Published in Immunity on June 01, 2005
Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin. J Clin Invest (2008) 2.77
Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases. Pharmacol Rev (2010) 1.97
Mast cell peptidases: chameleons of innate immunity and host defense. Am J Respir Cell Mol Biol (2009) 1.58
Mechanisms of immune complex-mediated neutrophil recruitment and tissue injury. Circulation (2009) 1.56
Critical role of dipeptidyl peptidase I in neutrophil recruitment during the development of experimental abdominal aortic aneurysms. Proc Natl Acad Sci U S A (2007) 1.32
Tailor-made inflammation: how neutrophil serine proteases modulate the inflammatory response. J Mol Med (Berl) (2010) 1.13
Neutrophil serine proteases fine-tune the inflammatory response. Int J Biochem Cell Biol (2007) 1.12
Role of NADPH oxidase versus neutrophil proteases in antimicrobial host defense. PLoS One (2011) 1.06
NETosis and NADPH oxidase: at the intersection of host defense, inflammation, and injury. Front Immunol (2013) 1.04
Cutting edge: CD49d+ neutrophils induce FcepsilonRI expression on lung dendritic cells in a mouse model of postviral asthma. J Immunol (2010) 0.98
Cathepsin g is required for sustained inflammation and tissue injury after reperfusion of ischemic kidneys. Am J Pathol (2007) 0.96
Dipeptidyl peptidase I-dependent neutrophil recruitment modulates the inflammatory response to Sendai virus infection. J Immunol (2008) 0.92
How immune peptidases change specificity: cathepsin G gained tryptic function but lost efficiency during primate evolution. J Immunol (2010) 0.92
Cathepsin G: roles in antigen presentation and beyond. Mol Immunol (2009) 0.89
Functional analysis of monocyte MHC class II compartments. FASEB J (2008) 0.87
Guinea pig chymase is leucine-specific: a novel example of functional plasticity in the chymase/granzyme family of serine peptidases. J Biol Chem (2008) 0.86
Short Gel, Long Gradient Liquid Chromatography Tandem Mass Spectrometry to Discover Urinary Biomarkers of Chronic Pancreatitis. Open Proteomics J (2013) 0.86
Pivotal role for alpha1-antichymotrypsin in skin repair. J Biol Chem (2011) 0.83
A Pulmonary Perspective on GASPIDs: Granule-Associated Serine Peptidases of Immune Defense. Curr Respir Med Rev (2006) 0.83
SerpinB1 is critical for neutrophil survival through cell-autonomous inhibition of cathepsin G. Blood (2013) 0.82
Cathepsin G-regulated release of formyl peptide receptor agonists modulate neutrophil effector functions. J Biol Chem (2012) 0.81
DNA structures decorated with cathepsin G/secretory leukocyte proteinase inhibitor stimulate IFNI production by plasmacytoid dendritic cells. Am J Clin Exp Immunol (2013) 0.81
Mast cell proteases as pharmacological targets. Eur J Pharmacol (2015) 0.78
Neutrophil cathepsin G, but not elastase, induces aggregation of MCF-7 mammary carcinoma cells by a protease activity-dependent cell-oriented mechanism. Mediators Inflamm (2014) 0.78
Protrusive and Contractile Forces of Spreading Human Neutrophils. Biophys J (2015) 0.77
Proteolytic characteristics of cathepsin D related to the recognition and cleavage of its target proteins. PLoS One (2013) 0.76
Neutrophils and neutrophil serine proteases are increased in the spleens of estrogen-treated C57BL/6 mice and several strains of spontaneous lupus-prone mice. PLoS One (2017) 0.75
Regulation of hepatocyte growth factor in mice with pneumonia by peptidases and trans-alveolar flux. PLoS One (2015) 0.75
Neutrophil Extracellular Traps Enhance Early Inflammatory Response in Sendai Virus-Induced Asthma Phenotype. Front Immunol (2016) 0.75
Motile Human Neutrophils Sense Ligand Density Over Their Entire Contact Area. Ann Biomed Eng (2015) 0.75
Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema. Nature (2003) 4.02
MMP12, lung function, and COPD in high-risk populations. N Engl J Med (2009) 3.96
Association of radiographic emphysema and airflow obstruction with lung cancer. Am J Respir Crit Care Med (2008) 3.94
Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice. J Exp Med (2002) 3.24
Elastin fragments drive disease progression in a murine model of emphysema. J Clin Invest (2006) 3.11
Loss of collagenase-2 confers increased skin tumor susceptibility to male mice. Nat Genet (2003) 2.69
Macrophage metalloelastase mediates acute cigarette smoke-induced inflammation via tumor necrosis factor-alpha release. Am J Respir Crit Care Med (2003) 2.64
Leukocyte-derived matrix metalloproteinase-9 mediates blood-brain barrier breakdown and is proinflammatory after transient focal cerebral ischemia. Am J Physiol Heart Circ Physiol (2005) 2.59
ERM is required for transcriptional control of the spermatogonial stem cell niche. Nature (2005) 2.58
Dipeptidyl peptidase I activates neutrophil-derived serine proteases and regulates the development of acute experimental arthritis. J Clin Invest (2002) 2.56
Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13-induced inflammation and remodeling. J Clin Invest (2002) 2.52
The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Am J Hum Genet (2005) 2.46
Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth. Nat Med (2010) 2.44
Expression profiling of the developing mouse lung: insights into the establishment of the extracellular matrix. Am J Respir Cell Mol Biol (2002) 2.26
Neutrophil elastase targets virulence factors of enterobacteria. Nature (2002) 2.17
Essential role of MMP-12 in Fas-induced lung fibrosis. Am J Respir Cell Mol Biol (2007) 2.16
A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development. Blood (2004) 2.06
Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice. Proc Natl Acad Sci U S A (2005) 1.98
CD8+ T Cells are required for inflammation and destruction in cigarette smoke-induced emphysema in mice. J Immunol (2007) 1.92
Lysyl oxidase is required for vascular and diaphragmatic development in mice. J Biol Chem (2002) 1.90
Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy. Immunity (2006) 1.88
Peripheral blood mononuclear cell gene expression profiles predict poor outcome in idiopathic pulmonary fibrosis. Sci Transl Med (2013) 1.81
Neutrophil-derived cathelicidin promotes adhesion of classical monocytes. Circ Res (2013) 1.80
Pathophysiology of abdominal aortic aneurysms: insights from the elastase-induced model in mice with different genetic backgrounds. Ann N Y Acad Sci (2006) 1.80
Lung cancer and chronic obstructive pulmonary disease: needs and opportunities for integrated research. J Natl Cancer Inst (2009) 1.75
Mast cell dipeptidyl peptidase I mediates survival from sepsis. J Clin Invest (2004) 1.75
Increased inflammation delays wound healing in mice deficient in collagenase-2 (MMP-8). FASEB J (2007) 1.74
Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema. Nat Med (2010) 1.67
Stem cells in lung disease, repair, and the potential for therapeutic interventions: State-of-the-art and future challenges. Am J Respir Cell Mol Biol (2006) 1.63
Neutrophils from MMP-9- or neutrophil elastase-deficient mice show no defect in transendothelial migration under flow in vitro. J Leukoc Biol (2002) 1.62
Epithelial cell PPAR[gamma] contributes to normal lung maturation. FASEB J (2006) 1.61
The role of the Grb2-p38 MAPK signaling pathway in cardiac hypertrophy and fibrosis. J Clin Invest (2003) 1.61
IL-17RA is required for CCL2 expression, macrophage recruitment, and emphysema in response to cigarette smoke. PLoS One (2011) 1.61
Membrane-bound matrix metalloproteinase-8 on activated polymorphonuclear cells is a potent, tissue inhibitor of metalloproteinase-resistant collagenase and serpinase. J Immunol (2004) 1.57
Accelerated enlargement of experimental abdominal aortic aneurysms in a mouse model of chronic cigarette smoke exposure. J Am Coll Surg (2004) 1.53
Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene. Am J Hum Genet (2009) 1.52
Acute cigarette smoke-induced connective tissue breakdown requires both neutrophils and macrophage metalloelastase in mice. Am J Respir Cell Mol Biol (2002) 1.52
Molecular biomarkers for quantitative and discrete COPD phenotypes. Am J Respir Cell Mol Biol (2008) 1.51
MMP-8 promotes polymorphonuclear cell migration through collagen barriers in obliterative bronchiolitis. J Leukoc Biol (2009) 1.49
Macrophage elastase kills bacteria within murine macrophages. Nature (2009) 1.42
Neutrophil elastase in human atherosclerotic plaques: production by macrophages. Circulation (2003) 1.42
Common origins of lung cancer and COPD. Nat Med (2008) 1.41
Macrophage elastase (matrix metalloproteinase-12) suppresses growth of lung metastases. Cancer Res (2006) 1.41
Polymers of Z alpha1-antitrypsin co-localize with neutrophils in emphysematous alveoli and are chemotactic in vivo. Am J Pathol (2005) 1.36
Deletion of exon I of SMAD7 in mice results in altered B cell responses. J Immunol (2006) 1.36
Effects of intra-abdominal sepsis on atherosclerosis in mice. Crit Care (2014) 1.34
Critical role of dipeptidyl peptidase I in neutrophil recruitment during the development of experimental abdominal aortic aneurysms. Proc Natl Acad Sci U S A (2007) 1.32
Inducible expression of tissue inhibitor of metalloproteinases-resistant matrix metalloproteinase-9 on the cell surface of neutrophils. Am J Respir Cell Mol Biol (2003) 1.29
Neutrophil elastase is needed for neutrophil emigration into lungs in ventilator-induced lung injury. Am J Respir Cell Mol Biol (2008) 1.27
Differential requirement for LAT and SLP-76 in GPVI versus T cell receptor signaling. J Exp Med (2002) 1.24
Interleukin-13-dependent expression of matrix metalloproteinase-12 is required for the development of airway eosinophilia in mice. Am J Respir Cell Mol Biol (2003) 1.18
An elevated matrix metalloproteinase (MMP) in an animal model of multiple sclerosis is protective by affecting Th1/Th2 polarization. FASEB J (2005) 1.18
Smoke gets in your cells. Am J Respir Cell Mol Biol (2004) 1.17
Cigarette smoke exposure impairs dendritic cell maturation and T cell proliferation in thoracic lymph nodes of mice. J Immunol (2008) 1.15
Mice lacking neutrophil elastase are resistant to bleomycin-induced pulmonary fibrosis. Am J Pathol (2007) 1.13
Complement-dependent neutrophil recruitment is critical for the development of elastase-induced abdominal aortic aneurysm. Circulation (2009) 1.13
Alphavbeta3-targeted nanotherapy suppresses inflammatory arthritis in mice. FASEB J (2009) 1.13
Epithelial cell apoptosis causes acute lung injury masquerading as emphysema. Am J Respir Cell Mol Biol (2009) 1.11
Scavenger Receptors SR-AI/II and MARCO limit pulmonary dendritic cell migration and allergic airway inflammation. J Immunol (2007) 1.10
Scaffolds, adaptors and linkers of TCR signaling: theory and practice. Curr Opin Immunol (2002) 1.09
Osteoclasts are important for bone angiogenesis. Blood (2009) 1.08
Neutrophil serine proteases promote IL-1β generation and injury in necrotizing crescentic glomerulonephritis. J Am Soc Nephrol (2012) 1.06
Role of NADPH oxidase versus neutrophil proteases in antimicrobial host defense. PLoS One (2011) 1.06
A survey of airway responsiveness in 36 inbred mouse strains facilitates gene mapping studies and identification of quantitative trait loci. Mol Genet Genomics (2010) 1.05
Epithelial cell PPARgamma is an endogenous regulator of normal lung maturation and maintenance. Proc Am Thorac Soc (2006) 1.05
NADPH oxidase restrains the matrix metalloproteinase activity of macrophages. J Biol Chem (2005) 1.04
Polymorphisms in surfactant protein-D are associated with chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol (2010) 1.04
Dipeptidyl peptidase I regulates the development of collagen-induced arthritis. Arthritis Rheum (2005) 1.04
Regulation of lutropin circulatory half-life by the mannose/N-acetylgalactosamine-4-SO4 receptor is critical for implantation in vivo. J Clin Invest (2002) 1.02
Simultaneous dual frequency 1H and 19F open coil imaging of arthritic rabbit knee at 3T. IEEE Trans Med Imaging (2010) 1.02
Metalloelastase (MMP-12) expression by tumour cells in squamous cell carcinoma of the vulva correlates with invasiveness, while that by macrophages predicts better outcome. J Pathol (2002) 1.00
Peripheral blood gene expression profiles in COPD subjects. J Clin Bioinforma (2011) 0.99
Surfactant protein-D regulates soluble CD14 through matrix metalloproteinase-12. J Immunol (2005) 0.97
Role of metalloelastase in a model of allergic lung responses induced by cockroach allergen. Am J Pathol (2004) 0.96
Emerging genetics of COPD. EMBO Mol Med (2012) 0.96
Matrix metalloproteinase-12 (MMP-12) in osteoclasts: new lesson on the involvement of MMPs in bone resorption. Bone (2004) 0.96
Antibody directs properdin-dependent activation of the complement alternative pathway in a mouse model of abdominal aortic aneurysm. Proc Natl Acad Sci U S A (2012) 0.96
Epidermal growth factor receptor and claudin-2 participate in A549 permeability and remodeling: implications for non-small cell lung cancer tumor colonization. Mol Carcinog (2009) 0.95
Synergistic effect of antiangiogenic nanotherapy combined with methotrexate in the treatment of experimental inflammatory arthritis. Nanomedicine (Lond) (2010) 0.94
Suppression of inflammation in a mouse model of rheumatoid arthritis using targeted lipase-labile fumagillin prodrug nanoparticles. Biomaterials (2012) 0.93
CX3CR1+ lung mononuclear phagocytes spatially confined to the interstitium produce TNF-α and IL-6 and promote cigarette smoke-induced emphysema. J Immunol (2011) 0.93
Comparison of unrestrained plethysmography and forced oscillation for identifying genetic variability of airway responsiveness in inbred mice. Physiol Genomics (2010) 0.93
Dipeptidyl peptidase I-dependent neutrophil recruitment modulates the inflammatory response to Sendai virus infection. J Immunol (2008) 0.92
Peptide-siRNA nanocomplexes targeting NF-κB subunit p65 suppress nascent experimental arthritis. J Clin Invest (2014) 0.91
Neither SP-A nor NH2-terminal domains of SP-A can substitute for SP-D in regulation of alveolar homeostasis. Am J Physiol Lung Cell Mol Physiol (2006) 0.90
Cigarette smoking affects oxidative protein folding in endoplasmic reticulum by modifying protein disulfide isomerase. FASEB J (2012) 0.89
COPD unwound. N Engl J Med (2005) 0.89
Matrix metalloproteinase Mmp-1a is dispensable for normal growth and fertility in mice and promotes lung cancer progression by modulating inflammatory responses. J Biol Chem (2013) 0.89
Clinical predictors of frequent exacerbations in subjects with severe chronic obstructive pulmonary disease (COPD). Respir Med (2010) 0.89
Cigarette smoke inhibits engulfment of apoptotic cells by macrophages through inhibition of actin rearrangement. Am J Respir Cell Mol Biol (2010) 0.89
Animal models of asthma: Pro: Allergic avoidance of animal (model[s]) is not an option. Am J Respir Crit Care Med (2006) 0.87
Smoke and mirrors: Mouse models as a reflection of human chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2004) 0.87
Lung transplantation in children following treatment for malignancy. J Heart Lung Transplant (2003) 0.86
Clarithromycin prevents smoke-induced emphysema in mice. Am J Respir Crit Care Med (2008) 0.86
Fumagillin prodrug nanotherapy suppresses macrophage inflammatory response via endothelial nitric oxide. ACS Nano (2014) 0.86
The bone marrow leaves its scar: new concepts in pulmonary fibrosis. J Clin Invest (2004) 0.86
An inhaled matrix metalloprotease inhibitor prevents cigarette smoke-induced emphysema in the mouse. COPD (2005) 0.85