Published in J Am Chem Soc on August 10, 2005
Thiopeptide biosynthesis featuring ribosomally synthesized precursor peptides and conserved posttranslational modifications. Chem Biol (2009) 1.93
Codon randomization for rapid exploration of chemical space in thiopeptide antibiotic variants. Chem Biol (2012) 1.55
Identification of distinct thiopeptide-antibiotic precursor lead compounds using translation machinery assays. Chem Biol (2009) 1.53
The art of total synthesis through cascade reactions. Chem Soc Rev (2009) 1.48
Recent advances in the chemistry and biology of naturally occurring antibiotics. Angew Chem Int Ed Engl (2009) 1.39
Chemoenzymatic synthesis of thiazolyl peptide natural products featuring an enzyme-catalyzed formal [4 + 2] cycloaddition. J Am Chem Soc (2015) 1.12
Thiostrepton inhibits stable 70S ribosome binding and ribosome-dependent GTPase activation of elongation factor G and elongation factor 4. Nucleic Acids Res (2011) 1.00
Differential effects of thiopeptide and orthosomycin antibiotics on translational GTPases. Chem Biol (2011) 0.96
From nature to the laboratory and into the clinic. Bioorg Med Chem (2008) 0.95
Synthesis of sansalvamide A peptidomimetics: triazole, oxazole, thiazole, and pseudoproline containing compounds. Tetrahedron (2012) 0.91
NosA catalyzing carboxyl-terminal amide formation in nosiheptide maturation via an enamine dealkylation on the serine-extended precursor peptide. J Am Chem Soc (2010) 0.90
Total synthesis of atrochamins F, H, I, and J through cascade reactions. Tetrahedron (2008) 0.84
Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance. Chem Soc Rev (2012) 0.84
Progress towards the synthesis of Urukthapelstatin A and two analogues. Tetrahedron Lett (2012) 0.81
Inspirations, discoveries, and future perspectives in total synthesis. J Org Chem (2009) 0.79
Saturation mutagenesis of TsrA Ala4 unveils a highly mutable residue of thiostrepton A. ACS Chem Biol (2015) 0.78
Structure-based Mechanistic Insights into Terminal Amide Synthase in Nosiheptide-Represented Thiopeptides Biosynthesis. Sci Rep (2015) 0.77
Total synthesis of the antimitotic bicyclic peptide celogentin C. J Am Chem Soc (2010) 0.77
How thiostrepton was made in the laboratory. Angew Chem Int Ed Engl (2012) 0.75
A mild and selective method for the hydrolysis of esters with trimethyltin hydroxide. Angew Chem Int Ed Engl (2005) 2.09
Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations. Sci Transl Med (2012) 1.62
[Risk factors for development and recurrence of peptic ulcer disease]. Korean J Gastroenterol (2010) 1.59
Relationship between intraocular pressure and systemic health parameters in a Korean population. Clin Experiment Ophthalmol (2002) 1.58
Effect of myopia on the thickness of the retinal nerve fiber layer measured by Cirrus HD optical coherence tomography. Invest Ophthalmol Vis Sci (2010) 1.53
Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers. Nature (2013) 1.52
[Assessment of factors affecting the accuracy of endoscopic ultrasonography in T2 stage gastric cancer]. Korean J Gastroenterol (2008) 1.51
[Effects of proton pump inhibitors in asthmatics with gastroesophageal reflux disease]. Korean J Gastroenterol (2011) 1.42
Recent advances in the chemistry and biology of naturally occurring antibiotics. Angew Chem Int Ed Engl (2009) 1.39
Total synthesis of thiostrepton. Retrosynthetic analysis and construction of key building blocks. J Am Chem Soc (2005) 1.30
The effects of probiotics on PPI-triple therapy for Helicobacter pylori eradication. Helicobacter (2008) 1.23
Discovery of a biologically active thiostrepton fragment. J Am Chem Soc (2005) 1.20
Identification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitors. J Med Chem (2012) 1.10
Semisynthetic cyclopamine analogues as potent and orally bioavailable hedgehog pathway antagonists. J Med Chem (2008) 1.07
Adamantaplatensimycin: a bioactive analogue of platensimycin. Angew Chem Int Ed Engl (2007) 1.06
Sustained-release praziquantel tablet: pharmacokinetics and the treatment of clonorchiasis in beagle dogs. Parasitol Res (2003) 1.02
Relationship between intraocular pressure and systemic health parameters in the Korean population. Korean J Ophthalmol (2002) 0.96
Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors. J Med Chem (2012) 0.96
Universal solid-phase approach for the immobilization, derivatization, and resin-to-resin transfer reactions of boronic acids. J Org Chem (2002) 0.93
Acute toxicity of Ag and CuO nanoparticle suspensions against Daphnia magna: the importance of their dissolved fraction varying with preparation methods. J Hazard Mater (2012) 0.93
Total synthesis of thiostrepton, part 2: construction of the quinaldic acid macrocycle and final stages of the synthesis. Angew Chem Int Ed Engl (2004) 0.91
Discovery of selective LRRK2 inhibitors guided by computational analysis and molecular modeling. J Med Chem (2012) 0.90
Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors. J Med Chem (2013) 0.89
Revision total hip arthroplasty using an extensively porous coated femoral stem. Clin Orthop Surg (2009) 0.87
A biomimetically inspired synthesis of the dehydropiperidine domain of thiostrepton. Angew Chem Int Ed Engl (2002) 0.86
Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (Nampt) inhibitors. J Med Chem (2013) 0.86
Total synthesis of thiostrepton, part 1: construction of the dehydropiperidine/thiazoline-containing macrocycle. Angew Chem Int Ed Engl (2004) 0.86
Preclinical disposition and pharmacokinetics-pharmacodynamic modeling of biomarker response and tumour growth inhibition in xenograft mouse models of G-573, a MEK inhibitor. Xenobiotica (2010) 0.84
A restricted role for TYK2 catalytic activity in human cytokine responses revealed by novel TYK2-selective inhibitors. J Immunol (2013) 0.83
Construction of substituted N-hydroxyindoles: synthesis of a nocathiacin I model system. Angew Chem Int Ed Engl (2005) 0.83
Potent and selective inhibitors of PI3Kδ: obtaining isoform selectivity from the affinity pocket and tryptophan shelf. Bioorg Med Chem Lett (2012) 0.83
Long-term follow up of Helicobacter pylori IgG serology after eradication and reinfection rate of H. pylori in South Korea. Helicobacter (2008) 0.82
[Clinical characteristics of patients diagnosed as peptic ulcer disease in the third referral center in 2007]. Korean J Gastroenterol (2012) 0.82
The total synthesis of coleophomones B and C. Angew Chem Int Ed Engl (2002) 0.82
A case of inadvertent anterior chamber and corneal stromal injection with antibiotics during cataract operation. Korean J Ophthalmol (2006) 0.82
Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg Med Chem Lett (2013) 0.81
Fragment-based identification of amides derived from trans-2-(pyridin-3-yl)cyclopropanecarboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). J Med Chem (2014) 0.81
Synthesis of highly substituted N-hydroxyindoles through 1,5-addition of carbon nucleophiles to in situ generated unsaturated nitrones. Angew Chem Int Ed Engl (2006) 0.81
Synthetic studies on thiostrepton: construction of thiostrepton analogues with the thiazoline-containing macrocycle. Angew Chem Int Ed Engl (2003) 0.80
A new entry of copper-catalyzed four-component reaction: facile access to alpha-aryl beta-hydroxy imidates. Org Lett (2009) 0.80
[A case of intestinal tuberculosis presenting massive hematochezia controlled by endoscopic coagulation therapy]. Korean J Gastroenterol (2005) 0.80
Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models. J Med Chem (2014) 0.79
Studies on activation mechanism of a mitomycin dimer, 7-N,7'-N'-(1″,2″-dithiepanyl-3″,7″-dimethylenyl)bismitomycin C. Arch Pharm Res (2012) 0.79
Total synthesis of 6-deoxypladienolide D and Assessment of Splicing Inhibitory Activity in a Mutant SF3B1 cancer cell line. Org Lett (2014) 0.78
Ethanol potentiates hepatitis B virus replication through oxidative stress-dependent and -independent transcriptional activation. Biochem Biophys Res Commun (2012) 0.78
Synthesis and mechanistic studies of a mitomycin dimer containing an eight-membered cyclic disulfide. Bioorg Med Chem (2011) 0.77
Relationship between the retinal thickness analyzer and the GDx VCC scanning laser polarimeter, Stratus OCT optical coherence tomograph, and Heidelberg retina tomograph II confocal scanning laser ophthalmoscopy. Korean J Ophthalmol (2008) 0.77
[Comparison among conventional 4 L polyethylene glycol, split method of 4 L polyethylene glycol and combination of 2 L polyethylene glycol and sodium phosphate solution for colonoscopy preparation]. Korean J Gastroenterol (2012) 0.77
Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties. Bioorg Med Chem Lett (2013) 0.77
Structural and biochemical analyses of the catalysis and potency impact of inhibitor phosphoribosylation by human nicotinamide phosphoribosyltransferase. Chembiochem (2014) 0.77
Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg Med Chem Lett (2013) 0.76
Design and evaluation of novel 8-oxo-pyridopyrimidine Jak1/2 inhibitors. Bioorg Med Chem Lett (2013) 0.76
New synthetic technology for the construction of N-hydroxyindoles and synthesis of nocathiacin I model systems. Tetrahedron (2007) 0.76
Total synthesis of pareitropone via radical anion coupling. Org Lett (2010) 0.76
Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1. Bioorg Med Chem Lett (2013) 0.76
A probabilistic method to report predictions from a human liver microsomes stability QSAR model: a practical tool for drug discovery. J Comput Aided Mol Des (2015) 0.75
Measuring NAD(+) levels in mouse blood and tissue samples via a surrogate matrix approach using LC-MS/MS. Bioanalysis (2014) 0.75
Stereocontrolled synthesis of the quinaldic acid macrocyclic system of thiostrepton. Angew Chem Int Ed Engl (2002) 0.75
Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2. Bioorg Med Chem Lett (2012) 0.75
Hospital Outbreaks of Middle East Respiratory Syndrome, Daejeon, South Korea, 2015. Emerg Infect Dis (2017) 0.75
Studies on synthesis and activation mechanism of mitomycin dimers connected by 1,2-dithiolane and diol linkers. Bioorg Med Chem (2012) 0.75
Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer's Disease. J Med Chem (2017) 0.75
Sorption of Pb(II) and Cu(II) onto multi-amine grafted mesoporous silica embedded with nano-magnetite: effects of steric factors. J Hazard Mater (2012) 0.75
Segmental transposition of ileal muscle layers: a rare cause of myopathic pseudoobstruction in a newborn. J Pediatr Surg (2011) 0.75
Design and synthesis of new mitomycin dimers containing a seven-membered cyclic disulfide and a diol linkers. Arch Pharm Res (2012) 0.75
Is Beta-Blocker Use Beneficial in Breast Cancer? A Meta-Analysis. Oncology (2017) 0.75