Published in N Engl J Med on May 19, 2005
Center for Reducing Asthma Disparities - Meharry/Vanderbilt Centers | NCT00281151
Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. J Allergy Clin Immunol (2007) 6.33
Increased risk of serious pneumococcal disease in patients with asthma. J Allergy Clin Immunol (2008) 2.97
Association of bacteria and viruses with wheezy episodes in young children: prospective birth cohort study. BMJ (2010) 2.65
A multivariate analysis of risk factors for the air-trapping asthmatic phenotype as measured by quantitative CT analysis. Chest (2008) 2.38
Toward primary prevention of asthma. Reviewing the evidence for early-life respiratory viral infections as modifiable risk factors to prevent childhood asthma. Am J Respir Crit Care Med (2015) 2.33
Muc5b is required for airway defence. Nature (2013) 2.01
Sickle cell trait, hemoglobin C trait, and invasive pneumococcal disease. Epidemiology (2010) 1.63
Asthma-associated differences in microbial composition of induced sputum. J Allergy Clin Immunol (2012) 1.60
Risks for infection in patients with asthma (or other atopic conditions): is asthma more than a chronic airway disease? J Allergy Clin Immunol (2014) 1.52
Antagonism of miR-328 increases the antimicrobial function of macrophages and neutrophils and rapid clearance of non-typeable Haemophilus influenzae (NTHi) from infected lung. PLoS Pathog (2015) 1.48
Alveolar macrophage phagocytosis is impaired in children with poorly controlled asthma. J Allergy Clin Immunol (2008) 1.45
The burden of invasive pneumococcal disease in children with underlying risk factors in North America and Europe. Int J Clin Pract (2013) 1.43
Host Factors and Biomarkers Associated with Poor Outcomes in Adults with Invasive Pneumococcal Disease. PLoS One (2016) 1.39
Viral infections and atopy in asthma pathogenesis: new rationales for asthma prevention and treatment. Nat Med (2012) 1.22
Increased risk of serious pneumococcal disease in patients with atopic conditions other than asthma. J Allergy Clin Immunol (2010) 1.16
The microbiology of asthma. Nat Rev Microbiol (2012) 1.14
Increased risk of pertussis in patients with asthma. J Allergy Clin Immunol (2011) 1.11
Atopic asthmatic patients have reduced airway inflammatory cell recruitment after inhaled endotoxin challenge compared with healthy volunteers. J Allergy Clin Immunol (2012) 1.09
Innate and adaptive T cells in asthmatic patients: Relationship to severity and disease mechanisms. J Allergy Clin Immunol (2015) 1.07
Altered regulation of Toll-like receptor responses impairs antibacterial immunity in the allergic lung. Mucosal Immunol (2012) 1.04
Respiratory infection and the impact of pulmonary immunity on lung health and disease. Am J Respir Crit Care Med (2012) 1.04
Socioeconomic risk factors for bacteraemic pneumococcal pneumonia in adults. Epidemiol Infect (2008) 1.04
Association of CD14 promoter polymorphism with otitis media and pneumococcal vaccine responses. Clin Vaccine Immunol (2006) 1.02
Parental decline of pneumococcal vaccination and risk of pneumococcal related disease in children. Vaccine (2010) 0.97
Epidemiology and management of common pulmonary diseases in older persons. J Gerontol A Biol Sci Med Sci (2012) 0.95
Role of infection in the development and exacerbation of asthma. Expert Rev Respir Med (2010) 0.95
Pathogenic bacteria and viruses in induced sputum or pharyngeal secretions of adults with stable asthma. Thorax (2006) 0.95
Response to infections in patients with asthma and atopic disease: an epiphenomenon or reflection of host susceptibility? J Allergy Clin Immunol (2012) 0.92
Sputum inflammatory cells from patients with allergic rhinitis and asthma have decreased inflammasome gene expression. J Allergy Clin Immunol (2011) 0.92
Clinical profile of recurrent community-acquired pneumonia in children. BMC Pulm Med (2013) 0.91
Asthma and risk of non-respiratory tract infection: a population-based case-control study. BMJ Open (2013) 0.90
Comorbidities as a driver of the excess costs of community-acquired pneumonia in U.S. commercially-insured working age adults. BMC Health Serv Res (2012) 0.90
Bacteria in sputum of stable severe asthma and increased airway wall thickness. Respir Res (2012) 0.90
Assessment of the association between atopic conditions and tympanostomy tube placement in children. Allergy Asthma Proc (2012) 0.90
Impact of delay in asthma diagnosis on chest X-ray and antibiotic utilization by clinicians. J Asthma (2011) 0.90
Allergic airway inflammation and susceptibility to pneumococcal pneumonia in a murine model with real-time in vivo evaluation. Clin Exp Immunol (2009) 0.89
Trigger recognition and management in poorly controlled asthmatics. Allergy Asthma Proc (2010) 0.87
TLR3, TLR4 and TLRs7-9 Induced Interferons Are Not Impaired in Airway and Blood Cells in Well Controlled Asthma. PLoS One (2013) 0.86
Impact of pneumococcal vaccination on pneumonia rates in patients with COPD and asthma. J Gen Intern Med (2007) 0.86
Optimal management of severe/refractory asthma. Clin Med Insights Circ Respir Pulm Med (2011) 0.86
Allergic lung inflammation alters neither susceptibility to Streptococcus pneumoniae infection nor inducibility of innate resistance in mice. Respir Res (2009) 0.86
Toll-like receptors 2, 3 and 4 and thymic stromal lymphopoietin expression in fatal asthma. Clin Exp Allergy (2012) 0.86
Adherence to Immunoprophylaxis Regimens for Respiratory Syncytial Virus Infection in Insured and Medicaid Populations. J Pediatric Infect Dis Soc (2013) 0.83
Allergic airway inflammation decreases lung bacterial burden following acute Klebsiella pneumoniae infection in a neutrophil- and CCL8-dependent manner. Infect Immun (2014) 0.82
Pneumococcal Disease in the Era of Pneumococcal Conjugate Vaccine. Infect Dis Clin North Am (2015) 0.82
Asthma increases susceptibility to heterologous but not homologous secondary influenza. J Virol (2014) 0.82
Asthma as a risk factor for zoster in adults: A population-based case-control study. J Allergy Clin Immunol (2015) 0.81
Influence of asthma epidemiology on the risk for other diseases. Allergy Asthma Immunol Res (2012) 0.81
Advances in adult asthma diagnosis and treatment and health outcomes, education, delivery, and quality in 2008. J Allergy Clin Immunol (2009) 0.79
Budesonide suppresses pulmonary antibacterial host defense by down-regulating cathelicidin-related antimicrobial peptide in allergic inflammation mice and in lung epithelial cells. BMC Immunol (2013) 0.79
Mucosal-associated invariant T cells in autoimmunity, immune-mediated diseases and airways disease. Immunology (2016) 0.78
Nasopharyngeal bacterial colonization during the first wheezing episode is associated with longer duration of hospitalization and higher risk of relapse in young children. Eur J Clin Microbiol Infect Dis (2010) 0.78
A community-based cross-sectional immunisation survey in parents of primary school students. NPJ Prim Care Respir Med (2016) 0.78
Asthma and invasive pneumococcal disease. N Engl J Med (2005) 0.78
Management of necrotizing pneumonia and pulmonary gangrene: a case series and review of the literature. Can Respir J (2014) 0.78
Epidemiology of invasive pneumococcal infections: manifestations, incidence and case fatality rate correlated to age, gender and risk factors. BMC Infect Dis (2016) 0.77
Passive cigarette smoke exposure and other risk factors for invasive pneumococcal disease in children: a case-control study. Perm J (2014) 0.77
Development and initial testing of Asthma Predictive Index for a retrospective study: an exploratory study. J Asthma (2014) 0.77
Long-term management of asthma in First Nations and Inuit children: A knowledge translation tool based on Canadian paediatric asthma guidelines, intended for use by front-line health care professionals working in isolated communities. Paediatr Child Health (2012) 0.76
Clinical characteristics of adults with chronic rhinosinusitis and specific antibody deficiency. J Allergy Clin Immunol Pract (2014) 0.76
Immune response to Streptococcus pneumoniae in asthma patients: comparison between stable situation and exacerbation. Clin Exp Immunol (2013) 0.76
Time-resolved dual RNA-seq reveals extensive rewiring of lung epithelial and pneumococcal transcriptomes during early infection. Genome Biol (2016) 0.76
Asthma and antibodies to pneumococcal virulence proteins. Infection (2013) 0.76
Asthma and risk of selective IgA deficiency or common variable immunodeficiency: a population-based case-control study. Mayo Clin Proc (2013) 0.76
Postoperative Adverse Outcomes in Patients With Asthma: A Nationwide Population-based Cohort Study. Medicine (Baltimore) (2016) 0.75
The risk and outcomes of pneumonia in patients on inhaled corticosteroids. Pulm Pharmacol Ther (2015) 0.75
First-Breath-Induced Type 2 Pathways Shape the Lung Immune Environment. Cell Rep (2017) 0.75
An association between pulmonary Mycobacterium avium-intracellulare complex infections and biomarkers of Th2-type inflammation. Respir Res (2017) 0.75
Seasonal variation in penicillin susceptibility and invasive pneumococcal disease. Pediatr Infect Dis J (2015) 0.75
The association between asthma and invasive pneumococcal disease: a nationwide study in Korea. J Korean Med Sci (2014) 0.75
Relationship of secondhand smoke and infant lower respiratory tract infection severity by familial atopy status. Ann Allergy Asthma Immunol (2013) 0.75
Nasal Levels of Antimicrobial Peptides in Allergic Asthma Patients and Healthy Controls: Differences and Effect of a Short 1,25(OH)2 Vitamin D3 Treatment. PLoS One (2015) 0.75
Asthma and invasive pneumococcal disease. N Engl J Med (2005) 0.75
Population-based study of the association between asthma and pneumococcal disease in children. Clin Epidemiol (2015) 0.75
What does tympanostomy tube placement in children teach us about the association between atopic conditions and otitis media? Curr Allergy Asthma Rep (2014) 0.75
STAT6 Signaling Attenuates Interleukin-17-Producing γδ T Cells during Acute Klebsiella pneumoniae Infection. Infect Immun (2016) 0.75
Integrated safety and efficacy analysis of once-daily fluticasone furoate for the treatment of asthma. Respir Res (2016) 0.75
The Role of IL-17 in the Association between Pneumococcal Pneumonia and Allergic Sensitization. Int J Microbiol (2011) 0.75
How many individuals with asthma need to be vaccinated to prevent one case of invasive pneumococcal disease? Can J Infect Dis Med Microbiol (2014) 0.75
Assessing asthma severity based on claims data: a systematic review. Eur J Health Econ (2016) 0.75
Asthma and the Risk of Rheumatoid Arthritis: An Insight into the Heterogeneity and Phenotypes of Asthma. Tuberc Respir Dis (Seoul) (2017) 0.75
Impact of Asthma on the Severity of Serious Pneumococcal Disease. Epidemiology (Sunnyvale) (2011) 0.75
Role of pneumococcal vaccination in prevention of pneumococcal disease among adults in Singapore. Int J Gen Med (2014) 0.75
Pneumonia Risk in Asthma Patients using Inhaled Corticosteroids: A Quasi-Cohort Study. Br J Clin Pharmacol (2017) 0.75
Asthma is Associated with a Lower Risk of Sepsis and Sepsis Related Mortality. Am J Respir Crit Care Med (2017) 0.75
Invasive methicillin-resistant Staphylococcus aureus infections in the United States. JAMA (2007) 26.98
The burden of respiratory syncytial virus infection in young children. N Engl J Med (2009) 8.95
Sustained reductions in invasive pneumococcal disease in the era of conjugate vaccine. J Infect Dis (2010) 8.37
The underrecognized burden of influenza in young children. N Engl J Med (2006) 8.25
Azithromycin and the risk of cardiovascular death. N Engl J Med (2012) 8.18
Effect of introduction of the pneumococcal conjugate vaccine on drug-resistant Streptococcus pneumoniae. N Engl J Med (2006) 7.68
Major congenital malformations after first-trimester exposure to ACE inhibitors. N Engl J Med (2006) 6.83
Incidence of pneumococcal disease due to non-pneumococcal conjugate vaccine (PCV7) serotypes in the United States during the era of widespread PCV7 vaccination, 1998-2004. J Infect Dis (2007) 6.45
Epidemiology of invasive group B streptococcal disease in the United States, 1999-2005. JAMA (2008) 6.13
Population-based surveillance for hospitalizations associated with respiratory syncytial virus, influenza virus, and parainfluenza viruses among young children. Pediatrics (2004) 5.74
Effectiveness of seven-valent pneumococcal conjugate vaccine against invasive pneumococcal disease: a matched case-control study. Lancet (2006) 5.56
Decline in pneumonia admissions after routine childhood immunisation with pneumococcal conjugate vaccine in the USA: a time-series analysis. Lancet (2007) 5.50
Changing epidemiology of invasive pneumococcal disease among older adults in the era of pediatric pneumococcal conjugate vaccine. JAMA (2005) 5.29
Non-steroidal anti-inflammatory drugs and risk of serious coronary heart disease: an observational cohort study. Lancet (2002) 5.17
Population snapshot of emergent Streptococcus pneumoniae serotype 19A in the United States, 2005. J Infect Dis (2008) 4.91
A population-based comparison of strategies to prevent early-onset group B streptococcal disease in neonates. N Engl J Med (2002) 4.88
Health care-associated invasive MRSA infections, 2005-2008. JAMA (2010) 4.79
Antibiotic prescription rates for acute respiratory tract infections in US ambulatory settings. JAMA (2009) 4.61
Effect of pneumococcal conjugate vaccine on pneumococcal meningitis. N Engl J Med (2009) 4.38
National burden of invasive methicillin-resistant Staphylococcus aureus infections, United States, 2011. JAMA Intern Med (2013) 4.21
Evidence of a causal role of winter virus infection during infancy in early childhood asthma. Am J Respir Crit Care Med (2008) 3.84
Burden of interpandemic influenza in children younger than 5 years: a 25-year prospective study. J Infect Dis (2001) 3.73
Improving blood pressure control through provider education, provider alerts, and patient education: a cluster randomized trial. Ann Intern Med (2006) 3.72
Changes in Neisseria meningitidis disease epidemiology in the United States, 1998-2007: implications for prevention of meningococcal disease. Clin Infect Dis (2010) 3.61
Initiation of tumor necrosis factor-α antagonists and the risk of hospitalization for infection in patients with autoimmune diseases. JAMA (2011) 3.58
Geographic diversity and temporal trends of antimicrobial resistance in Streptococcus pneumoniae in the United States. Nat Med (2003) 3.54
Rhinovirus-associated hospitalizations in young children. J Infect Dis (2007) 3.35
Superiority of reverse-transcription polymerase chain reaction to conventional viral culture in the diagnosis of acute respiratory tract infections in children. J Infect Dis (2004) 3.25
ADHD drugs and serious cardiovascular events in children and young adults. N Engl J Med (2011) 3.12
Bacterial meningitis in the United States, 1998-2007. N Engl J Med (2011) 2.99
Immortal time bias in critical care research: application of time-varying Cox regression for observational cohort studies. Crit Care Med (2009) 2.96
Invasive pneumococcal disease among infants before and after introduction of pneumococcal conjugate vaccine. JAMA (2006) 2.93
Effectiveness of seasonal influenza vaccines in the United States during a season with circulation of all three vaccine strains. Clin Infect Dis (2012) 2.91
Outcomes with concurrent use of clopidogrel and proton-pump inhibitors: a cohort study. Ann Intern Med (2010) 2.90
Prevention of hepatitis A with the hepatitis A vaccine. N Engl J Med (2004) 2.87
New users of antipsychotic medications among children enrolled in TennCare. Arch Pediatr Adolesc Med (2004) 2.80
ADHD medications and risk of serious cardiovascular events in young and middle-aged adults. JAMA (2011) 2.77
Safety of herpes zoster vaccine in the shingles prevention study: a randomized trial. Ann Intern Med (2010) 2.73
Incidence of invasive pneumococcal disease among individuals with sickle cell disease before and after the introduction of the pneumococcal conjugate vaccine. Clin Infect Dis (2007) 2.60
Increasing burden of invasive group B streptococcal disease in nonpregnant adults, 1990-2007. Clin Infect Dis (2009) 2.56
A novel group of rhinoviruses is associated with asthma hospitalizations. J Allergy Clin Immunol (2008) 2.53
COX-2 selective non-steroidal anti-inflammatory drugs and risk of serious coronary heart disease. Lancet (2002) 2.49
Density interactions among Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus in the nasopharynx of young Peruvian children. Pediatr Infect Dis J (2013) 2.47
Validation of ICD-9 codes with a high positive predictive value for incident strokes resulting in hospitalization using Medicaid health data. Pharmacoepidemiol Drug Saf (2008) 2.46
Accuracy and interpretation of rapid influenza tests in children. Pediatrics (2007) 2.43
Increased risk of adrenal insufficiency following etomidate exposure in critically injured patients. Arch Surg (2008) 2.38
Toward primary prevention of asthma. Reviewing the evidence for early-life respiratory viral infections as modifiable risk factors to prevent childhood asthma. Am J Respir Crit Care Med (2015) 2.33
Use of a reduced (4-dose) vaccine schedule for postexposure prophylaxis to prevent human rabies: recommendations of the advisory committee on immunization practices. MMWR Recomm Rep (2010) 2.31
Increasing burden and risk factors for bronchiolitis-related medical visits in infants enrolled in a state health care insurance plan. Pediatrics (2008) 2.29
Influence of maternal asthma on the cause and severity of infant acute respiratory tract infections. J Allergy Clin Immunol (2012) 2.26
Evaluation of universal antenatal screening for group B streptococcus. N Engl J Med (2009) 2.25
Community-associated methicillin-resistant Staphylococcus aureus and healthcare risk factors. Emerg Infect Dis (2006) 2.25
Maternal asthma and maternal smoking are associated with increased risk of bronchiolitis during infancy. Pediatrics (2007) 2.20
Fluoroquinolone resistance in Mycobacterium tuberculosis: the effect of duration and timing of fluoroquinolone exposure. Am J Respir Crit Care Med (2009) 2.18
Comparative effectiveness of sulfonylurea and metformin monotherapy on cardiovascular events in type 2 diabetes mellitus: a cohort study. Ann Intern Med (2012) 2.18
Maternal antidepressant use and adverse outcomes: a cohort study of 228,876 pregnancies. Am J Obstet Gynecol (2012) 2.16
An outbreak of community-acquired foodborne illness caused by methicillin-resistant Staphylococcus aureus. Emerg Infect Dis (2002) 2.15
Novel mechanism of resistance to oxazolidinones, macrolides, and chloramphenicol in ribosomal protein L4 of the pneumococcus. Antimicrob Agents Chemother (2005) 2.14
Influenza burden for children with asthma. Pediatrics (2008) 2.10
Maternal morbidity and perinatal outcomes among pregnant women with respiratory hospitalizations during influenza season. Am J Obstet Gynecol (2003) 2.09
Increasing incidence of empyema complicating childhood community-acquired pneumonia in the United States. Clin Infect Dis (2010) 2.09
Pseudomonas aeruginosa and Serratia marcescens contamination associated with a manufacturing defect in bronchoscopes. N Engl J Med (2003) 2.09
Beta-blocker exposure is associated with improved survival after severe traumatic brain injury. J Trauma (2007) 2.08
Characterization of methicillin-resistant Staphylococcus aureus isolates collected in 2005 and 2006 from patients with invasive disease: a population-based analysis. J Clin Microbiol (2009) 2.06
National impact of universal childhood immunization with pneumococcal conjugate vaccine on outpatient medical care visits in the United States. Pediatrics (2006) 2.01
Bronchiolitis to asthma: a review and call for studies of gene-virus interactions in asthma causation. Am J Respir Crit Care Med (2006) 1.96
Human coronavirus in young children hospitalized for acute respiratory illness and asymptomatic controls. Pediatr Infect Dis J (2012) 1.93
Human rhinovirus species associated with hospitalizations for acute respiratory illness in young US children. J Infect Dis (2011) 1.93
Comparative effectiveness of incident oral antidiabetic drugs on kidney function. Kidney Int (2012) 1.92
Association between use of statins and mortality among patients hospitalized with laboratory-confirmed influenza virus infections: a multistate study. J Infect Dis (2011) 1.91