Published in Blood on July 13, 2004
Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells. Cell Stem Cell (2010) 4.21
Hematopoietic stem cell fate is established by the Notch-Runx pathway. Genes Dev (2005) 3.27
The emergence of hematopoietic stem cells is initiated in the placental vasculature in the absence of circulation. Cell Stem Cell (2008) 3.09
Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cells. Cell Stem Cell (2008) 3.08
Hematopoietic stem cells proliferate until after birth and show a reversible phase-specific engraftment defect. J Clin Invest (2006) 2.79
Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development (2007) 2.70
Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE. Development (2007) 1.94
Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma. Blood (2005) 1.84
Runx1-mediated hematopoietic stem-cell emergence is controlled by a Gata/Ets/SCL-regulated enhancer. Blood (2007) 1.82
A somitic Wnt16/Notch pathway specifies haematopoietic stem cells. Nature (2011) 1.76
RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development. Development (2010) 1.72
Roles of Pofut1 and O-fucose in mammalian Notch signaling. J Biol Chem (2008) 1.71
Impaired embryonic haematopoiesis yet normal arterial development in the absence of the Notch ligand Jagged1. EMBO J (2008) 1.71
Identification of a new intrinsically timed developmental checkpoint that reprograms key hematopoietic stem cell properties. Proc Natl Acad Sci U S A (2007) 1.68
Somite-Derived Retinoic Acid Regulates Zebrafish Hematopoietic Stem Cell Formation. PLoS One (2016) 1.39
Numb mediates the interaction between Wnt and Notch to modulate primitive erythropoietic specification from the hemangioblast. Development (2008) 1.30
ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification. Genes Dev (2011) 1.30
Proinflammatory signaling regulates hematopoietic stem cell emergence. Cell (2014) 1.27
Cited2 is required for normal hematopoiesis in the murine fetal liver. Blood (2007) 1.21
Signalling pathways that control vertebrate haematopoietic stem cell specification. Nat Rev Immunol (2013) 1.21
Regulation of endothelial cell differentiation and specification. Circ Res (2013) 1.20
Notch signaling distinguishes 2 waves of definitive hematopoiesis in the zebrafish embryo. Blood (2010) 1.19
Human definitive haemogenic endothelium and arterial vascular endothelium represent distinct lineages. Nat Cell Biol (2015) 1.16
Endothelio-mesenchymal interaction controls runx1 expression and modulates the notch pathway to initiate aortic hematopoiesis. Dev Cell (2013) 1.13
Erythro-myeloid progenitors: "definitive" hematopoiesis in the conceptus prior to the emergence of hematopoietic stem cells. Blood Cells Mol Dis (2013) 1.11
Hematopoietic stem cell emergence in the conceptus and the role of Runx1. Int J Dev Biol (2010) 1.11
Rac1 is essential for intraembryonic hematopoiesis and for the initial seeding of fetal liver with definitive hematopoietic progenitor cells. Blood (2007) 1.10
Mind bomb-1 is essential for intraembryonic hematopoiesis in the aortic endothelium and the subaortic patches. Mol Cell Biol (2008) 1.07
Discrete Notch signaling requirements in the specification of hematopoietic stem cells. EMBO J (2014) 1.02
NF-Y is necessary for hematopoietic stem cell proliferation and survival. Blood (2011) 1.01
Jam1a-Jam2a interactions regulate haematopoietic stem cell fate through Notch signalling. Nature (2014) 0.98
Mind bomb 1 in the lymphopoietic niches is essential for T and marginal zone B cell development. J Exp Med (2008) 0.98
Conditional Cre/LoxP strategies for the study of hematopoietic stem cell formation. Blood Cells Mol Dis (2009) 0.97
Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells. J Clin Invest (2015) 0.97
Radiation leukemia virus common integration at the Kis2 locus: simultaneous overexpression of a novel noncoding RNA and of the proximal Phf6 gene. J Virol (2005) 0.95
The transcriptional coactivator Maml1 is required for Notch2-mediated marginal zone B-cell development. Blood (2007) 0.95
Global analysis of the haematopoietic and endothelial transcriptome during zebrafish development. Mech Dev (2012) 0.94
The convergence of Notch and MAPK signaling specifies the blood progenitor fate in the Drosophila mesoderm. Dev Biol (2011) 0.93
TAT-mediated transduction of NF-Ya peptide induces the ex vivo proliferation and engraftment potential of human hematopoietic progenitor cells. Blood (2010) 0.93
OLIG2 (BHLHB1), a bHLH transcription factor, contributes to leukemogenesis in concert with LMO1. Cancer Res (2005) 0.92
Definitive Hematopoiesis in the Yolk Sac Emerges from Wnt-Responsive Hemogenic Endothelium Independently of Circulation and Arterial Identity. Stem Cells (2015) 0.92
GATA-1 utilizes Ikaros and polycomb repressive complex 2 to suppress Hes1 and to promote erythropoiesis. Mol Cell Biol (2012) 0.91
GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1. Nat Cell Biol (2015) 0.91
The bone marrow stroma in hematological neoplasms--a guilty bystander. Nat Rev Clin Oncol (2011) 0.89
In vivo consequences of deleting EGF repeats 8-12 including the ligand binding domain of mouse Notch1. BMC Dev Biol (2008) 0.89
Gata2b is a restricted early regulator of hemogenic endothelium in the zebrafish embryo. Development (2015) 0.87
Notch1 activation in embryonic VE-cadherin populations selectively blocks hematopoietic stem cell generation and fetal liver hematopoiesis. Transgenic Res (2012) 0.86
The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells. Genes Dev (2014) 0.85
The notch ligand delta-like 4 regulates multiple stages of early hemato-vascular development. PLoS One (2012) 0.85
Cell signaling pathways involved in hematopoietic stem cell specification. Exp Cell Res (2014) 0.84
Specification and function of hemogenic endothelium during embryogenesis. Cell Mol Life Sci (2016) 0.83
Challenges and strategies for generating therapeutic patient-specific hemangioblasts and hematopoietic stem cells from human pluripotent stem cells. Int J Dev Biol (2010) 0.83
Complex regulation of HSC emergence by the Notch signaling pathway. Dev Biol (2015) 0.82
Effects of varying Notch1 signal strength on embryogenesis and vasculogenesis in compound mutant heterozygotes. BMC Dev Biol (2010) 0.82
Ligand activation leads to regulated intramembrane proteolysis of fibroblast growth factor receptor 3. Mol Biol Cell (2011) 0.82
A view of human haematopoietic development from the Petri dish. Nat Rev Mol Cell Biol (2016) 0.80
The Instructive Role of the Vasculature in Stem Cell Niches. Biomater Sci (2014) 0.79
A Quantitative Proteomic Analysis of Hemogenic Endothelium Reveals Differential Regulation of Hematopoiesis by SOX17. Stem Cell Reports (2015) 0.79
FGF signalling specifies haematopoietic stem cells through its regulation of somitic Notch signalling. Nat Commun (2014) 0.79
Osteoblastic and vascular endothelial niches, their control on normal hematopoietic stem cells, and their consequences on the development of leukemia. Stem Cells Int (2011) 0.78
Utility of LRF/Pokemon and NOTCH1 protein expression in the distinction between nodular lymphocyte-predominant Hodgkin lymphoma and classical Hodgkin lymphoma. Int J Surg Pathol (2013) 0.76
Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling. Elife (2015) 0.76
Engineering Hematopoietic Stem Cells: Lessons from Development. Cell Stem Cell (2016) 0.76
Modeling murine yolk sac hematopoiesis with embryonic stem cell culture systems. Front Biol (Beijing) (2014) 0.75
Engineered Murine HSCs Reconstitute Multi-lineage Hematopoiesis and Adaptive Immunity. Cell Rep (2016) 0.75
R-spondin-1 is required for specification of hematopoietic stem cells through Wnt16 and Vegfa signaling pathways. Development (2017) 0.75
A Common Origin for B-1a and B-2 Lymphocytes in Clonal Pre- Hematopoietic Stem Cells. Stem Cell Reports (2017) 0.75
Developing HSCs become Notch independent by the end of maturation in the AGM region. Blood (2016) 0.75
In silico evidence of signaling pathways of notch mediated networks in leukemia. Comput Struct Biotechnol J (2012) 0.75
Myeloproliferation and hematopoietic stem cell dysfunction due to defective Notch receptor modification by O-fucose glycans. Semin Immunopathol (2012) 0.75
Efforts to enhance blood stem cell engraftment: Recent insights from zebrafish hematopoiesis. J Exp Med (2017) 0.75
Regulation of the germinal center response by microRNA-155. Science (2007) 12.25
High-throughput engineering of the mouse genome coupled with high-resolution expression analysis. Nat Biotechnol (2003) 7.47
Lrp5 functions in bone to regulate bone mass. Nat Med (2011) 5.33
Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants. Genes Dev (2004) 3.95
A distinctive role for focal adhesion proteins in three-dimensional cell motility. Nat Cell Biol (2010) 3.84
Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration. Annu Rev Neurosci (2003) 3.79
Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development. Dev Cell (2010) 3.78
Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nat Med (2008) 3.64
Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells. Genes Dev (2002) 3.55
Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice. J Exp Med (2002) 3.24
Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity (2007) 3.19
Beta-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse. Dev Biol (2006) 3.17
Intramembrane proteolysis: theme and variations. Science (2004) 3.06
Notch3 is required for arterial identity and maturation of vascular smooth muscle cells. Genes Dev (2004) 3.00
AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch. Nat Immunol (2011) 2.99
Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity. PLoS Biol (2008) 2.98
Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells. Gastroenterology (2011) 2.94
Developmental transcription factor slug is required for effective re-epithelialization by adult keratinocytes. J Cell Physiol (2005) 2.91
A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency. Development (2002) 2.88
Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development (2007) 2.70
gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis. Dev Cell (2004) 2.68
Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer. Proc Natl Acad Sci U S A (2009) 2.63
Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. Dev Biol (2004) 2.59
ERM is required for transcriptional control of the spermatogonial stem cell niche. Nature (2005) 2.58
The Notch ligand JAG1 is required for sensory progenitor development in the mammalian inner ear. PLoS Genet (2006) 2.56
Medical sequencing of candidate genes for nonsyndromic cleft lip and palate. PLoS Genet (2005) 2.52
Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks. EMBO J (2008) 2.44
FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man. Dev Cell (2012) 2.43
The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear. Development (2005) 2.36
Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice. Proc Natl Acad Sci U S A (2010) 2.34
Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability. J Biol Chem (2005) 2.33
Interaction between Reelin and Notch signaling regulates neuronal migration in the cerebral cortex. Neuron (2008) 2.31
Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment. Cancer Cell (2009) 2.19
Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate. J Cell Sci (2010) 2.07
F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation. Cell (2003) 2.05
Palatogenesis: morphogenetic and molecular mechanisms of secondary palate development. Development (2012) 2.01
The LIM protein AJUBA recruits protein arginine methyltransferase 5 to mediate SNAIL-dependent transcriptional repression. Mol Cell Biol (2008) 2.00
NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells. J Biol Chem (2007) 1.99
Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE. Development (2007) 1.94
The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis. Nat Cell Biol (2013) 1.93
A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis. Proc Natl Acad Sci U S A (2003) 1.92
Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin. PLoS One (2010) 1.92
Critical role of endothelial Notch1 signaling in postnatal angiogenesis. Circ Res (2006) 1.91
Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens. Nat Immunol (2013) 1.87
Gamma-secretase activity is dispensable for mesenchyme-to-epithelium transition but required for podocyte and proximal tubule formation in developing mouse kidney. Development (2003) 1.87
Characterization of Notch3-deficient mice: normal embryonic development and absence of genetic interactions with a Notch1 mutation. Genesis (2003) 1.84
Metalloprotease ADAM10 is required for Notch1 site 2 cleavage. J Biol Chem (2009) 1.83
Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells. Genes Dev (2005) 1.81
Developmental expression analysis of the mouse and chick orthologues of IRF6: the gene mutated in Van der Woude syndrome. Dev Dyn (2006) 1.79
Bile duct proliferation in liver-specific Jag1 conditional knockout mice: effects of gene dosage. Hepatology (2007) 1.78
Notch signaling regulates left-right asymmetry determination by inducing Nodal expression. Genes Dev (2003) 1.76
Skin-derived TSLP triggers progression from epidermal-barrier defects to asthma. PLoS Biol (2009) 1.76
Loss of alpha-catenin decreases the strength of single E-cadherin bonds between human cancer cells. J Biol Chem (2009) 1.73
Antagonistic actions of Msx1 and Osr2 pattern mammalian teeth into a single row. Science (2009) 1.73
Wnt/beta-catenin signaling plays an essential role in activation of odontogenic mesenchyme during early tooth development. Dev Biol (2009) 1.73
Ajuba LIM proteins are negative regulators of the Hippo signaling pathway. Curr Biol (2010) 1.73
Impaired embryonic haematopoiesis yet normal arterial development in the absence of the Notch ligand Jagged1. EMBO J (2008) 1.71
The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with alpha-catenin. J Biol Chem (2002) 1.70
Odd-skipped related 1 is required for development of the metanephric kidney and regulates formation and differentiation of kidney precursor cells. Development (2006) 1.69
Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis. Mol Cell Biol (2008) 1.68
Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesoderm. Development (2002) 1.66
Loss of notch activity in the developing central nervous system leads to increased cell death. Dev Neurosci (2006) 1.65
The essential role of Cited2, a negative regulator for HIF-1alpha, in heart development and neurulation. Proc Natl Acad Sci U S A (2002) 1.64
SnapShot: notch signaling pathway. Cell (2007) 1.63
Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation. Dev Cell (2005) 1.62
Anchoring notch genetics and biochemistry; structural analysis of the ankyrin domain sheds light on existing data. Mol Cell (2004) 1.62
The role of the Grb2-p38 MAPK signaling pathway in cardiac hypertrophy and fibrosis. J Clin Invest (2003) 1.61
Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL. Blood (2010) 1.60
Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration. Nat Med (2004) 1.60
Notch signaling regulates bile duct morphogenesis in mice. PLoS One (2008) 1.59
Smooth muscle Notch1 mediates neointimal formation after vascular injury. Circulation (2009) 1.58
Snail family genes are required for left-right asymmetry determination, but not neural crest formation, in mice. Proc Natl Acad Sci U S A (2006) 1.58
Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis. Development (2004) 1.58
Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition. PLoS One (2008) 1.56
Generation of new Notch2 mutant alleles. Genesis (2006) 1.56
Elevated epidermal thymic stromal lymphopoietin levels establish an antitumor environment in the skin. Cancer Cell (2012) 1.54
The cellular and molecular etiology of the cleft secondary palate in Fgf10 mutant mice. Dev Biol (2005) 1.53
Notch signaling regulates formation of the three-dimensional architecture of intrahepatic bile ducts in mice. Hepatology (2010) 1.53
Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus. Dev Cell (2008) 1.51
Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice. J Clin Invest (2011) 1.51
Slug is a novel downstream target of MyoD. Temporal profiling in muscle regeneration. J Biol Chem (2002) 1.50
Odd-skipped related 1 (Odd 1) is an essential regulator of heart and urogenital development. Dev Biol (2005) 1.47
Bi-compartmental communication contributes to the opposite proliferative behavior of Notch1-deficient hair follicle and epidermal keratinocytes. Development (2007) 1.46
Ectodomain shedding and intramembrane cleavage of mammalian Notch proteins is not regulated through oligomerization. J Biol Chem (2004) 1.45
Integration of IRF6 and Jagged2 signalling is essential for controlling palatal adhesion and fusion competence. Hum Mol Genet (2009) 1.45
Multiple functions of Snail family genes during palate development in mice. Development (2007) 1.45
Expression of Wnt9b and activation of canonical Wnt signaling during midfacial morphogenesis in mice. Dev Dyn (2006) 1.44
Temporal and spatial cooperation of Snail1 and Twist1 during epithelial-mesenchymal transition predicts for human breast cancer recurrence. Mol Cancer Res (2011) 1.42
Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth. Development (2009) 1.37
Jag2-Notch1 signaling regulates oral epithelial differentiation and palate development. Dev Dyn (2006) 1.37
Quantitative dissection of the Notch:CSL interaction: insights into the Notch-mediated transcriptional switch. J Mol Biol (2006) 1.36
Deletion of exon I of SMAD7 in mice results in altered B cell responses. J Immunol (2006) 1.36
The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration. J Cell Biol (2005) 1.33
Presenilin: RIP and beyond. Semin Cell Dev Biol (2008) 1.33
Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes. Nat Struct Mol Biol (2010) 1.33