Published in J Theor Biol on March 16, 2005
Nonlinear modelling of cancer: bridging the gap between cells and tumours. Nonlinearity (2010) 2.08
Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer. Br J Cancer (2007) 2.00
Dissecting cancer through mathematics: from the cell to the animal model. Nat Rev Cancer (2010) 1.92
Adaptive landscapes and emergent phenotypes: why do cancers have high glycolysis? J Bioenerg Biomembr (2007) 1.83
Multiscale cancer modeling. Annu Rev Biomed Eng (2011) 1.65
An evolutionary hybrid cellular automaton model of solid tumour growth. J Theor Biol (2007) 1.55
A hybrid cellular automaton model of clonal evolution in cancer: the emergence of the glycolytic phenotype. J Theor Biol (2007) 1.37
In silico models of cancer. Wiley Interdiscip Rev Syst Biol Med (2010) 1.01
Altered energy metabolism in cancer: a unique opportunity for therapeutic intervention. Cancer Biol Ther (2012) 1.00
The metastasis suppressor, N-myc downregulated gene 1 (NDRG1), is a prognostic biomarker for human colorectal cancer. PLoS One (2013) 0.95
Towards a multiscale model of colorectal cancer. World J Gastroenterol (2007) 0.95
The role of dysregulated glucose metabolism in epithelial ovarian cancer. J Oncol (2010) 0.84
Stage-related alterations in renal cell carcinoma--comprehensive quantitative analysis by 2D-DIGE and protein network analysis. PLoS One (2011) 0.83
Buffer Therapy for Cancer. J Nutr Food Sci (2012) 0.81
PET-specific parameters and radiotracers in theoretical tumour modelling. Comput Math Methods Med (2015) 0.80
ATP synthase ecto-α-subunit: a novel therapeutic target for breast cancer. J Transl Med (2011) 0.80
A cellular automaton model for tumor dormancy: emergence of a proliferative switch. PLoS One (2014) 0.79
Lactate transporters and vascular factors in HPV-induced squamous cell carcinoma of the uterine cervix. BMC Cancer (2014) 0.79
Metabolic reprogramming: a new relevant pathway in adult adrenocortical tumors. Oncotarget (2015) 0.77
Tumor microenvironment promotes dicarboxylic acid carrier-mediated transport of succinate to fuel prostate cancer mitochondria. Am J Cancer Res (2015) 0.77
Heterogeneity and proliferation of invasive cancer subclones in game theory models of the Warburg effect. Cell Prolif (2015) 0.77
Quiescence as a mechanism for cyclical hypoxia and acidosis. J Math Biol (2007) 0.76
A general reaction-diffusion model of acidity in cancer invasion. J Math Biol (2013) 0.76
Theoretical predictions of lactate and hydrogen ion distributions in tumours. PLoS One (2013) 0.75
The metabolic microenvironment of melanomas: Prognostic value of MCT1 and MCT4. Cell Cycle (2016) 0.75
Effects of omeprazole in improving concurrent chemoradiotherapy efficacy in rectal cancer. World J Gastroenterol (2017) 0.75
Mathematical modelling of spatio-temporal glioma evolution. Theor Biol Med Model (2013) 0.75
Constructal approach to cell membranes transport: Amending the 'Norton-Simon' hypothesis for cancer treatment. Sci Rep (2016) 0.75
DNMT3A and TET2 in the Pre-Leukemic Phase of Hematopoietic Disorders. Front Oncol (2016) 0.75
Acid-mediated tumour cell invasion: a discrete modelling approach using the extended Potts model. Clin Exp Metastasis (2013) 0.75
CD44 regulates prostate cancer proliferation, invasion and migration via PDK1 and PFKFB4. Oncotarget (2017) 0.75
Initial/boundary-value problems of tumor growth within a host tissue. J Math Biol (2013) 0.75
Model of Vascular Desmoplastic Multispecies Tumor Growth. J Theor Biol (2017) 0.75
Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration. Nature (2008) 4.67
Causes and consequences of increased glucose metabolism of cancers. J Nucl Med (2008) 3.79
Environment-mediated drug resistance: a major contributor to minimal residual disease. Nat Rev Cancer (2009) 3.49
Bicarbonate increases tumor pH and inhibits spontaneous metastases. Cancer Res (2009) 3.40
Conformational spread as a mechanism for cooperativity in the bacterial flagellar switch. Science (2010) 3.08
Evolutionary dynamics of carcinogenesis and why targeted therapy does not work. Nat Rev Cancer (2012) 2.71
pH imaging. A review of pH measurement methods and applications in cancers. IEEE Eng Med Biol Mag (2004) 2.68
Radiomics: the process and the challenges. Magn Reson Imaging (2012) 2.65
Acidity generated by the tumor microenvironment drives local invasion. Cancer Res (2013) 2.63
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk. Cardiovasc Res (2011) 2.41
Chaste: an open source C++ library for computational physiology and biology. PLoS Comput Biol (2013) 2.22
Inherent noise can facilitate coherence in collective swarm motion. Proc Natl Acad Sci U S A (2009) 2.19
Mathematical modeling of cell population dynamics in the colonic crypt and in colorectal cancer. Proc Natl Acad Sci U S A (2007) 1.99
Self-organizing and stochastic behaviors during the regeneration of hair stem cells. Science (2011) 1.96
The potential role of systemic buffers in reducing intratumoral extracellular pH and acid-mediated invasion. Cancer Res (2009) 1.92
Development of an anatomically detailed MRI-derived rabbit ventricular model and assessment of its impact on simulations of electrophysiological function. Am J Physiol Heart Circ Physiol (2009) 1.84
Adaptive landscapes and emergent phenotypes: why do cancers have high glycolysis? J Bioenerg Biomembr (2007) 1.83
Adaptation to hypoxia and acidosis in carcinogenesis and tumor progression. Semin Cancer Biol (2008) 1.76
A theoretical quantitative model for evolution of cancer chemotherapy resistance. Biol Direct (2010) 1.69
Hypoxia and adaptive landscapes in the evolution of carcinogenesis. Cancer Metastasis Rev (2007) 1.68
Mathematical oncology: cancer summed up. Nature (2003) 1.67
A PHABULOSA/cytokinin feedback loop controls root growth in Arabidopsis. Curr Biol (2012) 1.61
Beyond mammography: new frontiers in breast cancer screening. Am J Med (2013) 1.61
Metabolic changes during carcinogenesis: potential impact on invasiveness. J Theor Biol (2006) 1.59
Chaste: using agile programming techniques to develop computational biology software. Philos Trans A Math Phys Eng Sci (2008) 1.57
Angiogenesis and vascular remodelling in normal and cancerous tissues. J Math Biol (2008) 1.55
Prediction of drug response in breast cancer using integrative experimental/computational modeling. Cancer Res (2009) 1.53
The role of photon scattering in optical signal distortion during arrhythmia and defibrillation. Biophys J (2007) 1.49
Synthesis of voltage-sensitive optical signals: application to panoramic optical mapping. Biophys J (2006) 1.48
Acid treatment of melanoma cells selects for invasive phenotypes. Clin Exp Metastasis (2008) 1.44
Sweat but no gain: inhibiting proliferation of multidrug resistant cancer cells with "ersatzdroges". Int J Cancer (2014) 1.44
Automated Delineation of Lung Tumors from CT Images Using a Single Click Ensemble Segmentation Approach. Pattern Recognit (2013) 1.36
Multiscale modelling of vascular tumour growth in 3D: the roles of domain size and boundary conditions. PLoS One (2011) 1.36
A physical sciences network characterization of non-tumorigenic and metastatic cells. Sci Rep (2013) 1.33
An analysis of B cell selection mechanisms in germinal centers. Math Med Biol (2006) 1.32
Systemic buffers inhibit carcinogenesis in TRAMP mice. J Urol (2012) 1.28
Regulation of the Warburg effect in early-passage breast cancer cells. Neoplasia (2008) 1.23
A numerical guide to the solution of the bi-domain equations of cardiac electrophysiology. Prog Biophys Mol Biol (2010) 1.22
Exploiting evolution to treat drug resistance: combination therapy and the double bind. Mol Pharm (2012) 1.22
Reduction of metastasis using a non-volatile buffer. Clin Exp Metastasis (2011) 1.21
Interactions between Shh, Sostdc1 and Wnt signaling and a new feedback loop for spatial patterning of the teeth. Development (2011) 1.21
Variance of SUVs for FDG-PET/CT is greater in clinical practice than under ideal study settings. Clin Nucl Med (2013) 1.19
Evolutionary approaches to prolong progression-free survival in breast cancer. Cancer Res (2012) 1.19
CHASTE: incorporating a novel multi-scale spatial and temporal algorithm into a large-scale open source library. Philos Trans A Math Phys Eng Sci (2009) 1.17
Life history trade-offs in cancer evolution. Nat Rev Cancer (2013) 1.16
Pooling data for number needed to treat: no problems for apples. BMC Med Res Methodol (2002) 1.15
Proton dynamics in cancer. J Transl Med (2010) 1.14
Mixed-mode pattern in Doublefoot mutant mouse limb--Turing reaction-diffusion model on a growing domain during limb development. J Theor Biol (2005) 1.12
Examples of mathematical modeling: tales from the crypt. Cell Cycle (2007) 1.11
A theoretical investigation of the effect of proliferation and adhesion on monoclonal conversion in the colonic crypt. J Theor Biol (2012) 1.07
Multiscale mechanisms of cell migration during development: theory and experiment. Development (2012) 1.07
A model invalidation-based approach for elucidating biological signalling pathways, applied to the chemotaxis pathway in R. sphaeroides. BMC Syst Biol (2009) 1.04
Predicting tumor location by modeling the deformation of the breast. IEEE Trans Biomed Eng (2008) 1.04
Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment. J Pharmacol Toxicol Methods (2013) 1.04
Spots and stripes: pleomorphic patterning of stem cells via p-ERK-dependent cell chemotaxis shown by feather morphogenesis and mathematical simulation. Dev Biol (2009) 1.03
Evolutionary dynamics in cancer therapy. Mol Pharm (2011) 1.03
Multi-cellular rosettes in the mouse visceral endoderm facilitate the ordered migration of anterior visceral endoderm cells. PLoS Biol (2012) 1.02
Mathematical modelling of oxygen transport to tissue. J Math Biol (2002) 1.02
Evaluation of an in silico cardiac safety assay: using ion channel screening data to predict QT interval changes in the rabbit ventricular wedge. J Pharmacol Toxicol Methods (2013) 1.01
Directional persistence and the optimality of run-and-tumble chemotaxis. Comput Biol Chem (2009) 0.99
Speed of pattern appearance in reaction-diffusion models: implications in the pattern formation of limb bud mesenchyme cells. Bull Math Biol (2004) 0.99
Non-linear incidence and stability of infectious disease models. Math Med Biol (2005) 0.98
Minimization of thermodynamic costs in cancer cell invasion. Proc Natl Acad Sci U S A (2013) 0.98
Test-retest reproducibility analysis of lung CT image features. J Digit Imaging (2014) 0.98
Modelling the role of the basement membrane beneath a growing epithelial monolayer. J Theor Biol (2011) 0.97
On the proportion of cancer stem cells in a tumour. J Theor Biol (2010) 0.97
STOCHSIMGPU: parallel stochastic simulation for the Systems Biology Toolbox 2 for MATLAB. Bioinformatics (2011) 0.97
A mathematical model of tumour and blood pHe regulation: The HCO3-/CO2 buffering system. Math Biosci (2010) 0.97
Molecular and functional imaging of breast cancer. Cancer Control (2010) 0.96
Information dynamics in living systems: prokaryotes, eukaryotes, and cancer. PLoS One (2011) 0.95
Order in a multidimensional system. Phys Rev E Stat Nonlin Soft Matter Phys (2011) 0.95
Reptile scale paradigm: Evo-Devo, pattern formation and regeneration. Int J Dev Biol (2009) 0.95
Free Base Lysine Increases Survival and Reduces Metastasis in Prostate Cancer Model. J Cancer Sci Ther (2011) 0.94
A two-dimensional model of the colonic crypt accounting for the role of the basement membrane and pericryptal fibroblast sheath. PLoS Comput Biol (2012) 0.94
Tumour-stromal interactions in acid-mediated invasion: a mathematical model. J Theor Biol (2010) 0.94
Systems model of T cell receptor proximal signaling reveals emergent ultrasensitivity. PLoS Comput Biol (2013) 0.94
Modeling chemotaxis reveals the role of reversed phosphotransfer and a bi-functional kinase-phosphatase. PLoS Comput Biol (2010) 0.94
The role of the Na+/Ca2+ exchangers in Ca2+ dynamics in ventricular myocytes. Prog Biophys Mol Biol (2007) 0.94
A quantitative theoretical model for the development of malignancy in ductal carcinoma in situ. J Theor Biol (2009) 0.94
Age-related changes in speed and mechanism of adult skeletal muscle stem cell migration. Stem Cells (2012) 0.93
Interpreting two-photon imaging data of lymphocyte motility. Phys Rev E Stat Nonlin Soft Matter Phys (2005) 0.93
Systems biologists seek fuller integration of systems biology approaches in new cancer research programs. Cancer Res (2009) 0.92
From segment to somite: segmentation to epithelialization analyzed within quantitative frameworks. Dev Dyn (2007) 0.92
Growth-induced mass flows in fungal networks. Proc Biol Sci (2010) 0.92
Photon scattering effects in optical mapping of propagation and arrhythmogenesis in the heart. J Electrocardiol (2007) 0.92
Mode transitions in a model reaction-diffusion system driven by domain growth and noise. Bull Math Biol (2006) 0.91
Distinct mechanisms underlie pattern formation in the skin and skin appendages. Birth Defects Res C Embryo Today (2006) 0.91
A numerical approach to the study of spatial pattern formation in the ligaments of arcoid bivalves. Bull Math Biol (2002) 0.90
Waves and patterning in developmental biology: vertebrate segmentation and feather bud formation as case studies. Int J Dev Biol (2009) 0.90
Collagen bundle morphometry in skin and scar tissue: a novel distance mapping method provides superior measurements compared to Fourier analysis. J Microsc (2011) 0.90
Novel methods for analysing bacterial tracks reveal persistence in Rhodobacter sphaeroides. PLoS Comput Biol (2013) 0.90
A fibrocontractive mechanochemical model of dermal wound closure incorporating realistic growth factor kinetics. Bull Math Biol (2012) 0.90
Modelling spatially regulated beta-catenin dynamics and invasion in intestinal crypts. Biophys J (2010) 0.89
Implementing vertex dynamics models of cell populations in biology within a consistent computational framework. Prog Biophys Mol Biol (2013) 0.89