An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe(-/-) mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia.

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Published in Blood on December 06, 2012

Authors

Paul J Schmidt1, Iva Toudjarska, Anoop K Sendamarai, Tim Racie, Stuart Milstein, Brian R Bettencourt, Julia Hettinger, David Bumcrot, Mark D Fleming

Author Affiliations

1: Department of Pathology, Children's Hospital Boston and Harvard Medical School, Boston, MA 02115, USA. pschmidt@enders.tch.harvard.edu

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