Published in Nature on February 04, 1999
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Structural organization of yeast and mammalian mediator complexes. Proc Natl Acad Sci U S A (2000) 1.76
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Leptin stimulates fatty acid oxidation and peroxisome proliferator-activated receptor alpha gene expression in mouse C2C12 myoblasts by changing the subcellular localization of the alpha2 form of AMP-activated protein kinase. Mol Cell Biol (2007) 1.62
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Functional characterization of core promoter elements: the downstream core element is recognized by TAF1. Mol Cell Biol (2005) 1.46
TFIID and human mediator coactivator complexes assemble cooperatively on promoter DNA. Genes Dev (2002) 1.45
Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator. Proc Natl Acad Sci U S A (2000) 1.43
Recruitment of N-CoR/SMRT-TBLR1 corepressor complex by unliganded thyroid hormone receptor for gene repression during frog development. Mol Cell Biol (2004) 1.43
Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2. J Biol Chem (2001) 1.41
The DRIP complex and SRC-1/p160 coactivators share similar nuclear receptor binding determinants but constitute functionally distinct complexes. Mol Cell Biol (2000) 1.38
The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development. EMBO J (2002) 1.38
Drosophila homologs of transcriptional mediator complex subunits are required for adult cell and segment identity specification. Genes Dev (2000) 1.34
Conservation of glutamine-rich transactivation function between yeast and humans. Mol Cell Biol (2000) 1.32
Ubiquitous expression and embryonic requirement for RNA polymerase II coactivator subunit Srb7 in mice. Genes Dev (1999) 1.31
TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4. Mol Cell Biol (2002) 1.31
Smads orchestrate specific histone modifications and chromatin remodeling to activate transcription. EMBO J (2006) 1.30
Two modes of transcriptional activation at native promoters by NF-kappaB p65. PLoS Biol (2009) 1.25
Members of the SAGA and Mediator complexes are partners of the transcription elongation factor TFIIS. EMBO J (2004) 1.24
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Transcription initiation by human RNA polymerase II visualized at single-molecule resolution. Genes Dev (2012) 1.24
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Specific structural motifs determine TRAP220 interactions with nuclear hormone receptors. Mol Cell Biol (2000) 1.23
Origins and activity of the Mediator complex. Semin Cell Dev Biol (2011) 1.23
Activator-independent functions of the yeast mediator sin4 complex in preinitiation complex formation and transcription reinitiation. Mol Cell Biol (2003) 1.22
Role of metazoan mediator proteins in interferon-responsive transcription. Mol Cell Biol (2003) 1.22
Subunit architecture and functional modular rearrangements of the transcriptional mediator complex. Cell (2014) 1.22
Human mediator enhances activator-facilitated recruitment of RNA polymerase II and promoter recognition by TATA-binding protein (TBP) independently of TBP-associated factors. Mol Cell Biol (2003) 1.16
Drosophila Mediator complex is broadly utilized by diverse gene-specific transcription factors at different types of core promoters. Mol Cell Biol (2001) 1.16
Mediator-dependent nuclear receptor function. Semin Cell Dev Biol (2011) 1.12
The new core promoter element XCPE1 (X Core Promoter Element 1) directs activator-, mediator-, and TATA-binding protein-dependent but TFIID-independent RNA polymerase II transcription from TATA-less promoters. Mol Cell Biol (2007) 1.11
Structural and functional characterization of PC2 and RNA polymerase II-associated subpopulations of metazoan Mediator. Mol Cell Biol (2005) 1.10
The Mediator complex in plants: structure, phylogeny, and expression profiling of representative genes in a dicot (Arabidopsis) and a monocot (rice) during reproduction and abiotic stress. Plant Physiol (2011) 1.09
Characterization of mediator complexes from HeLa cell nuclear extract. Mol Cell Biol (2001) 1.09
Characterization of transcription from TATA-less promoters: identification of a new core promoter element XCPE2 and analysis of factor requirements. PLoS One (2009) 1.07
Purification of transcription cofactor complex CRSP. Proc Natl Acad Sci U S A (1999) 1.07
Promoter-proximal regulatory elements involved in oriP-EBNA1-independent and -dependent activation of the Epstein-Barr virus C promoter in B-lymphoid cell lines. J Virol (2001) 1.07
Multiple roles for Med12 in vertebrate endoderm development. Dev Biol (2008) 1.06
Varicella-zoster virus IE62 protein utilizes the human mediator complex in promoter activation. J Virol (2008) 1.02
Nuclear receptors modulate the interaction of Sp1 and GC-rich DNA via ternary complex formation. Biochem J (2000) 0.99
Mediator kinase module and human tumorigenesis. Crit Rev Biochem Mol Biol (2015) 0.98
Robust mRNA transcription in chicken DT40 cells depleted of TAF(II)31 suggests both functional degeneracy and evolutionary divergence. Mol Cell Biol (2000) 0.97
Phosphorylation of transcription factor Sp1 during herpes simplex virus type 1 infection. J Virol (2002) 0.96
Selenium inhibition of survivin expression by preventing Sp1 binding to its promoter. Mol Cancer Ther (2007) 0.96
Caenorhabditis elegans mediator complexes are required for developmental-specific transcriptional activation. Proc Natl Acad Sci U S A (1999) 0.95
Elevated MED28 expression predicts poor outcome in women with breast cancer. BMC Cancer (2010) 0.94
External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator. Proc Natl Acad Sci U S A (2002) 0.94
Promoter activation by the varicella-zoster virus major transactivator IE62 and the cellular transcription factor USF. J Virol (2006) 0.94
Transforming growth factor beta/Smad3 signaling regulates IRF-7 function and transcriptional activation of the beta interferon promoter. Mol Cell Biol (2004) 0.93
Spatial organization of RNA polymerase II transcription in the nucleus. Nucleic Acids Res (2000) 0.92
Peroxisome proliferators and peroxisome proliferator-activated receptor alpha: biotic and xenobiotic sensing. Am J Pathol (2004) 0.91
A sequence motif conserved in diverse nuclear proteins identifies a protein interaction domain utilised for nuclear targeting by human TFIIS. Nucleic Acids Res (2006) 0.91
Nuclear respiratory factor 1 plays an essential role in transcriptional initiation from the hepatitis B virus x gene promoter. J Virol (2004) 0.89
Signal-induced transcriptional activation by Dif requires the dTRAP80 mediator module. Mol Cell Biol (2003) 0.87
Recruitment of an RNA polymerase II complex is mediated by the constitutive activation domain in CREB, independently of CREB phosphorylation. Mol Cell Biol (2001) 0.86
Sp1 and AP2 regulate but do not constitute TATA-less human TAF(II)55 core promoter activity. Nucleic Acids Res (2002) 0.84
The metazoan-specific mediator subunit 26 (Med26) is essential for viability and is found at both active genes and pericentric heterochromatin in Drosophila melanogaster. Mol Cell Biol (2014) 0.83
Adenovirus L-E1A activates transcription through mediator complex-dependent recruitment of the super elongation complex. J Virol (2013) 0.83
Chemical perturbation of an intrinsically disordered region of TFIID distinguishes two modes of transcription initiation. Elife (2015) 0.83
Promoter analysis of intestinal genes induced during iron-deprivation reveals enrichment of conserved SP1-like binding sites. BMC Genomics (2007) 0.83
Hepatic TRAP80 selectively regulates lipogenic activity of liver X receptor. J Clin Invest (2014) 0.82
Effects of 15d-PGJ(2) on VEGF-induced angiogenic activities and expression of VEGF receptors in endothelial cells. Prostaglandins Other Lipid Mediat (2006) 0.82
Transcriptional regulation of human 3'-phosphoadenosine 5'-phosphosulphate synthase 2. Biochem J (2002) 0.81
The Med1 subunit of the mediator complex induces liver cell proliferation and is phosphorylated by AMP kinase. J Biol Chem (2013) 0.81
Drosophila Med6 is required for elevated expression of a large but distinct set of developmentally regulated genes. Mol Cell Biol (2001) 0.81
Activator-mediator binding stabilizes RNA polymerase II orientation within the human mediator-RNA polymerase II-TFIIF assembly. J Mol Biol (2012) 0.81
Constitutive expression of murine decay-accelerating factor 1 is controlled by the transcription factor Sp1. J Immunol (2006) 0.81
Mithramycin targets sp1 and the androgen receptor transcription level-potential therapeutic role in advanced prostate cancer. Transl Oncogenomics (2006) 0.79
Genome-Wide Gene Expression Analysis Shows AKAP13-Mediated PKD1 Signaling Regulates the Transcriptional Response to Cardiac Hypertrophy. PLoS One (2015) 0.78
Differential roles of transcriptional mediator complex subunits Crsp34/Med27, Crsp150/Med14 and Trap100/Med24 during zebrafish retinal development. Genetics (2006) 0.78
Architecture of the human XPC DNA repair and stem cell coactivator complex. Proc Natl Acad Sci U S A (2015) 0.77
Specificity proteins Sp1 and Sp3 interact with the rat GTP cyclohydrolase I proximal promoter to regulate transcription. J Neurochem (2007) 0.77
Identification of mediator complex 26 (Crsp7) gametologs on platypus X1 and Y5 sex chromosomes: a candidate testis-determining gene in monotremes? Chromosome Res (2012) 0.77
Small molecule probes to target the human Mediator complex. Isr J Chem (2013) 0.76
Bilaterian-like promoters in the highly compact Amphimedon queenslandica genome. Sci Rep (2016) 0.75
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