The role of the retromer complex in aging-related neurodegeneration: a molecular and genomic review.

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Published in Mol Genet Genomics on October 21, 2014

Authors

Christiane Reitz1

Author Affiliations

1: The Department of Neurology, The Department of Epidemiology, The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, The Gertrude H. Sergievsky Center, Columbia University, 630 West 168th Street, New York, NY, 10032, USA, cr2101@cumc.columbia.edu.

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A nucleator arms race: cellular control of actin assembly. Nat Rev Mol Cell Biol (2010) 5.33

Retracted Directed conversion of Alzheimer's disease patient skin fibroblasts into functional neurons. Cell (2011) 5.09

A FAM21-containing WASH complex regulates retromer-dependent sorting. Dev Cell (2009) 4.89

RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk. Neuron (2013) 4.67

A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease. Am J Hum Genet (2011) 4.52

A membrane coat complex essential for endosome-to-Golgi retrograde transport in yeast. J Cell Biol (1998) 4.41

VPS35 mutations in Parkinson disease. Am J Hum Genet (2011) 4.16

Activity-dependent regulation of inhibitory synapse development by Npas4. Nature (2008) 4.10

Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides. Curr Biol (2004) 3.76

Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. Cell (1994) 3.70

Neurotrophins regulate dendritic growth in developing visual cortex. Neuron (1995) 3.64

Endosome to Golgi retrieval of the vacuolar protein sorting receptor, Vps10p, requires the function of the VPS29, VPS30, and VPS35 gene products. J Cell Biol (1997) 3.61

Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. Nat Genet (2011) 3.46

Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin. Neuron (2010) 3.44

Diabetes mellitus and risk of Alzheimer's disease and dementia with stroke in a multiethnic cohort. Am J Epidemiol (2001) 3.43

The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein. EMBO J (2001) 3.13

Endosomal sorting and signalling: an emerging role for sorting nexins. Nat Rev Mol Cell Biol (2008) 3.11

Model-guided microarray implicates the retromer complex in Alzheimer's disease. Ann Neurol (2005) 3.01

Architectural and mechanistic insights into an EHD ATPase involved in membrane remodelling. Nature (2007) 2.96

SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors. Nat Cell Biol (2011) 2.92

Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations. Am J Pathol (2000) 2.78

The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments. J Neurosci (2006) 2.77

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Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. BMC Med Genet (2007) 2.51

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Rare copy number variation discovery and cross-disorder comparisons identify risk genes for ADHD. Sci Transl Med (2011) 2.29

Functional architecture of the retromer cargo-recognition complex. Nature (2007) 2.26

The association between genetic variants in SORL1 and Alzheimer disease in an urban, multiethnic, community-based cohort. Arch Neurol (2007) 2.21

A global analysis of SNX27-retromer assembly and cargo specificity reveals a function in glucose and metal ion transport. Nat Cell Biol (2013) 2.18

A sorting nexin-1 homologue, Vps5p, forms a complex with Vps17p and is required for recycling the vacuolar protein-sorting receptor. Mol Biol Cell (1997) 2.14

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The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain. Nat Struct Mol Biol (2006) 2.09

The retromer complex - endosomal protein recycling and beyond. J Cell Sci (2012) 2.08

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A role for the CHC22 clathrin heavy-chain isoform in human glucose metabolism. Science (2009) 2.02

SORCS1 alters amyloid precursor protein processing and variants may increase Alzheimer's disease risk. Ann Neurol (2011) 2.01

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SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1. J Biol Chem (2007) 1.88

Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome. Neurobiol Aging (2004) 1.88

High frequency of potentially pathogenic SORL1 mutations in autosomal dominant early-onset Alzheimer disease. Mol Psychiatry (2012) 1.84

Association of diabetes mellitus and dementia: the Rotterdam Study. Diabetologia (1996) 1.82

EHD proteins: key conductors of endocytic transport. Trends Cell Biol (2010) 1.82

Identification of a novel conserved sorting motif required for retromer-mediated endosome-to-TGN retrieval. J Cell Sci (2007) 1.81

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Association between SORL1 and Alzheimer's disease in a genome-wide study. Neuroreport (2007) 1.57

The function of activity-regulated genes in the nervous system. Physiol Rev (2009) 1.54

DNAJC13 mutations in Parkinson disease. Hum Mol Genet (2013) 1.54

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Retromer: a master conductor of endosome sorting. Cold Spring Harb Perspect Biol (2014) 1.46

Neuronal LR11/sorLA expression is reduced in mild cognitive impairment. Ann Neurol (2007) 1.45

Sortilin: a receptor to regulate neuronal viability and function. Trends Neurosci (2012) 1.45

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Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases. J Biol Chem (2001) 1.38

EHD1 interacts with retromer to stabilize SNX1 tubules and facilitate endosome-to-Golgi retrieval. Traffic (2007) 1.38

Activation and functional characterization of the mosaic receptor SorLA/LR11. J Biol Chem (2001) 1.35

Understanding proneurotrophin actions: Recent advances and challenges. Dev Neurobiol (2010) 1.35

Structure of Vps26B and mapping of its interaction with the retromer protein complex. Traffic (2007) 1.33

The retromer component SNX6 interacts with dynactin p150(Glued) and mediates endosome-to-TGN transport. Cell Res (2009) 1.33

Deficiency of sorting nexin 27 (SNX27) leads to growth retardation and elevated levels of N-methyl-D-aspartate receptor 2C (NR2C). Mol Cell Biol (2011) 1.32

Sorl1 as an Alzheimer's disease predisposition gene? Neurodegener Dis (2007) 1.31

Identification of Alzheimer disease-associated variants in genes that regulate retromer function. Neurobiol Aging (2012) 1.30

SORCS1: a novel human type 2 diabetes susceptibility gene suggested by the mouse. Diabetes (2007) 1.30

Evolutionary reconstruction of the retromer complex and its function in Trypanosoma brucei. J Cell Sci (2011) 1.29

Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling. Nat Neurosci (2010) 1.29

Mechanism underlying selective regulation of G protein-gated inwardly rectifying potassium channels by the psychostimulant-sensitive sorting nexin 27. Proc Natl Acad Sci U S A (2011) 1.28

SNX-BAR-mediated endosome tubulation is co-ordinated with endosome maturation. Traffic (2011) 1.27

Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated. Mol Neurodegener (2010) 1.25

The Vps35 D620N mutation linked to Parkinson's disease disrupts the cargo sorting function of retromer. Traffic (2013) 1.23

SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians. PLoS One (2013) 1.23

Genomic convergence to identify candidate genes for Alzheimer disease on chromosome 10. Hum Mutat (2009) 1.21

Pharmacological chaperones stabilize retromer to limit APP processing. Nat Chem Biol (2014) 1.21

The three sorCS genes are differentially expressed and regulated by synaptic activity. J Neurochem (2004) 1.21