Published in J Biol Chem on February 27, 2002
Nitric oxide and peroxynitrite in health and disease. Physiol Rev (2007) 15.49
Nitric oxide, oxidants, and protein tyrosine nitration. Proc Natl Acad Sci U S A (2004) 4.81
Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease. J Clin Invest (2004) 3.63
Serum myeloperoxidase levels independently predict endothelial dysfunction in humans. Circulation (2004) 2.79
Oxidative stress and nitration in neurodegeneration: cause, effect, or association? J Clin Invest (2003) 2.60
Oxidative stress and antioxidant defense. World Allergy Organ J (2012) 2.35
Loss of total and visceral adipose tissue mass predicts decreases in oxidative stress after weight-loss surgery. Obesity (Silver Spring) (2008) 2.23
Hyperbaric oxygen: its mechanisms and efficacy. Plast Reconstr Surg (2011) 2.12
Nitro-fatty acid formation and signaling. J Biol Chem (2008) 1.95
Methods to detect nitric oxide and its metabolites in biological samples. Free Radic Biol Med (2007) 1.81
On the selectivity of superoxide dismutase mimetics and its importance in pharmacological studies. Br J Pharmacol (2003) 1.77
Correlation of systemic superoxide dismutase deficiency to airflow obstruction in asthma. Am J Respir Crit Care Med (2005) 1.72
Myeloperoxidase and plasminogen activator inhibitor 1 play a central role in ventricular remodeling after myocardial infarction. J Exp Med (2003) 1.59
Protein nitration is mediated by heme and free metals through Fenton-type chemistry: an alternative to the NO/O2- reaction. Proc Natl Acad Sci U S A (2002) 1.53
Oxidative stress is fundamental to hyperbaric oxygen therapy. J Appl Physiol (1985) (2008) 1.51
Modification of high density lipoprotein by myeloperoxidase generates a pro-inflammatory particle. J Biol Chem (2009) 1.51
Redox control of asthma: molecular mechanisms and therapeutic opportunities. Antioxid Redox Signal (2010) 1.43
What part of NO don't you understand? Some answers to the cardinal questions in nitric oxide biology. J Biol Chem (2010) 1.43
An abundant dysfunctional apolipoprotein A1 in human atheroma. Nat Med (2014) 1.33
Myeloperoxidase, modified lipoproteins, and atherogenesis. J Lipid Res (2008) 1.32
The nature of heme/iron-induced protein tyrosine nitration. Proc Natl Acad Sci U S A (2003) 1.28
Peroxynitrite, a stealthy biological oxidant. J Biol Chem (2013) 1.27
Hemodynamics influences vascular peroxynitrite formation: Implication for low-density lipoprotein apo-B-100 nitration. Free Radic Biol Med (2006) 1.25
Oxidative risk for atherothrombotic cardiovascular disease. Free Radic Biol Med (2009) 1.24
Protein carbamylation predicts mortality in ESRD. J Am Soc Nephrol (2013) 1.22
Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex. J Clin Invest (2013) 1.21
Measuring myeloperoxidase activity in biological samples. PLoS One (2013) 1.21
Albumin mediates the transcytosis of myeloperoxidase by means of caveolae in endothelial cells. Proc Natl Acad Sci U S A (2004) 1.20
Intraphagosomal peroxynitrite as a macrophage-derived cytotoxin against internalized Trypanosoma cruzi: consequences for oxidative killing and role of microbial peroxiredoxins in infectivity. J Biol Chem (2010) 1.17
Redox signaling in cardiovascular health and disease. Free Radic Biol Med (2013) 1.16
Myeloperoxidase-derived oxidation: mechanisms of biological damage and its prevention. J Clin Biochem Nutr (2010) 1.15
Reactive species mediate inhibition of alveolar type II sodium transport during mycoplasma infection. Am J Respir Crit Care Med (2005) 1.13
Inhibition of arginase activity enhances inflammation in mice with allergic airway disease, in association with increases in protein S-nitrosylation and tyrosine nitration. J Immunol (2008) 1.13
Decreased neointimal formation in Nox2-deficient mice reveals a direct role for NADPH oxidase in the response to arterial injury. Proc Natl Acad Sci U S A (2004) 1.13
Hyperammonemia-mediated autophagy in skeletal muscle contributes to sarcopenia of cirrhosis. Am J Physiol Endocrinol Metab (2012) 1.12
CSF neutrophils are implicated in the development of vasospasm in subarachnoid hemorrhage. Neurocrit Care (2010) 1.11
An airway epithelial iNOS-DUOX2-thyroid peroxidase metabolome drives Th1/Th2 nitrative stress in human severe asthma. Mucosal Immunol (2014) 1.09
The marine isolate Novosphingobium sp. PP1Y shows specific adaptation to use the aromatic fraction of fuels as the sole carbon and energy source. Microb Ecol (2011) 1.06
Intravascular neutrophil activation due to carbon monoxide poisoning. Am J Respir Crit Care Med (2006) 1.06
Shear stress influences spatial variations in vascular Mn-SOD expression: implication for LDL nitration. Am J Physiol Cell Physiol (2008) 1.04
Fibrinogen beta-chain tyrosine nitration is a prothrombotic risk factor. J Biol Chem (2008) 1.04
Reactive nitrogen species-induced cell death requires Fas-dependent activation of c-Jun N-terminal kinase. Mol Cell Biol (2004) 0.99
Site-specific nitration of apolipoprotein A-I at tyrosine 166 is both abundant within human atherosclerotic plaque and dysfunctional. J Biol Chem (2014) 0.98
Chemical and cytokine features of innate immunity characterize serum and tissue profiles in inflammatory bowel disease. Proc Natl Acad Sci U S A (2013) 0.97
Bicarbonate enhances alpha-synuclein oligomerization and nitration: intermediacy of carbonate radical anion and nitrogen dioxide radical. Biochem J (2004) 0.96
Oxidation increases mucin polymer cross-links to stiffen airway mucus gels. Sci Transl Med (2015) 0.95
Protein Radical Formation Resulting from Eosinophil Peroxidase-catalyzed Oxidation of Sulfite. J Biol Chem (2010) 0.95
Neutrophils-derived peroxynitrite contributes to acute hyperalgesia and cell influx in zymosan arthritis. Naunyn Schmiedebergs Arch Pharmacol (2006) 0.94
Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood (2005) 0.93
Myeloperoxidase interacts with endothelial cell-surface cytokeratin 1 and modulates bradykinin production by the plasma Kallikrein-Kinin system. Am J Pathol (2007) 0.93
Kinetic and mechanistic considerations to assess the biological fate of peroxynitrite. Biochim Biophys Acta (2013) 0.91
Epithelial, dendritic, and CD4(+) T cell regulation of and by reactive oxygen and nitrogen species in allergic sensitization. Biochim Biophys Acta (2011) 0.90
Nitric oxide metabolism in asthma pathophysiology. Biochim Biophys Acta (2011) 0.89
Protein tyrosine nitration and thiol oxidation by peroxynitrite-strategies to prevent these oxidative modifications. Int J Mol Sci (2013) 0.89
Airway epithelial regulation of allergic sensitization in asthma. Pulm Pharmacol Ther (2012) 0.88
Functional impact of oxidative posttranslational modifications on fibrinogen and fibrin clots. Free Radic Biol Med (2013) 0.88
Whence nitrotyrosine? J Clin Invest (2002) 0.88
Reactive nitrogen species scavenging, rather than nitric oxide inhibition, protects from articular cartilage damage in rat zymosan-induced arthritis. Br J Pharmacol (2003) 0.87
Normoxic cyclic GMP-independent oxidative signaling by nitrite enhances airway epithelial cell proliferation and wound healing. Nitric Oxide (2012) 0.86
Radical energies and the regiochemistry of addition to heme groups. Methylperoxy and nitrite radical additions to the heme of horseradish peroxidase. J Am Chem Soc (2007) 0.85
Modulation of arachidonic and linoleic acid metabolites in myeloperoxidase-deficient mice during acute inflammation. Free Radic Biol Med (2010) 0.85
Functional significance of inducible nitric oxide synthase induction and protein nitration in the thermally injured cutaneous microvasculature. Am J Pathol (2003) 0.85
The role of nitrite ion in phagocyte function--perspectives and puzzles. Arch Biochem Biophys (2009) 0.84
Inflammation induces fibrinogen nitration in experimental human endotoxemia. Free Radic Biol Med (2009) 0.84
Dysfunctional high-density lipoprotein. Curr Opin Endocrinol Diabetes Obes (2009) 0.84
Leghemoglobin green derivatives with nitrated hemes evidence production of highly reactive nitrogen species during aging of legume nodules. Proc Natl Acad Sci U S A (2012) 0.83
Chemistry meets biology in colitis-associated carcinogenesis. Free Radic Res (2013) 0.83
Bioanalytical profile of the L-arginine/nitric oxide pathway and its evaluation by capillary electrophoresis. J Chromatogr B Analyt Technol Biomed Life Sci (2007) 0.83
Peroxynitrite, a potent macrophage-derived oxidizing cytotoxin to combat invading pathogens. Biofactors (2013) 0.82
Protein nitration is predominantly mediated by a peroxynitrite-dependent pathway in cultured human leucocytes. Biochem J (2002) 0.82
Nitrated fibrinogen is a biomarker of oxidative stress in venous thromboembolism. Free Radic Biol Med (2012) 0.81
The proverbial chicken or the egg? Dissection of the role of cell-free hemoglobin versus reactive oxygen species in sickle cell pathophysiology. Am J Physiol Heart Circ Physiol (2008) 0.81
The effect of neighboring methionine residue on tyrosine nitration and oxidation in peptides treated with MPO, H2O2, and NO2(-) or peroxynitrite and bicarbonate: role of intramolecular electron transfer mechanism? Arch Biochem Biophys (2008) 0.81
Mechanism of nitrite oxidation by eosinophil peroxidase: implications for oxidant production and nitration by eosinophils. Biochem J (2006) 0.80
Nitro-oxidative stress after neuronal ischemia induces protein nitrotyrosination and cell death. Oxid Med Cell Longev (2013) 0.80
Assessment of myeloperoxidase activity by the conversion of hydroethidine to 2-chloroethidium. J Biol Chem (2014) 0.80
Carbon monoxide inhalation increases microparticles causing vascular and CNS dysfunction. Toxicol Appl Pharmacol (2013) 0.80
Quantification of Modified Tyrosines in Healthy and Diabetic Human Urine using Liquid Chromatography/Tandem Mass Spectrometry. J Clin Biochem Nutr (2008) 0.80
Formation of 2-nitrophenol from salicylaldehyde as a suitable test for low peroxynitrite fluxes. Redox Biol (2015) 0.79
Formation of chlorinated lipids post-chlorine gas exposure. J Lipid Res (2016) 0.78
Lipoprotein-associated oxidative stress: a new twist to the postprandial hypothesis. Int J Mol Sci (2014) 0.78
Preparation and Characterization of a Polyclonal Antibody against Brominated Protein. J Clin Biochem Nutr (2008) 0.78
Differential abilities of nitrogen dioxide and nitrite to nitrate proteins in thylakoid membranes isolated from Arabidopsis leaves. Plant Signal Behav (2016) 0.78
Modulation of Asthma Pathogenesis by Nitric Oxide Pathways and Therapeutic Opportunities. Drug Discov Today Dis Mech (2012) 0.78
Eosinophil Peroxidase Catalyzed Protein Carbamylation Participates in Asthma. J Biol Chem (2016) 0.77
Nucleotides function as endogenous chemical sensors for oxidative stress signaling. J Clin Biochem Nutr (2010) 0.77
Role of cyclic GMP on inhibition by nitric oxide donors of human eosinophil chemotaxis in vitro. Br J Pharmacol (2004) 0.77
SOD inactivation in asthma: bad or no news? Am J Pathol (2005) 0.76
Lung Neutrophilia in Myeloperoxidase Deficient Mice during the Course of Acute Pulmonary Inflammation. Oxid Med Cell Longev (2016) 0.76
Airway peroxidases catalyze nitration of the {beta}2-agonist salbutamol and decrease its pharmacological activity. J Pharmacol Exp Ther (2010) 0.76
Blood flow modulation of vascular dynamics. Curr Opin Lipidol (2015) 0.76
New Insights in Oxidant Biology in Asthma. Ann Am Thorac Soc (2016) 0.76
Tyrosine-Nitrated Proteins: Proteomic and Bioanalytical Aspects. Antioxid Redox Signal (2016) 0.76
Taking up the cudgels for the traditional reactive oxygen and nitrogen species detection assays and their use in the cardiovascular system. Redox Biol (2017) 0.75
Olecular mechanism underlying the myeloperoxidase induced apoptosis of HUVEC-12 cells. Int J Clin Exp Med (2014) 0.75
Identification of Critical Paraoxonase 1 Residues Involved in High Density Lipoprotein Interaction. J Biol Chem (2015) 0.75
A halotyrosine antibody that detects increased protein modifications in asthma patients. J Immunol Methods (2013) 0.75
Silver nanoparticles can attenuate nitrative stress. Redox Biol (2017) 0.75
Myeloperoxidase-mediated protein lysine oxidation generates 2-aminoadipic acid and lysine nitrile in vivo. Free Radic Biol Med (2017) 0.75
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol (2007) 37.10
Genetics of gene expression surveyed in maize, mouse and man. Nature (2003) 22.17
Mapping the genetic architecture of gene expression in human liver. PLoS Biol (2008) 19.44
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature (2011) 13.53
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25
PD-1 Blockade in Tumors with Mismatch-Repair Deficiency. N Engl J Med (2015) 13.08
Variations in DNA elucidate molecular networks that cause disease. Nature (2008) 12.04
An integrative genomics approach to infer causal associations between gene expression and disease. Nat Genet (2005) 11.40
Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med (2013) 9.44
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N Engl J Med (2013) 8.21
Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet (2012) 7.59
Cis-acting expression quantitative trait loci in mice. Genome Res (2005) 6.66
Tissue-specific expression and regulation of sexually dimorphic genes in mice. Genome Res (2006) 6.45
Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease. JAMA (2005) 6.14
Prognostic value of myeloperoxidase in patients with chest pain. N Engl J Med (2003) 5.89
Integrating genetic and network analysis to characterize genes related to mouse weight. PLoS Genet (2006) 5.82
Peroxynitrite: biochemistry, pathophysiology and development of therapeutics. Nat Rev Drug Discov (2007) 5.65
Defining a link with asthma in mice congenitally deficient in eosinophils. Science (2004) 5.20
Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense. Nat Med (2008) 4.93
Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle. Science (2009) 4.92
Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease. J Neurosci (2002) 4.38
Protein carbamylation links inflammation, smoking, uremia and atherogenesis. Nat Med (2007) 4.30
Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proc Natl Acad Sci U S A (2002) 4.23
Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype. Nat Med (2007) 4.11
Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis. N Engl J Med (2004) 4.06
Phase II trial of cetuximab with or without paclitaxel in patients with advanced urothelial tract carcinoma. J Clin Oncol (2012) 3.98
Common variants in KCNN3 are associated with lone atrial fibrillation. Nat Genet (2010) 3.97
A high-resolution association mapping panel for the dissection of complex traits in mice. Genome Res (2010) 3.81
Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits. Nat Genet (2005) 3.74
Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk. JAMA (2008) 3.64
Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease. J Clin Invest (2004) 3.63
Weighted gene coexpression network analysis strategies applied to mouse weight. Mamm Genome (2007) 3.59
Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations. Free Radic Biol Med (2011) 3.58
Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity. PLoS Genet (2006) 3.51
Elucidating the role of gonadal hormones in sexually dimorphic gene coexpression networks. Endocrinology (2008) 3.38
Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress. Circ Res (2008) 3.26
Statins, high-density lipoprotein cholesterol, and regression of coronary atherosclerosis. JAMA (2007) 3.25
Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy. J Clin Invest (2008) 3.23
Comparative analysis of proteome and transcriptome variation in mouse. PLoS Genet (2011) 3.23
A novel family of atherogenic oxidized phospholipids promotes macrophage foam cell formation via the scavenger receptor CD36 and is enriched in atherosclerotic lesions. J Biol Chem (2002) 3.17
New gene functions in megakaryopoiesis and platelet formation. Nature (2011) 3.14
Myeloperoxidase, a leukocyte-derived vascular NO oxidase. Science (2002) 3.13
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. PLoS Genet (2011) 3.07
Paradoxical association of enhanced cholesterol efflux with increased incident cardiovascular risks. Arterioscler Thromb Vasc Biol (2013) 3.07
A CD36-dependent signaling cascade is necessary for macrophage foam cell formation. Cell Metab (2006) 3.06
Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis. Diabetes (2008) 3.05
Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipids. Proc Natl Acad Sci U S A (2006) 3.03
Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation. Cell Metab (2013) 3.01
Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks. Nat Genet (2009) 2.97
Identification of a novel family of oxidized phospholipids that serve as ligands for the macrophage scavenger receptor CD36. J Biol Chem (2002) 2.94
NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. Proc Natl Acad Sci U S A (2003) 2.91
The unfolded protein response is an important regulator of inflammatory genes in endothelial cells. Arterioscler Thromb Vasc Biol (2006) 2.90
DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase. Proc Natl Acad Sci U S A (2007) 2.87
Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1). Nat Genet (2004) 2.86
Eosinophils are required for the maintenance of plasma cells in the bone marrow. Nat Immunol (2011) 2.83
Serum myeloperoxidase levels independently predict endothelial dysfunction in humans. Circulation (2004) 2.79
TIMI myocardial perfusion frame count: a new method to assess myocardial perfusion and its predictive value for short-term prognosis. Catheter Cardiovasc Interv (2010) 2.78
Seventy-five genetic loci influencing the human red blood cell. Nature (2012) 2.77
Myeloperoxidase and cardiovascular disease. Arterioscler Thromb Vasc Biol (2005) 2.77
The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL. J Lipid Res (2004) 2.72
Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice. Circ Res (2002) 2.69
T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection. J Clin Invest (2012) 2.66
Integrating QTL and high-density SNP analyses in mice to identify Insig2 as a susceptibility gene for plasma cholesterol levels. Genomics (2005) 2.61
Identification of S-nitrosylation motifs by site-specific mapping of the S-nitrosocysteine proteome in human vascular smooth muscle cells. Proc Natl Acad Sci U S A (2006) 2.58
Identification of macrophage liver X receptors as inhibitors of atherosclerosis. Proc Natl Acad Sci U S A (2002) 2.56
Using genetic markers to orient the edges in quantitative trait networks: the NEO software. BMC Syst Biol (2008) 2.51
Oxidized phosphatidylserine-CD36 interactions play an essential role in macrophage-dependent phagocytosis of apoptotic cells. J Exp Med (2006) 2.51
Growing dendrites and axons differ in their reliance on the secretory pathway. Cell (2007) 2.51
Control of the postmating behavioral switch in Drosophila females by internal sensory neurons. Neuron (2009) 2.50
The refined structure of nascent HDL reveals a key functional domain for particle maturation and dysfunction. Nat Struct Mol Biol (2007) 2.47
Neutrophils and NADPH oxidase mediate intrapancreatic trypsin activation in murine experimental acute pancreatitis. Gastroenterology (2002) 2.45
The role of the TRP channel NompC in Drosophila larval and adult locomotion. Neuron (2010) 2.44
An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits. PLoS Genet (2010) 2.43
Increased arginase II and decreased NO synthesis in endothelial cells of patients with pulmonary arterial hypertension. FASEB J (2004) 2.37
Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease. J Clin Invest (2011) 2.37
Diminished global arginine bioavailability and increased arginine catabolism as metabolic profile of increased cardiovascular risk. J Am Coll Cardiol (2009) 2.35
The lipid whisker model of the structure of oxidized cell membranes. J Biol Chem (2007) 2.31
Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia. J Lipid Res (2002) 2.28
Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy. Blood (2009) 2.26
A treasure trove for lipoprotein biology. Nat Genet (2008) 2.25
Effect of plasma uric acid on antioxidant capacity, oxidative stress, and insulin sensitivity in obese subjects. Diabetes (2013) 2.25
Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE. J Clin Invest (2007) 2.24
A flexible interface between DNA ligase and PCNA supports conformational switching and efficient ligation of DNA. Mol Cell (2006) 2.23
Serum myeloperoxidase levels are associated with the future risk of coronary artery disease in apparently healthy individuals: the EPIC-Norfolk Prospective Population Study. J Am Coll Cardiol (2007) 2.22
A newly identified role for superoxide in inflammatory pain. J Pharmacol Exp Ther (2004) 2.21
Muscle mitohormesis promotes longevity via systemic repression of insulin signaling. Cell (2013) 2.21
Serum uric acid is an independent predictor of all-cause mortality in patients at high risk of cardiovascular disease: a preventive cardiology information system (PreCIS) database cohort study. Arthritis Rheum (2008) 2.19