Published in JAMA on October 10, 2007
Development of a large-scale de-identified DNA biobank to enable personalized medicine. Clin Pharmacol Ther (2008) 11.67
Social networkers' attitudes toward direct-to-consumer personal genome testing. Am J Bioeth (2009) 8.28
Disclosure of APOE genotype for risk of Alzheimer's disease. N Engl J Med (2009) 6.43
Electronic medical records for genetic research: results of the eMERGE consortium. Sci Transl Med (2011) 5.82
The Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Initiative: methods of the EGAPP Working Group. Genet Med (2009) 5.69
Research ethics and the challenge of whole-genome sequencing. Nat Rev Genet (2008) 4.03
Rapid-learning system for cancer care. J Clin Oncol (2010) 3.13
A formal risk-benefit framework for genomic tests: facilitating the appropriate translation of genomics into clinical practice. Genet Med (2010) 2.40
Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies. Diabetes Care (2010) 2.14
Personalized medicine for depression: can we match patients with treatments? Am J Psychiatry (2010) 2.06
Motivations and perceptions of early adopters of personalized genomics: perspectives from research participants. Public Health Genomics (2011) 1.96
Genetics, genomics, and cancer risk assessment: State of the Art and Future Directions in the Era of Personalized Medicine. CA Cancer J Clin (2011) 1.90
Communicating results in post-Belmont era biomonitoring studies: lessons from genetics and neuroimaging research. Environ Res (2014) 1.68
Considerations for designing a prototype genetic test for use in translational research. Public Health Genomics (2009) 1.67
Identifiability in biobanks: models, measures, and mitigation strategies. Hum Genet (2011) 1.66
The clinical application of genetic testing in type 2 diabetes: a patient and physician survey. Diabetologia (2009) 1.63
Genomic risk profiling: attitudes and use in personal and clinical care of primary care physicians who offer risk profiling. J Gen Intern Med (2011) 1.56
Cumulative association of 22 genetic variants with seropositive rheumatoid arthritis risk. Ann Rheum Dis (2010) 1.53
A national clinical decision support infrastructure to enable the widespread and consistent practice of genomic and personalized medicine. BMC Med Inform Decis Mak (2009) 1.49
Debating clinical utility. Public Health Genomics (2010) 1.41
Using Alzheimer's disease as a model for genetic risk disclosure: implications for personal genomics. Clin Genet (2011) 1.34
Application of pharmacogenomics to vaccines. Pharmacogenomics (2009) 1.30
Genetic architecture of type 2 diabetes: recent progress and clinical implications. Diabetes Care (2009) 1.29
Linking molecular classification of hepatocellular carcinoma and personalized medicine: preliminary steps. Curr Opin Oncol (2008) 1.26
Mapping the incidentalome: estimating incidental findings generated through clinical pharmacogenomics testing. Genet Med (2012) 1.17
Public awareness and use of direct-to-consumer genetic tests: results from 3 state population-based surveys, 2006. Am J Public Health (2008) 1.15
After the revolution? Ethical and social challenges in 'personalized genomic medicine' Per Med (2012) 1.14
Using lifetime risk estimates in personal genomic profiles: estimation of uncertainty. Am J Hum Genet (2009) 1.14
Comparisons of prevention programs for homeless youth. Prev Sci (2009) 1.07
Extending comprehensive cancer center expertise in clinical cancer genetics and genomics to diverse communities: the power of partnership. J Natl Compr Canc Netw (2010) 1.05
Meta-analysis investigating associations between healthy diet and fasting glucose and insulin levels and modification by loci associated with glucose homeostasis in data from 15 cohorts. Am J Epidemiol (2012) 1.03
Does genomic risk information motivate people to change their behavior? Genome Med (2009) 1.03
Physicians' attitudes toward race, genetics, and clinical medicine. Genet Med (2009) 1.01
Genetic counselor opinions of, and experiences with telephone communication of BRCA1/2 test results. Clin Genet (2010) 1.00
When parents disclose BRCA1/2 test results: their communication and perceptions of offspring response. Cancer (2012) 0.99
Tissue-level modeling of xenobiotic metabolism in liver: An emerging tool for enabling clinical translational research. Clin Transl Sci (2009) 0.97
Clinical Application of Multigene Panels: Challenges of Next-Generation Counseling and Cancer Risk Management. Front Oncol (2015) 0.95
Closing the gap between knowledge and clinical application: challenges for genomic translation. PLoS Genet (2015) 0.94
The use of personalized medicine for patient selection for renal transplantation: physicians' views on the clinical and ethical implications. BMC Med Ethics (2010) 0.93
An ontology-based, mobile-optimized system for pharmacogenomic decision support at the point-of-care. PLoS One (2014) 0.91
Design of a randomized trial of diabetes genetic risk testing to motivate behavior change: the Genetic Counseling/lifestyle Change (GC/LC) Study for Diabetes Prevention. Clin Trials (2011) 0.91
The benefits of using genetic information to design prevention trials. Am J Hum Genet (2013) 0.91
Genes, the environment and personalized medicine: We need to harness both environmental and genetic data to maximize personal and population health. EMBO Rep (2014) 0.89
Genetic tests: clinical validity and clinical utility. Curr Protoc Hum Genet (2014) 0.88
Pharmacogenetics of smoking cessation in general practice: results from the patch II and patch in practice trials. Nicotine Tob Res (2011) 0.88
"Is it really worth it to get tested?": primary care patients' impressions of predictive SNP testing for colon cancer. J Genet Couns (2012) 0.87
Pediatric data sharing in genomic research: attitudes and preferences of parents. Pediatrics (2014) 0.87
Translating genomics into the clinic: moving to the post-Mendelian world. Genome Med (2009) 0.87
Why personalized medicine will fail if we stay the course. Per Med (2012) 0.86
Patient-controlled encrypted genomic data: an approach to advance clinical genomics. BMC Med Genomics (2012) 0.85
BOOGIE: Predicting Blood Groups from High Throughput Sequencing Data. PLoS One (2015) 0.84
Why should genomic medicine become more evidence-based? Genomic Med (2007) 0.83
Development of a communication protocol for telephone disclosure of genetic test results for cancer predisposition. JMIR Res Protoc (2014) 0.83
Knowledge and perceptions of familial and genetic risks for breast cancer risk in adolescent girls. Breast Cancer Res Treat (2012) 0.83
Human difference in the genomic era: Facilitating a socially responsible dialogue. BMC Med Genomics (2010) 0.82
The Human Genome Project, and recent advances in personalized genomics. Risk Manag Healthc Policy (2015) 0.82
Mass spectrometry-based proteomics in Chest Medicine, Gerontology, and Nephrology: subgroups omics for personalized medicine. Biomedicine (Taipei) (2014) 0.80
Implementation and outcomes of telephone disclosure of clinical BRCA1/2 test results. Patient Educ Couns (2013) 0.79
Use of Factor V Leiden genetic testing in practice and impact on management. Genet Med (2009) 0.79
Loss-of-function CYP2C9 variants: finding the correct clinical role for Type 2 diabetes pharmacogenetic testing. Expert Rev Cardiovasc Ther (2010) 0.79
An Altered Treatment Plan Based on Direct to Consumer (DTC) Genetic Testing: Personalized Medicine from the Patient/Pin-cushion Perspective. J Pers Med (2012) 0.78
Ethical and practical challenges to studying patients who opt out of large-scale biorepository research. J Am Med Inform Assoc (2013) 0.77
Unwarranted optimism in media portrayals of genetic research on addiction overshadows critical ethical and social concerns. J Health Commun (2015) 0.77
Impact of the environment on the skeleton: is it modulated by genetic factors? Curr Osteoporos Rep (2013) 0.77
Comparative Effectiveness of Personalized Lifestyle Management Strategies for Cardiovascular Disease Risk Reduction. J Am Heart Assoc (2016) 0.76
Physio-environmental sensing and live modeling. Interact J Med Res (2013) 0.76
ASHG Presidential Address: Who is under the umbrella--and why are we here? Am J Hum Genet (2008) 0.75
The Significance of an Enhanced Concept of the Organism for Medicine. Evid Based Complement Alternat Med (2016) 0.75
Exposure to Pre- and Perinatal Risk Factors Partially Explains Mean Differences in Self-Regulation between Races. PLoS One (2016) 0.75
Conceptual and terminological confusion around personalised medicine: a coping strategy. BMC Med Ethics (2016) 0.75
Anticipating the arrival of low-penetrance genetic testing to primary care medicine. J Community Genet (2013) 0.75
Targeted Therapy Database (TTD): a model to match patient's molecular profile with current knowledge on cancer biology. PLoS One (2010) 0.75
Attitude toward Prenatal Testing and Termination of Pregnancy among Health Professionals and Medical Students in Saudi Arabia. J Pediatr Genet (2017) 0.75
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Opioid prescriptions for chronic pain and overdose: a cohort study. Ann Intern Med (2010) 11.99
Genome-wide association study of blood pressure and hypertension. Nat Genet (2009) 11.54
Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA (2010) 9.52
Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet (2010) 8.89
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66
C-reactive protein, fibrinogen, and cardiovascular disease prediction. N Engl J Med (2012) 6.39
New loci associated with kidney function and chronic kidney disease. Nat Genet (2010) 5.58
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet (2012) 5.48
Loss-of-function mutations in APOC3, triglycerides, and coronary disease. N Engl J Med (2014) 5.47
Genomewide association studies of stroke. N Engl J Med (2009) 5.29
Leukocyte telomere length and cardiovascular disease in the cardiovascular health study. Am J Epidemiol (2006) 5.28
Common variants at ten loci influence QT interval duration in the QTGEN Study. Nat Genet (2009) 5.20
Inflammation as a risk factor for atrial fibrillation. Circulation (2003) 4.95
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73
Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet (2012) 4.63
Cystatin C concentration as a risk factor for heart failure in older adults. Ann Intern Med (2005) 4.57
Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. Nat Genet (2009) 4.56
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. Nat Genet (2009) 4.28
Common variants in KCNN3 are associated with lone atrial fibrillation. Nat Genet (2010) 3.97
Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies. Lancet Neurol (2012) 3.93
Lipid-related markers and cardiovascular disease prediction. JAMA (2012) 3.91
Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry. Nat Genet (2009) 3.80
Elevations of inflammatory and procoagulant biomarkers in elderly persons with renal insufficiency. Circulation (2003) 3.76
Genome-wide association study of PR interval. Nat Genet (2010) 3.73
Meta-analysis identifies six new susceptibility loci for atrial fibrillation. Nat Genet (2012) 3.71
Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation (2011) 3.68
Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nat Genet (2010) 3.55
Comparison of self-report, hospital discharge codes, and adjudication of cardiovascular events in the Women's Health Initiative. Am J Epidemiol (2004) 3.53
Association of genetic variations with nonfatal venous thrombosis in postmenopausal women. JAMA (2007) 3.50
Estrogen plus progestin and risk of venous thrombosis. JAMA (2004) 3.46
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet (2011) 3.40
Association of polymorphisms in the CRP gene with circulating C-reactive protein levels and cardiovascular events. JAMA (2006) 3.26
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium. PLoS Genet (2009) 3.18
New gene functions in megakaryopoiesis and platelet formation. Nature (2011) 3.14
Dyslipidemia prevalence, treatment, and control in the Multi-Ethnic Study of Atherosclerosis (MESA): gender, ethnicity, and coronary artery calcium. Circulation (2006) 3.11
Genetic variants and associations of 25-hydroxyvitamin D concentrations with major clinical outcomes. JAMA (2012) 3.10
LDL particle subclasses, LDL particle size, and carotid atherosclerosis in the Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis (2007) 3.08
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. PLoS Genet (2011) 3.07
The landscape of recombination in African Americans. Nature (2011) 3.06
Validation of an atrial fibrillation risk algorithm in whites and African Americans. Arch Intern Med (2010) 3.05
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet (2012) 3.04
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet (2011) 3.03
Association of carotid artery intima-media thickness, plaques, and C-reactive protein with future cardiovascular disease and all-cause mortality: the Cardiovascular Health Study. Circulation (2007) 2.93
Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet (2013) 2.92
Functional status is a confounder of the association of influenza vaccine and risk of all cause mortality in seniors. Int J Epidemiol (2005) 2.92
Candidate gene association resource (CARe): design, methods, and proof of concept. Circ Cardiovasc Genet (2010) 2.91
Physical activity and incidence of atrial fibrillation in older adults: the cardiovascular health study. Circulation (2008) 2.85
The presence of frailty in elderly persons with chronic renal insufficiency. Am J Kidney Dis (2004) 2.83
Fish intake and risk of incident atrial fibrillation. Circulation (2004) 2.82
Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity. Aging Cell (2009) 2.79
Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium. Circulation (2010) 2.78
FTO genotype is associated with phenotypic variability of body mass index. Nature (2012) 2.77
Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors. Circ Cardiovasc Genet (2010) 2.76
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat Genet (2011) 2.73
CUBN is a gene locus for albuminuria. J Am Soc Nephrol (2011) 2.70
Net reclassification indices for evaluating risk prediction instruments: a critical review. Epidemiology (2014) 2.67
Use of alendronate and risk of incident atrial fibrillation in women. Arch Intern Med (2008) 2.66
Best practices and joint calling of the HumanExome BeadChip: the CHARGE Consortium. PLoS One (2013) 2.65
Whole-genome sequence-based analysis of high-density lipoprotein cholesterol. Nat Genet (2013) 2.62
Beta2-adrenergic receptor genetic variants and risk of sudden cardiac death. Circulation (2006) 2.57
Genetic variations in nitric oxide synthase 1 adaptor protein are associated with sudden cardiac death in US white community-based populations. Circulation (2009) 2.55
C-reactive protein and the 10-year incidence of coronary heart disease in older men and women: the cardiovascular health study. Circulation (2005) 2.48
Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology. Proc Natl Acad Sci U S A (2010) 2.47
Risk of new-onset atrial fibrillation in relation to body mass index. Arch Intern Med (2006) 2.45
Relationship of opioid use and dosage levels to fractures in older chronic pain patients. J Gen Intern Med (2010) 2.43
Inflammatory markers and incident heart failure risk in older adults: the Health ABC (Health, Aging, and Body Composition) study. J Am Coll Cardiol (2010) 2.43
Rosiglitazone and cardiovascular risk. N Engl J Med (2007) 2.41
Population structure, admixture, and aging-related phenotypes in African American adults: the Cardiovascular Health Study. Am J Hum Genet (2005) 2.41
COX-2 inhibitors--lessons in drug safety. N Engl J Med (2005) 2.39
Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium. Ann Neurol (2011) 2.37
Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. Arterioscler Thromb Vasc Biol (2007) 2.36
Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium. PLoS Genet (2011) 2.33
Detection, verification, and quantification of adverse drug reactions. BMJ (2004) 2.26
Leukocyte telomere length and mortality in the Cardiovascular Health Study. J Gerontol A Biol Sci Med Sci (2011) 2.19
Statins and intracerebral hemorrhage: collaborative systematic review and meta-analysis. Circulation (2011) 2.17
Interaction between the Gly460Trp alpha-adducin gene variant and diuretics on the risk of myocardial infarction. J Hypertens (2009) 2.14
Glucose, blood pressure, and lipid control in older people with and without diabetes mellitus: the Cardiovascular Health Study. J Am Geriatr Soc (2002) 2.13
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nat Genet (2012) 2.12
Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. JAMA (2009) 2.10
A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. Diabetes (2011) 2.09
Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels. Hum Mol Genet (2010) 2.05
Congestive heart failure incidence and prognosis: case identification using central adjudication versus hospital discharge diagnoses. Ann Epidemiol (2005) 2.03
Methods to assess intended effects of drug treatment in observational studies are reviewed. J Clin Epidemiol (2004) 2.03
Re-using Mini-Sentinel data following rapid assessments of potential safety signals via modular analytic programs. Pharmacoepidemiol Drug Saf (2013) 2.01
Newly detected atrial fibrillation and compliance with antithrombotic guidelines. Arch Intern Med (2007) 2.00
Survival associated with two sets of diagnostic criteria for congestive heart failure. Am J Epidemiol (2004) 1.99
Serum amyloid P and cardiovascular disease in older men and women: results from the Cardiovascular Health Study. Arterioscler Thromb Vasc Biol (2006) 1.97
Primary prevention of cardiovascular disease: time to get more or less personal? JAMA (2009) 1.96
Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction. Circulation (2011) 1.96
Agreement between nosologist and cardiovascular health study review of deaths: implications of coding differences. J Am Geriatr Soc (2008) 1.94
C-reactive protein, carotid intima-media thickness, and incidence of ischemic stroke in the elderly: the Cardiovascular Health Study. Circulation (2003) 1.93
Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque. Nat Genet (2011) 1.92
Genome-wide association studies of serum magnesium, potassium, and sodium concentrations identify six Loci influencing serum magnesium levels. PLoS Genet (2010) 1.91