Respiratory infection and the impact of pulmonary immunity on lung health and disease.

Foxp3+ regulatory T cells promote lung epithelial proliferation. Mucosal Immunol (2014) 1.06

Experimental human pneumococcal carriage augments IL-17A-dependent T-cell defence of the lung. PLoS Pathog (2013) 1.01

Roles of lung epithelium in neutrophil recruitment during pneumococcal pneumonia. Am J Respir Cell Mol Biol (2014) 0.96

Dynamics of lung defense in pneumonia: resistance, resilience, and remodeling. Annu Rev Physiol (2014) 0.89

Roles of STAT3 in protein secretion pathways during the acute-phase response. Infect Immun (2013) 0.83

p120-catenin expressed in alveolar type II cells is essential for the regulation of lung innate immune response. Am J Pathol (2015) 0.81

The Lung-Liver Axis: A Requirement for Maximal Innate Immunity and Hepatoprotection during Pneumonia. Am J Respir Cell Mol Biol (2015) 0.81

Mechanisms of interferon-γ production by neutrophils and its function during Streptococcus pneumoniae pneumonia. Am J Respir Cell Mol Biol (2015) 0.80

With Friends Like These: The Complex Role of Neutrophils in the Progression of Severe Pneumonia. Front Cell Infect Microbiol (2017) 0.78

Key role for scavenger receptor B-I in the integrative physiology of host defense during bacterial pneumonia. Mucosal Immunol (2014) 0.77

Evaluating the NET influence of inflammation on pneumonia biology. Am J Respir Crit Care Med (2012) 0.76

Endoplasmic reticulum chaperone gp96 in macrophages is essential for protective immunity during Gram-negative pneumonia. J Pathol (2015) 0.76

The infant nose. Introducing the respiratory tract to the world. Am J Respir Crit Care Med (2014) 0.75

Role for phospholipid acyl chains and cholesterol in pulmonary infections and inflammation. J Leukoc Biol (2016) 0.75

Humanized Mouse Models of Staphylococcus aureus Infection. Front Immunol (2017) 0.75

Transcriptomic Biomarkers to Discriminate Bacterial from Nonbacterial Infection in Adults Hospitalized with Respiratory Illness. Sci Rep (2017) 0.75

The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med (2004) 17.08

Evidence-based health policy--lessons from the Global Burden of Disease Study. Science (1996) 13.50

Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus. Nat Immunol (2011) 6.73

Resolvin E1 and protectin D1 activate inflammation-resolution programmes. Nature (2007) 6.53

Association of diagnostic coding with trends in hospitalizations and mortality of patients with pneumonia, 2003-2009. JAMA (2012) 5.95

Trends in hospitalizations for pneumonia among persons aged 65 years or older in the United States, 1988-2002. JAMA (2005) 5.84

Trends in infectious disease mortality in the United States during the 20th century. JAMA (1999) 4.97

Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans. Nat Med (2012) 4.74

Infection in the pathogenesis and course of chronic obstructive pulmonary disease. N Engl J Med (2008) 4.33

Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10. Nat Med (2009) 4.22

Asthma as a risk factor for invasive pneumococcal disease. N Engl J Med (2005) 4.04

Acute lower respiratory tract infection. N Engl J Med (2008) 3.70

Clearance of apoptotic cells: implications in health and disease. J Cell Biol (2010) 3.55

Clinical and economic burden of community-acquired pneumonia among adults in Europe. Thorax (2010) 3.34

Lung infection--a public health priority. PLoS Med (2006) 3.34

CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury. J Clin Invest (2009) 2.96

Innate and adaptive immune responses in asthma. Nat Med (2012) 2.73

Toll-like receptor 1 polymorphisms affect innate immune responses and outcomes in sepsis. Am J Respir Crit Care Med (2008) 2.64

Global health. Some neglected diseases are more neglected than others. Science (2009) 2.32

Cutting edge: myeloid differentiation factor 88 is essential for pulmonary host defense against Pseudomonas aeruginosa but not Staphylococcus aureus. J Immunol (2004) 2.26

Resident memory T cells (T(RM)) are abundant in human lung: diversity, function, and antigen specificity. PLoS One (2011) 2.22

Respiratory epithelial cells regulate lung inflammation in response to inhaled endotoxin. Am J Physiol Lung Cell Mol Physiol (2004) 2.19

Th17 cells mediate clade-specific, serotype-independent mucosal immunity. Immunity (2011) 2.15

Asthma exacerbations: origin, effect, and prevention. J Allergy Clin Immunol (2011) 2.09

Infectious diseases in patients with IRAK-4, MyD88, NEMO, or IκBα deficiency. Clin Microbiol Rev (2011) 2.08

A prominent role for airway epithelial NF-kappa B activation in lipopolysaccharide-induced airway inflammation. J Immunol (2003) 1.99

Fas determines differential fates of resident and recruited macrophages during resolution of acute lung injury. Am J Respir Crit Care Med (2011) 1.92

Lung NF-kappaB activation and neutrophil recruitment require IL-1 and TNF receptor signaling during pneumococcal pneumonia. J Immunol (2005) 1.82

The pathogenesis of chronic obstructive pulmonary disease: advances in the past 100 years. Am J Respir Cell Mol Biol (2005) 1.78

The anti-inflammatory and proresolving mediator resolvin E1 protects mice from bacterial pneumonia and acute lung injury. J Immunol (2009) 1.71

Neutrophils produce interleukin 17A (IL-17A) in a dectin-1- and IL-23-dependent manner during invasive fungal infection. Infect Immun (2011) 1.58

Alveolar epithelial STAT3, IL-6 family cytokines, and host defense during Escherichia coli pneumonia. Am J Respir Cell Mol Biol (2008) 1.49

Functions and regulation of NF-kappaB RelA during pneumococcal pneumonia. J Immunol (2007) 1.43

Marked reduction in 30-day mortality among elderly patients with community-acquired pneumonia. Am J Med (2011) 1.36

An essential role for non-bone marrow-derived cells in control of Pseudomonas aeruginosa pneumonia. Am J Respir Cell Mol Biol (2005) 1.34

Interferon-γ production by neutrophils during bacterial pneumonia in mice. Am J Respir Crit Care Med (2010) 1.29

Characterization of CD4+ memory T cell responses directed against common respiratory pathogens in peripheral blood and lung. J Infect Dis (2007) 1.27

Roles of interleukin-6 in activation of STAT proteins and recruitment of neutrophils during Escherichia coli pneumonia. J Infect Dis (2005) 1.24

Viral infections and atopy in asthma pathogenesis: new rationales for asthma prevention and treatment. Nat Med (2012) 1.22

Bronchoalveolar CD4+ T cell responses to respiratory antigens are impaired in HIV-infected adults. Thorax (2011) 1.17

Stat3 is required for cytoprotection of the respiratory epithelium during adenoviral infection. J Immunol (2006) 1.17

Hepatocyte-specific mutation of both NF-κB RelA and STAT3 abrogates the acute phase response in mice. J Clin Invest (2012) 1.16

NF-κB and STAT3 signaling hubs for lung innate immunity. Cell Tissue Res (2010) 1.09

Next-generation regeneration: the hope and hype of lung stem cell research. Am J Respir Crit Care Med (2012) 1.07

Pathogenesis of hyper IgE syndrome. Clin Rev Allergy Immunol (2010) 1.06

Acquisition of pneumococci specific effector and regulatory Cd4+ T cells localising within human upper respiratory-tract mucosal lymphoid tissue. PLoS Pathog (2011) 1.02

Community-acquired pneumonia as an emergency: time for an aggressive intervention to lower mortality. Eur Respir J (2011) 0.99

Earliest innate immune responses require macrophage RelA during pneumococcal pneumonia. Am J Respir Cell Mol Biol (2011) 0.98

Leukemia inhibitory factor signaling is required for lung protection during pneumonia. J Immunol (2012) 0.88

Twenty-five years of translational medicine in antiretroviral therapy: promises to keep. Sci Transl Med (2010) 0.80