predictions of one- and two-compartment microcomputer programs for long-term tobramycin therapy. Ther Drug Monit (1984) 0.78
Therapeutic substitution practices in short-term hospitals. Am J Hosp Pharm (1982) 0.78
Establishment of hybridoma secreting human monoclonal antibody against hepatitis B virus surface antigen. Biochem Biophys Res Commun (1987) 0.78
Principles and classification of soft tissues by grey scale echography. Ultrasound Med Biol (1976) 0.77
Risk for adverse events among patients receiving intravenous histamine2-receptor antagonists. Ann Pharmacother (1993) 0.77
Postoperative pulmonary complications and morbidity after abdominal aneurysmectomy: a comparison of postoperative epidural versus parenteral opioid analgesia. Am Surg (1996) 0.77
Efficacy of screening MR angiography and Doppler ultrasonography in the evaluation of carotid artery stenosis. Am Surg (1994) 0.77
A multimode real time scanner. Ultrasound Med Biol (1980) 0.77
Oxysterols and alcoholic liver disease. Alcohol Clin Exp Res (1990) 0.76
Appendicitis in mature patients. Ann Surg (1985) 0.75
Symposium No. 3: Radiation genetics. Introduction by the Chairman. Future research in mouse radiation genetics. Genetics (1974) 0.75
Radiation and chemical mutagenesis and repair in mice. Johns Hopkins Med J Suppl (1972) 0.75
Effect of antacids on predicted steady-state cimetidine concentrations. Dig Dis Sci (1984) 0.75
Ultrasonic echo imaging of tissues: instrumentation. Br J Radiol (1976) 0.75
A sonographic technique to reduce beam distortion by curved interfaces. Ultrasound Med Biol (1989) 0.75
Administration-route-related differences in the micronucleus test with N-ethyl-N-nitrosourea. Mutat Res (1989) 0.75
Recent developments in ultrasonic echoscopy at the commonwealth acoustic laboratories. Br J Radiol (1973) 0.75
Ring Y chromsome in the Norway rat, Rattus norvegicus. Cytogenet Cell Genet (1979) 0.75
Amoxapine overdose: case report and pharmacokinetic profile. J Toxicol Clin Toxicol (1983) 0.75
Formulary management through therapeutic substitution: factors behind the decision. Hosp Formul (1983) 0.75
Gray scale compound scan echography of the normal upper abdomen. J Clin Ultrasound (1975) 0.75
A reflection technique for measurement of high acoustic intensities. Ultrasound Med Biol (1985) 0.75
Effect of X-ray and ethylnitrosourea exposures separated by 24 h on specific-locus mutation frequency in mouse stem-cell spermatogonia. Mutat Res (1988) 0.75
Current applications of diagnostic ultrasound. Guys Hosp Rep (1974) 0.75
Accuracy of serum gentamicin concentration predictions generated by a personal-computer software system. Clin Pharm (1984) 0.75
Chromosome aberrations and dominant lethality of mouse embryos after paternal treatment with triethylenemelamine. Mutat Res (1977) 0.75
State regulatory positions concerning therapeutic substitutions in hospitals. Am J Hosp Pharm (1981) 0.75
Gray scale ultrasonography in the diagnosis of thyroid swellings. J Clin Ultrasound (1974) 0.75
Evaluation of the "condition correction factor" method of estimating theophylline clearance. Ther Drug Monit (1983) 0.75
Occurrence of premature chromosome condensation in mouse spermatogonia treated with busulfan. Cytogenet Cell Genet (1986) 0.75
Therapeutic substitution: has its time arrived? Hosp Formul (1984) 0.75
Unscheduled DNA synthesis induced in mouse spermatids after combined treatment with methyl methanesulfonate and X-rays. Mutat Res (1978) 0.75
Quality assurance in a clinical pharmacy program. QRB Qual Rev Bull (1984) 0.75
Exchange dynamics of nitric oxide in the human nose. J Appl Physiol (1985) (2001) 0.75
Mitomycin-C-induced dominant lethality in mice [proceedings]. Mutat Res (1976) 0.75
Therapeutic substitution and the hospital formulary system. Am J Hosp Pharm (1981) 0.75
Conversion from intravenous aminophylline to sustained-release theophylline: computer simulation versus in vivo results. Clin Pharm (1983) 0.75
Drug usage in newborn intensive care units. Hosp Formul (1983) 0.75