Published in J Biol Chem on November 02, 2011
Complement activation and choriocapillaris loss in early AMD: implications for pathophysiology and therapy. Prog Retin Eye Res (2014) 1.17
TCF7L2 variation and proliferative diabetic retinopathy. Diabetes (2013) 0.93
Glomerular cell cross-talk influences composition and assembly of extracellular matrix. J Am Soc Nephrol (2014) 0.93
HtrA1 is a novel antagonist controlling fibroblast growth factor (FGF) signaling via cleavage of FGF8. Mol Cell Biol (2012) 0.86
Oxidative stress, innate immunity, and age-related macular degeneration. AIMS Mol Sci (2016) 0.83
Restoration of mesenchymal retinal pigmented epithelial cells by TGFβ pathway inhibitors: implications for age-related macular degeneration. Genome Med (2015) 0.82
Growth differentiation factor 6 derived from mesenchymal stem/stromal cells reduces age-related functional deterioration in multiple tissues. Aging (Albany NY) (2016) 0.82
Growth differentiation factor 6 as a putative risk factor in neuromuscular degeneration. PLoS One (2014) 0.81
Genetic factors in cerebral small vessel disease and their impact on stroke and dementia. J Cereb Blood Flow Metab (2016) 0.81
gdf6a is required for cone photoreceptor subtype differentiation and for the actions of tbx2b in determining rod versus cone photoreceptor fate. PLoS One (2014) 0.79
Overexpression of HTRA1 leads to down-regulation of fibronectin and functional changes in RF/6A cells and HUVECs. PLoS One (2012) 0.78
Alpha-1-antitrypsin: a novel human high temperature requirement protease A1 (HTRA1) substrate in human placental tissue. PLoS One (2014) 0.77
Association of rs6982567 near GDF6 with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy in a Han Chinese cohort. BMC Ophthalmol (2014) 0.75
Exploring the role of VEGF in Indian Age related macular degeneration. Ann Neurosci (2015) 0.75
Association between polymorphism rs11200638 in the HTRA1 gene and the response to anti-VEGF treatment of exudative AMD: a meta-analysis. BMC Ophthalmol (2017) 0.75
Leber congenital amaurosis, from darkness to light: An ode to Irene Maumenee. Ophthalmic Genet (2017) 0.75
Prevalence of age-related macular degeneration in the United States. Arch Ophthalmol (2004) 18.86
Dysregulation of TGF-beta activation contributes to pathogenesis in Marfan syndrome. Nat Genet (2003) 11.01
HTRA1 promoter polymorphism in wet age-related macular degeneration. Science (2006) 7.12
Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1. Nat Genet (1994) 6.50
A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration. Science (2006) 5.67
Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2. Nat Genet (1996) 5.15
Extracellular control of TGFbeta signalling in vascular development and disease. Nat Rev Mol Cell Biol (2007) 4.28
A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E and beta carotene for age-related cataract and vision loss: AREDS report no. 9. Arch Ophthalmol (2001) 3.49
A combined syndrome of juvenile polyposis and hereditary haemorrhagic telangiectasia associated with mutations in MADH4 (SMAD4). Lancet (2004) 2.97
Transforming growth factor beta and atherosclerosis: so far, so good for the protective cytokine hypothesis. Arterioscler Thromb Vasc Biol (2003) 2.36
Association of HTRA1 mutations and familial ischemic cerebral small-vessel disease. N Engl J Med (2009) 1.96
The role of human HtrA1 in arthritic disease. J Biol Chem (2005) 1.91
HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteins. Development (2004) 1.91
Mutations in BMP4 cause eye, brain, and digit developmental anomalies: overlap between the BMP4 and hedgehog signaling pathways. Am J Hum Genet (2008) 1.86
Genetic and functional dissection of HTRA1 and LOC387715 in age-related macular degeneration. PLoS Genet (2010) 1.83
Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6. Invest Ophthalmol Vis Sci (2006) 1.60
VEGF polymorphisms are associated with neovascular age-related macular degeneration. Hum Mol Genet (2006) 1.57
A general approach for identifying distant regulatory elements applied to the Gdf6 gene. Genome Res (2003) 1.49
Implications of the serine protease HtrA1 in amyloid precursor protein processing. Proc Natl Acad Sci U S A (2005) 1.47
Primary structure of a putative serine protease specific for IGF-binding proteins. FEBS Lett (1996) 1.46
Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice. Proc Natl Acad Sci U S A (2011) 1.45
The role of vascular endothelial growth factor and other endogenous interplayers in age-related macular degeneration. Prog Retin Eye Res (2008) 1.38
GDF6, a novel locus for a spectrum of ocular developmental anomalies. Am J Hum Genet (2006) 1.35
Mutational screening of CHX10, GDF6, OTX2, RAX and SOX2 genes in 50 unrelated microphthalmia-anophthalmia-coloboma (MAC) spectrum cases. Br J Ophthalmol (2010) 1.34
Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses. J Biol Chem (2005) 1.28
Expression of mouse HtrA1 serine protease in normal bone and cartilage and its upregulation in joint cartilage damaged by experimental arthritis. Bone (2005) 1.23
HtrA1-dependent proteolysis of TGF-beta controls both neuronal maturation and developmental survival. Cell Death Differ (2008) 1.13
Xenopus GDF6, a new antagonist of noggin and a partner of BMPs. Development (1999) 1.06
Eye and neural defects associated with loss of GDF6. BMC Dev Biol (2006) 1.00
Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res (2003) 103.76
Integration of biological networks and gene expression data using Cytoscape. Nat Protoc (2007) 27.10
Cytoscape 2.8: new features for data integration and network visualization. Bioinformatics (2010) 26.76
Network-based classification of breast cancer metastasis. Mol Syst Biol (2007) 12.18
A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature (2012) 11.68
Is volume related to outcome in health care? A systematic review and methodologic critique of the literature. Ann Intern Med (2002) 11.14
Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. Cell (2008) 8.41
Global prevalence and major risk factors of diabetic retinopathy. Diabetes Care (2012) 7.83
Conserved patterns of protein interaction in multiple species. Proc Natl Acad Sci U S A (2005) 7.48
A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B. N Engl J Med (2006) 7.35
Sequence- and target-independent angiogenesis suppression by siRNA via TLR3. Nature (2008) 7.10
Transcriptional regulation of protein complexes within and across species. Proc Natl Acad Sci U S A (2007) 7.07
TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal. Proc Natl Acad Sci U S A (2013) 6.88
A travel guide to Cytoscape plugins. Nat Methods (2012) 6.53
Quantitative prediction of cellular metabolism with constraint-based models: the COBRA Toolbox. Nat Protoc (2007) 6.24
An atlas of combinatorial transcriptional regulation in mouse and man. Cell (2010) 6.24
A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration. Science (2006) 5.67
Damage recovery pathways in Saccharomyces cerevisiae revealed by genomic phenotyping and interactome mapping. Mol Cancer Res (2002) 5.42
Systematic interpretation of genetic interactions using protein networks. Nat Biotechnol (2005) 5.38
Human host factors required for influenza virus replication. Nature (2010) 5.28
Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. Cell (2004) 5.04
Modeling cellular machinery through biological network comparison. Nat Biotechnol (2006) 5.01
Conserved pathways within bacteria and yeast as revealed by global protein network alignment. Proc Natl Acad Sci U S A (2003) 4.68
TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formation. Nat Med (2009) 4.58
Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL. Nat Med (2003) 4.47
Toll-like receptor 3 and geographic atrophy in age-related macular degeneration. N Engl J Med (2008) 4.46
Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast. Science (2008) 4.36
A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate. Nat Immunol (2010) 4.32
Host cell factors in HIV replication: meta-analysis of genome-wide studies. PLoS Pathog (2009) 4.24
Innate and acquired immunity in atherogenesis. Nat Med (2002) 4.22
Targeted genome modification of crop plants using a CRISPR-Cas system. Nat Biotechnol (2013) 4.19
Rewiring of genetic networks in response to DNA damage. Science (2010) 4.03
enoLOGOS: a versatile web tool for energy normalized sequence logos. Nucleic Acids Res (2005) 4.03
Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin. Nature (2007) 4.00
Direct reprogramming of mouse fibroblasts to neural progenitors. Proc Natl Acad Sci U S A (2011) 3.93
Seven-year outcomes in ranibizumab-treated patients in ANCHOR, MARINA, and HORIZON: a multicenter cohort study (SEVEN-UP). Ophthalmology (2013) 3.92
Complementary profiling of gene expression at the transcriptome and proteome levels in Saccharomyces cerevisiae. Mol Cell Proteomics (2002) 3.89
Reprogramming of human primary somatic cells by OCT4 and chemical compounds. Cell Stem Cell (2010) 3.82
Seven new loci associated with age-related macular degeneration. Nat Genet (2013) 3.81
Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast. Nature (2010) 3.72
Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability. Nat Med (2008) 3.67
Functional genomic screen for modulators of ciliogenesis and cilium length. Nature (2010) 3.63
A systems approach to mapping DNA damage response pathways. Science (2006) 3.55
Inferring pathway activity toward precise disease classification. PLoS Comput Biol (2008) 3.48
Emergence and spread of oseltamivir-resistant A(H1N1) influenza viruses in Oceania, South East Asia and South Africa. Antiviral Res (2009) 3.39
Residual embryonic cells as precursors of a Barrett's-like metaplasia. Cell (2011) 3.36
Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). Proc Natl Acad Sci U S A (2010) 3.33
Drusen complement components C3a and C5a promote choroidal neovascularization. Proc Natl Acad Sci U S A (2006) 3.25
PathBLAST: a tool for alignment of protein interaction networks. Nucleic Acids Res (2004) 3.20
Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids. J Biol Chem (2003) 3.20
Sustained axon regeneration induced by co-deletion of PTEN and SOCS3. Nature (2011) 3.18
Network-based stratification of tumor mutations. Nat Methods (2013) 3.12
2009 influenza A(H1N1) seroconversion rates and risk factors among distinct adult cohorts in Singapore. JAMA (2010) 3.05
Ranibizumab for predominantly classic neovascular age-related macular degeneration: subgroup analysis of first-year ANCHOR results. Am J Ophthalmol (2007) 3.00
A genetic interaction map of RNA-processing factors reveals links between Sem1/Dss1-containing complexes and mRNA export and splicing. Mol Cell (2008) 2.96
A gene ontology inferred from molecular networks. Nat Biotechnol (2013) 2.95
Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunity. Circ Res (2011) 2.89
Daily dosing of rifapentine cures tuberculosis in three months or less in the murine model. PLoS Med (2007) 2.86
Modeling methanogenesis with a genome-scale metabolic reconstruction of Methanosarcina barkeri. Mol Syst Biol (2006) 2.80
Integrating physical and genetic maps: from genomes to interaction networks. Nat Rev Genet (2007) 2.77
Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans. J Clin Invest (2009) 2.75
Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q. Am J Hum Genet (2004) 2.70
A human MAP kinase interactome. Nat Methods (2010) 2.62
Low incidence of DNA sequence variation in human induced pluripotent stem cells generated by nonintegrating plasmid expression. Cell Stem Cell (2012) 2.61
Cerebrospinal fluid pressure in glaucoma: a prospective study. Ophthalmology (2009) 2.60
Exome sequencing identifies ZNF644 mutations in high myopia. PLoS Genet (2011) 2.52
Systematic identification of functional orthologs based on protein network comparison. Genome Res (2006) 2.47
Functional maps of protein complexes from quantitative genetic interaction data. PLoS Comput Biol (2008) 2.46
eQED: an efficient method for interpreting eQTL associations using protein networks. Mol Syst Biol (2008) 2.45
Physical network models. J Comput Biol (2004) 2.44
Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits. Cell (2013) 2.43
Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors. Proc Natl Acad Sci U S A (2011) 2.39
A review of the research literature on evidence-based healthcare design. HERD (2008) 2.36
Multiple pathways are co-regulated by the protein kinase Snf1 and the transcription factors Adr1 and Cat8. J Biol Chem (2003) 2.36
Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1. J Biol Chem (2004) 2.36
Murine ccl2/cx3cr1 deficiency results in retinal lesions mimicking human age-related macular degeneration. Invest Ophthalmol Vis Sci (2007) 2.36
Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations. Hum Mol Genet (2009) 2.34
Transcriptome profiling to identify genes involved in peroxisome assembly and function. J Cell Biol (2002) 2.30
A decade of systems biology. Annu Rev Cell Dev Biol (2010) 2.30
A jumping profile Hidden Markov Model and applications to recombination sites in HIV and HCV genomes. BMC Bioinformatics (2006) 2.25
Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice. J Clin Invest (2008) 2.24
High glucose induces toll-like receptor expression in human monocytes: mechanism of activation. Diabetes (2008) 2.23
Integrative approaches for finding modular structure in biological networks. Nat Rev Genet (2013) 2.19
The effects of prior light history on the suppression of melatonin by light in humans. J Pineal Res (2002) 2.18
A proteome-wide protein interaction map for Campylobacter jejuni. Genome Biol (2007) 2.13
Anal human papillomavirus infection in women and its relationship with cervical infection. Cancer Epidemiol Biomarkers Prev (2005) 2.11
The role of abnormal vitreomacular adhesion in age-related macular degeneration: spectral optical coherence tomography and surgical results. Am J Ophthalmol (2008) 2.10
Duration and clearance of anal human papillomavirus (HPV) infection among women: the Hawaii HPV cohort study. Clin Infect Dis (2009) 2.10
Valsalva manoeuver, intra-ocular pressure, cerebrospinal fluid pressure, optic disc topography: Beijing intracranial and intra-ocular pressure study. Acta Ophthalmol (2013) 2.09