Published in Curr Opin Lipidol on August 01, 2005
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A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
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New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81
Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake. Prog Lipid Res (2008) 4.88
Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI. Diabetes (2008) 3.76
PTEN mutations as a cause of constitutive insulin sensitivity and obesity. N Engl J Med (2012) 3.39
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet (2013) 2.83
Quantification of PtdInsP3 molecular species in cells and tissues by mass spectrometry. Nat Methods (2011) 2.56
Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-gamma. Diabetes (2003) 2.28
Mechanisms for the acute effect of fructose on postprandial lipemia. Am J Clin Nutr (2007) 2.04
Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans. Am J Clin Nutr (2012) 1.80
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A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One (2012) 1.72
Nitric oxide and beta-adrenergic stimulation are major regulators of preprandial and postprandial subcutaneous adipose tissue blood flow in humans. Circulation (2003) 1.64
Preferential uptake of dietary Fatty acids in adipose tissue and muscle in the postprandial period. Diabetes (2007) 1.59
Assessment of high-sensitivity C-reactive protein levels as diagnostic discriminator of maturity-onset diabetes of the young due to HNF1A mutations. Diabetes Care (2010) 1.58
Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity. Am J Physiol Endocrinol Metab (2013) 1.58
Regulation of human metabolism by hypoxia-inducible factor. Proc Natl Acad Sci U S A (2010) 1.56
Parallel activation of de novo lipogenesis and stearoyl-CoA desaturase activity after 3 d of high-carbohydrate feeding. Am J Clin Nutr (2008) 1.54
Circulating fibroblast growth factor 21 is induced by peroxisome proliferator-activated receptor agonists but not ketosis in man. J Clin Endocrinol Metab (2009) 1.47
Impaired postprandial adipose tissue blood flow response is related to aspects of insulin sensitivity. Diabetes (2002) 1.46
Cortisol release from adipose tissue by 11beta-hydroxysteroid dehydrogenase type 1 in humans. Diabetes (2008) 1.35
Coexpression network analysis in abdominal and gluteal adipose tissue reveals regulatory genetic loci for metabolic syndrome and related phenotypes. PLoS Genet (2012) 1.31
Fasted to fed trafficking of Fatty acids in human adipose tissue reveals a novel regulatory step for enhanced fat storage. J Clin Endocrinol Metab (2009) 1.28
The presence of methylation quantitative trait loci indicates a direct genetic influence on the level of DNA methylation in adipose tissue. PLoS One (2013) 1.25
Stearoyl-CoA desaturase: rogue or innocent bystander? Prog Lipid Res (2012) 1.23
The effects of APOE on the functional architecture of the resting brain. Neuroimage (2011) 1.22
Proteomic analysis of human adipose tissue after rosiglitazone treatment shows coordinated changes to promote glucose uptake. Obesity (Silver Spring) (2009) 1.21
Physical activity and exercise in the regulation of human adipose tissue physiology. Physiol Rev (2012) 1.20
Pancreatic ectopic fat is characterized by adipocyte infiltration and altered lipid composition. Obesity (Silver Spring) (2008) 1.14
Associations of variants in FTO and near MC4R with obesity traits in South Asian Indians. Obesity (Silver Spring) (2012) 1.14
Differences in partitioning of meal fatty acids into blood lipid fractions: a comparison of linoleate, oleate, and palmitate. Am J Physiol Endocrinol Metab (2008) 1.13
Recycling between cortisol and cortisone in human splanchnic, subcutaneous adipose, and skeletal muscle tissues in vivo. Diabetes (2012) 1.13
Exercise prevents fructose-induced hypertriglyceridemia in healthy young subjects. Diabetes (2013) 1.12
MicroRNA expression in abdominal and gluteal adipose tissue is associated with mRNA expression levels and partly genetically driven. PLoS One (2011) 1.11
Comprehensive human adipose tissue mRNA and microRNA endogenous control selection for quantitative real-time-PCR normalization. Obesity (Silver Spring) (2010) 1.11
Increased brain fatty acid uptake in metabolic syndrome. Diabetes (2010) 1.10
Metabolic signatures of human adipose tissue hypoxia in obesity. Diabetes (2012) 1.10
Upper and lower body adipose tissue function: a direct comparison of fat mobilization in humans. Obes Res (2004) 1.07
Reduced oxidation of dietary fat after a short term high-carbohydrate diet. Am J Clin Nutr (2008) 1.06
Effects of insulin on adipose tissue blood flow in man. J Physiol (2002) 1.05
Femoral adipose tissue may accumulate the fat that has been recycled as VLDL and nonesterified fatty acids. Diabetes (2010) 1.04
Familial hypercholesterolaemia. BMJ (2012) 1.04
Gluteofemoral adipose tissue plays a major role in production of the lipokine palmitoleate in humans. Diabetes (2012) 1.04
Adipose dipeptidyl peptidase-4 and obesity: correlation with insulin resistance and depot-specific release from adipose tissue in vivo and in vitro. Diabetes Care (2013) 1.03
Global adiposity rather than abnormal regional fat distribution characterizes women with polycystic ovary syndrome. J Clin Endocrinol Metab (2007) 1.02
The contribution of splanchnic fat to VLDL triglyceride is greater in insulin-resistant than insulin-sensitive men and women: studies in the postprandial state. Diabetes (2007) 1.02
Liver fat and lipid oxidation in humans. Liver Int (2009) 1.01
Sex differences in lipid and glucose kinetics after ingestion of an acute oral fructose load. Br J Nutr (2010) 0.98
Triglycerides and atherogenic dyslipidaemia: extending treatment beyond statins in the high-risk cardiovascular patient. Heart (2011) 0.98
RANTES release by human adipose tissue in vivo and evidence for depot-specific differences. Am J Physiol Endocrinol Metab (2009) 0.98
Selective partitioning of dietary fatty acids into the VLDL TG pool in the early postprandial period. J Lipid Res (2003) 0.97
DNA methylation of genes in adipose tissue. Proc Nutr Soc (2010) 0.97
Metabolic interaction of dietary sugars and plasma lipids with a focus on mechanisms and de novo lipogenesis. Proc Nutr Soc (2007) 0.97
Induction of vascular GTP-cyclohydrolase I and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis. Circulation (2011) 0.97
Variants of the microsomal triglyceride transfer protein gene are associated with plasma cholesterol levels and body mass index. J Lipid Res (2002) 0.97
Analysis of the frequency and spectrum of mutations recognised to cause familial hypercholesterolaemia in routine clinical practice in a UK specialist hospital lipid clinic. Atherosclerosis (2013) 0.96
Structural and functional properties of deep abdominal subcutaneous adipose tissue explain its association with insulin resistance and cardiovascular risk in men. Diabetes Care (2013) 0.96
Influence of common variants in the CETP, LPL, HL and APO E genes on LDL heterogeneity in healthy, middle-aged men. Atherosclerosis (2003) 0.95
Young women partition fatty acids towards ketone body production rather than VLDL-TAG synthesis, compared with young men. Br J Nutr (2011) 0.95
Vascular peptide endothelin-1 links fat accumulation with alterations of visceral adipocyte lipolysis. Diabetes (2007) 0.94
Comparative protein profiling of serum and plasma using an antibody suspension bead array approach. Proteomics (2010) 0.94
Obesity and metabolic disease: is adipose tissue the culprit? Proc Nutr Soc (2005) 0.94
Dietary fatty acids make a rapid and substantial contribution to VLDL-triacylglycerol in the fed state. Am J Physiol Endocrinol Metab (2006) 0.94
Determinants of VLDL-triglycerides production. Curr Opin Lipidol (2012) 0.94
Splanchnic balance of free fatty acids, endocannabinoids, and lipids in subjects with nonalcoholic fatty liver disease. Gastroenterology (2010) 0.93
The effects of APOE on brain activity do not simply reflect the risk of Alzheimer's disease. Neurobiol Aging (2011) 0.93
Olive oil increases the number of triacylglycerol-rich chylomicron particles compared with other oils: an effect retained when a second standard meal is fed. Am J Clin Nutr (2002) 0.92
Substrate utilization by the failing human heart by direct quantification using arterio-venous blood sampling. PLoS One (2009) 0.91
A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice. PLoS Med (2008) 0.91
Effects of peroxisome proliferator-activated receptor-alpha and -gamma agonists on 11beta-hydroxysteroid dehydrogenase type 1 in subcutaneous adipose tissue in men. J Clin Endocrinol Metab (2007) 0.91
The microsomal triglyceride transfer protein gene-493T variant lowers cholesterol but increases the risk of coronary heart disease. Circulation (2004) 0.90
Acute ingestion of a meal rich in n-3 polyunsaturated fatty acids results in rapid gastric emptying in humans. Am J Clin Nutr (2002) 0.89
Insulin resistance, impaired postprandial lipid metabolism and abdominal obesity. A deadly triad. Med Princ Pract (2002) 0.88
Is there something special about palmitoleate? Curr Opin Clin Nutr Metab Care (2013) 0.88
Greater dietary fat oxidation in obese compared with lean men: an adaptive mechanism to prevent liver fat accumulation? Am J Physiol Endocrinol Metab (2010) 0.87
Absence of birth-weight lowering effect of ADCY5 and near CCNL, but association of impaired glucose-insulin homeostasis with ADCY5 in Asian Indians. PLoS One (2011) 0.87
FTO genetic variants and risk of obesity and type 2 diabetes: a meta-analysis of 28,394 Indians. Obesity (Silver Spring) (2013) 0.86