Published in J Mol Cell Cardiol on September 01, 2006
Calmodulin mediates differential sensitivity of CaMKII and calcineurin to local Ca2+ in cardiac myocytes. Biophys J (2008) 1.61
Myosin regulatory light chain phosphorylation attenuates cardiac hypertrophy. J Biol Chem (2008) 1.23
Free and bound intracellular calmodulin measurements in cardiac myocytes. Cell Calcium (2006) 1.21
Differential integration of Ca2+-calmodulin signal in intact ventricular myocytes at low and high affinity Ca2+-calmodulin targets. J Biol Chem (2008) 1.06
Mechanisms of disease: detrimental adrenergic signaling in acute decompensated heart failure. Nat Clin Pract Cardiovasc Med (2008) 1.00
Calmodulin binding proteins provide domains of local Ca2+ signaling in cardiac myocytes. J Mol Cell Cardiol (2011) 1.00
Cardiac myocyte Z-line calmodulin is mainly RyR2-bound, and reduction is arrhythmogenic and occurs in heart failure. Circ Res (2013) 0.98
Visualizing CaMKII and CaM activity: a paradigm of compartmentalized signaling. J Mol Med (Berl) (2013) 0.81
Ca(2+)-stimulated adenylyl cyclases regulate the L-type Ca(2+) current in guinea-pig atrial myocytes. J Physiol (2012) 0.79
Biosensor-based approach identifies four distinct calmodulin-binding domains in the G protein-coupled estrogen receptor 1. PLoS One (2014) 0.79
Calcium-dependent energetics of calmodulin domain interactions with regulatory regions of the Ryanodine Receptor Type 1 (RyR1). Biophys Chem (2014) 0.77
Novel fluorescence resonance energy transfer-based reporter reveals differential calcineurin activation in neonatal and adult cardiomyocytes. J Physiol (2015) 0.77
Arrhythmogenic calmodulin mutations impede activation of small-conductance calcium-activated potassium current. Heart Rhythm (2016) 0.76
Divergent Soybean Calmodulins Respond Similarly to Calcium Transients: Insight into Differential Target Regulation. Front Plant Sci (2017) 0.75
S100A1 Protein Does Not Compete with Calmodulin for Ryanodine Receptor Binding but Structurally Alters the Ryanodine Receptor·Calmodulin Complex. J Biol Chem (2016) 0.75
Swallowing a spider to catch a fly: Ca-calmodulin dynamics in adult cardiomyocytes. J Mol Cell Cardiol (2006) 0.75
Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure. Circ Res (2005) 5.34
The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure. Circ Res (2003) 4.13
Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling. J Clin Invest (2006) 3.72
A mathematical treatment of integrated Ca dynamics within the ventricular myocyte. Biophys J (2004) 3.72
Ca2+ scraps: local depletions of free [Ca2+] in cardiac sarcoplasmic reticulum during contractions leave substantial Ca2+ reserve. Circ Res (2003) 3.47
Beta-adrenergic enhancement of sarcoplasmic reticulum calcium leak in cardiac myocytes is mediated by calcium/calmodulin-dependent protein kinase. Circ Res (2007) 3.46
Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels. J Clin Invest (2006) 3.33
Ca2+/Calmodulin-dependent protein kinase II phosphorylation of ryanodine receptor does affect calcium sparks in mouse ventricular myocytes. Circ Res (2006) 3.26
Elevated sarcoplasmic reticulum Ca2+ leak in intact ventricular myocytes from rabbits in heart failure. Circ Res (2003) 3.04
Transgenic CaMKIIdeltaC overexpression uniquely alters cardiac myocyte Ca2+ handling: reduced SR Ca2+ load and activated SR Ca2+ release. Circ Res (2003) 3.04
Cellular basis of triggered arrhythmias in heart failure. Trends Cardiovasc Med (2004) 2.97
Quantitative assessment of the SR Ca2+ leak-load relationship. Circ Res (2002) 2.93
Cellular basis of abnormal calcium transients of failing human ventricular myocytes. Circ Res (2003) 2.86
SparkMaster: automated calcium spark analysis with ImageJ. Am J Physiol Cell Physiol (2007) 2.84
Hypercontractile female hearts exhibit increased S-nitrosylation of the L-type Ca2+ channel alpha1 subunit and reduced ischemia/reperfusion injury. Circ Res (2006) 2.84
CaMKII in myocardial hypertrophy and heart failure. J Mol Cell Cardiol (2011) 2.65
Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity. Circulation (2013) 2.57
HSP72 protects against obesity-induced insulin resistance. Proc Natl Acad Sci U S A (2008) 2.52
Increased sarcoplasmic reticulum calcium leak but unaltered contractility by acute CaMKII overexpression in isolated rabbit cardiac myocytes. Circ Res (2005) 2.50
A novel computational model of the human ventricular action potential and Ca transient. J Mol Cell Cardiol (2009) 2.36
Abnormal calcium handling properties underlie familial hypertrophic cardiomyopathy pathology in patient-specific induced pluripotent stem cells. Cell Stem Cell (2013) 2.33
Intracellular Na(+) concentration is elevated in heart failure but Na/K pump function is unchanged. Circulation (2002) 2.32
Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure. Circulation (2010) 2.32
Role of Ca2+/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heart. Cardiovasc Res (2006) 2.30
Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks. Circ Res (2010) 2.29
Approximate model of cooperative activation and crossbridge cycling in cardiac muscle using ordinary differential equations. Biophys J (2008) 2.29
Sarcoplasmic reticulum Ca2+ and heart failure: roles of diastolic leak and Ca2+ transport. Circ Res (2003) 2.28
Sarcoplasmic reticulum and nuclear envelope are one highly interconnected Ca2+ store throughout cardiac myocyte. Circ Res (2006) 2.27
Cardiac alternans do not rely on diastolic sarcoplasmic reticulum calcium content fluctuations. Circ Res (2006) 2.25
Na(+)-Ca(2+) exchange current and submembrane [Ca(2+)] during the cardiac action potential. Circ Res (2002) 2.21
Termination of cardiac Ca2+ sparks: role of intra-SR [Ca2+], release flux, and intra-SR Ca2+ diffusion. Circ Res (2008) 2.12
Phospholamban ablation rescues sarcoplasmic reticulum Ca(2+) handling but exacerbates cardiac dysfunction in CaMKIIdelta(C) transgenic mice. Circ Res (2009) 2.12
Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation. Nature (2013) 2.08
Protein kinase A phosphorylation of the ryanodine receptor does not affect calcium sparks in mouse ventricular myocytes. Circ Res (2002) 2.06
Ca²+ spark-dependent and -independent sarcoplasmic reticulum Ca²+ leak in normal and failing rabbit ventricular myocytes. J Physiol (2010) 2.01
Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a therapeutic approach. Hum Mol Genet (2004) 2.00
Voltage dependence of cardiac excitation-contraction coupling: unitary Ca2+ current amplitude and open channel probability. Circ Res (2007) 1.96
Phospholemman-phosphorylation mediates the beta-adrenergic effects on Na/K pump function in cardiac myocytes. Circ Res (2005) 1.94
Calcium, calmodulin, and calcium-calmodulin kinase II: heartbeat to heartbeat and beyond. J Mol Cell Cardiol (2002) 1.94
Aberrant protein aggregation is essential for a mutant desmin to impair the proteolytic function of the ubiquitin-proteasome system in cardiomyocytes. J Mol Cell Cardiol (2006) 1.93
Expression and phosphorylation of the na-pump regulatory subunit phospholemman in heart failure. Circ Res (2005) 1.92
Phospholemman phosphorylation mediates the protein kinase C-dependent effects on Na+/K+ pump function in cardiac myocytes. Circ Res (2006) 1.89
Real-time evaluation of myosin light chain kinase activation in smooth muscle tissues from a transgenic calmodulin-biosensor mouse. Proc Natl Acad Sci U S A (2004) 1.88
Frequency-dependent acceleration of relaxation in the heart depends on CaMKII, but not phospholamban. J Mol Cell Cardiol (2002) 1.82
Human atrial action potential and Ca2+ model: sinus rhythm and chronic atrial fibrillation. Circ Res (2011) 1.82
Losing heart: the role of apoptosis in heart disease--a novel therapeutic target? FASEB J (2002) 1.81
Modulation of excitation-contraction coupling by isoproterenol in cardiomyocytes with controlled SR Ca2+ load and Ca2+ current trigger. J Physiol (2004) 1.81
Reactive oxygen species-activated Ca/calmodulin kinase IIδ is required for late I(Na) augmentation leading to cellular Na and Ca overload. Circ Res (2011) 1.69
Impairment of the ubiquitin-proteasome system in desminopathy mouse hearts. FASEB J (2005) 1.68
Intracellular [Na+] and Na+ pump rate in rat and rabbit ventricular myocytes. J Physiol (2002) 1.67
Calcium and cardiac rhythms: physiological and pathophysiological. Circ Res (2002) 1.67
Cardiac type 2 inositol 1,4,5-trisphosphate receptor: interaction and modulation by calcium/calmodulin-dependent protein kinase II. J Biol Chem (2005) 1.64
CaMKIIdelta isoforms differentially affect calcium handling but similarly regulate HDAC/MEF2 transcriptional responses. J Biol Chem (2007) 1.64
Calmodulin mediates differential sensitivity of CaMKII and calcineurin to local Ca2+ in cardiac myocytes. Biophys J (2008) 1.61
A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function. Circ Res (2011) 1.61
A promoter polymorphism of the endothelial nitric oxide synthase gene is associated with reduced mRNA and protein expression in failing human myocardium. J Card Fail (2010) 1.60
AKAP150 contributes to enhanced vascular tone by facilitating large-conductance Ca2+-activated K+ channel remodeling in hyperglycemia and diabetes mellitus. Circ Res (2013) 1.59
Ca2+/calmodulin-dependent protein kinase IIdelta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failure. Circ Res (2008) 1.58
Ryanodine receptor phosphorylation at Serine 2030, 2808 and 2814 in rat cardiomyocytes. Biochem Biophys Res Commun (2008) 1.57
Nitroxyl improves cellular heart function by directly enhancing cardiac sarcoplasmic reticulum Ca2+ cycling. Circ Res (2006) 1.56
Overexpression of HSP70 in mouse skeletal muscle protects against muscle damage and age-related muscle dysfunction. FASEB J (2003) 1.56
Impaired contractile function and calcium handling in hearts of cardiac-specific calcineurin b1-deficient mice. Am J Physiol Heart Circ Physiol (2009) 1.56
Screening drug-induced arrhythmia [corrected] using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays. Circulation (2013) 1.54
Local β-adrenergic stimulation overcomes source-sink mismatch to generate focal arrhythmia. Circ Res (2012) 1.53
Sarcoplasmic reticulum calcium overloading in junctin deficiency enhances cardiac contractility but increases ventricular automaticity. Circulation (2007) 1.51
Deranged sodium to sudden death. J Physiol (2015) 1.51
CaMKII inhibition targeted to the sarcoplasmic reticulum inhibits frequency-dependent acceleration of relaxation and Ca2+ current facilitation. J Mol Cell Cardiol (2006) 1.51
Modulation of SR Ca release by luminal Ca and calsequestrin in cardiac myocytes: effects of CASQ2 mutations linked to sudden cardiac death. Biophys J (2008) 1.49
Regulation of cardiac sarcoplasmic reticulum Ca release by luminal [Ca] and altered gating assessed with a mathematical model. Biophys J (2005) 1.47
Simultaneous measurements of mitochondrial NADH and Ca(2+) during increased work in intact rat heart trabeculae. Biophys J (2002) 1.47
Simulation of Ca-calmodulin-dependent protein kinase II on rabbit ventricular myocyte ion currents and action potentials. Biophys J (2007) 1.45
Troponin I levels in patients with preeclampsia. Am J Med (2007) 1.45
Spatiotemporal characteristics of SR Ca(2+) uptake and release in detubulated rat ventricular myocytes. J Mol Cell Cardiol (2005) 1.42
Biosensors to measure inositol 1,4,5-trisphosphate concentration in living cells with spatiotemporal resolution. J Biol Chem (2005) 1.42
Decreased cardiac L-type Ca²⁺ channel activity induces hypertrophy and heart failure in mice. J Clin Invest (2011) 1.41
Regulation of Ca2+ and Na+ in normal and failing cardiac myocytes. Ann N Y Acad Sci (2006) 1.41
Partial inhibition of sarcoplasmic reticulum ca release evokes long-lasting ca release events in ventricular myocytes: role of luminal ca in termination of ca release. Biophys J (2007) 1.40
Ca sparks do not explain all ryanodine receptor-mediated SR Ca leak in mouse ventricular myocytes. Biophys J (2010) 1.39
Ca/calmodulin kinase II differentially modulates potassium currents. Circ Arrhythm Electrophysiol (2009) 1.37
Intra-sarcoplasmic reticulum free [Ca2+] and buffering in arrhythmogenic failing rabbit heart. Circ Res (2007) 1.37
Na(+)/K)+)-ATPase α2-isoform preferentially modulates Ca2(+) transients and sarcoplasmic reticulum Ca2(+) release in cardiac myocytes. Cardiovasc Res (2012) 1.36
Temporal dissociation of frequency-dependent acceleration of relaxation and protein phosphorylation by CaMKII. J Mol Cell Cardiol (2006) 1.35
Hsp10 and Hsp60 modulate Bcl-2 family and mitochondria apoptosis signaling induced by doxorubicin in cardiac muscle cells. J Mol Cell Cardiol (2003) 1.34
The IP3 receptor regulates cardiac hypertrophy in response to select stimuli. Circ Res (2010) 1.34
Effect of lifelong overexpression of HSP70 in skeletal muscle on age-related oxidative stress and adaptation after nondamaging contractile activity. FASEB J (2006) 1.32
Interleukin-18 is a pro-hypertrophic cytokine that acts through a phosphatidylinositol 3-kinase-phosphoinositide-dependent kinase-1-Akt-GATA4 signaling pathway in cardiomyocytes. J Biol Chem (2004) 1.32
Monitoring the total available calmodulin concentration in intact cells over the physiological range in free Ca2+. Cell Calcium (2004) 1.31
Targeted overexpression of sarcolipin in the mouse heart decreases sarcoplasmic reticulum calcium transport and cardiac contractility. J Biol Chem (2005) 1.31
Spontaneous Ca waves in ventricular myocytes from failing hearts depend on Ca(2+)-calmodulin-dependent protein kinase II. J Mol Cell Cardiol (2010) 1.31
Ryanodine receptor S2808 phosphorylation in heart failure: smoking gun or red herring. Circ Res (2012) 1.31
Dynamic calcium movement inside cardiac sarcoplasmic reticulum during release. Circ Res (2011) 1.30
Intracellular coupling via limiting calmodulin. J Biol Chem (2003) 1.30
Phospholamban oligomerization, quaternary structure, and sarco(endo)plasmic reticulum calcium ATPase binding measured by fluorescence resonance energy transfer in living cells. J Biol Chem (2008) 1.29
Akt regulates L-type Ca2+ channel activity by modulating Cavalpha1 protein stability. J Cell Biol (2009) 1.28