Published in EMBO J on December 16, 2009
Isopeptide bonds block the mechanical extension of pili in pathogenic Streptococcus pyogenes. J Biol Chem (2010) 1.38
Sortase enzymes in Gram-positive bacteria. Mol Microbiol (2011) 1.37
A highly unusual thioester bond in a pilus adhesin is required for efficient host cell interaction. J Biol Chem (2010) 1.25
Crystal structure of the minor pilin FctB reveals determinants of Group A streptococcal pilus anchoring. J Biol Chem (2010) 1.16
Supramolecular organization of the repetitive backbone unit of the Streptococcus pneumoniae pilus. PLoS One (2010) 1.11
Structural insights into serine-rich fimbriae from Gram-positive bacteria. J Biol Chem (2010) 1.09
Roles of minor pilin subunits Spy0125 and Spy0130 in the serotype M1 Streptococcus pyogenes strain SF370. J Bacteriol (2010) 1.03
Stability and assembly of pilus subunits of Streptococcus pneumoniae. J Biol Chem (2010) 1.02
Vaccines, reverse vaccinology, and bacterial pathogenesis. Cold Spring Harb Perspect Med (2013) 1.01
Expression of the type 1 pneumococcal pilus is bistable and negatively regulated by the structural component RrgA. Infect Immun (2011) 1.00
The Streptococcus pneumoniae pilus-1 displays a biphasic expression pattern. PLoS One (2011) 0.99
Pilus biogenesis in Lactococcus lactis: molecular characterization and role in aggregation and biofilm formation. PLoS One (2012) 0.97
Changes in capsular serotype alter the surface exposure of pneumococcal adhesins and impact virulence. PLoS One (2011) 0.97
RrgB321, a fusion protein of the three variants of the pneumococcal pilus backbone RrgB, is protective in vivo and elicits opsonic antibodies. Infect Immun (2011) 0.96
Structure of the full-length major pilin from Streptococcus pneumoniae: implications for isopeptide bond formation in gram-positive bacterial pili. PLoS One (2011) 0.93
The two variants of the Streptococcus pneumoniae pilus 1 RrgA adhesin retain the same function and elicit cross-protection in vivo. Infect Immun (2010) 0.90
Cooperative folding of intrinsically disordered domains drives assembly of a strong elongated protein. Nat Commun (2015) 0.88
Pilus adhesin RrgA interacts with complement receptor 3, thereby affecting macrophage function and systemic pneumococcal disease. MBio (2012) 0.88
Unencapsulated Streptococcus pneumoniae from conjunctivitis encode variant traits and belong to a distinct phylogenetic cluster. Nat Commun (2014) 0.86
Structural basis for group B streptococcus pilus 1 sortases C regulation and specificity. PLoS One (2012) 0.86
The ancillary protein 1 of Streptococcus pyogenes FCT-1 pili mediates cell adhesion and biofilm formation through heterophilic as well as homophilic interactions. Mol Microbiol (2012) 0.85
Structural and functional characterization of the Streptococcus pneumoniae RrgB pilus backbone D1 domain. J Biol Chem (2011) 0.85
Structural basis of pilus anchoring by the ancillary pilin RrgC of Streptococcus pneumoniae. J Biol Chem (2014) 0.85
Development and application of STEM for the biological sciences. Ultramicroscopy (2012) 0.84
Sortase A substrate specificity in GBS pilus 2a cell wall anchoring. PLoS One (2011) 0.83
Isopeptide bonds of the major pilin protein BcpA influence pilus structure and bundle formation on the surface of Bacillus cereus. Mol Microbiol (2012) 0.82
Expression of the Streptococcus pneumoniae pilus-1 undergoes on and off switching during colonization in mice. Sci Rep (2013) 0.82
Preliminary crystallographic study of the Streptococcus agalactiae sortases, sortase A and sortase C1. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.79
CnaA domains in bacterial pili are efficient dissipaters of large mechanical shocks. Proc Natl Acad Sci U S A (2016) 0.77
A structural snapshot of type II pilus formation in Streptococcus pneumoniae. J Biol Chem (2015) 0.77
Pilus biogenesis of Gram-positive bacteria: Roles of sortases and implications for assembly. Protein Sci (2017) 0.76
A distinct sortase SrtB anchors and processes a streptococcal adhesin AbpA with a novel structural property. Sci Rep (2016) 0.76
The Nanomechanical Properties of Lactococcus lactis Pili Are Conditioned by the Polymerized Backbone Pilin. PLoS One (2016) 0.75
New insights about pilus formation in gut-adapted Lactobacillus rhamnosus GG from the crystal structure of the SpaA backbone-pilin subunit. Sci Rep (2016) 0.75
Role of Streptococcus pneumoniae Proteins in Evasion of Complement-Mediated Immunity. Front Microbiol (2017) 0.75
Understanding pneumococcal serotype 1 biology through population genomic analysis. BMC Infect Dis (2016) 0.75
Novel Molecular Insights about Lactobacillar Sortase-Dependent Piliation. Int J Mol Sci (2017) 0.75
EMAN: semiautomated software for high-resolution single-particle reconstructions. J Struct Biol (1999) 27.52
Complete genome sequence of a virulent isolate of Streptococcus pneumoniae. Science (2001) 21.99
Large-scale identification of serotype 4 Streptococcus pneumoniae virulence factors. Mol Microbiol (2002) 6.03
Sortases and the art of anchoring proteins to the envelopes of gram-positive bacteria. Microbiol Mol Biol Rev (2006) 4.88
A pneumococcal pilus influences virulence and host inflammatory responses. Proc Natl Acad Sci U S A (2006) 4.40
Pili in gram-positive pathogens. Nat Rev Microbiol (2006) 4.21
Stabilizing isopeptide bonds revealed in gram-positive bacterial pilus structure. Science (2007) 4.10
Genome analysis reveals pili in Group B Streptococcus. Science (2005) 3.85
Assembly of pili on the surface of Corynebacterium diphtheriae. Mol Microbiol (2003) 3.79
Group A Streptococcus produce pilus-like structures containing protective antigens and Lancefield T antigens. Proc Natl Acad Sci U S A (2005) 3.59
Endocarditis and biofilm-associated pili of Enterococcus faecalis. J Clin Invest (2006) 3.33
Assembly and role of pili in group B streptococci. Mol Microbiol (2006) 2.92
The V-antigen of Yersinia forms a distinct structure at the tip of injectisome needles. Science (2005) 2.90
Pili in Gram-positive bacteria: assembly, involvement in colonization and biofilm development. Trends Microbiol (2008) 2.83
Sortases and pilin elements involved in pilus assembly of Corynebacterium diphtheriae. Mol Microbiol (2004) 2.80
Assembly of pili in Gram-positive bacteria. Trends Microbiol (2004) 2.76
Pili in Gram-negative and Gram-positive bacteria - structure, assembly and their role in disease. Cell Mol Life Sci (2009) 2.69
Genome of the opportunistic pathogen Streptococcus sanguinis. J Bacteriol (2007) 2.21
RrgA and RrgB are components of a multisubunit pilus encoded by the Streptococcus pneumoniae rlrA pathogenicity islet. Infect Immun (2006) 2.18
RrgA is a pilus-associated adhesin in Streptococcus pneumoniae. Mol Microbiol (2007) 2.01
Pili mediate specific adhesion of Streptococcus pyogenes to human tonsil and skin. Cell Microbiol (2007) 1.97
Housekeeping sortase facilitates the cell wall anchoring of pilus polymers in Corynebacterium diphtheriae. Mol Microbiol (2007) 1.82
Group B streptococcal pilus proteins contribute to adherence to and invasion of brain microvascular endothelial cells. J Bacteriol (2006) 1.78
The molecular switch that activates the cell wall anchoring step of pilus assembly in gram-positive bacteria. Proc Natl Acad Sci U S A (2008) 1.75
A second pilus type in Streptococcus pneumoniae is prevalent in emerging serotypes and mediates adhesion to host cells. J Bacteriol (2008) 1.72
Assembly of pili on the surface of Bacillus cereus vegetative cells. Mol Microbiol (2007) 1.67
An IgG-like domain in the minor pilin GBS52 of Streptococcus agalactiae mediates lung epithelial cell adhesion. Structure (2007) 1.64
Sortase A utilizes an ancillary protein anchor for efficient cell wall anchoring of pili in Streptococcus agalactiae. Infect Immun (2008) 1.51
Characterization of Streptococcus suis genes encoding proteins homologous to sortase of gram-positive bacteria. J Bacteriol (2002) 1.49
Architectures and biogenesis of non-flagellar protein appendages in Gram-negative bacteria. EMBO J (2008) 1.48
Intramolecular isopeptide bonds give thermodynamic and proteolytic stability to the major pilin protein of Streptococcus pyogenes. J Biol Chem (2009) 1.45
Pneumococcal pili are composed of protofilaments exposing adhesive clusters of Rrg A. PLoS Pathog (2008) 1.45
Function and molecular architecture of the Yersinia injectisome tip complex. Mol Microbiol (2007) 1.45
Roles of the sortases of Streptococcus pneumoniae in assembly of the RlrA pilus. J Bacteriol (2008) 1.25
Molecular strategies for fimbrial expression and assembly. Crit Rev Oral Biol Med (2001) 1.25
Sortase-mediated assembly and surface topology of adhesive pneumococcal pili. Mol Microbiol (2008) 1.22
Convergence of regulatory networks on the pilus locus of Streptococcus pneumoniae. Infect Immun (2008) 1.20
Sortase-mediated pilus fiber biogenesis in Streptococcus pneumoniae. Structure (2008) 1.17
Cell wall anchor structure of BcpA pili in Bacillus anthracis. J Biol Chem (2008) 1.10
Two crystal structures of pneumococcal pilus sortase C provide novel insights into catalysis and substrate specificity. J Mol Biol (2009) 1.05
Structure and mass analysis by scanning transmission electron microscopy. Micron (2001) 0.99
Clinical impact of antibiotic-resistant Gram-positive pathogens. Clin Microbiol Infect (2009) 0.96
MASDET-A fast and user-friendly multiplatform software for mass determination by dark-field electron microscopy. J Struct Biol (2008) 0.93
Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial "pan-genome". Proc Natl Acad Sci U S A (2005) 14.59
Molecular anatomy of a trafficking organelle. Cell (2006) 11.47
The microbial pan-genome. Curr Opin Genet Dev (2005) 5.93
Atomic-force microscopy: Rhodopsin dimers in native disc membranes. Nature (2003) 5.85
Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae. Proc Natl Acad Sci U S A (2002) 5.28
An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus. Nat Med (2004) 4.89
Microbiology in the post-genomic era. Nat Rev Microbiol (2008) 4.88
A universal vaccine for serogroup B meningococcus. Proc Natl Acad Sci U S A (2006) 4.45
Pili in gram-positive pathogens. Nat Rev Microbiol (2006) 4.21
Genome analysis reveals pili in Group B Streptococcus. Science (2005) 3.85
Identification of a universal Group B streptococcus vaccine by multiple genome screen. Science (2005) 3.83
Vaccination against Neisseria meningitidis using three variants of the lipoprotein GNA1870. J Exp Med (2003) 3.83
Aquaporin water channels--from atomic structure to clinical medicine. J Physiol (2002) 3.70
NadA, a novel vaccine candidate of Neisseria meningitidis. J Exp Med (2002) 3.26
c-Src/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifs. Mol Microbiol (2002) 3.20
Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients. Proc Natl Acad Sci U S A (2007) 3.11
Predicted strain coverage of a meningococcal multicomponent vaccine (4CMenB) in Europe: a qualitative and quantitative assessment. Lancet Infect Dis (2013) 2.95
The V-antigen of Yersinia forms a distinct structure at the tip of injectisome needles. Science (2005) 2.90
MF59 adjuvant enhances diversity and affinity of antibody-mediated immune response to pandemic influenza vaccines. Sci Transl Med (2011) 2.75
Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species. Genome Biol (2010) 2.60
Efficient coupling of transducin to monomeric rhodopsin in a phospholipid bilayer. J Biol Chem (2007) 2.59
Nonviral delivery of self-amplifying RNA vaccines. Proc Natl Acad Sci U S A (2012) 2.59
Rational design of a meningococcal antigen inducing broad protective immunity. Sci Transl Med (2011) 2.59
Adjuvanted H5N1 vaccine induces early CD4+ T cell response that predicts long-term persistence of protective antibody levels. Proc Natl Acad Sci U S A (2009) 2.41
A novel glyco-conjugate vaccine against fungal pathogens. J Exp Med (2005) 2.35
Hemagglutination inhibition antibody titers as a correlate of protection for inactivated influenza vaccines in children. Pediatr Infect Dis J (2011) 2.33
Qualitative and quantitative assessment of meningococcal antigens to evaluate the potential strain coverage of protein-based vaccines. Proc Natl Acad Sci U S A (2010) 2.30
SARS--beginning to understand a new virus. Nat Rev Microbiol (2003) 2.30
Reverse vaccinology: developing vaccines in the era of genomics. Immunity (2010) 2.25
Vaccines with MF59 adjuvant expand the antibody repertoire to target protective sites of pandemic avian H5N1 influenza virus. Sci Transl Med (2010) 2.21
Invariant NKT cells sustain specific B cell responses and memory. Proc Natl Acad Sci U S A (2007) 2.20
Identification of iron-activated and -repressed Fur-dependent genes by transcriptome analysis of Neisseria meningitidis group B. Proc Natl Acad Sci U S A (2003) 2.17
Group B Streptococcus: global incidence and vaccine development. Nat Rev Microbiol (2006) 2.16
Multiple assembly pathways underlie amyloid-beta fibril polymorphisms. J Mol Biol (2005) 2.14
Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. Mol Cell (2005) 2.09
Fur functions as an activator and as a repressor of putative virulence genes in Neisseria meningitidis. Mol Microbiol (2004) 2.08
Structural basis for immunization with postfusion respiratory syncytial virus fusion F glycoprotein (RSV F) to elicit high neutralizing antibody titers. Proc Natl Acad Sci U S A (2011) 2.08
Neisseria meningitidis NadA is a new invasin which promotes bacterial adhesion to and penetration into human epithelial cells. Mol Microbiol (2005) 2.06
Structure of the rhodopsin dimer: a working model for G-protein-coupled receptors. Curr Opin Struct Biol (2006) 2.03
Influenza vaccine immunology. Immunol Rev (2011) 2.02
New adjuvants for human vaccines. Curr Opin Immunol (2010) 1.98
A concept for G protein activation by G protein-coupled receptor dimers: the transducin/rhodopsin interface. Photochem Photobiol Sci (2004) 1.92
Neisseria meningitidis is structured in clades associated with restriction modification systems that modulate homologous recombination. Proc Natl Acad Sci U S A (2011) 1.84
Conformational changes in surface structures of isolated connexin 26 gap junctions. EMBO J (2002) 1.84
Previously unrecognized vaccine candidates against group B meningococcus identified by DNA microarrays. Nat Biotechnol (2002) 1.83
Transient facial nerve paralysis (Bell's palsy) following intranasal delivery of a genetically detoxified mutant of Escherichia coli heat labile toxin. PLoS One (2009) 1.82
Exploring the 3D molecular architecture of Escherichia coli type 1 pili. J Mol Biol (2002) 1.81
Human endogenous retrovirus K (HML-2) elements in the plasma of people with lymphoma and breast cancer. J Virol (2008) 1.79
Studies on three E. coli DEAD-box helicases point to an unwinding mechanism different from that of model DNA helicases. Biochemistry (2004) 1.76
Atomic structure and hierarchical assembly of a cross-β amyloid fibril. Proc Natl Acad Sci U S A (2013) 1.75
Identification of protective and broadly conserved vaccine antigens from the genome of extraintestinal pathogenic Escherichia coli. Proc Natl Acad Sci U S A (2010) 1.75
Comparative genomics of Neisseria meningitidis: core genome, islands of horizontal transfer and pathogen-specific genes. Microbiology (2006) 1.75
Streptococcus pneumoniae pilus subunits protect mice against lethal challenge. Infect Immun (2006) 1.74
Vaccine manufacturing: challenges and solutions. Nat Biotechnol (2006) 1.73
Antibody to genome-derived neisserial antigen 2132, a Neisseria meningitidis candidate vaccine, confers protection against bacteremia in the absence of complement-mediated bactericidal activity. J Infect Dis (2003) 1.73
A second pilus type in Streptococcus pneumoniae is prevalent in emerging serotypes and mediates adhesion to host cells. J Bacteriol (2008) 1.72
The new multicomponent vaccine against meningococcal serogroup B, 4CMenB: immunological, functional and structural characterization of the antigens. Vaccine (2012) 1.71
The region comprising amino acids 100 to 255 of Neisseria meningitidis lipoprotein GNA 1870 elicits bactericidal antibodies. Infect Immun (2005) 1.68
Structure-based antigen design: a strategy for next generation vaccines. Trends Biotechnol (2008) 1.68
Neisseria meningitidis GNA2132, a heparin-binding protein that induces protective immunity in humans. Proc Natl Acad Sci U S A (2010) 1.66
Mucosal administration of Ag85B-ESAT-6 protects against infection with Mycobacterium tuberculosis and boosts prior bacillus Calmette-Guerin immunity. J Immunol (2006) 1.66
Clonal success of piliated penicillin nonsusceptible pneumococci. Proc Natl Acad Sci U S A (2007) 1.64
Rhodopsin signaling and organization in heterozygote rhodopsin knockout mice. J Biol Chem (2004) 1.64
Structure and assembly of the pseudopilin PulG. Mol Microbiol (2004) 1.61
Distribution and genetic variability of three vaccine components in a panel of strains representative of the diversity of serogroup B meningococcus. Vaccine (2009) 1.58
Functional characterization of rhodopsin monomers and dimers in detergents. J Biol Chem (2004) 1.57
Aquaporins: Phylogeny, Structure, and Physiology of Water Channels. News Physiol Sci (1999) 1.56
Phylogeny of the SARS coronavirus. Science (2003) 1.56
Structure and function of water channels. Curr Opin Struct Biol (2002) 1.55
Exploring amyloid formation by a de novo design. Proc Natl Acad Sci U S A (2004) 1.55
The diphtheria and pertussis components of diphtheria-tetanus toxoids-pertussis vaccine should be genetically inactivated mutant toxins. J Infect Dis (2004) 1.55
Bacterial outer membrane secretin PulD assembles and inserts into the inner membrane in the absence of its pilotin. EMBO J (2006) 1.52
Molecular mechanisms of complement evasion: learning from staphylococci and meningococci. Nat Rev Microbiol (2010) 1.52
Structural insights into the secretin PulD and its trypsin-resistant core. J Biol Chem (2005) 1.50
Structure of the dodecameric Yersinia enterocolitica secretin YscC and its trypsin-resistant core. Structure (2013) 1.49
Streptococcus pneumoniae contains 3 rlrA pilus variants that are clonally related. J Infect Dis (2008) 1.49
Synthetic generation of influenza vaccine viruses for rapid response to pandemics. Sci Transl Med (2013) 1.47
Molecular architecture of photosynthetic membranes in Rhodobacter sphaeroides: the role of PufX. EMBO J (2004) 1.47
Imaging and manipulation of biological structures with the AFM. Micron (2002) 1.46
Atomic force microscopy and spectroscopy of native membrane proteins. Nat Protoc (2007) 1.46
Five challenges to bringing single-molecule force spectroscopy into living cells. Nat Methods (2011) 1.45
Pneumococcal pili are composed of protofilaments exposing adhesive clusters of Rrg A. PLoS Pathog (2008) 1.45
Function and molecular architecture of the Yersinia injectisome tip complex. Mol Microbiol (2007) 1.45
YscU recognizes translocators as export substrates of the Yersinia injectisome. EMBO J (2007) 1.44
Adjuvanticity of the oil-in-water emulsion MF59 is independent of Nlrp3 inflammasome but requires the adaptor protein MyD88. Proc Natl Acad Sci U S A (2011) 1.44
Cytotoxin ClyA from Escherichia coli assembles to a 13-meric pore independent of its redox-state. EMBO J (2006) 1.43