PubRank

Harry Ischiropoulos

Author PubWeight™ 114.42‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Peroxynitrite: biochemistry, pathophysiology and development of therapeutics. Nat Rev Drug Discov 2007 5.65
2 Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease. J Neurosci 2002 4.38
3 Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease. J Clin Invest 2004 3.63
4 Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations. Free Radic Biol Med 2011 3.58
5 Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy. J Clin Invest 2008 3.23
6 NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. Proc Natl Acad Sci U S A 2003 2.91
7 DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase. Proc Natl Acad Sci U S A 2007 2.87
8 T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection. J Clin Invest 2012 2.66
9 Identification of S-nitrosylation motifs by site-specific mapping of the S-nitrosocysteine proteome in human vascular smooth muscle cells. Proc Natl Acad Sci U S A 2006 2.58
10 A tale of two controversies: defining both the role of peroxidases in nitrotyrosine formation in vivo using eosinophil peroxidase and myeloperoxidase-deficient mice, and the nature of peroxidase-generated reactive nitrogen species. J Biol Chem 2002 2.34
11 A newly identified role for superoxide in inflammatory pain. J Pharmacol Exp Ther 2004 2.21
12 Role of alpha-synuclein carboxy-terminus on fibril formation in vitro. Biochemistry 2003 2.18
13 Biological significance of nitric oxide-mediated protein modifications. Am J Physiol Lung Cell Mol Physiol 2004 2.16
14 Basal and stimulated protein S-nitrosylation in multiple cell types and tissues. J Biol Chem 2002 2.14
15 The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice. Proc Natl Acad Sci U S A 2006 1.90
16 Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and aging. Proc Natl Acad Sci U S A 2006 1.88
17 Structural profiling of endogenous S-nitrosocysteine residues reveals unique features that accommodate diverse mechanisms for protein S-nitrosylation. Proc Natl Acad Sci U S A 2010 1.87
18 Functional consequences of alpha-synuclein tyrosine nitration: diminished binding to lipid vesicles and increased fibril formation. J Biol Chem 2004 1.58
19 Distinct region-specific alpha-synuclein oligomers in A53T transgenic mice: implications for neurodegeneration. J Neurosci 2010 1.49
20 Reactive oxygen and nitrogen species: weapons of neuronal destruction in models of Parkinson's disease. Antioxid Redox Signal 2005 1.47
21 Reversible inhibition of alpha-synuclein fibrillization by dopaminochrome-mediated conformational alterations. J Biol Chem 2005 1.47
22 Cigarette smoke exposure and hypercholesterolemia increase mitochondrial damage in cardiovascular tissues. Circulation 2002 1.46
23 Nitric oxide regulates mitochondrial fatty acid metabolism through reversible protein S-nitrosylation. Sci Signal 2013 1.45
24 Cytosolic catechols inhibit alpha-synuclein aggregation and facilitate the formation of intracellular soluble oligomeric intermediates. J Neurosci 2006 1.43
25 Immunoglobulins against tyrosine-nitrated epitopes in coronary artery disease. Circulation 2012 1.42
26 Mitochondrial respiratory chain dysfunction variably increases oxidant stress in Caenorhabditis elegans. Mitochondrion 2009 1.41
27 Pro-thrombotic state induced by post-translational modification of fibrinogen by reactive nitrogen species. J Biol Chem 2003 1.36
28 Regulation of protein function and signaling by reversible cysteine S-nitrosylation. J Biol Chem 2013 1.35
29 The relationship between oxidative/nitrative stress and pathological inclusions in Alzheimer's and Parkinson's diseases. Free Radic Biol Med 2002 1.32
30 Effects of oxidative and nitrative challenges on alpha-synuclein fibrillogenesis involve distinct mechanisms of protein modifications. J Biol Chem 2003 1.29
31 Nitric oxide and reactive oxygen species in Parkinson's disease. IUBMB Life 2003 1.26
32 Distinct cleavage patterns of normal and pathologic forms of alpha-synuclein by calpain I in vitro. J Neurochem 2003 1.22
33 Co-compartmentalization of the astroglial glutamate transporter, GLT-1, with glycolytic enzymes and mitochondria. J Neurosci 2011 1.18
34 Mass spectrometric and computational analysis of cytokine-induced alterations in the astrocyte secretome. Proteomics 2009 1.17
35 Cleavage of alpha-synuclein by calpain: potential role in degradation of fibrillized and nitrated species of alpha-synuclein. Biochemistry 2005 1.16
36 Subcellular localization of tyrosine-nitrated proteins is dictated by reactive oxygen species generating enzymes and by proximity to nitric oxide synthase. Free Radic Biol Med 2005 1.13
37 Quantitative mass spectrometry-based proteomics reveals the dynamic range of primary mouse astrocyte protein secretion. J Proteome Res 2010 1.11
38 Cellular oligomerization of alpha-synuclein is determined by the interaction of oxidized catechols with a C-terminal sequence. J Biol Chem 2007 1.08
39 Expression of inducible nitric-oxide synthase and intracellular protein tyrosine nitration in vascular smooth muscle cells: role of reactive oxygen species. J Biol Chem 2003 1.08
40 Lymphocyte development requires S-nitrosoglutathione reductase. J Immunol 2010 1.05
41 Oxidative modifications, mitochondrial dysfunction, and impaired protein degradation in Parkinson's disease: how neurons are lost in the Bermuda triangle. Mol Neurodegener 2009 1.05
42 Fibrinogen beta-chain tyrosine nitration is a prothrombotic risk factor. J Biol Chem 2008 1.04
43 Nitration of tau protein is linked to neurodegeneration in tauopathies. Am J Pathol 2003 1.00
44 Nitric oxide antagonizes the acid tolerance response that protects Salmonella against innate gastric defenses. PLoS One 2008 0.98
45 Increased protein nitration burden in the atherosclerotic lesions and plasma of apolipoprotein A-I deficient mice. Circ Res 2007 0.98
46 The 4-cysteine zinc-finger motif of the RNA polymerase regulator DksA serves as a thiol switch for sensing oxidative and nitrosative stress. Mol Microbiol 2014 0.96
47 Nitric oxide-nitric oxide synthase regulates key maturational events during chondrocyte terminal differentiation. Bone 2005 0.95
48 Immunohistochemical detection of S-nitrosylated proteins. Methods Mol Biol 2004 0.93
49 Metabolism of 3-nitrotyrosine induces apoptotic death in dopaminergic cells. J Neurosci 2006 0.93
50 Vascular immunotargeting of glucose oxidase to the endothelial antigens induces distinct forms of oxidant acute lung injury: targeting to thrombomodulin, but not to PECAM-1, causes pulmonary thrombosis and neutrophil transmigration. Am J Pathol 2002 0.92
51 Identification of immunoglobulins that recognize 3-nitrotyrosine in patients with acute lung injury after major trauma. Am J Respir Cell Mol Biol 2006 0.92
52 Nitric oxide stimulates proliferation and differentiation of fetal calvarial osteoblasts and dural cells. Plast Reconstr Surg 2008 0.91
53 Roles of nitric oxide and superoxide in inflammation. Methods Mol Biol 2003 0.91
54 Protein microarray characterization of the S-nitrosoproteome. Mol Cell Proteomics 2013 0.89
55 Regional deficiencies in chaperone-mediated autophagy underlie α-synuclein aggregation and neurodegeneration. Neurobiol Dis 2012 0.89
56 Differential effects of exercise on aortic mitochondria. Am J Physiol Heart Circ Physiol 2004 0.88
57 Pulmonary and systemic nitric oxide metabolites in a baboon model of neonatal chronic lung disease. Am J Respir Cell Mol Biol 2005 0.88
58 Genomics and proteomics of lung disease: conference summary. Am J Physiol Lung Cell Mol Physiol 2007 0.88
59 Functional impact of oxidative posttranslational modifications on fibrinogen and fibrin clots. Free Radic Biol Med 2013 0.88
60 Sphingosine-1-phosphate receptor-3 is a novel biomarker in acute lung injury. Am J Respir Cell Mol Biol 2012 0.87
61 Strategies and tools to explore protein S-nitrosylation. Biochim Biophys Acta 2011 0.87
62 Biological stability of polyurethane modified with covalent attachment of di-tert-butyl-phenol. J Biomed Mater Res A 2007 0.86
63 'Multipurpose oxidase' in atherogenesis. Nat Med 2007 0.86
64 Parkinson's disease-like neuromuscular defects occur in prenyl diphosphate synthase subunit 2 (Pdss2) mutant mice. Mitochondrion 2011 0.85
65 Proteomic identification of S-nitrosylated Golgi proteins: new insights into endothelial cell regulation by eNOS-derived NO. PLoS One 2012 0.85
66 Inflammation induces fibrinogen nitration in experimental human endotoxemia. Free Radic Biol Med 2009 0.84
67 Urinary metabolites of oxidative stress and nitric oxide in preterm and term infants. Biol Neonate 2006 0.84
68 Mass spectrometry-based identification of S-nitrosocysteine in vivo using organic mercury assisted enrichment. Methods 2012 0.84
69 Site specific identification of endogenous S-nitrosocysteine proteomes. J Proteomics 2013 0.84
70 Evidence of native α-synuclein conformers in the human brain. J Biol Chem 2014 0.84
71 Plasma 3-nitrotyrosine and outcome in neonates with severe bronchopulmonary dysplasia after inhaled nitric oxide. Free Radic Biol Med 2003 0.83
72 DJ-1 deficient mice demonstrate similar vulnerability to pathogenic Ala53Thr human alpha-syn toxicity. Hum Mol Genet 2010 0.83
73 Oxygen tension and inhaled nitric oxide modulate pulmonary levels of S-nitrosocysteine and 3-nitrotyrosine in rats. Pediatr Res 2004 0.82
74 Nitrated fibrinogen is a biomarker of oxidative stress in venous thromboembolism. Free Radic Biol Med 2012 0.81
75 Detection of peroxynitrite-induced protein and DNA modifications. Methods Mol Biol 2002 0.80
76 Autologous apoptotic cell engulfment stimulates chemokine secretion by vascular smooth muscle cells. Am J Pathol 2005 0.80
77 Transient injury to rat lung mitochondrial DNA after exposure to hyperoxia and inhaled nitric oxide. Am J Physiol Lung Cell Mol Physiol 2003 0.79
78 Interaction with phospholipids modulates alpha-synuclein nitration and lipid-protein adduct formation. Biochem J 2006 0.79
79 NO running on MT: regulation of zinc homeostasis by interaction of nitric oxide with metallothionein. Am J Physiol Lung Cell Mol Physiol 2002 0.78
80 Enhanced lysis and accelerated establishment of viscoelastic properties of fibrin clots are associated with pulmonary embolism. Am J Physiol Lung Cell Mol Physiol 2014 0.77
81 Opposing regulation of human alveolar type II cell differentiation by nitric oxide and hyperoxia. Pediatr Res 2010 0.77
82 Nitric oxide counteracts the hyperoxia-induced proliferation and proinflammatory responses of mouse astrocytes. Free Radic Biol Med 2011 0.76
83 Super-SOD: superoxide dismutase chimera fights off inflammation. Am J Physiol Lung Cell Mol Physiol 2003 0.76
84 Neutralizing Th2 inflammation in neonatal islets prevents β-cell failure in adult IUGR rats. Diabetes 2014 0.75
85 Intermittent hydrostatic compression promotes nitric oxide production and osteodifferentiation of fetal dural cells. Ann Plast Surg 2005 0.75