Published in Circ Res on July 07, 2005
Human atrial action potential and Ca2+ model: sinus rhythm and chronic atrial fibrillation. Circ Res (2011) 1.82
Adrenergic nervous system in heart failure: pathophysiology and therapy. Circ Res (2013) 1.62
Beta-adrenergic stimulation and myocardial function in the failing heart. Heart Fail Rev (2009) 1.40
Phospholemman inhibition of the cardiac Na+/Ca2+ exchanger. Role of phosphorylation. J Biol Chem (2006) 1.39
Phospholemman-mediated activation of Na/K-ATPase limits [Na]i and inotropic state during beta-adrenergic stimulation in mouse ventricular myocytes. Circulation (2008) 1.27
Regulation of intracellular and mitochondrial sodium in health and disease. Circ Res (2009) 1.24
Structure of the Na,K-ATPase regulatory protein FXYD1 in micelles. Biochemistry (2007) 1.23
Isoform specificity of the Na/K-ATPase association and regulation by phospholemman. J Biol Chem (2009) 1.23
Regulation of cardiac myocyte contractility by phospholemman: Na+/Ca2+ exchange versus Na+ -K+ -ATPase. Am J Physiol Heart Circ Physiol (2008) 1.22
FXYD1 phosphorylation in vitro and in adult rat cardiac myocytes: threonine 69 is a novel substrate for protein kinase C. Am J Physiol Cell Physiol (2009) 1.20
Altered contractility and [Ca2+]i homeostasis in phospholemman-deficient murine myocytes: role of Na+/Ca2+ exchange. Am J Physiol Heart Circ Physiol (2006) 1.16
Na⁺ transport in the normal and failing heart - remember the balance. J Mol Cell Cardiol (2013) 1.14
Phospholemman modulates the gating of cardiac L-type calcium channels. Biophys J (2010) 1.08
Na+/Ca2+ exchange and Na+/K+-ATPase in the heart. J Physiol (2015) 1.06
Induced overexpression of Na+/Ca2+ exchanger transgene: altered myocyte contractility, [Ca2+]i transients, SR Ca2+ contents, and action potential duration. Am J Physiol Heart Circ Physiol (2009) 1.06
Regulation of in vivo cardiac contractility by phospholemman: role of Na+/Ca2+ exchange. Am J Physiol Heart Circ Physiol (2010) 1.06
Phospholemman and beta-adrenergic stimulation in the heart. Am J Physiol Heart Circ Physiol (2009) 1.05
Measuring local gradients of intramitochondrial [Ca(2+)] in cardiac myocytes during sarcoplasmic reticulum Ca(2+) release. Circ Res (2012) 1.05
Cytoplasmic tail of phospholemman interacts with the intracellular loop of the cardiac Na+/Ca2+ exchanger. J Biol Chem (2006) 1.02
Constitutive overexpression of phosphomimetic phospholemman S68E mutant results in arrhythmias, early mortality, and heart failure: potential involvement of Na+/Ca2+ exchanger. Am J Physiol Heart Circ Physiol (2011) 1.01
Redox regulation of sodium and calcium handling. Antioxid Redox Signal (2012) 1.00
Structural basis for the high Ca2+ affinity of the ubiquitous SERCA2b Ca2+ pump. Proc Natl Acad Sci U S A (2009) 0.99
Activation of cAMP-dependent signaling induces oxidative modification of the cardiac Na+-K+ pump and inhibits its activity. J Biol Chem (2010) 0.98
A mathematical model of action potentials of mouse sinoatrial node cells with molecular bases. Am J Physiol Heart Circ Physiol (2011) 0.98
Extracellular potassium dependence of the Na+-K+-ATPase in cardiac myocytes: isoform specificity and effect of phospholemman. Am J Physiol Cell Physiol (2009) 0.97
Phosphomimetic mutations enhance oligomerization of phospholemman and modulate its interaction with the Na/K-ATPase. J Biol Chem (2011) 0.96
Na/K pump regulation of cardiac repolarization: insights from a systems biology approach. Pflugers Arch (2013) 0.95
Overexpression of the Na+/K+ ATPase α2 but not α1 isoform attenuates pathological cardiac hypertrophy and remodeling. Circ Res (2013) 0.95
Sodium and proton effects on inward proton transport through Na/K pumps. Biophys J (2014) 0.94
Na/K-ATPase--an integral player in the adrenergic fight-or-flight response. Trends Cardiovasc Med (2009) 0.94
A novel computational model of mouse myocyte electrophysiology to assess the synergy between Na+ loading and CaMKII. J Physiol (2014) 0.94
Tachycardia-induced silencing of subcellular Ca2+ signaling in atrial myocytes. J Clin Invest (2014) 0.93
The human phospholamban Arg14-deletion mutant localizes to plasma membrane and interacts with the Na/K-ATPase. J Mol Cell Cardiol (2011) 0.93
The inhibitory effect of phospholemman on the sodium pump requires its palmitoylation. J Biol Chem (2011) 0.92
Regulation of the cardiac sodium pump. Cell Mol Life Sci (2012) 0.92
A separate pool of cardiac phospholemman that does not regulate or associate with the sodium pump: multimers of phospholemman in ventricular muscle. J Biol Chem (2013) 0.91
Regulation of excitation-contraction coupling in mouse cardiac myocytes: integrative analysis with mathematical modelling. BMC Physiol (2009) 0.91
β-adrenergic effects on cardiac myofilaments and contraction in an integrated rabbit ventricular myocyte model. J Mol Cell Cardiol (2015) 0.90
Na+ transport in cardiac myocytes; Implications for excitation-contraction coupling. IUBMB Life (2009) 0.89
Phospholemman: a novel cardiac stress protein. Clin Transl Sci (2010) 0.89
Phospholemman regulates cardiac Na+/Ca2+ exchanger by interacting with the exchanger's proximal linker domain. Am J Physiol Cell Physiol (2009) 0.88
Phospholemman is a negative feed-forward regulator of Ca2+ in β-adrenergic signaling, accelerating β-adrenergic inotropy. J Mol Cell Cardiol (2012) 0.88
Downregulation of miR-151-5p contributes to increased susceptibility to arrhythmogenesis during myocardial infarction with estrogen deprivation. PLoS One (2013) 0.88
Protein kinase-dependent oxidative regulation of the cardiac Na+-K+ pump: evidence from in vivo and in vitro modulation of cell signalling. J Physiol (2013) 0.88
Role of phospholemman phosphorylation sites in mediating kinase-dependent regulation of the Na+-K+-ATPase. Am J Physiol Cell Physiol (2010) 0.87
MRP4 and CFTR in the regulation of cAMP and β-adrenergic contraction in cardiac myocytes. Eur J Pharmacol (2012) 0.87
BAG3 regulates contractility and Ca(2+) homeostasis in adult mouse ventricular myocytes. J Mol Cell Cardiol (2016) 0.86
Amino acid substitutions in the FXYD motif enhance phospholemman-induced modulation of cardiac L-type calcium channels. Am J Physiol Cell Physiol (2010) 0.86
Endurance exercise training reduces cardiac sodium/calcium exchanger expression in animals susceptible to ventricular fibrillation. Front Physiol (2011) 0.85
Na⁺/K⁺-ATPase E960 and phospholemman F28 are critical for their functional interaction. Proc Natl Acad Sci U S A (2012) 0.84
RGS2 overexpression or G(i) inhibition rescues the impaired PKA signaling and slow AP firing of cultured adult rabbit pacemaker cells. J Mol Cell Cardiol (2012) 0.83
Human-induced pluripotent stem cell-derived cardiomyocytes for studies of cardiac ion transporters. Am J Physiol Cell Physiol (2013) 0.83
Nitric oxide regulates cardiac intracellular Na⁺ and Ca²⁺ by modulating Na/K ATPase via PKCε and phospholemman-dependent mechanism. J Mol Cell Cardiol (2013) 0.83
Effects of PKA phosphorylation on the conformation of the Na,K-ATPase regulatory protein FXYD1. Biochim Biophys Acta (2009) 0.83
Transcriptome-guided functional analyses reveal novel biological properties and regulatory hierarchy of human embryonic stem cell-derived ventricular cardiomyocytes crucial for maturation. PLoS One (2013) 0.81
Importance of a Potential Protein Kinase A Phosphorylation Site of Na+,K+-ATPase and Its Interaction Network for Na+ Binding. J Biol Chem (2016) 0.81
Sex differences in repolarization and slow delayed rectifier potassium current and their regulation by sympathetic stimulation in rabbits. Pflugers Arch (2012) 0.80
Residues 248-252 and 300-304 of the cardiac Na+/Ca2+ exchanger are involved in its regulation by phospholemman. Am J Physiol Cell Physiol (2011) 0.79
Induced overexpression of phospholemman S68E mutant improves cardiac contractility and mortality after ischemia-reperfusion. Am J Physiol Heart Circ Physiol (2014) 0.79
Agrin regulation of alpha3 sodium-potassium ATPase activity modulates cardiac myocyte contraction. J Biol Chem (2009) 0.79
Intracellular trafficking of FXYD1 (phospholemman) and FXYD7 proteins in Xenopus oocytes and mammalian cells. J Biol Chem (2012) 0.79
Molecular Mechanisms and Kinetic Effects of FXYD1 and Phosphomimetic Mutants on Purified Human Na,K-ATPase. J Biol Chem (2015) 0.79
"Oxygen Sensing" by Na,K-ATPase: These Miraculous Thiols. Front Physiol (2016) 0.79
Regulation of L-type calcium channel by phospholemman in cardiac myocytes. J Mol Cell Cardiol (2015) 0.78
Importance of the Voltage Dependence of Cardiac Na/K ATPase Isozymes. Biophys J (2015) 0.78
Effect of thyroid hormone on the distribution and activity of Na, K-ATPase in ventricular myocardium. Arch Biochem Biophys (2008) 0.77
Regulation of intracellular Na(+) in health and disease: pathophysiological mechanisms and implications for treatment. Glob Cardiol Sci Pract (2013) 0.77
Phospholemman deficiency in postinfarct hearts: enhanced contractility but increased mortality. Clin Transl Sci (2012) 0.76
Pyruvate stabilizes electrocardiographic and hemodynamic function in pigs recovering from cardiac arrest. Exp Biol Med (Maywood) (2015) 0.75
Profound regulation of Na/K pump activity by transient elevations of cytoplasmic calcium in murine cardiac myocytes. Elife (2016) 0.75
Impact of phosphomimetic and non-phosphorylatable mutations of phospholemman on L-type calcium channels gating in HEK 293T cells. J Cell Mol Med (2015) 0.75
L30A Mutation of Phospholemman Mimics Effects of Cardiac Glycosides in Isolated Cardiomyocytes. Biochemistry (2016) 0.75
A compartmentalized mathematical model of the β1-adrenergic signaling system in mouse ventricular myocytes. PLoS One (2014) 0.75
Early vertebrate origin and diversification of small transmembrane regulators of cellular ion transport. J Physiol (2017) 0.75
Phospholemman, a major regulator of skeletal muscle Na(+)/K(+)-ATPase, is not mutated in probands with hypokalemic periodic paralysis. Exp Ther Med (2017) 0.75
Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure. Circ Res (2005) 5.34
The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure. Circ Res (2003) 4.13
Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling. J Clin Invest (2006) 3.72
A mathematical treatment of integrated Ca dynamics within the ventricular myocyte. Biophys J (2004) 3.72
Ca2+ scraps: local depletions of free [Ca2+] in cardiac sarcoplasmic reticulum during contractions leave substantial Ca2+ reserve. Circ Res (2003) 3.47
Beta-adrenergic enhancement of sarcoplasmic reticulum calcium leak in cardiac myocytes is mediated by calcium/calmodulin-dependent protein kinase. Circ Res (2007) 3.46
Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels. J Clin Invest (2006) 3.33
Ca2+/Calmodulin-dependent protein kinase II phosphorylation of ryanodine receptor does affect calcium sparks in mouse ventricular myocytes. Circ Res (2006) 3.26
Elevated sarcoplasmic reticulum Ca2+ leak in intact ventricular myocytes from rabbits in heart failure. Circ Res (2003) 3.04
Transgenic CaMKIIdeltaC overexpression uniquely alters cardiac myocyte Ca2+ handling: reduced SR Ca2+ load and activated SR Ca2+ release. Circ Res (2003) 3.04
Cellular basis of triggered arrhythmias in heart failure. Trends Cardiovasc Med (2004) 2.97
Quantitative assessment of the SR Ca2+ leak-load relationship. Circ Res (2002) 2.93
Cellular basis of abnormal calcium transients of failing human ventricular myocytes. Circ Res (2003) 2.86
SparkMaster: automated calcium spark analysis with ImageJ. Am J Physiol Cell Physiol (2007) 2.84
Hypercontractile female hearts exhibit increased S-nitrosylation of the L-type Ca2+ channel alpha1 subunit and reduced ischemia/reperfusion injury. Circ Res (2006) 2.84
CaMKII in myocardial hypertrophy and heart failure. J Mol Cell Cardiol (2011) 2.65
Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity. Circulation (2013) 2.57
Increased sarcoplasmic reticulum calcium leak but unaltered contractility by acute CaMKII overexpression in isolated rabbit cardiac myocytes. Circ Res (2005) 2.50
A novel computational model of the human ventricular action potential and Ca transient. J Mol Cell Cardiol (2009) 2.36
Abnormal calcium handling properties underlie familial hypertrophic cardiomyopathy pathology in patient-specific induced pluripotent stem cells. Cell Stem Cell (2013) 2.33
Intracellular Na(+) concentration is elevated in heart failure but Na/K pump function is unchanged. Circulation (2002) 2.32
Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure. Circulation (2010) 2.32
Role of Ca2+/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heart. Cardiovasc Res (2006) 2.30
Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks. Circ Res (2010) 2.29
Approximate model of cooperative activation and crossbridge cycling in cardiac muscle using ordinary differential equations. Biophys J (2008) 2.29
Sarcoplasmic reticulum Ca2+ and heart failure: roles of diastolic leak and Ca2+ transport. Circ Res (2003) 2.28
Sarcoplasmic reticulum and nuclear envelope are one highly interconnected Ca2+ store throughout cardiac myocyte. Circ Res (2006) 2.27
Cardiac alternans do not rely on diastolic sarcoplasmic reticulum calcium content fluctuations. Circ Res (2006) 2.25
Na(+)-Ca(2+) exchange current and submembrane [Ca(2+)] during the cardiac action potential. Circ Res (2002) 2.21
Termination of cardiac Ca2+ sparks: role of intra-SR [Ca2+], release flux, and intra-SR Ca2+ diffusion. Circ Res (2008) 2.12
Phospholamban ablation rescues sarcoplasmic reticulum Ca(2+) handling but exacerbates cardiac dysfunction in CaMKIIdelta(C) transgenic mice. Circ Res (2009) 2.12
Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation. Nature (2013) 2.08
Protein kinase A phosphorylation of the ryanodine receptor does not affect calcium sparks in mouse ventricular myocytes. Circ Res (2002) 2.06
Ca²+ spark-dependent and -independent sarcoplasmic reticulum Ca²+ leak in normal and failing rabbit ventricular myocytes. J Physiol (2010) 2.01
Voltage dependence of cardiac excitation-contraction coupling: unitary Ca2+ current amplitude and open channel probability. Circ Res (2007) 1.96
Calcium, calmodulin, and calcium-calmodulin kinase II: heartbeat to heartbeat and beyond. J Mol Cell Cardiol (2002) 1.94
Expression and phosphorylation of the na-pump regulatory subunit phospholemman in heart failure. Circ Res (2005) 1.92
Long-term outcomes of early-stage nasopharyngeal carcinoma patients treated with intensity-modulated radiotherapy alone. Int J Radiat Oncol Biol Phys (2010) 1.91
Phospholemman phosphorylation mediates the protein kinase C-dependent effects on Na+/K+ pump function in cardiac myocytes. Circ Res (2006) 1.89
Frequency-dependent acceleration of relaxation in the heart depends on CaMKII, but not phospholamban. J Mol Cell Cardiol (2002) 1.82
Human atrial action potential and Ca2+ model: sinus rhythm and chronic atrial fibrillation. Circ Res (2011) 1.82
Modulation of excitation-contraction coupling by isoproterenol in cardiomyocytes with controlled SR Ca2+ load and Ca2+ current trigger. J Physiol (2004) 1.81
Characterization of the phospholemman knockout mouse heart: depressed left ventricular function with increased Na-K-ATPase activity. Am J Physiol Heart Circ Physiol (2007) 1.77
Reactive oxygen species-activated Ca/calmodulin kinase IIδ is required for late I(Na) augmentation leading to cellular Na and Ca overload. Circ Res (2011) 1.69
Results of a phase 2 study examining the effects of omitting elective neck irradiation to nodal levels IV and Vb in patients with N(0-1) nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys (2012) 1.68
Intracellular [Na+] and Na+ pump rate in rat and rabbit ventricular myocytes. J Physiol (2002) 1.67
Calcium and cardiac rhythms: physiological and pathophysiological. Circ Res (2002) 1.67
Cardiac type 2 inositol 1,4,5-trisphosphate receptor: interaction and modulation by calcium/calmodulin-dependent protein kinase II. J Biol Chem (2005) 1.64
CaMKIIdelta isoforms differentially affect calcium handling but similarly regulate HDAC/MEF2 transcriptional responses. J Biol Chem (2007) 1.64
Dynamic changes in free Ca-calmodulin levels in adult cardiac myocytes. J Mol Cell Cardiol (2006) 1.62
Calmodulin mediates differential sensitivity of CaMKII and calcineurin to local Ca2+ in cardiac myocytes. Biophys J (2008) 1.61
A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function. Circ Res (2011) 1.61
AKAP150 contributes to enhanced vascular tone by facilitating large-conductance Ca2+-activated K+ channel remodeling in hyperglycemia and diabetes mellitus. Circ Res (2013) 1.59
Ca2+/calmodulin-dependent protein kinase IIdelta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failure. Circ Res (2008) 1.58
Ryanodine receptor phosphorylation at Serine 2030, 2808 and 2814 in rat cardiomyocytes. Biochem Biophys Res Commun (2008) 1.57
Nitroxyl improves cellular heart function by directly enhancing cardiac sarcoplasmic reticulum Ca2+ cycling. Circ Res (2006) 1.56
Impaired contractile function and calcium handling in hearts of cardiac-specific calcineurin b1-deficient mice. Am J Physiol Heart Circ Physiol (2009) 1.56
Screening drug-induced arrhythmia [corrected] using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays. Circulation (2013) 1.54
Local β-adrenergic stimulation overcomes source-sink mismatch to generate focal arrhythmia. Circ Res (2012) 1.53
Sarcoplasmic reticulum calcium overloading in junctin deficiency enhances cardiac contractility but increases ventricular automaticity. Circulation (2007) 1.51
Deranged sodium to sudden death. J Physiol (2015) 1.51
CaMKII inhibition targeted to the sarcoplasmic reticulum inhibits frequency-dependent acceleration of relaxation and Ca2+ current facilitation. J Mol Cell Cardiol (2006) 1.51
Modulation of SR Ca release by luminal Ca and calsequestrin in cardiac myocytes: effects of CASQ2 mutations linked to sudden cardiac death. Biophys J (2008) 1.49
Regulation of cardiac sarcoplasmic reticulum Ca release by luminal [Ca] and altered gating assessed with a mathematical model. Biophys J (2005) 1.47
Simultaneous measurements of mitochondrial NADH and Ca(2+) during increased work in intact rat heart trabeculae. Biophys J (2002) 1.47
Simulation of Ca-calmodulin-dependent protein kinase II on rabbit ventricular myocyte ion currents and action potentials. Biophys J (2007) 1.45
Spatiotemporal characteristics of SR Ca(2+) uptake and release in detubulated rat ventricular myocytes. J Mol Cell Cardiol (2005) 1.42
Biosensors to measure inositol 1,4,5-trisphosphate concentration in living cells with spatiotemporal resolution. J Biol Chem (2005) 1.42
Decreased cardiac L-type Ca²⁺ channel activity induces hypertrophy and heart failure in mice. J Clin Invest (2011) 1.41
Assessment of the delta opioid agonist DADLE in a rat model of lethal hemorrhage treated by emergency preservation and resuscitation. Resuscitation (2008) 1.41
Regulation of Ca2+ and Na+ in normal and failing cardiac myocytes. Ann N Y Acad Sci (2006) 1.41
[Intensity modulated radiotherapy for local-regional advanced nasopharyngeal carcinoma]. Ai Zheng (2004) 1.41
Partial inhibition of sarcoplasmic reticulum ca release evokes long-lasting ca release events in ventricular myocytes: role of luminal ca in termination of ca release. Biophys J (2007) 1.40
Ca sparks do not explain all ryanodine receptor-mediated SR Ca leak in mouse ventricular myocytes. Biophys J (2010) 1.39
Phospholemman inhibition of the cardiac Na+/Ca2+ exchanger. Role of phosphorylation. J Biol Chem (2006) 1.39
Ca/calmodulin kinase II differentially modulates potassium currents. Circ Arrhythm Electrophysiol (2009) 1.37
Intra-sarcoplasmic reticulum free [Ca2+] and buffering in arrhythmogenic failing rabbit heart. Circ Res (2007) 1.37
Na(+)/K)+)-ATPase α2-isoform preferentially modulates Ca2(+) transients and sarcoplasmic reticulum Ca2(+) release in cardiac myocytes. Cardiovasc Res (2012) 1.36
Temporal dissociation of frequency-dependent acceleration of relaxation and protein phosphorylation by CaMKII. J Mol Cell Cardiol (2006) 1.35
The IP3 receptor regulates cardiac hypertrophy in response to select stimuli. Circ Res (2010) 1.34
Hypertrophy, increased ejection fraction, and reduced Na-K-ATPase activity in phospholemman-deficient mice. Am J Physiol Heart Circ Physiol (2004) 1.34
Long-term treatment outcome of recurrent nasopharyngeal carcinoma treated with salvage intensity modulated radiotherapy. Eur J Cancer (2012) 1.33
Initial experience using intensity-modulated radiotherapy for recurrent nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys (2004) 1.32
Ryanodine receptor S2808 phosphorylation in heart failure: smoking gun or red herring. Circ Res (2012) 1.31
Spontaneous Ca waves in ventricular myocytes from failing hearts depend on Ca(2+)-calmodulin-dependent protein kinase II. J Mol Cell Cardiol (2010) 1.31
Direct detection of phospholamban and sarcoplasmic reticulum Ca-ATPase interaction in membranes using fluorescence resonance energy transfer. Biochemistry (2004) 1.30
Serine 68 of phospholemman is critical in modulation of contractility, [Ca2+]i transients, and Na+/Ca2+ exchange in adult rat cardiac myocytes. Am J Physiol Heart Circ Physiol (2005) 1.30
Dynamic calcium movement inside cardiac sarcoplasmic reticulum during release. Circ Res (2011) 1.30