Published in Nat Genet on June 01, 1997
The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev (2002) 8.19
A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene. EMBO J (1998) 5.15
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Shh establishes an Nkx3.2/Sox9 autoregulatory loop that is maintained by BMP signals to induce somitic chondrogenesis. Genes Dev (2002) 1.48
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A far-upstream (-70 kb) enhancer mediates Sox9 auto-regulation in somatic tissues during development and adult regeneration. Nucleic Acids Res (2013) 1.03
Rho kinase-dependent activation of SOX9 in chondrocytes. Arthritis Rheum (2010) 1.02
An in situ hybridization study of Runx2, Osterix, and Sox9 in the anlagen of mouse mandibular condylar cartilage in the early stages of embryogenesis. J Anat (2008) 1.00
Shh signaling from the nucleus pulposus is required for the postnatal growth and differentiation of the mouse intervertebral disc. PLoS One (2012) 1.00
Altered chondrocyte differentiation and extracellular matrix homeostasis in a zebrafish model for mucolipidosis II. Am J Pathol (2009) 0.99
The versatile functions of Sox9 in development, stem cells, and human diseases. Genes Dis (2014) 0.98
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Inactivation of Patched1 in the mouse limb has novel inhibitory effects on the chondrogenic program. J Biol Chem (2010) 0.98
Expression profiling of zebrafish sox9 mutants reveals that Sox9 is required for retinal differentiation. Dev Biol (2009) 0.97
Novel electrospun scaffolds for the molecular analysis of chondrocytes under dynamic compression. Tissue Eng Part A (2009) 0.96
Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNFalpha-induced MEK/ERK signalling. Arthritis Res Ther (2009) 0.96
SOX9, through interaction with microphthalmia-associated transcription factor (MITF) and OTX2, regulates BEST1 expression in the retinal pigment epithelium. J Biol Chem (2010) 0.95
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Runx2 regulates endochondral ossification through control of chondrocyte proliferation and differentiation. J Bone Miner Res (2014) 0.93
Divergent expression patterns of Sox9 duplicates in teleosts indicate a lineage specific subfunctionalization. Dev Genes Evol (2005) 0.93
BMP-2 functions independently of SHH signaling and triggers cell condensation and apoptosis in regenerating axolotl limbs. BMC Dev Biol (2010) 0.93
Silencing of microRNA-101 prevents IL-1β-induced extracellular matrix degradation in chondrocytes. Arthritis Res Ther (2012) 0.92
Analysis of medaka sox9 orthologue reveals a conserved role in germ cell maintenance. PLoS One (2012) 0.92
Smad3 activates the Sox9-dependent transcription on chromatin. Int J Biochem Cell Biol (2008) 0.92
Interplay of Nkx3.2, Sox9 and Pax3 regulates chondrogenic differentiation of muscle progenitor cells. PLoS One (2012) 0.91
Constitutive E2F1 overexpression delays endochondral bone formation by inhibiting chondrocyte differentiation. Mol Cell Biol (2003) 0.91
Role of Sox-9, ER81 and VE-cadherin in retinoic acid-mediated trans-differentiation of breast cancer cells. PLoS One (2008) 0.91
Transcriptional control of mesenchymal stem cell differentiation. Transfus Med Hemother (2008) 0.90
Sox3 functions in a cell-autonomous manner to regulate spermatogonial differentiation in mice. Endocrinology (2011) 0.90
Mesenchymal and mechanical mechanisms of secondary cartilage induction. Dev Biol (2011) 0.90
Chondrogenically tuned expansion enhances the cartilaginous matrix-forming capabilities of primary, adult, leporine chondrocytes. Cell Transplant (2012) 0.89
Basic helix-loop-helix transcription factor Twist1 inhibits transactivator function of master chondrogenic regulator Sox9. J Biol Chem (2012) 0.89
CCAAT/enhancer-binding protein β regulates the repression of type II collagen expression during the differentiation from proliferative to hypertrophic chondrocytes. J Biol Chem (2013) 0.89
Fat-Dachsous signaling coordinates cartilage differentiation and polarity during craniofacial development. PLoS Genet (2014) 0.89
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Zebrafish and medaka as models for bone research including implications regarding space-related issues. Protoplasma (2006) 0.88
Arid5a cooperates with Sox9 to stimulate chondrocyte-specific transcription. Mol Biol Cell (2011) 0.88
A case of campomelic dysplasia without sex reversal. J Korean Med Sci (2010) 0.88
Transcriptional regulation of heart valve development and disease. Cardiovasc Pathol (2010) 0.88
The dimerization domain of SOX9 is required for transcription activation of a chondrocyte-specific chromatin DNA template. Nucleic Acids Res (2010) 0.87
Twist1 mediates repression of chondrogenesis by β-catenin to promote cranial bone progenitor specification. Development (2012) 0.87
Kindlin-2 controls TGF-β signalling and Sox9 expression to regulate chondrogenesis. Nat Commun (2015) 0.87
The immediate early gene product EGR1 and polycomb group proteins interact in epigenetic programming during chondrogenesis. PLoS One (2013) 0.86
Regulation of SOX9 in normal and osteoarthritic equine articular chondrocytes by hyperosmotic loading. Osteoarthritis Cartilage (2010) 0.86
The multifaceted role of the vasculature in endochondral fracture repair. Front Endocrinol (Lausanne) (2015) 0.85
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