Published in Cell on May 05, 2006
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Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis. J Cell Biol (2008) 3.29
Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein. Genes Dev (2011) 3.15
Hippo pathway-independent restriction of TAZ and YAP by angiomotin. J Biol Chem (2011) 2.47
The YAP and TAZ transcription co-activators: key downstream effectors of the mammalian Hippo pathway. Semin Cell Dev Biol (2012) 2.21
β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer. Nat Med (2012) 2.02
Remodeling epithelial cell organization: transitions between front-rear and apical-basal polarity. Cold Spring Harb Perspect Biol (2009) 2.01
A CD317/tetherin-RICH2 complex plays a critical role in the organization of the subapical actin cytoskeleton in polarized epithelial cells. J Cell Biol (2009) 1.90
Polarity-dependent distribution of angiomotin localizes Hippo signaling in preimplantation embryos. Curr Biol (2013) 1.86
A tight junction-associated Merlin-angiomotin complex mediates Merlin's regulation of mitogenic signaling and tumor suppressive functions. Cancer Cell (2011) 1.86
Cdc42 and Par proteins stabilize dynamic adherens junctions in the Drosophila neuroectoderm through regulation of apical endocytosis. J Cell Biol (2008) 1.85
Cell polarity signaling in Arabidopsis. Annu Rev Cell Dev Biol (2008) 1.81
Biology and regulation of ectoplasmic specialization, an atypical adherens junction type, in the testis. Biochim Biophys Acta (2007) 1.74
The Cdc42 GEF Intersectin 2 controls mitotic spindle orientation to form the lumen during epithelial morphogenesis. J Cell Biol (2010) 1.70
Cigarette smoking reprograms apical junctional complex molecular architecture in the human airway epithelium in vivo. Cell Mol Life Sci (2010) 1.66
The type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways. J Cell Biol (2007) 1.66
Mechanisms that determine the internal environment of the developing brain: a transcriptomic, functional and ultrastructural approach. PLoS One (2013) 1.64
Tuba, a Cdc42 GEF, is required for polarized spindle orientation during epithelial cyst formation. J Cell Biol (2010) 1.58
Signaling pathway cooperation in TGF-β-induced epithelial-mesenchymal transition. Curr Opin Cell Biol (2014) 1.55
Angiomotin regulates endothelial cell migration during embryonic angiogenesis. Genes Dev (2007) 1.49
Recycling, clustering, and endocytosis jointly maintain PIN auxin carrier polarity at the plasma membrane. Mol Syst Biol (2011) 1.44
The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells. Blood (2008) 1.36
KIBRA modulates directional migration of podocytes. J Am Soc Nephrol (2008) 1.36
Polarity and endocytosis: reciprocal regulation. Trends Cell Biol (2010) 1.36
Organization of multiprotein complexes at cell-cell junctions. Histochem Cell Biol (2008) 1.33
Nck adaptor proteins control the organization of neuronal circuits important for walking. Proc Natl Acad Sci U S A (2007) 1.33
Merlin: a tumour suppressor with functions at the cell cortex and in the nucleus. EMBO Rep (2012) 1.30
Par6B and atypical PKC regulate mitotic spindle orientation during epithelial morphogenesis. J Biol Chem (2011) 1.30
Protein phosphatase 1 regulates the phosphorylation state of the polarity scaffold Par-3. Proc Natl Acad Sci U S A (2008) 1.28
Phosphorylation of angiomotin by Lats1/2 kinases inhibits F-actin binding, cell migration, and angiogenesis. J Biol Chem (2013) 1.27
Serum deprivation inhibits the transcriptional co-activator YAP and cell growth via phosphorylation of the 130-kDa isoform of Angiomotin by the LATS1/2 protein kinases. Proc Natl Acad Sci U S A (2013) 1.27
Growth control by committee: intercellular junctions, cell polarity, and the cytoskeleton regulate Hippo signaling. Dev Cell (2012) 1.26
The p130 isoform of angiomotin is required for Yap-mediated hepatic epithelial cell proliferation and tumorigenesis. Sci Signal (2013) 1.25
PATJ regulates directional migration of mammalian epithelial cells. EMBO Rep (2007) 1.22
Protein complexes that control renal epithelial polarity. Am J Physiol Renal Physiol (2011) 1.22
Polarity proteins and cell-cell interactions in the testis. Int Rev Cell Mol Biol (2009) 1.21
Exclusion of a proton ATPase from the apical membrane is associated with cell polarity and tip growth in Nicotiana tabacum pollen tubes. Plant Cell (2008) 1.19
A tip-localized RhoGAP controls cell polarity by globally inhibiting Rho GTPase at the cell apex. Curr Biol (2008) 1.16
Complex changes in alternative pre-mRNA splicing play a central role in the epithelial-to-mesenchymal transition (EMT). Semin Cancer Biol (2012) 1.13
Syx, a RhoA guanine exchange factor, is essential for angiogenesis in Vivo. Circ Res (2008) 1.12
The MAGUK protein MPP7 binds to the polarity protein hDlg1 and facilitates epithelial tight junction formation. Mol Biol Cell (2007) 1.12
Lulu2 regulates the circumferential actomyosin tensile system in epithelial cells through p114RhoGEF. J Cell Biol (2011) 1.10
Normal morphogenesis of epithelial tissues and progression of epithelial tumors. Wiley Interdiscip Rev Syst Biol Med (2011) 1.10
Angiomotin prevents pluripotent lineage differentiation in mouse embryos via Hippo pathway-dependent and -independent mechanisms. Nat Commun (2013) 1.09
Actin-binding and cell proliferation activities of angiomotin family members are regulated by Hippo pathway-mediated phosphorylation. J Biol Chem (2013) 1.08
The Angiomotins--from discovery to function. FEBS Lett (2014) 1.07
aPKC phosphorylates JAM-A at Ser285 to promote cell contact maturation and tight junction formation. J Cell Biol (2012) 1.07
Paracingulin regulates the activity of Rac1 and RhoA GTPases by recruiting Tiam1 and GEF-H1 to epithelial junctions. Mol Biol Cell (2008) 1.06
A role for ZO-1 and PLEKHA7 in recruiting paracingulin to tight and adherens junctions of epithelial cells. J Biol Chem (2011) 1.03
Molecular insights into NF2/Merlin tumor suppressor function. FEBS Lett (2014) 1.03
Regulation of tight junction assembly and epithelial polarity by a resident protein of apical endosomes. Traffic (2010) 1.02
Tight junctions: a barrier to the initiation and progression of breast cancer? J Biomed Biotechnol (2009) 1.01
Amot130 adapts atrophin-1 interacting protein 4 to inhibit yes-associated protein signaling and cell growth. J Biol Chem (2013) 1.01
Amot recognizes a juxtanuclear endocytic recycling compartment via a novel lipid binding domain. J Biol Chem (2010) 1.00
The Cdc42-selective GAP rich regulates postsynaptic development and retrograde BMP transsynaptic signaling. J Cell Biol (2010) 1.00
Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex. J Cell Biol (2012) 0.99
Identification of an autoinhibitory mechanism that restricts C1 domain-mediated activation of the Rac-GAP alpha2-chimaerin. J Biol Chem (2008) 0.98
The adaptor protein AMOT promotes the proliferation of mammary epithelial cells via the prolonged activation of the extracellular signal-regulated kinases. Cancer Res (2011) 0.97
Function of glycoprotein E of herpes simplex virus requires coordinated assembly of three tegument proteins on its cytoplasmic tail. Proc Natl Acad Sci U S A (2012) 0.95
Direct and specific binding of the UL16 tegument protein of herpes simplex virus to the cytoplasmic tail of glycoprotein E. J Virol (2011) 0.94
EspF Interacts with nucleation-promoting factors to recruit junctional proteins into pedestals for pedestal maturation and disruption of paracellular permeability. Infect Immun (2008) 0.94
RHO GTPase in plants: Conservation and invention of regulators and effectors. Small GTPases (2010) 0.93
Rab13-dependent trafficking of RhoA is required for directional migration and angiogenesis. J Biol Chem (2011) 0.92
The interdependence of the Rho GTPases and apicobasal cell polarity. Small GTPases (2014) 0.91
Epithelial junctions and Rho family GTPases: the zonular signalosome. Small GTPases (2014) 0.91
Angiomotin decreases lung cancer progression by sequestering oncogenic YAP/TAZ and decreasing Cyr61 expression. Oncogene (2014) 0.90
Polar delivery in plants; commonalities and differences to animal epithelial cells. Open Biol (2014) 0.90
Angiomotin p80/p130 ratio: a new indicator of exercise-induced angiogenic activity in skeletal muscles from obese and non-obese rats? J Physiol (2009) 0.89
Dbl3 drives Cdc42 signaling at the apical margin to regulate junction position and apical differentiation. J Cell Biol (2013) 0.88
T cell receptor-dependent tyrosine phosphorylation of beta2-chimaerin modulates its Rac-GAP function in T cells. J Biol Chem (2009) 0.88
Angiomotin-like2 gene (amotl2) is required for migration and proliferation of endothelial cells during angiogenesis. J Biol Chem (2011) 0.88
Highly rapid and efficient conversion of human fibroblasts to keratinocyte-like cells. J Invest Dermatol (2013) 0.88
Proteins recruited by SH3 domains of Ruk/CIN85 adaptor identified by LC-MS/MS. Proteome Sci (2009) 0.88
Control of Rho GTPase function by BAR-domains. Small GTPases (2012) 0.87
The Amotl2 gene inhibits Wnt/β-catenin signaling and regulates embryonic development in zebrafish. J Biol Chem (2012) 0.87
Tight junctions: from simple barriers to multifunctional molecular gates. Nat Rev Mol Cell Biol (2016) 0.87
Phosphatase of regenerating liver 3 (PRL3) provokes a tyrosine phosphoproteome to drive prometastatic signal transduction. Mol Cell Proteomics (2013) 0.86
Regulation of actin dynamics and protein trafficking during spermatogenesis--insights into a complex process. Crit Rev Biochem Mol Biol (2013) 0.86
MgcRacGAP interacts with cingulin and paracingulin to regulate Rac1 activation and development of the tight junction barrier during epithelial junction assembly. Mol Biol Cell (2014) 0.86
PIV5 M protein interaction with host protein angiomotin-like 1. Virology (2009) 0.85
Establishment of epithelial polarity--GEF who's minding the GAP? J Cell Sci (2014) 0.84
BAR domain proteins regulate Rho GTPase signaling. Small GTPases (2014) 0.83
Angiomotin is a novel component of cadherin-11/β-catenin/p120 complex and is critical for cadherin-11-mediated cell migration. FASEB J (2014) 0.83
Soluble melanoma cell adhesion molecule (sMCAM/sCD146) promotes angiogenic effects on endothelial progenitor cells through angiomotin. J Biol Chem (2013) 0.83
Polarization and myelination in myelinating glia. ISRN Neurol (2012) 0.82
Rho GAPs and GEFs: controling switches in endothelial cell adhesion. Cell Adh Migr (2014) 0.82
Cell polarity signaling in the plasticity of cancer cell invasiveness. Oncotarget (2016) 0.82
Crumbs promotes expanded recognition and degradation by the SCF(Slimb/β-TrCP) ubiquitin ligase. Proc Natl Acad Sci U S A (2014) 0.81
Membrane palmitoylated proteins regulate trafficking and processing of nectins. Eur J Cell Biol (2011) 0.81
The Vac14-interaction network is linked to regulators of the endolysosomal and autophagic pathway. Mol Cell Proteomics (2014) 0.80
ASPP2 links the apical lateral polarity complex to the regulation of YAP activity in epithelial cells. PLoS One (2014) 0.80
Role of Angiomotin-like 2 mono-ubiquitination on YAP inhibition. EMBO Rep (2015) 0.80
The role of angiomotin phosphorylation in the Hippo pathway during preimplantation mouse development. Tissue Barriers (2014) 0.79
MicroRNA-205 targets tight junction-related proteins during urothelial cellular differentiation. Mol Cell Proteomics (2014) 0.79
Polarity protein complex Scribble/Lgl/Dlg and epithelial cell barriers. Adv Exp Med Biol (2012) 0.79
Ectopic expression of cadherin 8 is sufficient to cause cyst formation in a novel 3D collagen matrix renal tubule culture. Am J Physiol Cell Physiol (2011) 0.79
BAR proteins in cancer and blood disorders. Int J Biochem Mol Biol (2012) 0.79
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer. Int J Biochem Cell Biol (2015) 0.78
Mechanisms of cell polarity and aquaporin sorting in the nephron. Pflugers Arch (2011) 0.78
Closing the GAP between polarity and vesicle transport. Cell (2006) 0.78
Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature (2002) 37.66
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature (2006) 24.29
Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature (2005) 8.19
Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol (2007) 8.16
Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. Cell (2002) 8.08
Systematic discovery of in vivo phosphorylation networks. Cell (2007) 6.94
PreBIND and Textomy--mining the biomedical literature for protein-protein interactions using a support vector machine. BMC Bioinformatics (2003) 6.31
A global protein kinase and phosphatase interaction network in yeast. Science (2010) 5.95
Dynamic modularity in protein interaction networks predicts breast cancer outcome. Nat Biotechnol (2009) 5.41
Dissecting virulence: systematic and functional analyses of a pathogenicity island. Proc Natl Acad Sci U S A (2004) 5.34
An experimentally derived confidence score for binary protein-protein interactions. Nat Methods (2008) 5.27
Histone recognition and large-scale structural analysis of the human bromodomain family. Cell (2012) 5.15
Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst. Development (2005) 4.89
Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2-MAPK pathway. Dev Cell (2006) 4.77
Reading protein modifications with interaction domains. Nat Rev Mol Cell Biol (2006) 4.55
The Hippo pathway regulates Wnt/beta-catenin signaling. Dev Cell (2010) 4.49
The CRAPome: a contaminant repository for affinity purification-mass spectrometry data. Nat Methods (2013) 4.34
High-definition macromolecular composition of yeast RNA-processing complexes. Mol Cell (2004) 4.18
Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes. Nature (2006) 4.05
Cell signaling in space and time: where proteins come together and when they're apart. Science (2009) 3.88
Linear motif atlas for phosphorylation-dependent signaling. Sci Signal (2008) 3.77
Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. Curr Biol (2004) 3.45
The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture. Oncogene (2004) 3.44
Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control. Nat Cell Biol (2006) 3.42
Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice. J Exp Med (2002) 3.24
Protein phosphorylation in signaling--50 years and counting. Trends Biochem Sci (2005) 3.19
Spatial and temporal patterns of ERK signaling during mouse embryogenesis. Development (2003) 3.14
A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl. Nat Cell Biol (2003) 3.11
Imprinted X-inactivation in extra-embryonic endoderm cell lines from mouse blastocysts. Development (2005) 2.91
EphB receptor activity suppresses colorectal cancer progression. Nature (2005) 2.84
NetworKIN: a resource for exploring cellular phosphorylation networks. Nucleic Acids Res (2007) 2.69
The human and mouse complement of SH2 domain proteins-establishing the boundaries of phosphotyrosine signaling. Mol Cell (2006) 2.51
Identification and characterization of NleA, a non-LEE-encoded type III translocated virulence factor of enterohaemorrhagic Escherichia coli O157:H7. Mol Microbiol (2004) 2.51
Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation. Cell (2008) 2.46
Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer. Nat Genet (2004) 2.44
Transgenic RNA interference in ES cell-derived embryos recapitulates a genetic null phenotype. Nat Biotechnol (2003) 2.34
Temporal regulation of EGF signalling networks by the scaffold protein Shc1. Nature (2013) 2.33
Positive selection of tyrosine loss in metazoan evolution. Science (2009) 2.28
Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV. EMBO J (2004) 2.24
Post-translational modifications in signal integration. Nat Struct Mol Biol (2010) 2.23
ProHits: integrated software for mass spectrometry-based interaction proteomics. Nat Biotechnol (2010) 2.22
Adipose vascular endothelial growth factor regulates metabolic homeostasis through angiogenesis. Cell Metab (2013) 2.21
Podocyte-specific loss of Cdc42 leads to congenital nephropathy. J Am Soc Nephrol (2012) 2.16
Comparative analysis reveals conserved protein phosphorylation networks implicated in multiple diseases. Sci Signal (2009) 2.16
Targeting the SH2-kinase interface in Bcr-Abl inhibits leukemogenesis. Cell (2011) 2.11
Phosphotyrosine signaling: evolving a new cellular communication system. Cell (2010) 2.09
Eukaryotic protein domains as functional units of cellular evolution. Sci Signal (2009) 2.06
Modification of the Creator recombination system for proteomics applications--improved expression by addition of splice sites. BMC Biotechnol (2006) 2.01
WW domains provide a platform for the assembly of multiprotein networks. Mol Cell Biol (2005) 1.97
Plk4 haploinsufficiency causes mitotic infidelity and carcinogenesis. Nat Genet (2005) 1.97
Krüppel-like factor 5 is essential for blastocyst development and the normal self-renewal of mouse ESCs. Cell Stem Cell (2008) 1.94
Par3 and dynein associate to regulate local microtubule dynamics and centrosome orientation during migration. Curr Biol (2009) 1.93
Nck proteins maintain the adult glomerular filtration barrier. J Am Soc Nephrol (2009) 1.92
Cell-specific information processing in segregating populations of Eph receptor ephrin-expressing cells. Science (2009) 1.91
A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint. PLoS Biol (2010) 1.90
Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor. Nat Biotechnol (2011) 1.90
The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network. Mol Cell Biol (2003) 1.86
Phosphorylation networks regulating JNK activity in diverse genetic backgrounds. Science (2008) 1.86
Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease. Cell (2011) 1.83
ShcA signalling is essential for tumour progression in mouse models of human breast cancer. EMBO J (2008) 1.82
Soluble FLT1 binds lipid microdomains in podocytes to control cell morphology and glomerular barrier function. Cell (2012) 1.79
Defining the specificity space of the human SRC homology 2 domain. Mol Cell Proteomics (2007) 1.78
The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling. Nat Cell Biol (2002) 1.77
Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi. Proc Natl Acad Sci U S A (2009) 1.73
High-throughput phosphotyrosine profiling using SH2 domains. Mol Cell (2007) 1.72
Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. Sci Signal (2013) 1.69
Deciphering arginine methylation: Tudor tells the tale. Nat Rev Mol Cell Biol (2011) 1.69
Polarity proteins in axon specification and synaptogenesis. Dev Cell (2005) 1.66