Published in Nature on April 29, 1999
Quantitative proteomic analysis of distinct mammalian Mediator complexes using normalized spectral abundance factors. Proc Natl Acad Sci U S A (2006) 3.71
The glucocorticoid receptor inhibits NFkappaB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain. Genes Dev (2000) 3.71
The human Mediator complex: a versatile, genome-wide regulator of transcription. Trends Biochem Sci (2010) 3.38
The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function. Genes Dev (2009) 2.69
Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes Dev (2010) 2.55
A DNA repair complex functions as an Oct4/Sox2 coactivator in embryonic stem cells. Cell (2011) 2.29
A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans. Genes Dev (2006) 2.29
A high resolution protein interaction map of the yeast Mediator complex. Nucleic Acids Res (2004) 2.15
Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation. Genes Dev (2002) 2.02
A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen. Mol Cell Biol (2000) 1.99
Factor recruitment and TIF2/GRIP1 corepressor activity at a collagenase-3 response element that mediates regulation by phorbol esters and hormones. EMBO J (2001) 1.91
Glucocorticoids repress NF-kappaB-driven genes by disturbing the interaction of p65 with the basal transcription machinery, irrespective of coactivator levels in the cell. Proc Natl Acad Sci U S A (2000) 1.87
Requirement of TRAP/mediator for both activator-independent and activator-dependent transcription in conjunction with TFIID-associated TAF(II)s. Mol Cell Biol (2002) 1.86
BRG-1 is recruited to estrogen-responsive promoters and cooperates with factors involved in histone acetylation. Mol Cell Biol (2000) 1.80
Coactivator-dependent acetylation stabilizes members of the SREBP family of transcription factors. Mol Cell Biol (2003) 1.79
A novel docking site on Mediator is critical for activation by VP16 in mammalian cells. EMBO J (2003) 1.78
Structural organization of yeast and mammalian mediator complexes. Proc Natl Acad Sci U S A (2000) 1.76
Selective coactivator interactions in gene activation by SREBP-1a and -1c. Mol Cell Biol (2004) 1.75
The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator. Proc Natl Acad Sci U S A (2004) 1.70
Novel critical role of a human Mediator complex for basal RNA polymerase II transcription. EMBO Rep (2001) 1.67
CCAR1, a key regulator of mediator complex recruitment to nuclear receptor transcription complexes. Mol Cell (2008) 1.66
The Mediator complex and transcription regulation. Crit Rev Biochem Mol Biol (2013) 1.64
Mechanism of rapid transcriptional induction of tumor necrosis factor alpha-responsive genes by NF-kappaB. Mol Cell Biol (2002) 1.58
Amplification and overexpression of peroxisome proliferator-activated receptor binding protein (PBP/PPARBP) gene in breast cancer. Proc Natl Acad Sci U S A (1999) 1.54
Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1. J Clin Invest (2012) 1.52
A transcriptional corepressor of Stat1 with an essential LXXLL signature motif. Proc Natl Acad Sci U S A (2001) 1.50
Molecular characterization of Saccharomyces cerevisiae TFIID. Mol Cell Biol (2002) 1.46
TFIID and human mediator coactivator complexes assemble cooperatively on promoter DNA. Genes Dev (2002) 1.45
Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator. Proc Natl Acad Sci U S A (2000) 1.43
Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase. Proc Natl Acad Sci U S A (2002) 1.43
The DRIP complex and SRC-1/p160 coactivators share similar nuclear receptor binding determinants but constitute functionally distinct complexes. Mol Cell Biol (2000) 1.38
The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development. EMBO J (2002) 1.38
Mediator head module structure and functional interactions. Nat Struct Mol Biol (2010) 1.36
Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator. Proc Natl Acad Sci U S A (2002) 1.36
ERAP140, a conserved tissue-specific nuclear receptor coactivator. Mol Cell Biol (2002) 1.34
Drosophila homologs of transcriptional mediator complex subunits are required for adult cell and segment identity specification. Genes Dev (2000) 1.34
TRAP230/ARC240 and TRAP240/ARC250 Mediator subunits are functionally conserved through evolution. Proc Natl Acad Sci U S A (2003) 1.33
Ubiquitous expression and embryonic requirement for RNA polymerase II coactivator subunit Srb7 in mice. Genes Dev (1999) 1.31
TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4. Mol Cell Biol (2002) 1.31
AMF-1/Gps2 binds p300 and enhances its interaction with papillomavirus E2 proteins. J Virol (2000) 1.30
Transcriptional activation domains of human heat shock factor 1 recruit human SWI/SNF. Mol Cell Biol (2001) 1.29
Novel transcription coactivator complex containing activating signal cointegrator 1. Mol Cell Biol (2002) 1.29
Activation domain-mediator interactions promote transcription preinitiation complex assembly on promoter DNA. Proc Natl Acad Sci U S A (2003) 1.28
Two modes of transcriptional activation at native promoters by NF-kappaB p65. PLoS Biol (2009) 1.25
Identification of poly(ADP-ribose) polymerase as a transcriptional coactivator of the human T-cell leukemia virus type 1 Tax protein. J Virol (2000) 1.23
The Aspergillus parasiticus protein AFLJ interacts with the aflatoxin pathway-specific regulator AFLR. Mol Genet Genomics (2003) 1.23
Origins and activity of the Mediator complex. Semin Cell Dev Biol (2011) 1.23
Active repression and E2F inhibition by pRB are biochemically distinguishable. Genes Dev (2001) 1.22
Activator-independent functions of the yeast mediator sin4 complex in preinitiation complex formation and transcription reinitiation. Mol Cell Biol (2003) 1.22
Role of metazoan mediator proteins in interferon-responsive transcription. Mol Cell Biol (2003) 1.22
Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB. Mol Cell Biol (2000) 1.21
Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function. Proc Natl Acad Sci U S A (2001) 1.19
Structure of the VP16 transactivator target in the Mediator. Nat Struct Mol Biol (2011) 1.17
PTOV1 enables the nuclear translocation and mitogenic activity of flotillin-1, a major protein of lipid rafts. Mol Cell Biol (2005) 1.17
The nuclear hormone receptor coactivator NRC is a pleiotropic modulator affecting growth, development, apoptosis, reproduction, and wound repair. Mol Cell Biol (2004) 1.16
Drosophila Mediator complex is broadly utilized by diverse gene-specific transcription factors at different types of core promoters. Mol Cell Biol (2001) 1.16
Human mediator enhances activator-facilitated recruitment of RNA polymerase II and promoter recognition by TATA-binding protein (TBP) independently of TBP-associated factors. Mol Cell Biol (2003) 1.16
Discrete roles for peroxisome proliferator-activated receptor gamma and retinoid X receptor in recruiting nuclear receptor coactivators. Mol Cell Biol (2000) 1.15
All natural DR3-type vitamin D response elements show a similar functionality in vitro. Biochem J (2000) 1.14
MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation. EMBO J (2007) 1.14
Transcriptional activation of histone genes requires NPAT-dependent recruitment of TRRAP-Tip60 complex to histone promoters during the G1/S phase transition. Mol Cell Biol (2007) 1.13
Twist2, a novel ADD1/SREBP1c interacting protein, represses the transcriptional activity of ADD1/SREBP1c. Nucleic Acids Res (2003) 1.13
Mediator-dependent nuclear receptor function. Semin Cell Dev Biol (2011) 1.12
Mediator and p300/CBP-steroid receptor coactivator complexes have distinct roles, but function synergistically, during estrogen receptor alpha-dependent transcription with chromatin templates. Mol Cell Biol (2003) 1.12
Inactivation of the nuclear receptor coactivator RAP250 in mice results in placental vascular dysfunction. Mol Cell Biol (2003) 1.12
Identification and characterization of ART-27, a novel coactivator for the androgen receptor N terminus. Mol Biol Cell (2002) 1.11
Transcription-dependent degradation controls the stability of the SREBP family of transcription factors. Proc Natl Acad Sci U S A (2003) 1.10
Mediator and human disease. Semin Cell Dev Biol (2011) 1.10
MED16 and MED23 of Mediator are coactivators of lipopolysaccharide- and heat-shock-induced transcriptional activators. Proc Natl Acad Sci U S A (2004) 1.09
Characterization of mediator complexes from HeLa cell nuclear extract. Mol Cell Biol (2001) 1.09
Analysis of the RelA:CBP/p300 interaction reveals its involvement in NF-κB-driven transcription. PLoS Biol (2013) 1.08
Purification of transcription cofactor complex CRSP. Proc Natl Acad Sci U S A (1999) 1.07
Analysis of Schizosaccharomyces pombe mediator reveals a set of essential subunits conserved between yeast and metazoan cells. Proc Natl Acad Sci U S A (2001) 1.04
Coactivators in PPAR-Regulated Gene Expression. PPAR Res (2010) 1.04
Splicing potentiation by growth factor signals via estrogen receptor phosphorylation. Proc Natl Acad Sci U S A (2005) 1.04
NRC-interacting factor 1 is a novel cotransducer that interacts with and regulates the activity of the nuclear hormone receptor coactivator NRC. Mol Cell Biol (2002) 1.03
Noninvasive imaging of therapeutic gene expression using a bidirectional transcriptional amplification strategy. Mol Ther (2008) 1.02
Interaction of the mediator head module with RNA polymerase II. Structure (2012) 1.02
In vivo repression of an erythroid-specific gene by distinct corepressor complexes. EMBO J (2002) 1.02
Maintaining cholesterol homeostasis: sterol regulatory element-binding proteins. World J Gastroenterol (2004) 1.01
Herpes simplex virus 1 ICP4 forms complexes with TFIID and mediator in virus-infected cells. J Virol (2011) 1.00
PTOV-1, a novel protein overexpressed in prostate cancer, shuttles between the cytoplasm and the nucleus and promotes entry into the S phase of the cell division cycle. Am J Pathol (2003) 0.99
Chromatin remodeling complex interacts with ADD1/SREBP1c to mediate insulin-dependent regulation of gene expression. Mol Cell Biol (2006) 0.98
Mediator kinase module and human tumorigenesis. Crit Rev Biochem Mol Biol (2015) 0.98
Robust mRNA transcription in chicken DT40 cells depleted of TAF(II)31 suggests both functional degeneracy and evolutionary divergence. Mol Cell Biol (2000) 0.97
Nuclear receptor coactivator/coregulator NCoA6(NRC) is a pleiotropic coregulator involved in transcription, cell survival, growth and development. Nucl Recept Signal (2008) 0.95
Caenorhabditis elegans mediator complexes are required for developmental-specific transcriptional activation. Proc Natl Acad Sci U S A (1999) 0.95
External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator. Proc Natl Acad Sci U S A (2002) 0.94
Elevated MED28 expression predicts poor outcome in women with breast cancer. BMC Cancer (2010) 0.94
Interactions of a DNA-bound transcriptional activator with the TBP-TFIIA-TFIIB-promoter quaternary complex. J Biol Chem (2003) 0.93
Interaction of the 1alpha,25-dihydroxyvitamin D3 receptor at the distal promoter region of the bone-specific osteocalcin gene requires nucleosomal remodelling. Biochem J (2002) 0.91
Mediator complex dependent regulation of cardiac development and disease. Genomics Proteomics Bioinformatics (2013) 0.90
Modulation of gene expression regulated by the transcription factor NF-κB/RelA. J Biol Chem (2014) 0.90
The Mediator subunit MED1/TRAP220 is required for optimal glucocorticoid receptor-mediated transcription activation. Nucleic Acids Res (2007) 0.89
Heterogeneous nuclear ribonucleoprotein R enhances transcription from the naturally configured c-fos promoter in vitro. J Biol Chem (2009) 0.87
Signal-induced transcriptional activation by Dif requires the dTRAP80 mediator module. Mol Cell Biol (2003) 0.87
The mediator complex subunit 1 enhances transcription of genes needed for adrenal androgen production. Endocrinology (2009) 0.84
General molecular biology and architecture of nuclear receptors. Curr Top Med Chem (2012) 0.84
Sp1 and AP2 regulate but do not constitute TATA-less human TAF(II)55 core promoter activity. Nucleic Acids Res (2002) 0.84
Coactivation of estrogen receptor alpha (ER alpha)/Sp1 by vitamin D receptor interacting protein 150 (DRIP150). Arch Biochem Biophys (2007) 0.83
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