Published in Blood on June 16, 2005
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Iron transport machinery of human cells: players and their interactions. Curr Top Membr (2012) 0.82
Regulatory effects of Cu, Zn, and Ca on Fe absorption: the intricate play between nutrient transporters. Nutrients (2013) 0.82
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Iron transport proteins: Gateways of cellular and systemic iron homeostasis. J Biol Chem (2017) 0.80
The role of duodenal cytochrome b in intestinal iron absorption remains unclear. Blood (2005) 0.78
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A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol Cell (2000) 5.31
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An iron-regulated ferric reductase associated with the absorption of dietary iron. Science (2001) 2.90
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The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature (2008) 18.20
Pazopanib versus sunitinib in metastatic renal-cell carcinoma. N Engl J Med (2013) 10.74
Regulation of progenitor cell proliferation and granulocyte function by microRNA-223. Nature (2008) 8.69
Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet (2006) 8.32
Balancing acts: molecular control of mammalian iron metabolism. Cell (2004) 7.82
The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab (2005) 5.32
Recurrent BRAF mutations in Langerhans cell histiocytosis. Blood (2010) 4.96
Interleukin-6 induces hepcidin expression through STAT3. Blood (2006) 4.24
Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance. J Clin Invest (2007) 4.09
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07
Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA). Nat Genet (2008) 4.02
Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. Blood (2002) 3.93
Immortalization and transformation of primary human airway epithelial cells by gene transfer. Oncogene (2002) 3.80
Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia. Blood (2011) 3.41
Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Nat Genet (2005) 3.28
A mouse model of juvenile hemochromatosis. J Clin Invest (2005) 3.25
Bortezomib-based therapy for newly diagnosed mantle-cell lymphoma. N Engl J Med (2015) 3.18
Distinct microRNA expression profiles in acute myeloid leukemia with common translocations. Proc Natl Acad Sci U S A (2008) 3.13
Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses. Nature (2007) 3.06
MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia. Proc Natl Acad Sci U S A (2007) 3.00
Scara5 is a ferritin receptor mediating non-transferrin iron delivery. Dev Cell (2009) 2.60
Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. Science (2008) 2.59
Highly penetrant, rapid tumorigenesis through conditional inversion of the tumor suppressor gene Snf5. Cancer Cell (2002) 2.51
Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver. J Clin Invest (2005) 2.45
Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis. Nat Genet (2003) 2.43
Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis. Nat Genet (2003) 2.41
The Steap proteins are metalloreductases. Blood (2006) 2.37
Mutations in mitochondrial carrier family gene SLC25A38 cause nonsyndromic autosomal recessive congenital sideroblastic anemia. Nat Genet (2009) 2.37
The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression. Cell Metab (2008) 2.36
TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation. Cell (2010) 2.32
Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors. Development (2010) 2.31
Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing. J Biol Chem (2006) 2.28
Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis. Blood (2010) 2.20
Proinflammatory state, hepcidin, and anemia in older persons. Blood (2010) 2.19
Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice. J Clin Invest (2010) 2.18
Lymphomas of the breast: primary and secondary involvement. Cancer (2002) 2.06
Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression. Blood (2008) 2.01
Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation. Blood (2007) 1.97
Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins. Nature (2008) 1.95
An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe(-/-) mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia. Blood (2012) 1.94
Endogenous oncogenic Nras mutation promotes aberrant GM-CSF signaling in granulocytic/monocytic precursors in a murine model of chronic myelomonocytic leukemia. Blood (2010) 1.86
T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation. Cancer Cell (2010) 1.85
An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice. Nat Genet (2004) 1.68
Anemia of inflammation: the hepcidin link. Curr Opin Hematol (2005) 1.65
Erythropoietin stimulates phosphorylation and activation of GATA-1 via the PI3-kinase/AKT signaling pathway. Blood (2005) 1.63
The H3K27 demethylase UTX-1 regulates C. elegans lifespan in a germline-independent, insulin-dependent manner. Aging Cell (2011) 1.56
Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice. Blood (2011) 1.49
Prognostic significance of 2-hydroxyglutarate levels in acute myeloid leukemia in China. Proc Natl Acad Sci U S A (2013) 1.49
miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia. Nat Commun (2012) 1.49
Characteristics and prognosis analysis of additional chromosome abnormalities in newly diagnosed acute promyelocytic leukemia treated with arsenic trioxide as the front-line therapy. Leuk Res (2013) 1.48
OPCML is a broad tumor suppressor for multiple carcinomas and lymphomas with frequently epigenetic inactivation. PLoS One (2008) 1.47
The mitochondrial ATP-binding cassette transporter Abcb7 is essential in mice and participates in cytosolic iron-sulfur cluster biogenesis. Hum Mol Genet (2006) 1.47
Iron is essential for neuron development and memory function in mouse hippocampus. J Nutr (2009) 1.47
Iron-responsive degradation of iron-regulatory protein 1 does not require the Fe-S cluster. EMBO J (2006) 1.43
Hypoxia-inducible factor-1α expression indicates poor prognosis in myelodysplastic syndromes. Leuk Lymphoma (2012) 1.43
Systematic molecular genetic analysis of congenital sideroblastic anemia: evidence for genetic heterogeneity and identification of novel mutations. Pediatr Blood Cancer (2010) 1.43
Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers. Proc Natl Acad Sci U S A (2007) 1.43
Arsenic trioxide induces not only apoptosis but also autophagic cell death in leukemia cell lines via up-regulation of Beclin-1. Leuk Res (2006) 1.43
Interleukin-6-independent expression of glucocorticoid receptor is upregulated by triptolide in multiple myeloma. Leuk Lymphoma (2009) 1.42
Transferrin is a major determinant of hepcidin expression in hypotransferrinemic mice. Blood (2010) 1.41
Heat shock protein 90 inhibition results in altered downstream signaling of mutant KIT and exerts synergistic effects on Kasumi-1 cells when combining with histone deacetylase inhibitor. Leuk Res (2011) 1.40
Novel influenza A (H1N1) in patients with hematologic disease. Leuk Lymphoma (2010) 1.39
X-linked gray platelet syndrome due to a GATA1 Arg216Gln mutation. Blood (2007) 1.38
nm1054: a spontaneous, recessive, hypochromic, microcytic anemia mutation in the mouse. Blood (2005) 1.38
Failure of red blood cell maturation in mice with defects in the high-density lipoprotein receptor SR-BI. Blood (2002) 1.37
Probucol prevents early coronary heart disease and death in the high-density lipoprotein receptor SR-BI/apolipoprotein E double knockout mouse. Proc Natl Acad Sci U S A (2003) 1.33
Chronic deep brain stimulation in the rat nucleus accumbens and its effect on morphine reinforcement. Addict Biol (2008) 1.30
The channel kinase, TRPM7, is required for early embryonic development. Proc Natl Acad Sci U S A (2011) 1.29
Abcb7, the gene responsible for X-linked sideroblastic anemia with ataxia, is essential for hematopoiesis. Blood (2006) 1.28
MicroRNAs expression signatures are associated with lineage and survival in acute leukemias. Blood Cells Mol Dis (2010) 1.26
Heme-regulated eIF2alpha kinase modifies the phenotypic severity of murine models of erythropoietic protoporphyria and beta-thalassemia. J Clin Invest (2005) 1.26
Primary ciliary dyskinesia in mice lacking the novel ciliary protein Pcdp1. Mol Cell Biol (2007) 1.26
Iron homeostasis and erythropoiesis. Curr Top Dev Biol (2008) 1.26
A spontaneous, recurrent mutation in divalent metal transporter-1 exposes a calcium entry pathway. PLoS Biol (2004) 1.26
AKT induces erythroid-cell maturation of JAK2-deficient fetal liver progenitor cells and is required for Epo regulation of erythroid-cell differentiation. Blood (2005) 1.25
Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice. Nat Genet (2007) 1.23
SOD2-deficiency anemia: protein oxidation and altered protein expression reveal targets of damage, stress response, and antioxidant responsiveness. Blood (2004) 1.23
Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice. Blood (2011) 1.19
Oral tetra-arsenic tetra-sulfide formula versus intravenous arsenic trioxide as first-line treatment of acute promyelocytic leukemia: a multicenter randomized controlled trial. J Clin Oncol (2013) 1.19
Chronic hepcidin induction causes hyposideremia and alters the pattern of cellular iron accumulation in hemochromatotic mice. Blood (2005) 1.18
A mutation in Sec15l1 causes anemia in hemoglobin deficit (hbd) mice. Nat Genet (2005) 1.16
Clinical characteristics of T-cell lymphoma associated with hemophagocytic syndrome: comparison of T-cell lymphoma with and without hemophagocytic syndrome. Leuk Lymphoma (2008) 1.16
The function of heme-regulated eIF2alpha kinase in murine iron homeostasis and macrophage maturation. J Clin Invest (2007) 1.16
Immunosurveillance and survivin-specific T-cell immunity in children with high-risk neuroblastoma. J Clin Oncol (2006) 1.15
The IRP1-HIF-2α axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption. Cell Metab (2013) 1.14
Hypertension secondary to reninoma treated with laparoscopic nephron-sparing surgery in a child. Urology (2012) 1.13