Published in Cell on May 20, 2005
Autophagy in immunity and inflammation. Nature (2011) 11.16
Autophagy, immunity, and microbial adaptations. Cell Host Microbe (2009) 5.84
Toll-like receptor 4 is a sensor for autophagy associated with innate immunity. Immunity (2007) 5.36
The Atg5 Atg12 conjugate associates with innate antiviral immune responses. Proc Natl Acad Sci U S A (2007) 3.93
Autophagy protects against Sindbis virus infection of the central nervous system. Cell Host Microbe (2010) 3.79
Autophagy genes in immunity. Nat Immunol (2009) 3.76
The autophagy effector Beclin 1: a novel BH3-only protein. Oncogene (2008) 2.94
Autophagy is an essential component of Drosophila immunity against vesicular stomatitis virus. Immunity (2009) 2.91
Autophagy enhances the presentation of endogenous viral antigens on MHC class I molecules during HSV-1 infection. Nat Immunol (2009) 2.80
Assortment of phosphatidylinositol 3-kinase complexes--Atg14p directs association of complex I to the pre-autophagosomal structure in Saccharomyces cerevisiae. Mol Biol Cell (2006) 2.63
Convergent energy and stress signaling. Trends Plant Sci (2008) 2.44
Autophagy negatively regulates cell death by controlling NPR1-dependent salicylic acid signaling during senescence and the innate immune response in Arabidopsis. Plant Cell (2009) 2.32
Morphological classification of plant cell deaths. Cell Death Differ (2011) 2.28
Eating the enemy within: autophagy in infectious diseases. Cell Death Differ (2008) 2.17
Hepatitis C virus genotype 1a growth and induction of autophagy. J Virol (2007) 1.96
Mobilization of rubisco and stroma-localized fluorescent proteins of chloroplasts to the vacuole by an ATG gene-dependent autophagic process. Plant Physiol (2008) 1.91
Autophagy contributes to leaf starch degradation. Plant Cell (2013) 1.85
Efficient virus-induced gene silencing in Arabidopsis. Plant Physiol (2006) 1.81
Arabidopsis ACCELERATED CELL DEATH2 modulates programmed cell death. Plant Cell (2005) 1.79
Viruses and autophagy. Rev Med Virol (2009) 1.75
Autophagy plays a role in chloroplast degradation during senescence in individually darkened leaves. Plant Physiol (2008) 1.72
Autophagy: for better or for worse. Cell Res (2011) 1.65
The ATG12-conjugating enzyme ATG10 Is essential for autophagic vesicle formation in Arabidopsis thaliana. Genetics (2008) 1.63
Analysis of the role of autophagy in replication of herpes simplex virus in cell culture. J Virol (2007) 1.63
The crosstalk between autophagy and apoptosis: where does this lead? Protein Cell (2012) 1.60
Autophagy and pattern recognition receptors in innate immunity. Immunol Rev (2009) 1.51
Autophagy and innate immunity: triggering, targeting and tuning. Semin Cell Dev Biol (2010) 1.49
An inositolphosphorylceramide synthase is involved in regulation of plant programmed cell death associated with defense in Arabidopsis. Plant Cell (2008) 1.47
Knockdown of autophagy enhances the innate immune response in hepatitis C virus-infected hepatocytes. Hepatology (2011) 1.47
Inhibition of target of rapamycin signaling and stress activate autophagy in Chlamydomonas reinhardtii. Plant Physiol (2010) 1.46
An Arabidopsis homolog of yeast ATG6/VPS30 is essential for pollen germination. Plant Physiol (2007) 1.44
Autophagy and antiviral immunity. Curr Opin Immunol (2008) 1.44
The ATG autophagic conjugation system in maize: ATG transcripts and abundance of the ATG8-lipid adduct are regulated by development and nutrient availability. Plant Physiol (2008) 1.39
Degradation of the endoplasmic reticulum by autophagy during endoplasmic reticulum stress in Arabidopsis. Plant Cell (2012) 1.38
Coxsackievirus infection induces autophagy-like vesicles and megaphagosomes in pancreatic acinar cells in vivo. J Virol (2010) 1.38
Silencing GhNDR1 and GhMKK2 compromises cotton resistance to Verticillium wilt. Plant J (2011) 1.33
Viral Bcl-2-mediated evasion of autophagy aids chronic infection of gammaherpesvirus 68. PLoS Pathog (2009) 1.31
Autophagy in immunity against mycobacterium tuberculosis: a model system to dissect immunological roles of autophagy. Curr Top Microbiol Immunol (2009) 1.30
Chikungunya triggers an autophagic process which promotes viral replication. Virol J (2011) 1.26
The ATG1/ATG13 protein kinase complex is both a regulator and a target of autophagic recycling in Arabidopsis. Plant Cell (2011) 1.26
Varicella-zoster virus infection induces autophagy in both cultured cells and human skin vesicles. J Virol (2009) 1.26
Insect antiviral innate immunity: pathways, effectors, and connections. J Mol Biol (2013) 1.25
IFN-γ elicits macrophage autophagy via the p38 MAPK signaling pathway. J Immunol (2012) 1.24
BAC-mediated transgenic expression of fluorescent autophagic protein Beclin 1 reveals a role for Beclin 1 in lymphocyte development. Cell Death Differ (2008) 1.23
Viral evasion of autophagy. Autophagy (2007) 1.23
NBR1-mediated selective autophagy targets insoluble ubiquitinated protein aggregates in plant stress responses. PLoS Genet (2013) 1.21
The PP2A regulatory subunit Tap46, a component of the TOR signaling pathway, modulates growth and metabolism in plants. Plant Cell (2011) 1.20
Accelerated cell death in Podospora autophagy mutants. Eukaryot Cell (2005) 1.20
Autophagy, antiviral immunity, and viral countermeasures. Biochim Biophys Acta (2009) 1.20
Cell death control: the interplay of apoptosis and autophagy in the pathogenicity of Sclerotinia sclerotiorum. PLoS Pathog (2013) 1.20
A role for autophagic protein beclin 1 early in lymphocyte development. J Immunol (2011) 1.18
Variations on a theme: plant autophagy in comparison to yeast and mammals. Protoplasma (2011) 1.18
Inhibition of ERK attenuates autophagy and potentiates tumour necrosis factor-alpha-induced cell death in MCF-7 cells. J Cell Mol Med (2008) 1.18
Cross-species translocation of mRNA from host plants into the parasitic plant dodder. Plant Physiol (2006) 1.17
The autophagic degradation of chloroplasts via rubisco-containing bodies is specifically linked to leaf carbon status but not nitrogen status in Arabidopsis. Plant Physiol (2010) 1.17
EDR2 negatively regulates salicylic acid-based defenses and cell death during powdery mildew infections of Arabidopsis thaliana. BMC Plant Biol (2007) 1.16
The secretory system of Arabidopsis. Arabidopsis Book (2008) 1.16
The MI-1-mediated pest resistance requires Hsp90 and Sgt1. Plant Physiol (2007) 1.15
Role of autophagy in disease resistance and hypersensitive response-associated cell death. Cell Death Differ (2011) 1.12
An autophagy-associated Atg8 protein is involved in the responses of Arabidopsis seedlings to hormonal controls and abiotic stresses. J Exp Bot (2008) 1.12
TOR is a negative regulator of autophagy in Arabidopsis thaliana. PLoS One (2010) 1.11
Role of plant autophagy in stress response. Protein Cell (2011) 1.11
Autophagy as an important process in gut homeostasis and Crohn's disease pathogenesis. Gut (2008) 1.10
Autophagy and viruses: adversaries or allies? J Innate Immun (2013) 1.10
Reactive oxygen species and autophagy in plants and algae. Plant Physiol (2012) 1.08
Autophagy during proliferation and encystation in the protozoan parasite Entamoeba invadens. Infect Immun (2007) 1.08
When autophagy meets viruses: a double-edged sword with functions in defense and offense. Semin Immunopathol (2010) 1.07
Selective autophagy and viruses. Autophagy (2011) 1.07
Autophagy, an immunologic magic bullet: Mycobacterium tuberculosis phagosome maturation block and how to bypass it. Future Microbiol (2008) 1.05
The rice TAL effector-dependent resistance protein XA10 triggers cell death and calcium depletion in the endoplasmic reticulum. Plant Cell (2014) 1.04
Intertwined pathways of programmed cell death in immunity. Immunol Rev (2010) 1.04
Autophagy contributes to nighttime energy availability for growth in Arabidopsis. Plant Physiol (2013) 1.03
Herpes simplex virus γ34.5 interferes with autophagosome maturation and antigen presentation in dendritic cells. MBio (2012) 1.03
Lesion mimic mutants: A classical, yet still fundamental approach to study programmed cell death. Plant Signal Behav (2008) 1.02
The expanding universe of ubiquitin and ubiquitin-like modifiers. Plant Physiol (2012) 1.02
Manipulation or capitulation: virus interactions with autophagy. Microbes Infect (2011) 1.02
Sustained activation of Akt elicits mitochondrial dysfunction to block Plasmodium falciparum infection in the mosquito host. PLoS Pathog (2013) 1.01
Catalase and NO CATALASE ACTIVITY1 promote autophagy-dependent cell death in Arabidopsis. Plant Cell (2013) 1.01
A BAR-domain protein SH3P2, which binds to phosphatidylinositol 3-phosphate and ATG8, regulates autophagosome formation in Arabidopsis. Plant Cell (2013) 1.01
Beclin orthologs: integrative hubs of cell signaling, membrane trafficking, and physiology. Trends Cell Biol (2015) 1.00
Function of endoplasmic reticulum calcium ATPase in innate immunity-mediated programmed cell death. EMBO J (2010) 1.00
Tobacco calmodulin-like protein provides secondary defense by binding to and directing degradation of virus RNA silencing suppressors. Proc Natl Acad Sci U S A (2012) 1.00
A single intravenous injection of oncolytic picornavirus SVV-001 eliminates medulloblastomas in primary tumor-based orthotopic xenograft mouse models. Neuro Oncol (2010) 1.00
Autophagy and metacaspase determine the mode of cell death in plants. J Cell Biol (2013) 0.99
Identification of expressed genes during compatible interaction between stripe rust (Puccinia striiformis) and wheat using a cDNA library. BMC Genomics (2009) 0.98
Hepatitis C virus and cellular stress response: implications to molecular pathogenesis of liver diseases. Viruses (2012) 0.97
Autophagy enhances the replication of classical swine fever virus in vitro. Autophagy (2013) 0.96
When supply does not meet demand-ER stress and plant programmed cell death. Front Plant Sci (2014) 0.95
Intracellular recognition of pathogens and autophagy as an innate immune host defence. J Biochem (2011) 0.95
Regulation of autophagic activation by Rta of Epstein-Barr virus via the extracellular signal-regulated kinase pathway. J Virol (2014) 0.95
Impact of the autophagy machinery on hepatitis C virus infection. Viruses (2011) 0.95
The deubiquitinating enzyme AMSH1 and the ESCRT-III subunit VPS2.1 are required for autophagic degradation in Arabidopsis. Plant Cell (2013) 0.94
Herpesviruses and autophagy: catch me if you can! Viruses (2010) 0.94
Overexpression of Arabidopsis ACBP3 enhances NPR1-dependent plant resistance to Pseudomonas syringe pv tomato DC3000. Plant Physiol (2011) 0.94
A broad-spectrum, efficient and nontransgenic approach to control plant viruses by application of salicylic acid and jasmonic acid. Planta (2010) 0.93
Autophagy in innate and adaptive immunity. Proc Am Thorac Soc (2010) 0.92
Mutations in the central domain of potato virus X TGBp2 eliminate granular vesicles and virus cell-to-cell trafficking. J Virol (2006) 0.92
Xenophagy in herpes simplex virus replication and pathogenesis. Autophagy (2007) 0.92
Links between autophagy, innate immunity, inflammation and Crohn's disease. Dig Dis (2009) 0.91
Different degree in proteasome malfunction has various effects on root growth possibly through preventing cell division and promoting autophagic vacuolization. PLoS One (2012) 0.91
Autophagy fights disease through cellular self-digestion. Nature (2008) 33.83
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell (2005) 21.01
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Methods in mammalian autophagy research. Cell (2010) 20.08
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest (2003) 16.67
Autophagy and the integrated stress response. Mol Cell (2010) 11.21
Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science (2003) 9.17
Autophagy in human health and disease. N Engl J Med (2013) 8.71
Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy. Circ Res (2007) 8.44
HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein. Cell Host Microbe (2007) 7.34
JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell (2008) 7.14
The product of the tobacco mosaic virus resistance gene N: similarity to toll and the interleukin-1 receptor. Cell (1994) 6.88
Autophagic cell death: the story of a misnomer. Nat Rev Mol Cell Biol (2008) 6.78
Autophagy gene-dependent clearance of apoptotic cells during embryonic development. Cell (2007) 6.39
Abatacept for rheumatoid arthritis refractory to tumor necrosis factor alpha inhibition. N Engl J Med (2005) 6.37
Combination of infliximab and methotrexate therapy for early rheumatoid arthritis: a randomized, controlled trial. Arthritis Rheum (2004) 6.22
Autophagy in mammalian development and differentiation. Nat Cell Biol (2010) 5.99
Signaling in plant-microbe interactions. Science (1997) 5.94
Autophagy, immunity, and microbial adaptations. Cell Host Microbe (2009) 5.84
Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway. Proc Natl Acad Sci U S A (2001) 5.59
Virus-induced gene silencing in tomato. Plant J (2002) 5.55
Autophagy modulation as a potential therapeutic target for diverse diseases. Nat Rev Drug Discov (2012) 5.26
Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Invest (2007) 5.17
Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis. Nature (2012) 4.84
Cell biology: autophagy and cancer. Nature (2007) 4.40
The role of autophagy in mammalian development: cell makeover rather than cell death. Dev Cell (2008) 4.25
The Beclin 1 interactome. Curr Opin Cell Biol (2010) 4.13
The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J Clin Invest (2008) 4.09
The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function. Autophagy (2005) 4.02
IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses. Proc Natl Acad Sci U S A (2007) 3.98
Autophagy protects against Sindbis virus infection of the central nervous system. Cell Host Microbe (2010) 3.79
Treatment of rheumatoid arthritis with anakinra, a recombinant human interleukin-1 receptor antagonist, in combination with methotrexate: results of a twenty-four-week, multicenter, randomized, double-blind, placebo-controlled trial. Arthritis Rheum (2002) 3.78
Autophagy genes in immunity. Nat Immunol (2009) 3.76
Identification of a candidate therapeutic autophagy-inducing peptide. Nature (2013) 3.76
Tobacco Rar1, EDS1 and NPR1/NIM1 like genes are required for N-mediated resistance to tobacco mosaic virus. Plant J (2002) 3.50
Predictors of joint damage in patients with early rheumatoid arthritis treated with high-dose methotrexate with or without concomitant infliximab: results from the ASPIRE trial. Arthritis Rheum (2006) 3.29
Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation. Science (2012) 3.24
Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo. J Virol (2005) 3.10
A novel role for the TIR domain in association with pathogen-derived elicitors. PLoS Biol (2007) 3.04
PKR-dependent autophagic degradation of herpes simplex virus type 1. Autophagy (2006) 2.97
Applications and advantages of virus-induced gene silencing for gene function studies in plants. Plant J (2004) 2.88
Roles for rice membrane dynamics and plasmodesmata during biotrophic invasion by the blast fungus. Plant Cell (2007) 2.87
Translocation of Magnaporthe oryzae effectors into rice cells and their subsequent cell-to-cell movement. Plant Cell (2010) 2.80
Autophagy in human health and disease. N Engl J Med (2013) 2.73
Intestinal epithelial autophagy is essential for host defense against invasive bacteria. Cell Host Microbe (2013) 2.71
Autophagy is required for dietary restriction-mediated life span extension in C. elegans. Autophagy (2007) 2.71
EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance. Cell (2013) 2.63
Image-based genome-wide siRNA screen identifies selective autophagy factors. Nature (2011) 2.58
RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly. Cell (2011) 2.34
Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia. Proc Natl Acad Sci U S A (2013) 2.33
Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy. J Biol Chem (2008) 2.31
Autophagy genes protect against Salmonella typhimurium infection and mediate insulin signaling-regulated pathogen resistance. Proc Natl Acad Sci U S A (2009) 2.21
Role of SCF ubiquitin-ligase and the COP9 signalosome in the N gene-mediated resistance response to Tobacco mosaic virus. Plant Cell (2002) 2.21
Molecular chaperone Hsp90 associates with resistance protein N and its signaling proteins SGT1 and Rar1 to modulate an innate immune response in plants. J Biol Chem (2003) 2.19
Chloroplastic protein NRIP1 mediates innate immune receptor recognition of a viral effector. Cell (2008) 2.16
Differential binding of calmodulin-related proteins to their targets revealed through high-density Arabidopsis protein microarrays. Proc Natl Acad Sci U S A (2007) 2.15
Bcl-2 inhibition of autophagy: a new route to cancer? Cancer Res (2006) 2.11
Autophagy is an adaptive response in desmin-related cardiomyopathy. Proc Natl Acad Sci U S A (2008) 2.07
Two MAPK cascades, NPR1, and TGA transcription factors play a role in Pto-mediated disease resistance in tomato. Plant J (2003) 2.06
A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy (2011) 2.02
A comprehensive glossary of autophagy-related molecules and processes. Autophagy (2010) 2.00
Dual role of JNK1-mediated phosphorylation of Bcl-2 in autophagy and apoptosis regulation. Autophagy (2008) 1.95
p53: The Janus of autophagy? Nat Cell Biol (2008) 1.86
Molecular basis of the regulation of Beclin 1-dependent autophagy by the gamma-herpesvirus 68 Bcl-2 homolog M11. Autophagy (2008) 1.86
Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes. Nat Immunol (2012) 1.83
Efficient virus-induced gene silencing in Arabidopsis. Plant Physiol (2006) 1.81
The COP9 signalosome interacts physically with SCF COI1 and modulates jasmonate responses. Plant Cell (2003) 1.80
Head-to-head comparison of subcutaneous abatacept versus adalimumab for rheumatoid arthritis: findings of a phase IIIb, multinational, prospective, randomized study. Arthritis Rheum (2013) 1.80
Genome-wide ORFeome cloning and analysis of Arabidopsis transcription factor genes. Plant Physiol (2004) 1.79
Viruses and autophagy. Rev Med Virol (2009) 1.75
Autophagy in cellular growth control. FEBS Lett (2010) 1.74
Effects of prasterone on corticosteroid requirements of women with systemic lupus erythematosus: a double-blind, randomized, placebo-controlled trial. Arthritis Rheum (2002) 1.70
Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy. EMBO J (2011) 1.68
Analysis of the role of autophagy in replication of herpes simplex virus in cell culture. J Virol (2007) 1.63
Virus-induced gene silencing. Methods Mol Biol (2003) 1.63
Selective costimulation modulation using abatacept in patients with active rheumatoid arthritis while receiving etanercept: a randomised clinical trial. Ann Rheum Dis (2006) 1.56
Autophagy and innate immunity: triggering, targeting and tuning. Semin Cell Dev Biol (2010) 1.49
Involvement of MEK1 MAPKK, NTF6 MAPK, WRKY/MYB transcription factors, COI1 and CTR1 in N-mediated resistance to tobacco mosaic virus. Plant J (2004) 1.48
A phase 2 dose-finding study of PEGylated recombinant methionyl human soluble tumor necrosis factor type I in patients with rheumatoid arthritis. J Rheumatol (2005) 1.46
Evaluation of the efficacy of etoricoxib in ankylosing spondylitis: results of a fifty-two-week, randomized, controlled study. Arthritis Rheum (2005) 1.46
A plasmodesmata-localized protein mediates crosstalk between cell-to-cell communication and innate immunity in Arabidopsis. Plant Cell (2011) 1.45
Critical role of complement and viral evasion of complement in acute, persistent, and latent gamma-herpesvirus infection. Immunity (2002) 1.45
How shall I eat thee? Autophagy (2007) 1.44
Three-dimensional analysis and computer modeling of the capillary endothelial vesicular system with electron tomography. Microcirculation (2012) 1.42