Published in Leukemia on September 01, 2005
Resistance reversal by RNAi silencing of MDR1 in CML cells associated with increase in imatinib intracellular levels. Leukemia (2007) 1.89
Wnt/Ca2+/NFAT signaling maintains survival of Ph+ leukemia cells upon inhibition of Bcr-Abl. Cancer Cell (2010) 1.64
Sunitinib (Sutent, SU11248), a small-molecule receptor tyrosine kinase inhibitor, blocks function of the ATP-binding cassette (ABC) transporters P-glycoprotein (ABCB1) and ABCG2. Drug Metab Dispos (2008) 1.46
Tyrosine kinase inhibitors as modulators of ABC transporter-mediated drug resistance. Drug Resist Updat (2012) 1.12
Redox regulation of multidrug resistance in cancer chemotherapy: molecular mechanisms and therapeutic opportunities. Antioxid Redox Signal (2009) 1.11
Synthesis and characterization of a BODIPY conjugate of the BCR-ABL kinase inhibitor Tasigna (nilotinib): evidence for transport of Tasigna and its fluorescent derivative by ABC drug transporters. Mol Pharm (2011) 0.88
A comparative proteomic study identified LRPPRC and MCM7 as putative actors in imatinib mesylate cross-resistance in Lucena cell line. Proteome Sci (2012) 0.83
Fenretinide targets chronic myeloid leukemia stem/progenitor cells by regulation of redox signaling. Antioxid Redox Signal (2013) 0.82
Kinase-independent mechanisms of resistance of leukemia stem cells to tyrosine kinase inhibitors. Stem Cells Transl Med (2014) 0.82
The Interface between BCR-ABL-Dependent and -Independent Resistance Signaling Pathways in Chronic Myeloid Leukemia. Leuk Res Treatment (2012) 0.80
The role of P-glycoprotein in imatinib resistance. Leukemia (2006) 0.75
A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci U S A (1998) 24.58
Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science (1998) 17.91
Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli. Proc Natl Acad Sci U S A (2002) 13.83
The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype. Nat Med (2001) 11.94
Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein. Science (1999) 7.51
Purification and biochemical heterogeneity of the mammalian SWI-SNF complex. EMBO J (1996) 6.36
Diversity and specialization of mammalian SWI/SNF complexes. Genes Dev (1996) 6.01
Human Smad3 and Smad4 are sequence-specific transcription activators. Mol Cell (1998) 5.88
Human fibroblast growth factor receptor 1 is a co-receptor for infection by adeno-associated virus 2. Nat Med (1999) 5.50
Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T. Infect Immun (2003) 5.11
SOX9 directly regulates the type-II collagen gene. Nat Genet (1997) 4.88
Tandem AP-1-binding sites within the human beta-globin dominant control region function as an inducible enhancer in erythroid cells. Genes Dev (1990) 4.07
Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene. Proc Natl Acad Sci U S A (1996) 3.88
Composite co-activator ARC mediates chromatin-directed transcriptional activation. Nature (1999) 3.32
CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex. Proc Natl Acad Sci U S A (1999) 2.81
Identification of functionally variant MDR1 alleles among European Americans and African Americans. Clin Pharmacol Ther (2001) 2.79
A specificity and targeting subunit of a human SWI/SNF family-related chromatin-remodeling complex. Mol Cell Biol (2000) 2.70
Critical role for alpha/beta and gamma interferons in persistence of lymphocytic choriomeningitis virus by clonal exhaustion of cytotoxic T cells. J Virol (2001) 2.69
The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. Nature (1999) 2.61
Conservation. Reconsidering the consequences of selective fisheries. Science (2012) 2.57
High AAV vector purity results in serotype- and tissue-independent enhancement of transduction efficiency. Gene Ther (2009) 2.54
The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling. Genes Dev (1999) 2.52
RNA- and DNA-binding activities in hepatitis B virus capsid protein: a model for their roles in viral replication. J Virol (1992) 2.42
Architectural DNA binding by a high-mobility-group/kinesin-like subunit in mammalian SWI/SNF-related complexes. Proc Natl Acad Sci U S A (1998) 2.30
The chromo superfamily: new members, duplication of the chromo domain and possible role in delivering transcription regulators to chromatin. Nucleic Acids Res (1995) 2.26
Microsurgical replantation of the avulsed scalp: report of 20 cases. Plast Reconstr Surg (1996) 2.17
DNA array studies demonstrate convergent regulation of virulence factors by Cph1, Cph2, and Efg1 in Candida albicans. J Biol Chem (2001) 2.14
Abeta amyloid fibrils possess a core structure highly resistant to hydrogen exchange. Proc Natl Acad Sci U S A (2000) 2.02
Inducibility of the HS II enhancer depends on binding of an erythroid specific nuclear protein. Nucleic Acids Res (1990) 2.01
Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits. Science (1994) 1.98
Human TAFII 105 is a cell type-specific TFIID subunit related to hTAFII130. Cell (1996) 1.96
TATA box-binding protein (TBP)-related factor 2 (TRF2), a third member of the TBP family. Proc Natl Acad Sci U S A (1999) 1.86
Transient immunosuppression allows transgene expression following readministration of adeno-associated viral vectors. Hum Gene Ther (1998) 1.79
SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein. Genes Dev (1996) 1.76
Alterations of striatal NMDA receptor subunits associated with the development of dyskinesia in the MPTP-lesioned primate model of Parkinson's disease. Neuropharmacology (2005) 1.75
Enteric bacterial catalysts for fuel ethanol production. Biotechnol Prog (1999) 1.74
A human condensin complex containing hCAP-C-hCAP-E and CNAP1, a homolog of Xenopus XCAP-D2, colocalizes with phosphorylated histone H3 during the early stage of mitotic chromosome condensation. Mol Cell Biol (2000) 1.73
VirB1, a component of the T-complex transfer machinery of Agrobacterium tumefaciens, is processed to a C-terminal secreted product, VirB1. J Bacteriol (1997) 1.72
Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics. Proc Natl Acad Sci U S A (1998) 1.68
Exogenously regulated stem cell-mediated gene therapy for bone regeneration. Mol Ther (2001) 1.63
Requirement for a kinase-specific chaperone pathway in the production of a Cdk9/cyclin T1 heterodimer responsible for P-TEFb-mediated tat stimulation of HIV-1 transcription. J Biol Chem (2000) 1.59
A TRF1:BRF complex directs Drosophila RNA polymerase III transcription. Cell (2000) 1.59
Adeno-associated virus type 2-mediated gene transfer: role of cellular FKBP52 protein in transgene expression. J Virol (2001) 1.58
Pluripotent hematopoietic stem cells contain high levels of mRNA for c-kit, GATA-2, p45 NF-E2, and c-myb and low levels or no mRNA for c-fms and the receptors for granulocyte colony-stimulating factor and interleukins 5 and 7. Proc Natl Acad Sci U S A (1995) 1.58
Engineering the metabolism of Escherichia coli W3110 for the conversion of sugar to redox-neutral and oxidized products: homoacetate production. Proc Natl Acad Sci U S A (2003) 1.57
Molecular cloning and expression of the 32-kDa subunit of human TFIID reveals interactions with VP16 and TFIIB that mediate transcriptional activation. Proc Natl Acad Sci U S A (1995) 1.57
Identification and characterization of a TFIID-like multiprotein complex from Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1995) 1.56
X-ray crystal structure of rabbit N-acetylglucosaminyltransferase I: catalytic mechanism and a new protein superfamily. EMBO J (2000) 1.56
Efficiency of eight different AAV serotypes in transducing rat myocardium in vivo. Gene Ther (2007) 1.56
A micromolar pool of antigenically distinct precursors is required to initiate cooperative assembly of hepatitis B virus capsids in Xenopus oocytes. J Virol (1993) 1.55
Abnormal compartmentalization of cartilage matrix components in mice lacking collagen X: implications for function. J Cell Biol (1997) 1.55
Restoration of lymphocyte function in Janus kinase 3-deficient mice by retroviral-mediated gene transfer. Nat Med (1998) 1.54
Post-transcriptional modification in archaeal tRNAs: identities and phylogenetic relations of nucleotides from mesophilic and hyperthermophilic Methanococcales. Nucleic Acids Res (2001) 1.52
The basic helix-loop-helix transcription factor Cph2 regulates hyphal development in Candida albicans partly via TEC1. Mol Cell Biol (2001) 1.52
Systematic review of chimney and periscope grafts for endovascular aneurysm repair. Br J Surg (2013) 1.50
The Escherichia coli GTPase CgtAE cofractionates with the 50S ribosomal subunit and interacts with SpoT, a ppGpp synthetase/hydrolase. J Bacteriol (2004) 1.48
Nerve sprouting and sympathetic hyperinnervation in a canine model of atrial fibrillation produced by prolonged right atrial pacing. Circulation (2001) 1.45
A comparative study of the skeletal morphology of the temporo-mandibular joint of children and adults. J Postgrad Med (2008) 1.39
A gross and microscopic study of cerebral injuries accompanying maxillofacial high-velocity projectile wounding in dogs. J Oral Maxillofac Surg (1998) 1.39
Enforced P-glycoprotein pump function in murine bone marrow cells results in expansion of side population stem cells in vitro and repopulating cells in vivo. Blood (2000) 1.39
Fuzzy control system design via fuzzy Lyapunov functions. IEEE Trans Syst Man Cybern B Cybern (2008) 1.38
An integrated assessment model of carbon sequestration benefits: a case study of Liping county, China. J Environ Manage (2006) 1.38
Five unique compounds: xyloketals from mangrove fungus Xylaria sp. from the South China Sea coast. J Org Chem (2001) 1.37
Changes in the use of radiotherapy in Ontario 1984-1995. Int J Radiat Oncol Biol Phys (1999) 1.36
Protection and in vivo selection of hematopoietic stem cells using temozolomide, O6-benzylguanine, and an alkyltransferase-expressing retroviral vector. Mol Ther (2001) 1.33
In vivo selection of retrovirally transduced hematopoietic stem cells. Nat Med (1998) 1.33
Series "matrix metalloproteinases in lung health and disease": Matrix metalloproteinases in COPD. Eur Respir J (2011) 1.33
The Epstein-Barr virus lytic transactivator Zta interacts with the helicase-primase replication proteins. J Virol (1998) 1.31
Engineered human mesenchymal stem cells: a novel platform for skeletal cell mediated gene therapy. J Gene Med (2001) 1.30
Molecular cloning and characterization of dTAFII30 alpha and dTAFII30 beta: two small subunits of Drosophila TFIID. Genes Dev (1993) 1.30
Axonal transport of adeno-associated viral vectors is serotype-dependent. Gene Ther (2012) 1.29
N-methyl-D-aspartate-induced excitation and sensitization of normal and inflamed nociceptors. Neuroscience (2003) 1.27
Genetic immunization with adeno-associated virus vectors expressing herpes simplex virus type 2 glycoproteins B and D. J Virol (1997) 1.27
Variation in health and risk behavior among youth living with HIV. AIDS Educ Prev (2001) 1.26
Prophylactic immune tolerance induced by changing the ratio of antigen-specific effector to regulatory T cells. J Thromb Haemost (2009) 1.26
Factors affecting the use of palliative radiotherapy in Ontario. J Clin Oncol (2001) 1.25
Genetic changes to optimize carbon partitioning between ethanol and biosynthesis in ethanologenic Escherichia coli. Appl Environ Microbiol (2002) 1.22
A potential role for human cohesin in mitotic spindle aster assembly. J Biol Chem (2001) 1.22
Social and economic impacts of carbon sequestration and land use change on peasant households in rural China: a case study of Liping, Guizhou Province. J Environ Manage (2006) 1.21
Re-engineering Escherichia coli for ethanol production. Biotechnol Lett (2008) 1.20
Purification, cDNA cloning, and gene mapping of the small subunit of human DNA polymerase epsilon. J Biol Chem (1997) 1.20
A shorter fractionation schedule for postlumpectomy breast cancer patients. Int J Radiat Oncol Biol Phys (2000) 1.19
Substance use and its relationship to depression, anxiety, and isolation among youth living with HIV. Int J Behav Med (1999) 1.19
Peripheral glutamate release in the hindpaw following low and high intensity sciatic stimulation. Neuroreport (2000) 1.19
Peripheral GABA(A) receptors: evidence for peripheral primary afferent depolarization. Neuroscience (1999) 1.18
Prophylaxis in liver transplant recipients using a fixed dosing schedule of hepatitis B immunoglobulin. Hepatology (1996) 1.17
Measurement of direct photon production in p+p collisions at sqrt[s] = 200 GeV. Phys Rev Lett (2007) 1.16
Rapid and sensitive detection of Singapore grouper iridovirus by loop-mediated isothermal amplification. J Appl Microbiol (2008) 1.13
Long-term correction of obesity and diabetes in genetically obese mice by a single intramuscular injection of recombinant adeno-associated virus encoding mouse leptin. Proc Natl Acad Sci U S A (1997) 1.13
Opioid receptors on peripheral sensory axons. Brain Res (1997) 1.11
Methylglyoxal bypass identified as source of chiral contamination in l(+) and d(-)-lactate fermentations by recombinant Escherichia coli. Biotechnol Lett (2006) 1.10
Retinal degeneration is slowed in transgenic rats by AAV-mediated delivery of FGF-2. Invest Ophthalmol Vis Sci (2000) 1.10
Expression of three Caenorhabditis elegans N-acetylglucosaminyltransferase I genes during development. J Biol Chem (1999) 1.09