Published in Proc Natl Acad Sci U S A on March 11, 2005
Diverse molecular functions of Hu proteins. Cell Mol Life Sci (2008) 4.09
miR-375 maintains normal pancreatic alpha- and beta-cell mass. Proc Natl Acad Sci U S A (2009) 3.89
Competing interactions between micro-RNAs determine neural progenitor survival and proliferation after ethanol exposure: evidence from an ex vivo model of the fetal cerebral cortical neuroepithelium. J Neurosci (2007) 2.30
Signatures of RNA binding proteins globally coupled to effective microRNA target sites. Genome Res (2010) 1.75
Characterization of the proneural gene regulatory network during mouse telencephalon development. BMC Biol (2008) 1.59
Alcohol exposure alters DNA methylation profiles in mouse embryos at early neurulation. Epigenetics (2009) 1.53
EarlyCDT®-Lung test: improved clinical utility through additional autoantibody assays. Tumour Biol (2012) 1.52
miR-375 inhibits differentiation of neurites by lowering HuD levels. Mol Cell Biol (2010) 1.43
A nuclear function of Hu proteins as neuron-specific alternative RNA processing regulators. Mol Biol Cell (2006) 1.31
RNA protein interaction in neurons. Annu Rev Neurosci (2013) 1.31
Neuronal Elav-like (Hu) proteins regulate RNA splicing and abundance to control glutamate levels and neuronal excitability. Neuron (2012) 1.27
Regulation of neuron-specific alternative splicing of neurofibromatosis type 1 pre-mRNA. Mol Cell Biol (2007) 1.27
Novel recognition motifs and biological functions of the RNA-binding protein HuD revealed by genome-wide identification of its targets. Nucleic Acids Res (2009) 1.26
RNA-binding protein HuD controls insulin translation. Mol Cell (2012) 1.25
The survival of motor neuron (SMN) protein interacts with the mRNA-binding protein HuD and regulates localization of poly(A) mRNA in primary motor neuron axons. J Neurosci (2011) 1.25
Notch3 and the Notch3-upregulated RNA-binding protein HuD regulate Ikaros alternative splicing. EMBO J (2007) 1.20
CARM1 regulates proliferation of PC12 cells by methylating HuD. Mol Cell Biol (2006) 1.19
Networking in a global world: establishing functional connections between neural splicing regulators and their target transcripts. RNA (2011) 1.14
Neuron-specific ELAV/Hu proteins suppress HuR mRNA during neuronal differentiation by alternative polyadenylation. Nucleic Acids Res (2011) 1.13
Cytoplasmic RNA-binding proteins and the control of complex brain function. Cold Spring Harb Perspect Biol (2012) 1.12
Roles of microRNA on cancer cell metabolism. J Transl Med (2012) 1.11
Musashi1: a stem cell marker no longer in search of a function. Cell Cycle (2008) 1.09
Novel gene expression patterns along the proximo-distal axis of the mouse embryo before gastrulation. BMC Dev Biol (2007) 1.05
Promotion of exon 6 inclusion in HuD pre-mRNA by Hu protein family members. Nucleic Acids Res (2010) 0.95
HuD regulates coding and noncoding RNA to induce APP→Aβ processing. Cell Rep (2014) 0.92
The 3' untranslated region of human Cyclin-Dependent Kinase 5 Regulatory subunit 1 contains regulatory elements affecting transcript stability. BMC Mol Biol (2007) 0.91
The neurogenetics of alternative splicing. Nat Rev Neurosci (2016) 0.91
Emerging complexity of the HuD/ELAVl4 gene; implications for neuronal development, function, and dysfunction. RNA (2013) 0.90
Increased expression of axogenesis-related genes and mossy fibre length in dentate granule cells from adult HuD overexpressor mice. ASN Neuro (2011) 0.89
Prenatal deletion of the RNA-binding protein HuD disrupts postnatal cortical circuit maturation and behavior. J Neurosci (2014) 0.87
Regulation of mRNA transport, localization and translation in the nervous system of mammals (Review). Int J Mol Med (2014) 0.87
Post-transcriptional regulatory elements and spatiotemporal specification of neocortical stem cells and projection neurons. Neuroscience (2013) 0.86
Competing Interactions of RNA-Binding Proteins, MicroRNAs, and Their Targets Control Neuronal Development and Function. Biomolecules (2015) 0.86
Expression level of Hand2 affects specification of enteric neurons and gastrointestinal function in mice. Gastroenterology (2011) 0.85
Tolerance to the neuron-specific paraneoplastic HuD antigen. PLoS One (2009) 0.85
HuD promotes BDNF expression in brain neurons via selective stabilization of the BDNF long 3'UTR mRNA. PLoS One (2013) 0.84
Neuroprotection requires the functions of the RNA-binding protein HuR. Cell Death Differ (2014) 0.84
Rapid functional diversification in the structurally conserved ELAV family of neuronal RNA binding proteins. BMC Genomics (2008) 0.83
Evolution of eumetazoan nervous systems: insights from cnidarians. Philos Trans R Soc Lond B Biol Sci (2015) 0.82
The RNA-binding protein HuD regulates autophagosome formation in pancreatic β cells by promoting autophagy-related gene 5 expression. J Biol Chem (2013) 0.81
Neuron-enriched RNA-binding Proteins Regulate Pancreatic Beta Cell Function and Survival. J Biol Chem (2017) 0.80
Guardian of Genetic Messenger-RNA-Binding Proteins. Biomolecules (2016) 0.80
Regulatory consequences of neuronal ELAV-like protein binding to coding and non-coding RNAs in human brain. Elife (2016) 0.80
Dynamic regulation of mRNA decay during neural development. Neural Dev (2015) 0.79
HuD stimulates translation via eIF4A. Mol Cell (2009) 0.77
Concentration and Localization of Coexpressed ELAV/Hu Proteins Control Specificity of mRNA Processing. Mol Cell Biol (2015) 0.77
Positive feedback between RNA-binding protein HuD and transcription factor SATB1 promotes neurogenesis. Proc Natl Acad Sci U S A (2015) 0.77
A post-transcriptional mechanism pacing expression of neural genes with precursor cell differentiation status. Nat Commun (2015) 0.77
HuD interacts with Bdnf mRNA and is essential for activity-induced BDNF synthesis in dendrites. PLoS One (2015) 0.76
Enteric neuroplasticity in seawater-adapted European eel (Anguilla anguilla). J Anat (2013) 0.75
Several cis-regulatory elements control mRNA stability, translation efficiency, and expression pattern of Prrxl1 (paired related homeobox protein-like 1). J Biol Chem (2013) 0.75
Scale Invariant Disordered Nanotopography Promotes Hippocampal Neuron Development and Maturation with Involvement of Mechanotransductive Pathways. Front Cell Neurosci (2016) 0.75
Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science (1992) 19.30
Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell (1996) 12.59
Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell (1996) 8.77
Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo. Science (2001) 6.84
Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein. J Biol Chem (1996) 5.82
Neural stem cells in the adult mammalian forebrain: a relatively quiescent subpopulation of subependymal cells. Neuron (1994) 5.50
Hel-N1: an autoimmune RNA-binding protein with specificity for 3' uridylate-rich untranslated regions of growth factor mRNAs. Mol Cell Biol (1993) 4.63
Know your neighbors: three phenotypes in null mutants of the myogenic bHLH gene MRF4. Cell (1996) 4.55
ELAV/Hu proteins inhibit p27 translation via an IRES element in the p27 5'UTR. Genes Dev (2002) 3.71
Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells. Genes Dev (2002) 3.55
HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal. Cell (1991) 3.33
RNA-binding protein Musashi family: roles for CNS stem cells and a subpopulation of ependymal cells revealed by targeted disruption and antisense ablation. Proc Natl Acad Sci U S A (2002) 2.79
A hierarchy of Hu RNA binding proteins in developing and adult neurons. J Neurosci (1997) 2.76
ELAV tumor antigen, Hel-N1, increases translation of neurofilament M mRNA and induces formation of neurites in human teratocarcinoma cells. Genes Dev (1999) 2.65
Early striatal dendrite deficits followed by neuron loss with advanced age in the absence of anterograde cortical brain-derived neurotrophic factor. J Neurosci (2004) 2.16
The Elav-like proteins bind to a conserved regulatory element in the 3'-untranslated region of GAP-43 mRNA. J Biol Chem (1997) 2.07
The leaving or Q fraction of the murine cerebral proliferative epithelium: a general model of neocortical neuronogenesis. J Neurosci (1996) 2.04
Sequential expression and role of Hu RNA-binding proteins during neurogenesis. Development (1997) 1.96
Mammalian ELAV-like neuronal RNA-binding proteins HuB and HuC promote neuronal development in both the central and the peripheral nervous systems. Proc Natl Acad Sci U S A (1999) 1.93
p21(waf1) mRNA contains a conserved element in its 3'-untranslated region that is bound by the Elav-like mRNA-stabilizing proteins. J Biol Chem (1998) 1.75
The insulin-like growth factor mRNA binding-protein IMP-1 and the Ras-regulatory protein G3BP associate with tau mRNA and HuD protein in differentiated P19 neuronal cells. J Neurochem (2004) 1.66
Hu protein as an early marker of neuronal phenotypic differentiation by subependymal zone cells of the adult songbird forebrain. J Neurobiol (1995) 1.50
Embryonic lethal abnormal vision-like RNA-binding proteins regulate neurite outgrowth and tau expression in PC12 cells. J Neurosci (1999) 1.47
Cytoplasmic localization is required for the mammalian ELAV-like protein HuD to induce neuronal differentiation. Genes Cells (1999) 1.37
Pax-6 is involved in the specification of hindbrain motor neuron subtype. Development (1997) 1.32
Posttranscriptional regulation of gene expression in learning by the neuronal ELAV-like mRNA-stabilizing proteins. Proc Natl Acad Sci U S A (2001) 1.22
The mathematics of neocortical neuronogenesis. Dev Neurosci (1997) 1.03
HuD, a neuronal-specific RNA-binding protein, is a potential regulator of MYCN expression in human neuroblastoma cells. Eur J Cancer (1997) 0.93
Regulation of tau RNA maturation by thyroid hormone is mediated by the neural RNA-binding protein musashi-1. Mol Cell Neurosci (2002) 0.87
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature (2006) 24.39
Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst (2005) 13.00
Variation in the safety of induced pluripotent stem cell lines. Nat Biotechnol (2009) 6.39
Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice. J Cell Biol (2002) 5.51
Disruption of adiponectin causes insulin resistance and neointimal formation. J Biol Chem (2002) 4.79
Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche. Cell Stem Cell (2007) 4.31
Somatic mutations of the HER2 kinase domain in lung adenocarcinomas. Cancer Res (2005) 4.25
Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury. Nat Med (2006) 4.18
Generation of transgenic non-human primates with germline transmission. Nature (2009) 4.06
Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow. J Exp Med (2009) 4.03
New neurons follow the flow of cerebrospinal fluid in the adult brain. Science (2006) 3.98
Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake. Cell Metab (2007) 3.43
Identification of a putative intestinal stem cell and early lineage marker; musashi-1. Differentiation (2003) 3.41
Unexpectedly efficient homing capacity of purified murine hematopoietic stem cells. Immunity (2004) 3.35
Role of hepatic STAT3 in brain-insulin action on hepatic glucose production. Cell Metab (2006) 3.34
A selective Sema3A inhibitor enhances regenerative responses and functional recovery of the injured spinal cord. Nat Med (2006) 3.28
A putative human breast stem cell population is enriched for steroid receptor-positive cells. Dev Biol (2005) 3.19
Inflammasome activation of cardiac fibroblasts is essential for myocardial ischemia/reperfusion injury. Circulation (2011) 2.94
Notch inhibition induces cochlear hair cell regeneration and recovery of hearing after acoustic trauma. Neuron (2013) 2.90
RNA-binding protein Musashi family: roles for CNS stem cells and a subpopulation of ependymal cells revealed by targeted disruption and antisense ablation. Proc Natl Acad Sci U S A (2002) 2.79
Subventricular zone-derived neuroblasts migrate and differentiate into mature neurons in the post-stroke adult striatum. J Neurosci (2006) 2.79
Nonhematopoietic mesenchymal stem cells can be mobilized and differentiate into cardiomyocytes after myocardial infarction. Blood (2004) 2.72
Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice. Science (2005) 2.72
Ontogeny and multipotency of neural crest-derived stem cells in mouse bone marrow, dorsal root ganglia, and whisker pad. Cell Stem Cell (2008) 2.69
Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function. Nat Cell Biol (2004) 2.63
Function of RNA-binding protein Musashi-1 in stem cells. Exp Cell Res (2005) 2.62
IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism. Science (2005) 2.53
Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury. Proc Natl Acad Sci U S A (2010) 2.52
Kinetochore stretching inactivates the spindle assembly checkpoint. J Cell Biol (2009) 2.50
Bone marrow-derived cells express matrix metalloproteinases and contribute to regression of liver fibrosis in mice. Hepatology (2007) 2.34
Transient inhibition of BMP signaling by Noggin induces cardiomyocyte differentiation of mouse embryonic stem cells. Nat Biotechnol (2005) 2.34
Modeling familial Alzheimer's disease with induced pluripotent stem cells. Hum Mol Genet (2011) 2.26
PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity. J Clin Invest (2003) 2.23
Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue. Mol Brain (2012) 2.18
Retinoic-acid-concentration-dependent acquisition of neural cell identity during in vitro differentiation of mouse embryonic stem cells. Dev Biol (2004) 2.17
Increased l1 retrotransposition in the neuronal genome in schizophrenia. Neuron (2014) 2.16
ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules. Genes Cells (2004) 2.15
Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice. J Clin Invest (2011) 2.13
New neurons clear the path of astrocytic processes for their rapid migration in the adult brain. Neuron (2010) 2.12
Candidate markers for stem and early progenitor cells, Musashi-1 and Hes1, are expressed in crypt base columnar cells of mouse small intestine. FEBS Lett (2003) 2.10
Grafted human-induced pluripotent stem-cell-derived neurospheres promote motor functional recovery after spinal cord injury in mice. Proc Natl Acad Sci U S A (2011) 2.09
Development of mesenchymal stem cells partially originate from the neural crest. Biochem Biophys Res Commun (2009) 2.08
Transposition of the Tol2 element, an Ac-like element from the Japanese medaka fish Oryzias latipes, in mouse embryonic stem cells. Genetics (2004) 2.05
F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation. Cell (2003) 2.05
Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass. Nat Genet (2006) 2.05
Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression. Genes Dev (2005) 1.99
Cardiac neural crest cells contribute to the dormant multipotent stem cell in the mammalian heart. J Cell Biol (2005) 1.93
Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathways. J Biol Chem (2006) 1.93
HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteins. Development (2004) 1.91
Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus. J Clin Invest (2004) 1.88
Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding. Cell Metab (2008) 1.86
Lack of acrosome formation in mice lacking a Golgi protein, GOPC. Proc Natl Acad Sci U S A (2002) 1.86
Novel mutation of human DNA polymerase gamma associated with mitochondrial toxicity induced by anti-HIV treatment. J Infect Dis (2007) 1.85
Evolutionarily dynamic alternative splicing of GPR56 regulates regional cerebral cortical patterning. Science (2014) 1.85
Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons. Genes Dev (2002) 1.83
Inactivation of aPKClambda results in the loss of adherens junctions in neuroepithelial cells without affecting neurogenesis in mouse neocortex. Development (2006) 1.81
In vivo imaging of engrafted neural stem cells: its application in evaluating the optimal timing of transplantation for spinal cord injury. FASEB J (2005) 1.80
Methylation and gene silencing of the Ras-related GTPase gene in lung and breast cancers. Ann Surg Oncol (2006) 1.79
Effect of ADAM28 on carcinoma cell metastasis by cleavage of von Willebrand factor. J Natl Cancer Inst (2012) 1.76
Late complications of gelatin-resorcin-formalin glue in the repair of acute type A aortic dissection. Ann Thorac Surg (2007) 1.75
Surgical resection for lung cancer with infiltration of the thoracic aorta. J Thorac Cardiovasc Surg (2005) 1.75
Allelic and non-allelic heterogeneities in pyridoxine dependent seizures revealed by ALDH7A1 mutational analysis. Mol Genet Metab (2007) 1.75
Comparative functional genomics revealed conservation and diversification of three enhancers of the isl1 gene for motor and sensory neuron-specific expression. Dev Biol (2005) 1.72
Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain. Genes Dev (2012) 1.70
Visualization of peripheral nerve degeneration and regeneration: monitoring with diffusion tensor tractography. Neuroimage (2008) 1.70
Spatiotemporal recapitulation of central nervous system development by murine embryonic stem cell-derived neural stem/progenitor cells. Stem Cells (2008) 1.67
Dissection of the mitochondrial import and assembly pathway for human Tom40. J Biol Chem (2005) 1.66
Requirement for COUP-TFI and II in the temporal specification of neural stem cells in CNS development. Nat Neurosci (2008) 1.65
An oncolytic HSV-1 mutant expressing ICP34.5 under control of a nestin promoter increases survival of animals even when symptomatic from a brain tumor. Cancer Res (2005) 1.63
Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells. Mol Biol Cell (2008) 1.63
Efficacy of intravenous midazolam for status epilepticus in childhood. Pediatr Neurol (2007) 1.58
Diffusion-tensor neuronal fiber tractography and manganese-enhanced MR imaging of primate visual pathway in the common marmoset: preliminary results. Radiology (2008) 1.57
Neural RNA-binding protein Musashi1 inhibits translation initiation by competing with eIF4G for PABP. J Cell Biol (2008) 1.56
Coordinated ciliary beating requires Odf2-mediated polarization of basal bodies via basal feet. Cell (2012) 1.56
The endoplasmic reticulum stress-C/EBP homologous protein pathway-mediated apoptosis in macrophages contributes to the instability of atherosclerotic plaques. Arterioscler Thromb Vasc Biol (2010) 1.56
Molecular identity of periglomerular and short axon cells. J Neurosci (2010) 1.55
DISC1-dependent switch from progenitor proliferation to migration in the developing cortex. Nature (2011) 1.53
Sema3A regulates bone-mass accrual through sensory innervations. Nature (2013) 1.53
Beta-catenin signaling promotes proliferation of progenitor cells in the adult mouse subventricular zone. Stem Cells (2007) 1.53
Polymorphisms, mutations, and amplification of the EGFR gene in non-small cell lung cancers. PLoS Med (2007) 1.52
Hypoxic regulation of the cerebral microcirculation is mediated by a carbon monoxide-sensitive hydrogen sulfide pathway. Proc Natl Acad Sci U S A (2012) 1.50
Administration of BMP2/7 in utero partially reverses Rubinstein-Taybi syndrome-like skeletal defects induced by Pdk1 or Cbp mutations in mice. J Clin Invest (2011) 1.50
Side population in human uterine myometrium displays phenotypic and functional characteristics of myometrial stem cells. Proc Natl Acad Sci U S A (2007) 1.50
Isolation of multipotent neural crest-derived stem cells from the adult mouse cornea. Stem Cells (2006) 1.49
Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway. Nat Med (2004) 1.48
GATA6 mutations cause human cardiac outflow tract defects by disrupting semaphorin-plexin signaling. Proc Natl Acad Sci U S A (2009) 1.47
Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by MLH1 haploinsufficiency and complete deficiency. Genome Res (2011) 1.47