Published in Blood Cells Mol Dis on October 02, 2012
Genome-wide ENU mutagenesis in combination with high density SNP analysis and exome sequencing provides rapid identification of novel mouse models of developmental disease. PLoS One (2013) 0.85
The first mouse mutants of D14Abb1e (Fam208a) show that it is critical for early development. Mamm Genome (2014) 0.84
The use of mouse models to study epigenetics. Cold Spring Harb Perspect Biol (2013) 0.80
The functional diversity of essential genes required for mammalian cardiac development. Genesis (2014) 0.79
Time-dependent toxic effects of N-ethyl-N-nitrosourea on the testes of male C57BL/6J mice: a histological and ultrastructural study. Int J Clin Exp Pathol (2015) 0.78
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A mouse model of hereditary coproporphyria identified in an ENU mutagenesis screen. Dis Model Mech (2017) 0.75
Programmed anuclear cell death delimits platelet life span. Cell (2007) 5.98
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The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells. Nat Immunol (2008) 3.07
Understanding transgenerational epigenetic inheritance via the gametes in mammals. Nat Rev Genet (2012) 2.93
A homolog of Drosophila grainy head is essential for epidermal integrity in mice. Science (2005) 2.72
The Lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal. Science (2010) 2.64
Genetically tagging endothelial cells in vivo: bone marrow-derived cells do not contribute to tumor endothelium. Blood (2004) 2.30
SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation. Nat Genet (2008) 2.19
NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells. Immunity (2012) 2.14
The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12. Proc Natl Acad Sci U S A (2003) 2.12
Dynamic reprogramming of DNA methylation at an epigenetically sensitive allele in mice. PLoS Genet (2006) 2.07
Maternal ethanol consumption alters the epigenotype and the phenotype of offspring in a mouse model. PLoS Genet (2010) 2.03
Individual differences in the expression of a "general" learning ability in mice. J Neurosci (2003) 1.93
The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments. Immunity (2012) 1.89
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Single-chain antigen recognition receptors that costimulate potent rejection of established experimental tumors. Blood (2002) 1.83
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Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome. Blood (2009) 1.79
Modifiers of epigenetic reprogramming show paternal effects in the mouse. Nat Genet (2007) 1.79
Complex patterns of transcription at the insertion site of a retrotransposon in the mouse. Nucleic Acids Res (2004) 1.75
Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function. Blood (2009) 1.74
Erg is required for self-renewal of hematopoietic stem cells during stress hematopoiesis in mice. Blood (2011) 1.69
Deciphering the molecular and biologic processes that mediate histone deacetylase inhibitor-induced thrombocytopenia. Blood (2011) 1.69
Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival. Cell Stem Cell (2009) 1.69
Mutation discovery in mice by whole exome sequencing. Genome Biol (2011) 1.69
Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function. Blood (2012) 1.67
Transgenerational epigenetic inheritance: more questions than answers. Genome Res (2010) 1.67
Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically. Cancer Cell (2013) 1.67
A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead. Mech Dev (2002) 1.64
Targeting of the tumor suppressor GRHL3 by a miR-21-dependent proto-oncogenic network results in PTEN loss and tumorigenesis. Cancer Cell (2011) 1.63
Mcl-1 and Bcl-x(L) coordinately regulate megakaryocyte survival. Blood (2012) 1.57
Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets. Blood (2011) 1.56
The case for transgenerational epigenetic inheritance in humans. Mamm Genome (2008) 1.54
Inositol- and folate-resistant neural tube defects in mice lacking the epithelial-specific factor Grhl-3. Nat Med (2003) 1.51
An N-ethyl-N-nitrosourea screen for genes involved in variegation in the mouse. Proc Natl Acad Sci U S A (2005) 1.51
Underestimation of myelodysplastic syndrome incidence by cancer registries: Results from a population-based data linkage study. Cancer (2014) 1.50
Redistribution of H3K27me3 upon DNA hypomethylation results in de-repression of Polycomb target genes. Genome Biol (2013) 1.47
The culture of zygotes to the blastocyst stage changes the postnatal expression of an epigentically labile allele, agouti viable yellow, in mice. Biol Reprod (2008) 1.45
Perturbed desmosomal cadherin expression in grainy head-like 1-null mice. EMBO J (2008) 1.42
A mouse model of harlequin ichthyosis delineates a key role for Abca12 in lipid homeostasis. PLoS Genet (2008) 1.40
A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development. Genome Biol (2008) 1.35
Spatial and temporal expression of the Grainyhead-like transcription factor family during murine development. Gene Expr Patterns (2006) 1.35
A novel mutation in the Nfkb2 gene generates an NF-kappa B2 "super repressor". J Immunol (2007) 1.34
Prospective analysis of incidence and risk factors of dysphagia in spine surgery patients: comparison of anterior cervical, posterior cervical, and lumbar procedures. Spine (Phila Pa 1976) (2004) 1.31
Rejection of syngeneic colon carcinoma by CTLs expressing single-chain antibody receptors codelivering CD28 costimulation. J Immunol (2002) 1.31
ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification. Genes Dev (2011) 1.30
Identification of a PRMT5-dependent repressor complex linked to silencing of human fetal globin gene expression. Blood (2010) 1.28
Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets. J Exp Med (2011) 1.27
How lifetimes shape epigenotype within and across generations. Hum Mol Genet (2006) 1.27
Epigenetics and phenotypic variation in mammals. Mamm Genome (2006) 1.26
Systematic variation of the stellar initial mass function in early-type galaxies. Nature (2012) 1.25
Epidermal wound repair is regulated by the planar cell polarity signaling pathway. Dev Cell (2010) 1.25
Regional neural tube closure defined by the Grainy head-like transcription factors. Dev Biol (2010) 1.23
Hmgb3: an HMG-box family member expressed in primitive hematopoietic cells that inhibits myeloid and B-cell differentiation. Blood (2003) 1.20
SCL is required for normal function of short-term repopulating hematopoietic stem cells. Blood (2004) 1.20
LIM-domain-only proteins in cancer. Nat Rev Cancer (2013) 1.19
Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage. Proc Natl Acad Sci U S A (2009) 1.18
Distinct domains of erythroid Krüppel-like factor modulate chromatin remodeling and transactivation at the endogenous beta-globin gene promoter. Mol Cell Biol (2002) 1.17
The unique and cooperative roles of the Grainy head-like transcription factors in epidermal development reflect unexpected target gene specificity. Dev Biol (2010) 1.17
The identification and characterization of human Sister-of-Mammalian Grainyhead (SOM) expands the grainyhead-like family of developmental transcription factors. Biochem J (2003) 1.10
Adoptive transfer of gene-engineered CD4+ helper T cells induces potent primary and secondary tumor rejection. Blood (2005) 1.10
Reduced levels of two modifiers of epigenetic gene silencing, Dnmt3a and Trim28, cause increased phenotypic noise. Genome Biol (2010) 1.10
Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene. Proc Natl Acad Sci U S A (2006) 1.09
Critical roles for c-Myb in lymphoid priming and early B-cell development. Blood (2010) 1.09
Transgenerational epigenetic inheritance. Curr Biol (2003) 1.06
Ankyrin repeat and suppressors of cytokine signaling box protein asb-9 targets creatine kinase B for degradation. J Biol Chem (2006) 1.05
The functional basis for hemophagocytic lymphohistiocytosis in a patient with co-inherited missense mutations in the perforin (PFN1) gene. J Exp Med (2004) 1.05
Sensitive flow cytometric analysis reveals a novel type of parent-of-origin effect in the mouse genome. Curr Biol (2003) 1.04
Novel roles for erythroid Ankyrin-1 revealed through an ENU-induced null mouse mutant. Blood (2009) 1.04
Heritable germline epimutation is not the same as transgenerational epigenetic inheritance. Nat Genet (2007) 1.04
A functional role for CD28 costimulation in tumor recognition by single-chain receptor-modified T cells. Cancer Gene Ther (2004) 1.03
Agm1/Pgm3-mediated sugar nucleotide synthesis is essential for hematopoiesis and development. Mol Cell Biol (2007) 1.03
BMP4-dependent expression of Xenopus Grainyhead-like 1 is essential for epidermal differentiation. Development (2005) 1.02
Functional but abnormal adult erythropoiesis in the absence of the stem cell leukemia gene. Mol Cell Biol (2005) 1.02
ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis. Cell Metab (2013) 1.02
The role of the ETS factor erg in zebrafish vasculogenesis. Mech Dev (2008) 1.02
The generation and properties of human macrophage populations from hemopoietic stem cells. J Leukoc Biol (2009) 1.01
Aberrant mast-cell differentiation in mice lacking the stem-cell leukemia gene. Blood (2007) 1.01
Chromatin-binding regions of EBNA1 protein facilitate the enhanced transfection of Epstein-Barr virus-based vectors. Hum Gene Ther (2006) 1.01
Mutations in mouse Ift144 model the craniofacial, limb and rib defects in skeletal ciliopathies. Hum Mol Genet (2012) 1.00
The role of p22 NF-E4 in human globin gene switching. J Biol Chem (2004) 0.99
Site-specific acetylation of the fetal globin activator NF-E4 prevents its ubiquitination and regulates its interaction with the histone deacetylase, HDAC1. J Biol Chem (2004) 0.99
Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease. Proc Natl Acad Sci U S A (2013) 0.98