Published in Curr Respir Med Rev on August 01, 2006
Mast cell peptidases: chameleons of innate immunity and host defense. Am J Respir Cell Mol Biol (2009) 1.58
Granule Associated Serine Proteases of Hematopoietic Cells - An Analysis of Their Appearance and Diversification during Vertebrate Evolution. PLoS One (2015) 1.41
Serine protease activity contributes to control of Mycobacterium tuberculosis in hypoxic lung granulomas in mice. J Clin Invest (2010) 1.11
Guinea pig chymase is leucine-specific: a novel example of functional plasticity in the chymase/granzyme family of serine peptidases. J Biol Chem (2008) 0.86
Mast cell alpha and beta tryptases changed rapidly during primate speciation and evolved from gamma-like transmembrane peptidases in ancestral vertebrates. J Immunol (2007) 0.85
Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. Science (1997) 8.19
Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis. Genes Dev (1999) 6.10
Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-alpha. Nature (1996) 5.48
Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells. Cell (1994) 4.26
Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis. Nat Med (1998) 4.04
Human and mouse proteases: a comparative genomic approach. Nat Rev Genet (2003) 4.02
Kinetics of association of serine proteinases with native and oxidized alpha-1-proteinase inhibitor and alpha-1-antichymotrypsin. J Biol Chem (1980) 3.14
Long-range disruption of gene expression by a selectable marker cassette. Proc Natl Acad Sci U S A (1996) 2.83
Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice. Am J Pathol (2003) 2.66
Dipeptidyl peptidase I activates neutrophil-derived serine proteases and regulates the development of acute experimental arthritis. J Clin Invest (2002) 2.56
Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo. Proc Natl Acad Sci U S A (1999) 2.48
Identification of a highly specific chymase as the major angiotensin II-forming enzyme in the human heart. J Biol Chem (1990) 2.41
Mutations of the cathepsin C gene are responsible for Papillon-Lefèvre syndrome. J Med Genet (1999) 2.25
Chloroacyl esters as histochemical substrates. J Histochem Cytochem (1953) 2.21
Neutrophil elastase targets virulence factors of enterobacteria. Nature (2002) 2.17
Covalent structure of a group-specific protease from rat small intestine. Appendix: crystallographic data for a group specific protease from rat intestine. Biochemistry (1978) 2.17
Alpha1-antitrypsin deficiency--a model for conformational diseases. N Engl J Med (2002) 2.11
Quantitation of histamine, tryptase, and chymase in dispersed human T and TC mast cells. J Immunol (1987) 2.00
Delayed expulsion of the nematode Trichinella spiralis in mice lacking the mucosal mast cell-specific granule chymase, mouse mast cell protease-1. J Exp Med (2000) 1.98
Cell surface-bound elastase and cathepsin G on human neutrophils: a novel, non-oxidative mechanism by which neutrophils focus and preserve catalytic activity of serine proteinases. J Cell Biol (1995) 1.98
Degradation of outer membrane protein A in Escherichia coli killing by neutrophil elastase. Science (2000) 1.97
Mast cell-dependent B and T lymphocyte activation is mediated by the secretion of immunologically active exosomes. J Immunol (2001) 1.91
Adipsin and complement factor D activity: an immune-related defect in obesity. Science (1989) 1.87
Mast cell-derived exosomes induce phenotypic and functional maturation of dendritic cells and elicit specific immune responses in vivo. J Immunol (2003) 1.86
Regulation of tryptase from human lung mast cells by heparin. Stabilization of the active tetramer. J Biol Chem (1986) 1.79
Detection of MCT and MCTC types of human mast cells by immunohistochemistry using new monoclonal anti-tryptase and anti-chymase antibodies. J Histochem Cytochem (1989) 1.79
Different mouse mast cell populations express various combinations of at least six distinct mast cell serine proteases. Proc Natl Acad Sci U S A (1990) 1.76
Mast cell dipeptidyl peptidase I mediates survival from sepsis. J Clin Invest (2004) 1.75
Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue. J Biol Chem (1992) 1.74
A novel heparin-dependent processing pathway for human tryptase. Autocatalysis followed by activation with dipeptidyl peptidase I. J Clin Invest (1996) 1.73
Compartmentalization of angiotensin II generation in the dog heart. Evidence for independent mechanisms in intravascular and interstitial spaces. J Clin Invest (1997) 1.71
A key role for mast cell chymase in the activation of pro-matrix metalloprotease-9 and pro-matrix metalloprotease-2. J Biol Chem (2004) 1.70
Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice. Nat Genet (1995) 1.70
Elastase and cathepsin G of human monocytes. Quantification of cellular content, release in response to stimuli, and heterogeneity in elastase-mediated proteolytic activity. J Immunol (1989) 1.67
In vitro- and ex vivo-derived cytolytic leukocytes from granzyme A x B double knockout mice are defective in granule-mediated apoptosis but not lysis of target cells. J Exp Med (1997) 1.61
Complement activation in factor D-deficient mice. Proc Natl Acad Sci U S A (2001) 1.59
Dipeptidyl peptidase I is essential for activation of mast cell chymases, but not tryptases, in mice. J Biol Chem (2001) 1.57
Proteases and emphysema. Curr Opin Pulm Med (2005) 1.55
Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family. Proc Natl Acad Sci U S A (1990) 1.55
Normal neutrophil function in cathepsin G-deficient mice. Blood (1999) 1.53
Granzyme A-deficient mice retain potent cell-mediated cytotoxicity. EMBO J (1995) 1.52
Rapid conversion of angiotensin I to angiotensin II by neutrophil and mast cell proteinases. J Biol Chem (1982) 1.51
Generation of active myeloid and lymphoid granule serine proteases requires processing by the granule thiol protease dipeptidyl peptidase I. J Biol Chem (1993) 1.48
Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes. Proc Natl Acad Sci U S A (1999) 1.46
Structure of human neutrophil elastase in complex with a peptide chloromethyl ketone inhibitor at 1.84-A resolution. Proc Natl Acad Sci U S A (1989) 1.46
Acute cigarette smoke-induced connective tissue breakdown is mediated by neutrophils and prevented by alpha1-antitrypsin. Am J Respir Cell Mol Biol (2000) 1.44
Human beta-tryptase is a ring-like tetramer with active sites facing a central pore. Nature (1998) 1.43
Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia. Proc Natl Acad Sci U S A (1996) 1.42
Bioactive proteinase 3 on the cell surface of human neutrophils: quantification, catalytic activity, and susceptibility to inhibition. J Immunol (2000) 1.38
Expression of the secretory leukoprotease inhibitor gene in epithelial cells. J Clin Invest (1991) 1.37
Papillon-Lefèvre syndrome: correlating the molecular, cellular, and clinical consequences of cathepsin C/dipeptidyl peptidase I deficiency in humans. J Immunol (2004) 1.36
Evaluation of the substrate specificity of human mast cell tryptase beta I and demonstration of its importance in bacterial infections of the lung. J Biol Chem (2001) 1.34
Angiotensin II generation by mast cell alpha- and beta-chymases. Biochim Biophys Acta (2000) 1.33
Human lung tryptase. Purification and characterization. J Biol Chem (1984) 1.33
A critical role for neutrophil elastase in experimental bullous pemphigoid. J Clin Invest (2000) 1.30
Dog mastocytoma cells secrete a 92-kD gelatinase activated extracellularly by mast cell chymase. J Clin Invest (1996) 1.27
A genomic analysis of rat proteases and protease inhibitors. Genome Res (2004) 1.27
Granzyme B and the downstream granzymes C and/or F are important for cytotoxic lymphocyte functions. J Immunol (2005) 1.24
Serine protease cathepsin G regulates adhesion-dependent neutrophil effector functions by modulating integrin clustering. Immunity (2005) 1.20
The granzyme B inhibitor, protease inhibitor 9, is mainly expressed by dendritic cells and at immune-privileged sites. J Immunol (2001) 1.19
Identification of a cathepsin G-like proteinase in the MCTC type of human mast cell. J Immunol (1990) 1.19
The human cytotoxic T cell granule serine protease granzyme H has chymotrypsin-like (chymase) activity and is taken up into cytoplasmic vesicles reminiscent of granzyme B-containing endosomes. J Biol Chem (1999) 1.18
The 1.8 A crystal structure of human cathepsin G in complex with Suc-Val-Pro-PheP-(OPh)2: a Janus-faced proteinase with two opposite specificities. EMBO J (1996) 1.17
Structures of native and complexed complement factor D: implications of the atypical His57 conformation and self-inhibitory loop in the regulation of specific serine protease activity. J Mol Biol (1998) 1.16
Tryptase inhibition blocks airway inflammation in a mouse asthma model. J Immunol (2002) 1.16
Mast cells protect mice from Mycoplasma pneumonia. Am J Respir Crit Care Med (2005) 1.16
Characterization of human gamma-tryptases, novel members of the chromosome 16p mast cell tryptase and prostasin gene families. J Immunol (2000) 1.15
A leucine-to-proline substitution causes a defective alpha 1-antichymotrypsin allele associated with familial obstructive lung disease. Genomics (1993) 1.15
The structure of rat mast cell protease II at 1.9-A resolution. Biochemistry (1988) 1.15
Inhaled tryptase causes bronchoconstriction in sheep via histamine release. Am J Respir Crit Care Med (1996) 1.14
Secretory granule proteases in rat mast cells. Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations. J Exp Med (1997) 1.14
Genetic deficiency of human mast cell alpha-tryptase. Clin Exp Allergy (2002) 1.14
Histochemical demonstration of a species-specific trypsin-like enzyme in mast cells. Nature (1960) 1.13
The molecular basis of alpha 1-antichymotrypsin deficiency in a heterozygote with liver and lung disease. J Hepatol (1993) 1.12
Substrate specificity of the chymotrypsin-like protease in secretory granules isolated from rat mast cells. Proc Natl Acad Sci U S A (1987) 1.09
Regulated expression, processing, and secretion of dog mast cell dipeptidyl peptidase I. J Biol Chem (1998) 1.08
Mouse chromosome 17A3.3 contains 13 genes that encode functional tryptic-like serine proteases with distinct tissue and cell expression patterns. J Biol Chem (2003) 1.07
Structural basis of profactor D activation: from a highly flexible zymogen to a novel self-inhibited serine protease, complement factor D. EMBO J (1999) 1.07
Mast cell protease 5 mediates ischemia-reperfusion injury of mouse skeletal muscle. J Immunol (2005) 1.06
Inhibition of mast cell tryptase by inhaled APC 366 attenuates allergen-induced late-phase airway obstruction in asthma. J Allergy Clin Immunol (2001) 1.05
Characterization of genes encoding known and novel human mast cell tryptases on chromosome 16p13.3. J Biol Chem (1999) 1.05
Concerted action of the FasL/Fas and perforin/granzyme A and B pathways is mandatory for the development of early viral hepatitis but not for recovery from viral infection. J Virol (2001) 1.05
Rodent alpha-chymases are elastase-like proteases. Eur J Biochem (2002) 1.05
Mast cell tryptase causes airway smooth muscle hyperresponsiveness in dogs. J Clin Invest (1989) 1.04
The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity. Nat Struct Biol (2003) 1.04
Distribution of chymase-containing mast cells in human bronchi. J Histochem Cytochem (1992) 1.03
Crystal structure of the apoptosis-inducing human granzyme A dimer. Nat Struct Biol (2003) 1.03
Alveolar fluid neutrophil elastase activity in the adult respiratory distress syndrome is complexed to alpha-2-macroglobulin. J Clin Invest (1988) 1.03
A despecialization step underlying evolution of a family of serine proteases. Mol Cell (2003) 1.03
Identification of a new member of the tryptase family of mouse and human mast cell proteases which possesses a novel COOH-terminal hydrophobic extension. J Biol Chem (1999) 1.02
Loss-of-function mutations in cathepsin C in two families with Papillon-Lefèvre syndrome are associated with deficiency of serine proteinases in PMNs. Hum Mutat (2004) 1.02
Reaction of human skin chymotrypsin-like proteinase chymase with plasma proteinase inhibitors. J Biol Chem (1989) 1.01
Three-dimensional models of four mouse mast cell chymases. Identification of proteoglycan binding regions and protease-specific antigenic epitopes. J Biol Chem (1993) 1.01
The human mast cell chymase gene (CMA1): mapping to the cathepsin G/granzyme gene cluster and lineage-restricted expression. Genomics (1993) 1.01
The structure of the pro-apoptotic protease granzyme B reveals the molecular determinants of its specificity. Nat Struct Biol (2000) 1.01
Murine cytomegalovirus replication in salivary glands is controlled by both perforin and granzymes during acute infection. Eur J Immunol (2000) 1.01
The 2.2-A crystal structure of human pro-granzyme K reveals a rigid zymogen with unusual features. J Biol Chem (2002) 1.01
Comparative genomic analysis of human and chimpanzee proteases. Genomics (2005) 1.01
Lack of expression of the tryptase mouse mast cell protease 7 in mast cells of the C57BL/6J mouse. J Immunol (1994) 1.00