Published in J Am Chem Soc on November 02, 2005
Thiazole antibiotics target FoxM1 and induce apoptosis in human cancer cells. PLoS One (2009) 2.82
The transcription factor FOXM1 is a cellular target of the natural product thiostrepton. Nat Chem (2011) 1.82
Identification of distinct thiopeptide-antibiotic precursor lead compounds using translation machinery assays. Chem Biol (2009) 1.53
Manipulation of thiocillin variants by prepeptide gene replacement: structure, conformation, and activity of heterocycle substitution mutants. J Am Chem Soc (2010) 1.51
A new target for proteasome inhibitors: FoxM1. Expert Opin Investig Drugs (2010) 1.48
Recent advances in the chemistry and biology of naturally occurring antibiotics. Angew Chem Int Ed Engl (2009) 1.39
Genetic interception and structural characterization of thiopeptide cyclization precursors from Bacillus cereus. J Am Chem Soc (2010) 1.31
Generation of thiocillin variants by prepeptide gene replacement and in vivo processing by Bacillus cereus. J Am Chem Soc (2009) 1.28
Thiopeptide antibiotics: retrospective and recent advances. Mar Drugs (2014) 1.10
Thiostrepton tryptophan methyltransferase expands the chemistry of radical SAM enzymes. Nat Chem Biol (2012) 1.10
Apicoplast-targeting antibacterials inhibit the growth of Babesia parasites. Antimicrob Agents Chemother (2012) 1.00
Thiostrepton inhibits stable 70S ribosome binding and ribosome-dependent GTPase activation of elongation factor G and elongation factor 4. Nucleic Acids Res (2011) 1.00
New anti-tuberculosis agents amongst known drugs. Tuberculosis (Edinb) (2009) 0.97
From nature to the laboratory and into the clinic. Bioorg Med Chem (2008) 0.95
FoxM1: a potential drug target for glioma. Future Oncol (2012) 0.86
The dual inhibitory effect of thiostrepton on FoxM1 and EWS/FLI1 provides a novel therapeutic option for Ewing's sarcoma. Int J Oncol (2013) 0.80
YcaO-Dependent Posttranslational Amide Activation: Biosynthesis, Structure, and Function. Chem Rev (2017) 0.79
The Role of Forkhead Box Protein M1 in Breast Cancer Progression and Resistance to Therapy. Int J Breast Cancer (2016) 0.79
Structure-activity relationships of thiostrepton derivatives: implications for rational drug design. J Comput Aided Mol Des (2014) 0.77
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Cancer Cell (2003) 3.66
A single-molecule nanopore device detects DNA polymerase activity with single-nucleotide resolution. J Am Chem Soc (2008) 3.04
Recognizing a single base in an individual DNA strand: a step toward DNA sequencing in nanopores. Angew Chem Int Ed Engl (2005) 2.83
Taxane-induced blockade to nuclear accumulation of the androgen receptor predicts clinical responses in metastatic prostate cancer. Cancer Res (2011) 2.69
Microtubule interactions with chemically diverse stabilizing agents: thermodynamics of binding to the paclitaxel site predicts cytotoxicity. Chem Biol (2005) 2.11
Targeting microtubules for cancer chemotherapy. Curr Med Chem Anticancer Agents (2005) 2.10
A mild and selective method for the hydrolysis of esters with trimethyltin hydroxide. Angew Chem Int Ed Engl (2005) 2.09
Functional characterization of circulating tumor cells with a prostate-cancer-specific microfluidic device. PLoS One (2012) 1.86
Identification of a novel small-molecule inhibitor of the hypoxia-inducible factor 1 pathway. Cancer Res (2005) 1.67
Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics. Proc Natl Acad Sci U S A (2002) 1.64
Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations. Sci Transl Med (2012) 1.62
The importance of p53 location: nuclear or cytoplasmic zip code? Drug Resist Updat (2003) 1.61
[Risk factors for development and recurrence of peptic ulcer disease]. Korean J Gastroenterol (2010) 1.59
Relationship between intraocular pressure and systemic health parameters in a Korean population. Clin Experiment Ophthalmol (2002) 1.58
Effect of myopia on the thickness of the retinal nerve fiber layer measured by Cirrus HD optical coherence tomography. Invest Ophthalmol Vis Sci (2010) 1.53
Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers. Nature (2013) 1.52
[Assessment of factors affecting the accuracy of endoscopic ultrasonography in T2 stage gastric cancer]. Korean J Gastroenterol (2008) 1.51
Both microtubule-stabilizing and microtubule-destabilizing drugs inhibit hypoxia-inducible factor-1alpha accumulation and activity by disrupting microtubule function. Cancer Res (2005) 1.49
A virocidal amphipathic {alpha}-helical peptide that inhibits hepatitis C virus infection in vitro. Proc Natl Acad Sci U S A (2008) 1.48
Single DNA rotaxanes of a transmembrane pore protein. Angew Chem Int Ed Engl (2004) 1.48
Interaction of epothilone analogs with the paclitaxel binding site: relationship between binding affinity, microtubule stabilization, and cytotoxicity. Chem Biol (2004) 1.46
The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for activity. Biochemistry (2002) 1.45
[Effects of proton pump inhibitors in asthmatics with gastroesophageal reflux disease]. Korean J Gastroenterol (2011) 1.42
Evaluation of the tubulin-bound paclitaxel conformation: synthesis, biology, and SAR studies of C-4 to C-3' bridged paclitaxel analogues. J Med Chem (2007) 1.42
Self-assembling peptide nanotubes with antiviral activity against hepatitis C virus. Chem Biol (2011) 1.41
Recent advances in the chemistry and biology of naturally occurring antibiotics. Angew Chem Int Ed Engl (2009) 1.39
Androgen receptor on the move: boarding the microtubule expressway to the nucleus. Cancer Res (2012) 1.35
Heterocyclic peptide backbone modifications in an alpha-helical coiled coil. J Am Chem Soc (2004) 1.33
Total synthesis of thiostrepton. Retrosynthetic analysis and construction of key building blocks. J Am Chem Soc (2005) 1.30
HFT-T, a targeting nanoparticle, enhances specific delivery of paclitaxel to folate receptor-positive tumors. ACS Nano (2009) 1.29
The synergistic combination of the farnesyl transferase inhibitor lonafarnib and paclitaxel enhances tubulin acetylation and requires a functional tubulin deacetylase. Cancer Res (2005) 1.28
Mitotic kinesin inhibitors induce mitotic arrest and cell death in Taxol-resistant and -sensitive cancer cells. J Biol Chem (2005) 1.27
Microtubule disruption targets HIF-1alpha mRNA to cytoplasmic P-bodies for translational repression. J Cell Biol (2011) 1.26
Total synthesis of thiostrepton. Assembly of key building blocks and completion of the synthesis. J Am Chem Soc (2005) 1.26
Enantioselective dichlorination of allylic alcohols. J Am Chem Soc (2011) 1.25
Systemic antibacterial activity of novel synthetic cyclic peptides. Antimicrob Agents Chemother (2005) 1.25
EF24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits HIF-1. Cell Cycle (2008) 1.23
Modular multi-level circuits from immobilized DNA-based logic gates. J Am Chem Soc (2007) 1.23
Antitumor effect of 2-methoxyestradiol in a rat orthotopic brain tumor model. Cancer Res (2006) 1.23
The effects of probiotics on PPI-triple therapy for Helicobacter pylori eradication. Helicobacter (2008) 1.23
Paclitaxel-resistant human ovarian cancer cells undergo c-Jun NH2-terminal kinase-mediated apoptosis in response to noscapine. J Biol Chem (2002) 1.22
Carbonyl sulfide-mediated prebiotic formation of peptides. Science (2004) 1.22
Self-assembling sequence-adaptive peptide nucleic acids. Science (2009) 1.21
Coiled coils at the edge of configurational heterogeneity. Structural analyses of parallel and antiparallel homotetrameric coiled coils reveal configurational sensitivity to a single solvent-exposed amino acid substitution. Biochemistry (2006) 1.21
Chemistry and biology of diazonamide A: second total synthesis and biological investigations. J Am Chem Soc (2004) 1.16
A heterocyclic peptide nanotube. J Am Chem Soc (2003) 1.14
Design of a directed molecular network. Proc Natl Acad Sci U S A (2004) 1.13
Identification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitors. J Med Chem (2012) 1.10
Boolean logic functions of a synthetic peptide network. J Am Chem Soc (2004) 1.10
DNA detection and signal amplification via an engineered allosteric enzyme. J Am Chem Soc (2003) 1.08
DNA-based photonic logic gates: AND, NAND, and INHIBIT. J Am Chem Soc (2003) 1.08
Probing the bioactive conformation of an archetypal natural product HDAC inhibitor with conformationally homogeneous triazole-modified cyclic tetrapeptides. Angew Chem Int Ed Engl (2009) 1.08
Farnesyl transferase inhibitors impair chromosomal maintenance in cell lines and human tumors by compromising CENP-E and CENP-F function. Mol Cancer Ther (2007) 1.07
Total synthesis of apoptolidin: completion of the synthesis and analogue synthesis and evaluation. J Am Chem Soc (2003) 1.05
Total synthesis of epicoccin G. J Am Chem Soc (2011) 1.04
Real-time monitoring of DNA polymerase function and stepwise single-nucleotide DNA strand translocation through a protein nanopore. Angew Chem Int Ed Engl (2010) 1.03
Automated mass spectrometric sequence determination of cyclic peptide library members. J Comb Chem (2003) 1.02
Sustained-release praziquantel tablet: pharmacokinetics and the treatment of clonorchiasis in beagle dogs. Parasitol Res (2003) 1.02
Antiviral cyclic D,L-alpha-peptides: targeting a general biochemical pathway in virus infections. Bioorg Med Chem (2005) 1.02
Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides. J Med Chem (2009) 1.02
Design of self-assembling peptide nanotubes with delocalized electronic states. Small (2006) 1.02
Accumulation of hypoxia-inducible factor-1alpha is limited by transcription-dependent depletion. Oncogene (2005) 1.01
The neuropeptides GnRH-II and GnRH-I are produced by human T cells and trigger laminin receptor gene expression, adhesion, chemotaxis and homing to specific organs. Nat Med (2002) 1.01
Isolation and characterization of circulating tumor cells in prostate cancer. Front Oncol (2012) 0.98
The protein farnesyltransferase regulates HDAC6 activity in a microtubule-dependent manner. J Biol Chem (2009) 0.98
Molecules that mimic apolipoprotein A-I: potential agents for treating atherosclerosis. J Med Chem (2013) 0.98
Sequence-addressable DNA logic. Small (2008) 0.98
Structure-based engineering of internal cavities in coiled-coil peptides. Biochemistry (2005) 0.97
Relationship between intraocular pressure and systemic health parameters in the Korean population. Korean J Ophthalmol (2002) 0.96
Survivin deregulation in beta-tubulin mutant ovarian cancer cells underlies their compromised mitotic response to taxol. Cancer Res (2004) 0.95
Microtubules regulate hypoxia-inducible factor-1α protein trafficking and activity: implications for taxane therapy. J Biol Chem (2012) 0.95
Mimicry of high-density lipoprotein: functional peptide-lipid nanoparticles based on multivalent peptide constructs. J Am Chem Soc (2013) 0.94
Ion channel models based on self-assembling cyclic peptide nanotubes. Acc Chem Res (2013) 0.94
A folate receptor-targeting nanoparticle minimizes drug resistance in a human cancer model. ACS Nano (2011) 0.94
Universal solid-phase approach for the immobilization, derivatization, and resin-to-resin transfer reactions of boronic acids. J Org Chem (2002) 0.93
Efficient route to C2 symmetric heterocyclic backbone modified cyclic peptides. Org Lett (2005) 0.93
Acute toxicity of Ag and CuO nanoparticle suspensions against Daphnia magna: the importance of their dissolved fraction varying with preparation methods. J Hazard Mater (2012) 0.93
Cyclostreptin (FR182877), an antitumor tubulin-polymerizing agent deficient in enhancing tubulin assembly despite its high affinity for the taxoid site. Biochemistry (2005) 0.93
Modulating ion channel properties of transmembrane peptide nanotubes through heteromeric supramolecular assemblies. J Am Chem Soc (2002) 0.92
Total synthesis of thiostrepton, part 2: construction of the quinaldic acid macrocycle and final stages of the synthesis. Angew Chem Int Ed Engl (2004) 0.91
Molecular design and chemical synthesis of a highly potent epothilone. ChemMedChem (2006) 0.91
Farnesyltransferase inhibitors reverse taxane resistance. Cancer Res (2006) 0.90
Discovery of selective LRRK2 inhibitors guided by computational analysis and molecular modeling. J Med Chem (2012) 0.90
Catalyzed oxidative corrosion of porous silicon used as an optical transducer for ligand-receptor interactions. Chembiochem (2008) 0.90