PubRank

David S Latchman

Author PubWeight™ 132.21‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science 2004 15.91
2 PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death. Mol Cell 2009 3.17
3 Voltage-gated sodium channel expression and potentiation of human breast cancer metastasis. Clin Cancer Res 2005 1.99
4 Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress. J Neurochem 2006 1.91
5 Urocortin inhibits Beclin1-mediated autophagic cell death in cardiac myocytes exposed to ischaemia/reperfusion injury. J Mol Cell Cardiol 2006 1.83
6 STAT-1 interacts with p53 to enhance DNA damage-induced apoptosis. J Biol Chem 2003 1.79
7 Urocortin-II and urocortin-III are cardioprotective against ischemia reperfusion injury: an essential endogenous cardioprotective role for corticotropin releasing factor receptor type 2 in the murine heart. Endocrinology 2003 1.76
8 Urocortin prevents mitochondrial permeability transition in response to reperfusion injury indirectly by reducing oxidative stress. Am J Physiol Heart Circ Physiol 2007 1.70
9 A heterozygous effect for PINK1 mutations in Parkinson's disease? Ann Neurol 2006 1.61
10 Antibodies to apolipoprotein A-I, high-density lipoprotein, and C-reactive protein are associated with disease activity in patients with systemic lupus erythematosus. Arthritis Rheum 2010 1.60
11 Activation of CDK4 gene expression in human breast cancer cells by the Brn-3b POU family transcription factor. Cancer Biol Ther 2004 1.57
12 Enhanced IL-17 signalling following myocardial ischaemia/reperfusion injury. Int J Cardiol 2011 1.52
13 The transcriptional co-activators CREB-binding protein (CBP) and p300 play a critical role in cardiac hypertrophy that is dependent on their histone acetyltransferase activity. J Biol Chem 2002 1.45
14 STAT-1: a novel regulator of apoptosis. Int J Exp Pathol 2003 1.43
15 Dysregulation of histone acetylation in the APP/PS1 mouse model of Alzheimer's disease. J Alzheimers Dis 2009 1.34
16 PIAS-1 is a checkpoint regulator which affects exit from G1 and G2 by sumoylation of p73. Mol Cell Biol 2004 1.33
17 Role of the JAK-STAT pathway in myocardial injury. Trends Mol Med 2006 1.32
18 Deletion of the virion host shutoff protein (vhs) from herpes simplex virus (HSV) relieves the viral block to dendritic cell activation: potential of vhs- HSV vectors for dendritic cell-mediated immunotherapy. J Virol 2003 1.31
19 Epigallocatechin-3-gallate inhibits STAT-1 activation and protects cardiac myocytes from ischemia/reperfusion-induced apoptosis. FASEB J 2004 1.31
20 The neuroprotective effects of heat shock protein 27 overexpression in transgenic animals against kainate-induced seizures and hippocampal cell death. J Biol Chem 2003 1.24
21 Different signaling pathways induce apoptosis in endothelial cells and cardiac myocytes during ischemia/reperfusion injury. Circ Res 2002 1.18
22 Retracted STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage. J Cell Sci 2005 1.17
23 BAG-1: a multi-functional pro-survival molecule. Int J Biochem Cell Biol 2005 1.14
24 Binding of antiphospholipid antibodies to discontinuous epitopes on domain I of human beta(2)-glycoprotein I: mutation studies including residues R39 to R43. Arthritis Rheum 2007 1.12
25 Protective effects of heat shock protein 27 in a model of ALS occur in the early stages of disease progression. Neurobiol Dis 2007 1.11
26 Bimoclomol, a heat shock protein co-inducer, acts by the prolonged activation of heat shock factor-1. Biochem Biophys Res Commun 2003 1.10
27 Activation of protein kinase B/Akt by urocortin is essential for its ability to protect cardiac cells against hypoxia/reoxygenation-induced cell death. J Mol Cell Cardiol 2002 1.09
28 HSP27 but not HSP70 has a potent protective effect against alpha-synuclein-induced cell death in mammalian neuronal cells. J Neurochem 2004 1.09
29 Targeted disruption of the protein kinase C epsilon gene abolishes the infarct size reduction that follows ischaemic preconditioning of isolated buffer-perfused mouse hearts. Cardiovasc Res 2002 1.09
30 Molecular basis of Parkinson's disease. Neuroreport 2009 1.06
31 Neuroprotective effects of HSP70 overexpression after cerebral ischaemia--an MRI study. Exp Neurol 2005 1.05
32 Hsp27 overexpression in the R6/2 mouse model of Huntington's disease: chronic neurodegeneration does not induce Hsp27 activation. Hum Mol Genet 2007 1.03
33 The Brn-3a transcription factor inhibits the pro-apoptotic effect of p53 and enhances cell cycle arrest by differentially regulating the activity of the p53 target genes encoding Bax and p21(CIP1/Waf1). Oncogene 2002 1.03
34 IL-6 induces PI 3-kinase and nitric oxide-dependent protection and preserves mitochondrial function in cardiomyocytes. Cardiovasc Res 2005 1.02
35 STAT3 deletion sensitizes cells to oxidative stress. Biochem Biophys Res Commun 2009 1.02
36 Brn-3a transcription factor blocks p53-mediated activation of proapoptotic target genes Noxa and Bax in vitro and in vivo to determine cell fate. J Biol Chem 2004 1.02
37 Hsp27 and Hsp70 administered in combination have a potent protective effect against FALS-associated SOD1-mutant-induced cell death in mammalian neuronal cells. Brain Res Mol Brain Res 2004 1.02
38 The carboxyl-terminal activation domain of the STAT-1 transcription factor enhances ischemia/reperfusion-induced apoptosis in cardiac myocytes. FASEB J 2002 1.01
39 ERK and the F-box protein betaTRCP target STAT1 for degradation. J Biol Chem 2008 1.00
40 STAT3 modulates the DNA damage response pathway. Int J Exp Pathol 2010 1.00
41 Stressful preconditioning and HSP70 overexpression attenuate proteotoxicity of cellular ATP depletion. Am J Physiol Cell Physiol 2002 1.00
42 Urocortin protects the heart from reperfusion injury via upregulation of p42/p44 MAPK signaling pathway. Am J Physiol Heart Circ Physiol 2002 1.00
43 The effects of Brn-3a on neuronal differentiation and apoptosis are differentially modulated by EWS and its oncogenic derivative EWS/Fli-1. Oncogene 2004 0.99
44 STAT1 interacts directly with cyclin D1/Cdk4 and mediates cell cycle arrest. Cell Cycle 2010 0.99
45 Neuroprotective effects of virally delivered HSPs in experimental stroke. J Cereb Blood Flow Metab 2006 0.98
46 Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression. Nucleic Acids Res 2006 0.97
47 Protective effect of post-ischaemic viral delivery of heat shock proteins in vivo. J Cereb Blood Flow Metab 2008 0.96
48 Urocortin promotes hemodynamic and bioenergetic recovery and improves cell survival in the isolated rat heart exposed to ischemia/reperfusion. J Am Coll Cardiol 2002 0.95
49 BAG-1 proteins protect cardiac myocytes from simulated ischemia/reperfusion-induced apoptosis via an alternate mechanism of cell survival independent of the proteasome. J Biol Chem 2004 0.94
50 Free radical scavenging inhibits STAT phosphorylation following in vivo ischemia/reperfusion injury. FASEB J 2006 0.94
51 Cardiotrophin-1 (CT-1) can protect the adult heart from injury when added both prior to ischaemia and at reperfusion. Cardiovasc Res 2002 0.93
52 Parkin is recruited into aggresomes in a stress-specific manner: over-expression of parkin reduces aggresome formation but can be dissociated from parkin's effect on neuronal survival. Hum Mol Genet 2003 0.93
53 How do antiphospholipid antibodies bind beta2-glycoprotein I? Arthritis Rheum 2003 0.92
54 Overexpression of heat shock protein 27 reduces cortical damage after cerebral ischemia. J Cereb Blood Flow Metab 2009 0.92
55 Synphilin-1 and parkin show overlapping expression patterns in human brain and form aggresomes in response to proteasomal inhibition. Neurobiol Dis 2005 0.92
56 New targets of urocortin-mediated cardioprotection. J Mol Endocrinol 2010 0.91
57 CREB-binding protein activation by presenilin 1 but not by its M146L mutant. Neuroreport 2006 0.91
58 The transcriptional coactivator p300 plays a critical role in the hypertrophic and protective pathways induced by phenylephrine in cardiac cells but is specific to the hypertrophic effect of urocortin. Chembiochem 2005 0.91
59 Transcriptional modulation of heat-shock protein gene expression. Biochem Res Int 2010 0.91
60 Expression of the Brn-3b transcription factor correlates with expression of HSP-27 in breast cancer biopsies and is required for maximal activation of the HSP-27 promoter. Cancer Res 2005 0.90
61 The selective PPARgamma antagonist GW9662 reverses the protection of LPS in a model of renal ischemia-reperfusion. Kidney Int 2005 0.90
62 Heat shock protein 70 or heat shock protein 27 overexpressed in human endothelial cells during posthypoxic reoxygenation can protect from delayed apoptosis. Cell Stress Chaperones 2003 0.90
63 Relative importance of different human aPL derived heavy and light chains in the binding of aPL to cardiolipin. Mol Immunol 2003 0.90
64 A novel expression system of domain I of human beta2 glycoprotein I in Escherichia coli. BMC Biotechnol 2006 0.90
65 Targeting Brn-3b in breast cancer therapy. Expert Opin Ther Targets 2006 0.89
66 The cardioprotective effect of urocortin during ischaemia/reperfusion involves the prevention of mitochondrial damage. Biochem Biophys Res Commun 2004 0.89
67 Arginine mutation alters binding of a human monoclonal antibody to antigens linked to systemic lupus erythematosus and the antiphospholipid syndrome. Arthritis Rheum 2007 0.88
68 STAT1 regulates p73-mediated Bax gene expression. FEBS Lett 2007 0.88
69 The Brn-3b transcription factor regulates the growth, behavior, and invasiveness of human neuroblastoma cells in vitro and in vivo. J Biol Chem 2004 0.87
70 Heat shock protein 27 delivered via a herpes simplex virus vector can protect neurons of the hippocampus against kainic-acid-induced cell loss. Brain Res Mol Brain Res 2003 0.87
71 Hsf1-mediated stress response can transiently enhance cellular radioresistance. Radiat Res 2006 0.86
72 Induction of parkin expression in the presence of oxidative stress. Eur J Neurosci 2006 0.86
73 p73-mediated transcriptional activity is negatively regulated by polo-like kinase 1. Cell Cycle 2008 0.86
74 p300 activation by Presenilin 1 but not by its M146L mutant. Neurosci Lett 2007 0.86
75 Effects of polyclonal IgG derived from patients with different clinical types of the antiphospholipid syndrome on monocyte signaling pathways. J Immunol 2010 0.86
76 Anti-cardiolipin/beta-2 glycoprotein activities co-exist on human anti-DNA antibody light chains. Mol Immunol 2003 0.84
77 A systematic analysis of sequences of human antiphospholipid and anti-beta2-glycoprotein I antibodies: the importance of somatic mutations and certain sequence motifs. Semin Arthritis Rheum 2003 0.84
78 Nurr1 transcriptionally regulates the expression of alpha-synuclein. Neuroreport 2008 0.84
79 Estrogen and non-genomic upregulation of voltage-gated Na(+) channel activity in MDA-MB-231 human breast cancer cells: role in adhesion. J Cell Physiol 2010 0.83
80 Stable expression of a recombinant human antinucleosome antibody to investigate relationships between antibody sequence, binding properties, and pathogenicity. Arthritis Res Ther 2005 0.83
81 Regulation of Brn-3a N-terminal transcriptional activity by MEK1/2-ERK1/2 signalling in neural differentiation. Brain Res 2008 0.83
82 Retracted Antiapoptotic activity of the free caspase recruitment domain of procaspase-9: a novel endogenous rescue pathway in cell death. J Biol Chem 2002 0.83
83 Hypertrophic effects of urocortin homologous peptides are mediated via activation of the Akt pathway. Biochem Biophys Res Commun 2005 0.83
84 Cardiotrophin-1 and urocortin cause protection by the same pathway and hypertrophy via distinct pathways in cardiac myocytes. Cytokine 2002 0.82
85 Cell-specific regulation of the pro-survival Brn-3b transcription factor by microRNAs. Mol Cell Neurosci 2010 0.82
86 The Brn-3b POU family transcription factor represses plakoglobin gene expression in human breast cancer cells. Int J Cancer 2006 0.82
87 Somatic mutations to arginine residues affect the binding of human monoclonal antibodies to DNA, histones, SmD and Ro antigen. Mol Immunol 2004 0.82
88 Distinct serine residues in CBP and p300 are necessary for their activation by phenylephrine. Int J Biochem Cell Biol 2004 0.81
89 Regulation of myocardial interleukin-6 expression by p53 and STAT1. J Interferon Cytokine Res 2013 0.81
90 Post-transcriptional regulation of the Brn-3b transcription factor in differentiating neuroblastoma cells. FEBS Lett 2007 0.81
91 Modulation of cell death by alpha-synuclein is stimulus-dependent in mammalian cells. Neurosci Lett 2003 0.80
92 Autophagy in the stress-induced myocardium. Front Biosci (Elite Ed) 2012 0.80
93 Measurement of Brn-3a levels in Pap smears provides a novel diagnostic marker for the detection of cervical neoplasia. Gynecol Oncol 2003 0.80
94 A simple technique for the prediction of interacting proteins reveals a direct Brn-3a-androgen receptor interaction. J Biol Chem 2010 0.80
95 Identification and characterization of the promoter region of the Nav1.7 voltage-gated sodium channel gene (SCN9A). Mol Cell Neurosci 2007 0.80
96 The pro-oncoprotein EWS (Ewing's Sarcoma protein) interacts with the Brn-3a POU transcription factor and inhibits its ability to activate transcription. Cancer Biol Ther 2002 0.80
97 FLIP protects cardiomyocytes from apoptosis induced by simulated ischemia/reoxygenation, as demonstrated by short hairpin-induced (shRNA) silencing of FLIP mRNA. J Mol Cell Cardiol 2003 0.79
98 Cardiac expression of Brn-3a and Brn-3b POU transcription factors and regulation of Hsp27 gene expression. Cell Stress Chaperones 2008 0.78
99 The role of minocycline in ischemia-reperfusion injury: a comprehensive review of an old drug with new implications. Recent Pat Cardiovasc Drug Discov 2011 0.78
100 Amino acid supplementation differentially modulates STAT1 and STAT3 activation in the myocardium exposed to ischemia/reperfusion injury. Am J Cardiol 2008 0.78
101 Phosphorylation of the Brn-3a transcription factor is modulated during differentiation and regulates its functional activity. Brain Res Mol Brain Res 2005 0.78
102 Nutritional supplementation with mixed essential amino acids enhances myocyte survival, preserving mitochondrial functional capacity during ischemia-reperfusion injury. Am J Cardiol 2004 0.77
103 Sensory neurons from mice lacking the Brn-3b POU family transcription factor are resistant to death-inducing stimuli both in vitro and in vivo. Brain Res Mol Brain Res 2003 0.77
104 Distinct domains of Brn-3a regulate apoptosis and neurite outgrowth in vivo. Neuroreport 2004 0.77
105 Green tea polyphenol epigallocatechin gallate inhibits cell signaling by inducing SOCS1 gene expression. Int Immunol 2010 0.77
106 The Brn-3a POU family transcription factor stimulates p53 gene expression in human and mouse tumour cells. Neurosci Lett 2002 0.77
107 Functional interaction between Brn-3a and Src-1 co-activates Brn-3a-mediated transactivation. Biochem Biophys Res Commun 2002 0.77
108 Heat shock proteins can protect aged human and rodent cells from different stressful stimuli. Mech Ageing Dev 2004 0.77
109 Endothelial microparticle release is stimulated in vitro by purified IgG from patients with the antiphospholipid syndrome. Thromb Haemost 2012 0.77
110 Detection of cervical abnormalities in a developing country using measurement of Brn-3a in cervical smears. Gynecol Oncol 2005 0.77
111 STAT signalling in the heart and cardioprotection. Expert Rev Mol Med 2006 0.77
112 Gene expression studies on bio-electrosprayed primary cardiac myocytes. Biotechnol J 2008 0.77
113 The cardioprotective agent urocortin induces expression of CT-1. Cardiovasc Toxicol 2003 0.76
114 Transgenic overexpression of HSP56 does not result in cardiac hypertrophy nor protect from ischaemia/reperfusion injury. Int J Biochem Cell Biol 2010 0.75
115 Fine binding characteristics of human autoantibodies-partial molecular characterization. Mol Immunol 2004 0.75
116 Lupus autoantibodies to native DNA preferentially bind DNA presented on PolIV. Immunology 2005 0.75
117 The HPV Cellular Transactivator Brn-3a Can Be Used to Predict Cervical Adenocarcinoma and Squamous Carcinoma Precancer Lesions in the Developed and Developing Worlds. Obstet Gynecol Int 2010 0.75
118 Optimisation of herpes simplex virus-based vectors for delivery to human peripheral blood mononuclear cells. J Immunol Methods 2002 0.75
119 Brn-3a transcription factor blocks p53-mediated activation of proapoptotic target genes Noxa and Bax in vitro and in vivo to determine cell fate. J Biol Chem 2016 0.75
120 Reduction in endogenous parkin levels renders glial cells sensitive to both caspase-dependent and caspase-independent cell death. Eur J Neurosci 2004 0.75
121 Beta-2-glycoprotein specificity of human anti-phospholipid antibody resides on the light chain: a novel mechanism for acquisition of cross-reactivity by an autoantibody. Mol Immunol 2005 0.75