Published in Nat Genet on July 17, 2005
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Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy. Nat Rev Drug Discov (2010) 3.84
Shared and separate functions of polo-like kinases and aurora kinases in cancer. Nat Rev Cancer (2010) 3.74
The ploidy conveyor of mature hepatocytes as a source of genetic variation. Nature (2010) 3.27
The SCF Slimb ubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication. J Cell Biol (2009) 2.43
Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome. J Cell Biol (2010) 2.33
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Common variants spanning PLK4 are associated with mitotic-origin aneuploidy in human embryos. Science (2015) 1.51
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Autophosphorylation of polo-like kinase 4 and its role in centriole duplication. Mol Biol Cell (2009) 1.45
Plk4 is required for cytokinesis and maintenance of chromosomal stability. Proc Natl Acad Sci U S A (2010) 1.40
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Centrosome amplification causes microcephaly. Nat Cell Biol (2013) 1.33
Polo-like kinase 1 is essential for early embryonic development and tumor suppression. Mol Cell Biol (2008) 1.29
Polo-like kinase 3 functions as a tumor suppressor and is a negative regulator of hypoxia-inducible factor-1 alpha under hypoxic conditions. Cancer Res (2008) 1.26
The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle. Genes Dev (2012) 1.23
Mutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy. Nat Genet (2014) 1.21
Hierarchical recruitment of Plk4 and regulation of centriole biogenesis by two centrosomal scaffolds, Cep192 and Cep152. Proc Natl Acad Sci U S A (2013) 1.18
The Protein Phosphatase 2A regulatory subunit Twins stabilizes Plk4 to induce centriole amplification. J Cell Biol (2011) 1.16
Alternative functions of core cell cycle regulators in neuronal migration, neuronal maturation, and synaptic plasticity. Neuron (2009) 1.16
Targeting Polo-Like Kinases: A Promising Therapeutic Approach for Cancer Treatment. Transl Oncol (2015) 1.12
Plk1 protein phosphorylates phosphatase and tensin homolog (PTEN) and regulates its mitotic activity during the cell cycle. J Biol Chem (2014) 1.07
Plk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression. Mol Cell Biol (2011) 1.06
p53 protects against genome instability following centriole duplication failure. J Cell Biol (2015) 1.05
p53 regulates a mitotic transcription program and determines ploidy in normal mouse liver. Hepatology (2013) 1.05
Repeated cleavage failure does not establish centrosome amplification in untransformed human cells. J Cell Biol (2011) 1.04
Polo-like kinase 4: the odd one out of the family. Cell Div (2010) 1.03
Mutation of the murine Bloom's syndrome gene produces global genome destabilization. Mol Cell Biol (2006) 1.01
The balance of Polo-like kinase 1 in tumorigenesis. Cell Div (2009) 1.00
Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition. Semin Cancer Biol (2015) 0.99
Plk4-dependent phosphorylation of STIL is required for centriole duplication. Biol Open (2015) 0.99
Polo-like kinase 4 controls centriole duplication but does not directly regulate cytokinesis. Mol Biol Cell (2012) 0.99
Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis. Nat Struct Mol Biol (2014) 0.98
Downregulation of polo-like kinase 4 in hepatocellular carcinoma associates with poor prognosis. PLoS One (2012) 0.96
Centrosome dysfunction contributes to chromosome instability, chromoanagenesis, and genome reprograming in cancer. Front Oncol (2013) 0.96
Rewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas. Nat Commun (2013) 0.95
Role of cell cycle regulators in lung carcinogenesis. Cell Adh Migr (2010) 0.93
SAPK pathways and p53 cooperatively regulate PLK4 activity and centrosome integrity under stress. Nat Commun (2013) 0.92
Centriole duplication: A lesson in self-control. Cell Cycle (2010) 0.92
Nek2 and Plk4: prognostic markers, drivers of breast tumorigenesis and drug resistance. Front Biosci (Landmark Ed) (2014) 0.92
Recent Advances and New Strategies in Targeting Plk1 for Anticancer Therapy. Trends Pharmacol Sci (2015) 0.87
Centrosome dynamics as a source of chromosomal instability. Trends Cell Biol (2014) 0.84
Male hypogonadism and germ cell loss caused by a mutation in Polo-like kinase 4. Endocrinology (2011) 0.82
Gene expression patterns in heterozygous Plk4 murine embryonic fibroblasts. BMC Genomics (2009) 0.82
Aberrant methylation of Polo-like kinase CpG islands in Plk4 heterozygous mice. BMC Cancer (2011) 0.81
SGOL1 variant B induces abnormal mitosis and resistance to taxane in non-small cell lung cancers. Sci Rep (2013) 0.81
Hepatocellular carcinoma mouse models: Hepatitis B virus-associated hepatocarcinogenesis and haploinsufficient tumor suppressor genes. World J Gastroenterol (2016) 0.81
Cell cycle proteins as promising targets in cancer therapy. Nat Rev Cancer (2017) 0.81
p53-Dependent and cell specific epigenetic regulation of the polo-like kinases under oxidative stress. PLoS One (2014) 0.80
A novel role for Plk4 in regulating cell spreading and motility. Oncogene (2014) 0.79
Centrosome amplification, chromosomal instability and cancer: mechanistic, clinical and therapeutic issues. Chromosome Res (2016) 0.79
Loss of KLF14 triggers centrosome amplification and tumorigenesis. Nat Commun (2015) 0.79
Polo-like kinase 4 inhibition: a strategy for cancer therapy? Cancer Cell (2014) 0.79
Chromosomal instability in mammalian pre-implantation embryos: potential causes, detection methods, and clinical consequences. Cell Tissue Res (2015) 0.79
Centrosome aberrations associated with cellular senescence and p53 localization at supernumerary centrosomes. Oxid Med Cell Longev (2012) 0.79
Mitotic Kinases and p53 Signaling. Biochem Res Int (2012) 0.78
Over expression of Plk1 does not induce cell division in rat cardiac myocytes in vitro. PLoS One (2009) 0.78
A novel anti-tumor inhibitor identified by virtual screen with PLK1 structure and zebrafish assay. PLoS One (2013) 0.76
Novel compound heterozygous variants in PLK4 identified in a patient with autosomal recessive microcephaly and chorioretinopathy. Eur J Hum Genet (2016) 0.75
The Janus soul of centrosomes: a paradoxical role in disease? Chromosome Res (2016) 0.75
Analysis of centrosome and DNA damage response in PLK4 associated Seckel syndrome. Eur J Hum Genet (2017) 0.75
A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature (2006) 24.52
Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer. Science (2012) 4.92
Complex N-glycan number and degree of branching cooperate to regulate cell proliferation and differentiation. Cell (2007) 4.85
Regulation of cytokine receptors by Golgi N-glycan processing and endocytosis. Science (2004) 3.73
Feasibility and diagnostic performance of the FibroScan XL probe for liver stiffness measurement in overweight and obese patients. Hepatology (2011) 3.70
Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. Curr Biol (2004) 3.45
The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism. Genes Dev (2010) 3.40
A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells. Cell (2006) 3.38
A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl. Nat Cell Biol (2003) 3.11
Prevalence of male and female sexual dysfunction is high following surgery for rectal cancer. Ann Surg (2005) 2.46
Long-term results of two prospective trials of preoperative external beam radiotherapy for localized intermediate- or high-grade retroperitoneal soft tissue sarcoma. Ann Surg Oncol (2006) 2.43
Lattices, rafts, and scaffolds: domain regulation of receptor signaling at the plasma membrane. J Cell Biol (2009) 2.41
N-Glycans in cancer progression. Glycobiology (2008) 2.35
Temporal regulation of EGF signalling networks by the scaffold protein Shc1. Nature (2013) 2.33
Modification of the Creator recombination system for proteomics applications--improved expression by addition of splice sites. BMC Biotechnol (2006) 2.01
Nucleolar release of Hand1 acts as a molecular switch to determine cell fate. Nat Cell Biol (2007) 1.98
Controlled Attenuation Parameter (CAP): a noninvasive method for the detection of hepatic steatosis based on transient elastography. Liver Int (2012) 1.83
Initial results of a trial of preoperative external-beam radiation therapy and postoperative brachytherapy for retroperitoneal sarcoma. Ann Surg Oncol (2002) 1.82
Plasma membrane domain organization regulates EGFR signaling in tumor cells. J Cell Biol (2007) 1.82
Interferon alfacon-1 plus corticosteroids in severe acute respiratory syndrome: a preliminary study. JAMA (2003) 1.81
Significant regional variation in adequacy of lymph node assessment and survival in gastric cancer. Cancer (2006) 1.78
Stage-specific effect of adjuvant therapy following gastric cancer resection: a population-based analysis of 4,041 patients. Ann Surg Oncol (2007) 1.78
The Sak polo-box comprises a structural domain sufficient for mitotic subcellular localization. Nat Struct Biol (2002) 1.76
Gastrointestinal stromal tumours: consensus statement on diagnosis and treatment. Can J Gastroenterol (2006) 1.62
The investigation of primary rectal cancer by surgeons: current pattern of practice. Can J Surg (2005) 1.61
Glycosylation, galectins and cellular signaling. Curr Opin Cell Biol (2011) 1.59
Galectin binding to Mgat5-modified N-glycans regulates fibronectin matrix remodeling in tumor cells. Mol Cell Biol (2006) 1.57
Not a broken heart. Lancet (2007) 1.54
The dual-specificity phosphatase hYVH1 (DUSP12) is a novel modulator of cellular DNA content. Cell Cycle (2011) 1.46
Improving Outcomes in Resectable Gastric Cancer: A Review of Current and Future Strategies. Oncology (Williston Park) (2016) 1.43
Control of T Cell-mediated autoimmunity by metabolite flux to N-glycan biosynthesis. J Biol Chem (2007) 1.40
Plk4 is required for cytokinesis and maintenance of chromosomal stability. Proc Natl Acad Sci U S A (2010) 1.40
Enantioselective total synthesis of (+)-largazole, a potent inhibitor of histone deacetylase. Org Lett (2008) 1.40
Deletion of exon I of SMAD7 in mice results in altered B cell responses. J Immunol (2006) 1.36
alpha 2-HS glycoprotein/fetuin, a transforming growth factor-beta/bone morphogenetic protein antagonist, regulates postnatal bone growth and remodeling. J Biol Chem (2002) 1.33
The Rho GTP exchange factor Lfc promotes spindle assembly in early mitosis. Proc Natl Acad Sci U S A (2005) 1.28
Sak/Plk4 and mitotic fidelity. Oncogene (2005) 1.27
N-acetylglucosaminyltransferase V (Mgat5)-mediated N-glycosylation negatively regulates Th1 cytokine production by T cells. J Immunol (2004) 1.27
Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis. Nat Commun (2011) 1.19
Adjuvant therapy for resected gastric cancer--rapid, yet incomplete adoption following results of intergroup 0116 trial. Int J Radiat Oncol Biol Phys (2007) 1.18
Inhibition of the sodium/potassium ATPase impairs N-glycan expression and function. Cancer Res (2008) 1.17
Discordance in fibrosis staging between liver biopsy and transient elastography using the FibroScan XL probe. J Hepatol (2011) 1.16
Tumor cell pseudopodial protrusions. Localized signaling domains coordinating cytoskeleton remodeling, cell adhesion, glycolysis, RNA translocation, and protein translation. J Biol Chem (2005) 1.11
FF domains of CA150 bind transcription and splicing factors through multiple weak interactions. Mol Cell Biol (2004) 1.09
Promoter methylation of Wnt antagonists DKK1 and SFRP1 is associated with opposing tumor subtypes in two large populations of colorectal cancer patients. Carcinogenesis (2011) 1.07
Exacerbated tissue destruction in DSS-induced acute colitis of OPN-null mice is associated with downregulation of TNF-alpha expression and non-programmed cell death. J Cell Physiol (2006) 1.06
Gastrointestinal cancers and neurofibromatosis type 1 features in children with a germline homozygous MLH1 mutation. Gastroenterology (2004) 1.05
The eggshell is required for meiotic fidelity, polar-body extrusion and polarization of the C. elegans embryo. BMC Biol (2006) 1.05
Potent memapsin 2 (beta-secretase) inhibitors: design, synthesis, protein-ligand X-ray structure, and in vivo evaluation. Bioorg Med Chem Lett (2008) 1.04
Biological implications of SNPs in signal peptide domains of human proteins. Proteins (2008) 1.04
The lipid composition of autophagic vacuoles regulates expression of multilamellar bodies. J Cell Sci (2005) 1.04
The more the better?: the impact of surgeon and hospital volume on in-hospital mortality following colorectal resection. Ann Surg (2009) 1.04
Chemotherapy-induced liver injury in metastatic colorectal cancer: semiquantitative histologic analysis of 334 resected liver specimens shows that vascular injury but not steatohepatitis is associated with preoperative chemotherapy. Am J Surg Pathol (2010) 1.04
alpha2HS-glycoprotein, an antagonist of transforming growth factor beta in vivo, inhibits intestinal tumor progression. Cancer Res (2004) 1.03
Desmoid-type fibromatosis and pregnancy: a multi-institutional analysis of recurrence and obstetric risk. Ann Surg (2014) 1.03
Outcomes of salvage surgery for squamous cell carcinoma of the anal canal. Ann Surg Oncol (2007) 1.01
Patients with Lynch syndrome mismatch repair gene mutations are at higher risk for not only upper tract urothelial cancer but also bladder cancer. Eur Urol (2012) 1.00
Caveolin-1 regulation of dynamin-dependent, raft-mediated endocytosis of cholera toxin-B sub-unit occurs independently of caveolae. J Cell Mol Med (2009) 0.99
Tumor microsatellite instability in early onset gastric cancer. J Mol Diagn (2005) 0.98
Prognostic significance of mesenteric tumor nodules in patients with stage III colorectal cancer. Cancer (2008) 0.98
Complex N-glycan and metabolic control in tumor cells. Cancer Res (2007) 0.97
TMF/ARA160 is a BC-box-containing protein that mediates the degradation of Stat3. Oncogene (2004) 0.97
Galectin-3 protein regulates mobility of N-cadherin and GM1 ganglioside at cell-cell junctions of mammary carcinoma cells. J Biol Chem (2012) 0.96
Results of an aggressive approach to resection of locally recurrent rectal cancer. Ann Surg Oncol (2006) 0.95
Germline BRCA1 mutations predispose to pancreatic adenocarcinoma. Hum Genet (2008) 0.95
Platelet microparticle-associated protein disulfide isomerase promotes platelet aggregation and inactivates insulin. Biochim Biophys Acta (2008) 0.95
Asymmetric multicomponent reactions: diastereoselective synthesis of substituted pyrrolidines and prolines. Org Lett (2006) 0.95
Specific variants in the MLH1 gene region may drive DNA methylation, loss of protein expression, and MSI-H colorectal cancer. PLoS One (2010) 0.95
Asymmetric synthesis of anti-aldol segments via a nonaldol route: synthetic applications to statines and (-)-tetrahydrolipstatin. J Org Chem (2009) 0.94
Digital pathology: Attitudes and practices in the Canadian pathology community. J Pathol Inform (2013) 0.93
Redefining the role of arterial imaging in the management of penetrating zone 3 neck injuries. Vascular (2005) 0.93
Confirmation of the safety and accuracy of physical examination in the evaluation of knee dislocation for injury of the popliteal artery: a prospective study. J Trauma (2002) 0.92
Venous invasion in colorectal cancer: impact of an elastin stain on detection and interobserver agreement among gastrointestinal and nongastrointestinal pathologists. Am J Surg Pathol (2013) 0.92
Structural basis of functional group activation by sulfotransferases in complex metabolic pathways. ACS Chem Biol (2012) 0.92
The eggshell in the C. elegans oocyte-to-embryo transition. Genesis (2011) 0.92
A histology-based model for predicting microsatellite instability in colorectal cancers. Am J Surg Pathol (2010) 0.92
Design, synthesis, protein-ligand X-ray structure, and biological evaluation of a series of novel macrocyclic human immunodeficiency virus-1 protease inhibitors to combat drug resistance. J Med Chem (2009) 0.90
Juvenile polyposis, hereditary hemorrhagic telangiectasia, and early onset colorectal cancer in patients with SMAD4 mutation. J Gastroenterol (2012) 0.89
Metabolic homeostasis and tissue renewal are dependent on beta1,6GlcNAc-branched N-glycans. Glycobiology (2007) 0.89
Mgat5 and Pten interact to regulate cell growth and polarity. Glycobiology (2007) 0.89
Immature T-cell clustering and efficient differentiation require the polarity protein Scribble. Proc Natl Acad Sci U S A (2010) 0.88
Surgeons' knowledge of quality indicators for gastric cancer surgery. Gastric Cancer (2007) 0.88
Café-au-lait macules and pediatric malignancy caused by biallelic mutations in the DNA mismatch repair (MMR) gene PMS2. Pediatr Blood Cancer (2008) 0.88
Are radical compartmental resections for retroperitoneal sarcomas justified? Ann Surg Oncol (2010) 0.88
A high-content chemical screen identifies ellipticine as a modulator of p53 nuclear localization. Apoptosis (2008) 0.87
Use of mismatch repair immunohistochemistry and microsatellite instability testing: exploring Canadian practices. Am J Surg Pathol (2012) 0.87
Identification of genes expressed by immune cells of the colon that are regulated by colorectal cancer-associated variants. Int J Cancer (2013) 0.87
Eggshell chitin and chitin-interacting proteins prevent polyspermy in C. elegans. Curr Biol (2010) 0.87
Function and quality of life after transanal excision of rectal polyps and cancers. Dis Colon Rectum (2007) 0.86
Probing the hexosamine biosynthetic pathway in human tumor cells by multitargeted tandem mass spectrometry. ACS Chem Biol (2013) 0.85
Novel protease inhibitors (PIs) containing macrocyclic components and 3(R),3a(S),6a(R)-bis-tetrahydrofuranylurethane that are potent against multi-PI-resistant HIV-1 variants in vitro. Antimicrob Agents Chemother (2010) 0.85