Published in Arch Neurol on July 01, 2005
Epidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention. Dialogues Clin Neurosci (2009) 2.86
Angiotensin-converting enzyme inhibitors and cognitive decline in older adults with hypertension: results from the Cardiovascular Health Study. Arch Intern Med (2009) 2.82
A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease. Neurology (2011) 2.35
Age-varying association between statin use and incident Alzheimer's disease. J Am Geriatr Soc (2010) 2.34
Lower low-density lipoprotein cholesterol levels are associated with Parkinson's disease. Mov Disord (2007) 2.24
Vascular risk factors, cognitive decline, and dementia. Vasc Health Risk Manag (2008) 2.13
Effect of statins on a wide range of health outcomes: a cohort study validated by comparison with randomized trials. Br J Clin Pharmacol (2008) 2.03
Simvastatin is associated with a reduced incidence of dementia and Parkinson's disease. BMC Med (2007) 1.72
Alzheimer disease. Dis Mon (2010) 1.64
Association of statin use with cognitive decline in elderly African Americans. Neurology (2007) 1.34
Unintended effects of statins from observational studies in the general population: systematic review and meta-analysis. BMC Med (2014) 1.31
Effects of cardiovascular medications on rate of functional decline in Alzheimer disease. Am J Geriatr Psychiatry (2008) 1.27
Cholesterol level and statin use in Alzheimer disease: II. Review of human trials and recommendations. Arch Neurol (2011) 1.17
Higher serum total cholesterol levels in late middle age are associated with glucose hypometabolism in brain regions affected by Alzheimer's disease and normal aging. Neuroimage (2009) 1.17
Statins, risk of dementia, and cognitive function: secondary analysis of the ginkgo evaluation of memory study. J Stroke Cerebrovasc Dis (2011) 1.12
Modifiable Midlife Risk Factors for Late-Life Cognitive Impairment and Dementia. Curr Psychiatry Rev (2009) 1.09
3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors in the treatment of central nervous system diseases. Arch Neurol (2010) 1.08
Cholesterol: its regulation and role in central nervous system disorders. Cholesterol (2012) 1.08
Molecular insights into amyloid regulation by membrane cholesterol and sphingolipids: common mechanisms in neurodegenerative diseases. Expert Rev Mol Med (2010) 1.04
Increased atherogenic lipoproteins are associated with cognitive impairment: effects of statins and subclinical atherosclerosis. Alzheimer Dis Assoc Disord (2009) 1.02
Adult Changes in Thought study: dementia is an individually varying convergent syndrome with prevalent clinically silent diseases that may be modified by some commonly used therapeutics. Curr Alzheimer Res (2012) 1.01
Current therapeutic targets for the treatment of Alzheimer's disease. Expert Rev Neurother (2010) 0.99
Potential mechanisms linking cholesterol to Alzheimer's disease-like pathology in rabbit brain, hippocampal organotypic slices, and skeletal muscle. J Alzheimers Dis (2008) 0.97
HMGCR is a genetic modifier for risk, age of onset and MCI conversion to Alzheimer's disease in a three cohorts study. Mol Psychiatry (2014) 0.95
Lipid lowering agents, cognitive decline, and dementia: the three-city study. J Alzheimers Dis (2012) 0.95
Neuropsychiatric consequences of cardiovascular medications. Dialogues Clin Neurosci (2007) 0.92
[Stress and optimal ageing]. Z Gerontol Geriatr (2015) 0.90
Interventions for heart disease and their effects on Alzheimer's disease. Neurol Res (2006) 0.87
Use of statins and risk of hospitalization with dementia: a Danish population-based case-control study. Alzheimer Dis Assoc Disord (2009) 0.87
Medications and diet: protective factors for AD? Alzheimer Dis Assoc Disord (2006) 0.85
Statins, cognition, and dementia—systematic review and methodological commentary. Nat Rev Neurol (2015) 0.85
Dyslipidemia and the risk of Alzheimer's disease. Curr Atheroscler Rep (2013) 0.85
Regulation of cerebral cholesterol metabolism in Alzheimer disease. J Investig Med (2012) 0.85
Low-density lipoprotein receptor-related protein 1: a physiological Aβ homeostatic mechanism with multiple therapeutic opportunities. Pharmacol Ther (2012) 0.85
The prevention and treatment of cognitive decline and dementia: An overview of recent research on experimental treatments. Indian J Psychiatry (2009) 0.84
The Cache County Study on Memory in Aging: factors affecting risk of Alzheimer's disease and its progression after onset. Int Rev Psychiatry (2013) 0.84
Evaluation of the global association between cholesterol-associated polymorphisms and Alzheimer's disease suggests a role for rs3846662 and HMGCR splicing in disease risk. Mol Neurodegener (2011) 0.82
Exploiting the diversity of the heat-shock protein family for primary and secondary tauopathy therapeutics. Curr Neuropharmacol (2011) 0.81
Effects of simvastatin on cholesterol metabolism and Alzheimer disease biomarkers. Alzheimer Dis Assoc Disord (2010) 0.81
On cholesterol levels and statins in cognitive decline and Alzheimer disease: progress and setbacks. Alzheimer Dis Assoc Disord (2009) 0.81
Intracellular cholesterol homeostasis and amyloid precursor protein processing. Biochim Biophys Acta (2010) 0.81
Patterns of compensation and vulnerability in normal subjects at risk of Alzheimer's disease. J Alzheimers Dis (2013) 0.80
Statins more than cholesterol lowering agents in Alzheimer disease: their pleiotropic functions as potential therapeutic targets. Biochem Pharmacol (2013) 0.80
Effects of statins on incident dementia in patients with type 2 DM: a population-based retrospective cohort study in Taiwan. PLoS One (2014) 0.80
Possible modification of Alzheimer's disease by statins in midlife: interactions with genetic and non-genetic risk factors. Front Aging Neurosci (2014) 0.80
The impact of cholesterol, DHA, and sphingolipids on Alzheimer's disease. Biomed Res Int (2014) 0.79
Statin users without an APOE-epsilon4 allele have increased insulin resistance. J Alzheimers Dis (2010) 0.78
A review of the potential therapeutic role of statins in the treatment of Alzheimer's disease: current research and opinion. Neuropsychiatr Dis Treat (2013) 0.78
Toward onset prevention of cognitive decline in adults with Down syndrome (the TOP-COG study): study protocol for a randomized controlled trial. Trials (2014) 0.77
Cholesterol, statins, and dementia: what the cardiologist should know. Clin Cardiol (2015) 0.76
Therapeutic interventions targeting Beta amyloid pathogenesis in an aging dog model. Curr Neuropharmacol (2011) 0.76
Effects of human apolipoprotein E isoforms on the amyloid beta-protein concentration and lipid composition in brain low-density membrane domains. J Neurochem (2007) 0.76
Modeling cholesterol metabolism by gene expression profiling in the hippocampus. Mol Biosyst (2011) 0.76
Overcoming Challenges With Statin Therapy. J Am Heart Assoc (2016) 0.76
[Chronic inflammation and biomarkers. Is ageing an expression of chronic inflammation?]. Z Gerontol Geriatr (2011) 0.76
Statins Reduces the Risk of Dementia in Patients with Late-Onset Depression: A Retrospective Cohort Study. PLoS One (2015) 0.75
Towards onset prevention of cognition decline in adults with Down syndrome (The TOP-COG study): A pilot randomised controlled trial. Trials (2016) 0.75
Statins and therapy of Alzheimer's disease: questions of efficacy versus trial design. Alzheimers Res Ther (2012) 0.75
APP Function and Lipids: A Bidirectional Link. Front Mol Neurosci (2017) 0.75
Tocotrienol Affects Oxidative Stress, Cholesterol Homeostasis and the Amyloidogenic Pathway in Neuroblastoma Cells: Consequences for Alzheimer's Disease. Int J Mol Sci (2016) 0.75
Use of statins and antihypertensive medications in relation to risk of long-standing persistent atrial fibrillation. Ann Pharmacother (2015) 0.75
Commentary on "the Atorvastatin/Donepezil in Alzheimer's Disease Study (LEADe): design and baseline characteristics". Alzheimers Dement (2008) 0.75
Multi-Ethnic Study of Atherosclerosis: objectives and design. Am J Epidemiol (2002) 35.63
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Cystatin C and the risk of death and cardiovascular events among elderly persons. N Engl J Med (2005) 15.30
Gait speed and survival in older adults. JAMA (2011) 15.01
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Low-fat dietary pattern and risk of cardiovascular disease: the Women's Health Initiative Randomized Controlled Dietary Modification Trial. JAMA (2006) 12.44
Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med (2006) 12.09
Opioid prescriptions for chronic pain and overdose: a cohort study. Ann Intern Med (2010) 11.99
Genome-wide association study of blood pressure and hypertension. Nat Genet (2009) 11.54
Effectiveness of atypical antipsychotic drugs in patients with Alzheimer's disease. N Engl J Med (2006) 10.89
A roadmap for the prevention of dementia II: Leon Thal Symposium 2008. Alzheimers Dement (2009) 10.21
Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association. Stroke (2011) 10.11
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet (2011) 10.07
Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA (2010) 9.52
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet (2011) 9.23
Coronary artery calcium score and risk classification for coronary heart disease prediction. JAMA (2010) 8.90
Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet (2010) 8.89
Calcium plus vitamin D supplementation and the risk of colorectal cancer. N Engl J Med (2006) 8.73
Estrogen therapy and coronary-artery calcification. N Engl J Med (2007) 8.70
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
The loss of skeletal muscle strength, mass, and quality in older adults: the health, aging and body composition study. J Gerontol A Biol Sci Med Sci (2006) 7.38
Estrogen plus progestin and breast cancer incidence and mortality in postmenopausal women. JAMA (2010) 7.12
Sleep-disordered breathing and mortality: a prospective cohort study. PLoS Med (2009) 7.06
Association of usual sleep duration with hypertension: the Sleep Heart Health Study. Sleep (2006) 6.98
Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults. J Am Geriatr Soc (2006) 6.81
Ethical and practical guidelines for reporting genetic research results to study participants: updated guidelines from a National Heart, Lung, and Blood Institute working group. Circ Cardiovasc Genet (2010) 6.74
Frailty: emergence and consequences in women aged 65 and older in the Women's Health Initiative Observational Study. J Am Geriatr Soc (2005) 6.73
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66
Effects of a physical activity intervention on measures of physical performance: Results of the lifestyle interventions and independence for Elders Pilot (LIFE-P) study. J Gerontol A Biol Sci Med Sci (2006) 6.61
Cystatin C and prognosis for cardiovascular and kidney outcomes in elderly persons without chronic kidney disease. Ann Intern Med (2006) 6.58
Prognostic value of usual gait speed in well-functioning older people--results from the Health, Aging and Body Composition Study. J Am Geriatr Soc (2005) 6.54
Low-fat dietary pattern and risk of invasive breast cancer: the Women's Health Initiative Randomized Controlled Dietary Modification Trial. JAMA (2006) 6.51
Muscle mass, muscle strength, and muscle fat infiltration as predictors of incident mobility limitations in well-functioning older persons. J Gerontol A Biol Sci Med Sci (2005) 6.42
C-reactive protein, fibrinogen, and cardiovascular disease prediction. N Engl J Med (2012) 6.39
Comparison of novel risk markers for improvement in cardiovascular risk assessment in intermediate-risk individuals. JAMA (2012) 6.29
Ginkgo biloba for prevention of dementia: a randomized controlled trial. JAMA (2008) 6.00
Predictors of sleep-disordered breathing in community-dwelling adults: the Sleep Heart Health Study. Arch Intern Med (2002) 5.98
Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia. J Am Med Dir Assoc (2011) 5.96
HIV infection and the risk of acute myocardial infarction. JAMA Intern Med (2013) 5.90
Brachial flow-mediated dilation predicts incident cardiovascular events in older adults: the Cardiovascular Health Study. Circulation (2007) 5.87
Coronary artery calcification compared with carotid intima-media thickness in the prediction of cardiovascular disease incidence: the Multi-Ethnic Study of Atherosclerosis (MESA). Arch Intern Med (2008) 5.86
Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study. JAMA (2002) 5.77
Prospective study of obstructive sleep apnea and incident coronary heart disease and heart failure: the sleep heart health study. Circulation (2010) 5.70
New loci associated with kidney function and chronic kidney disease. Nat Genet (2010) 5.58
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet (2012) 5.48
Loss-of-function mutations in APOC3, triglycerides, and coronary disease. N Engl J Med (2014) 5.47
Markers of inflammation, coagulation, and renal function are elevated in adults with HIV infection. J Infect Dis (2010) 5.35
Genomewide association studies of stroke. N Engl J Med (2009) 5.29
Leukocyte telomere length and cardiovascular disease in the cardiovascular health study. Am J Epidemiol (2006) 5.28
Predictive value of brachial flow-mediated dilation for incident cardiovascular events in a population-based study: the multi-ethnic study of atherosclerosis. Circulation (2009) 5.26
Common variants at ten loci influence QT interval duration in the QTGEN Study. Nat Genet (2009) 5.20
Subclinical hypothyroidism and the risk of coronary heart disease and mortality. JAMA (2010) 5.20
The relationship of left ventricular mass and geometry to incident cardiovascular events: the MESA (Multi-Ethnic Study of Atherosclerosis) study. J Am Coll Cardiol (2008) 5.05
Inflammation as a risk factor for atrial fibrillation. Circulation (2003) 4.95
Developing a national strategy to prevent dementia: Leon Thal Symposium 2009. Alzheimers Dement (2010) 4.85
Prevalence and classification of mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 1. Arch Neurol (2003) 4.82
Mood disorders in the medically ill: scientific review and recommendations. Biol Psychiatry (2005) 4.81
Breast cancer after use of estrogen plus progestin in postmenopausal women. N Engl J Med (2009) 4.80
A genome-wide association study identifies protein quantitative trait loci (pQTLs). PLoS Genet (2008) 4.75
The metabolic syndrome, inflammation, and risk of cognitive decline. JAMA (2004) 4.73
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73
Inflammatory markers and onset of cardiovascular events: results from the Health ABC study. Circulation (2003) 4.67
Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet (2012) 4.63
Cystatin C concentration as a risk factor for heart failure in older adults. Ann Intern Med (2005) 4.57
Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. Nat Genet (2009) 4.56
Leg muscle mass and composition in relation to lower extremity performance in men and women aged 70 to 79: the health, aging and body composition study. J Am Geriatr Soc (2002) 4.55
Aging and infectious diseases: workshop on HIV infection and aging: what is known and future research directions. Clin Infect Dis (2008) 4.46
The 6-min walk test: a quick measure of functional status in elderly adults. Chest (2003) 4.29
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. Nat Genet (2009) 4.28
Association between regional adipose tissue distribution and both type 2 diabetes and impaired glucose tolerance in elderly men and women. Diabetes Care (2003) 4.23
Obesity, regional body fat distribution, and the metabolic syndrome in older men and women. Arch Intern Med (2005) 4.11
Personalized medicine in the era of genomics. JAMA (2007) 4.02
Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: the Health ABC Study. J Gerontol A Biol Sci Med Sci (2002) 4.00
Common variants in KCNN3 are associated with lone atrial fibrillation. Nat Genet (2010) 3.97
Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies. Lancet Neurol (2012) 3.93
Lipid-related markers and cardiovascular disease prediction. JAMA (2012) 3.91
Risk factors for the progression of coronary artery calcification in asymptomatic subjects: results from the Multi-Ethnic Study of Atherosclerosis (MESA). Circulation (2007) 3.90
Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry. Nat Genet (2009) 3.80
Is obesity associated with major depression? Results from the Third National Health and Nutrition Examination Survey. Am J Epidemiol (2003) 3.79
Elevations of inflammatory and procoagulant biomarkers in elderly persons with renal insufficiency. Circulation (2003) 3.76
Differences in the incidence of congestive heart failure by ethnicity: the multi-ethnic study of atherosclerosis. Arch Intern Med (2008) 3.76
Atlas-based whole brain white matter analysis using large deformation diffeomorphic metric mapping: application to normal elderly and Alzheimer's disease participants. Neuroimage (2009) 3.74
Genome-wide association study of PR interval. Nat Genet (2010) 3.73
Meta-analysis identifies six new susceptibility loci for atrial fibrillation. Nat Genet (2012) 3.71
Inflammation, coagulation and cardiovascular disease in HIV-infected individuals. PLoS One (2012) 3.68
Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation (2011) 3.68
Depressive symptoms, vascular disease, and mild cognitive impairment: findings from the Cardiovascular Health Study. Arch Gen Psychiatry (2006) 3.61