Fragment-based identification of amides derived from trans-2-(pyridin-3-yl)cyclopropanecarboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).

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Published in J Med Chem on January 22, 2014

Authors

Anthony M Giannetti1, Xiaozhang Zheng, Nicholas J Skelton, Weiru Wang, Brandon J Bravo, Kenneth W Bair, Timm Baumeister, Eric Cheng, Lisa Crocker, Yezhen Feng, Janet Gunzner-Toste, Yen-Ching Ho, Rongbao Hua, Bianca M Liederer, Yongbo Liu, Xiaolei Ma, Thomas O'Brien, Jason Oeh, Deepak Sampath, Youming Shen, Chengcheng Wang, Leslie Wang, Hongxing Wu, Yang Xiao, Po-wai Yuen, Mark Zak, Guiling Zhao, Qiang Zhao, Peter S Dragovich

Author Affiliations

1: Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.

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