PubRank

Jukka-Pekka Mecklin

Author PubWeight™ 93.88‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial. Lancet 2011 6.77
2 The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling. Nat Genet 2009 5.65
3 Effect of aspirin or resistant starch on colorectal neoplasia in the Lynch syndrome. N Engl J Med 2008 3.76
4 Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk. Nat Genet 2012 3.19
5 The risk of extra-colonic, extra-endometrial cancer in the Lynch syndrome. Int J Cancer 2008 2.95
6 Low-level microsatellite instability in most colorectal carcinomas. Cancer Res 2002 2.87
7 Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts. Gut 2013 2.86
8 Cancer risk in hereditary nonpolyposis colorectal cancer syndrome: later age of onset. Gastroenterology 2005 2.80
9 Early-onset renal cell carcinoma as a novel extraparaganglial component of SDHB-associated heritable paraganglioma. Am J Hum Genet 2003 2.43
10 Explaining the familial colorectal cancer risk associated with mismatch repair (MMR)-deficient and MMR-stable tumors. Clin Cancer Res 2007 2.24
11 SMAD4 levels and response to 5-fluorouracil in colorectal cancer. Clin Cancer Res 2005 2.05
12 Ten years after mutation testing for Lynch syndrome: cancer incidence and outcome in mutation-positive and mutation-negative family members. J Clin Oncol 2009 1.92
13 Surveillance for endometrial cancer in hereditary nonpolyposis colorectal cancer syndrome. Int J Cancer 2007 1.67
14 Allelic imbalance at rs6983267 suggests selection of the risk allele in somatic colorectal tumor evolution. Cancer Res 2008 1.59
15 Gene-expression profiling predicts recurrence in Dukes' C colorectal cancer. Gastroenterology 2005 1.56
16 SMAD4 as a prognostic marker in colorectal cancer. Clin Cancer Res 2005 1.50
17 Proportion and phenotype of MYH-associated colorectal neoplasia in a population-based series of Finnish colorectal cancer patients. Am J Pathol 2003 1.38
18 Biallelic inactivation of fumarate hydratase (FH) occurs in nonsyndromic uterine leiomyomas but is rare in other tumors. Am J Pathol 2004 1.37
19 Large genomic rearrangements and germline epimutations in Lynch syndrome. Int J Cancer 2009 1.24
20 Sharing genetic risk with next generation: mutation-positive parents' communication with their offspring in Lynch Syndrome. Fam Cancer 2011 1.23
21 Prevalence of adenomas and hyperplastic polyps in mismatch repair mutation carriers among CAPP2 participants: report by the colorectal adenoma/carcinoma prevention programme 2. J Clin Oncol 2008 1.23
22 Comprehensive characterization of HNPCC-related colorectal cancers reveals striking molecular features in families with no germline mismatch repair gene mutations. Oncogene 2005 1.22
23 Unregulated smooth-muscle myosin in human intestinal neoplasia. Proc Natl Acad Sci U S A 2008 1.20
24 Altered expression of MLH1, MSH2, and MSH6 in predisposition to hereditary nonpolyposis colorectal cancer. J Clin Oncol 2003 1.18
25 The genetics of HNPCC: application to diagnosis and screening. Crit Rev Oncol Hematol 2006 1.11
26 BMPR1A mutations in hereditary nonpolyposis colorectal cancer without mismatch repair deficiency. Gastroenterology 2011 1.10
27 Candidate driver genes in microsatellite-unstable colorectal cancer. Int J Cancer 2011 1.08
28 Molecular analysis of endometrial tumorigenesis: importance of complex hyperplasia regardless of atypia. Clin Cancer Res 2009 1.07
29 Breast carcinoma and Lynch syndrome: molecular analysis of tumors arising in mutation carriers, non-carriers, and sporadic cases. Breast Cancer Res 2012 1.05
30 Exome sequencing reveals frequent inactivating mutations in ARID1A, ARID1B, ARID2 and ARID4A in microsatellite unstable colorectal cancer. Int J Cancer 2014 1.02
31 Preferential amplification of AURKA 91A (Ile31) in familial colorectal cancers. Int J Cancer 2006 1.02
32 Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial. Lancet Oncol 2012 1.01
33 Low-penetrance susceptibility variants in familial colorectal cancer. Cancer Epidemiol Biomarkers Prev 2010 1.01
34 p53 codon 72 and MDM2 SNP309 polymorphisms and age of colorectal cancer onset in Lynch syndrome. Clin Cancer Res 2005 1.01
35 Background mutation frequency in microsatellite-unstable colorectal cancer. Cancer Res 2007 1.00
36 Carbonic anhydrase IX is highly expressed in hereditary nonpolyposis colorectal cancer. Cancer Epidemiol Biomarkers Prev 2007 1.00
37 Eleven candidate susceptibility genes for common familial colorectal cancer. PLoS Genet 2013 0.98
38 Colorectal pretumor progression before and after loss of DNA mismatch repair. Am J Pathol 2004 0.97
39 BRAF mutation in sporadic colorectal cancer and Lynch syndrome. Virchows Arch 2013 0.96
40 EXO1 variants occur commonly in normal population: evidence against a role in hereditary nonpolyposis colorectal cancer. Cancer Res 2003 0.94
41 A prospective randomized controlled multicenter trial comparing antibiotic therapy with appendectomy in the treatment of uncomplicated acute appendicitis (APPAC trial). BMC Surg 2013 0.94
42 Mutations in the circadian gene CLOCK in colorectal cancer. Mol Cancer Res 2010 0.93
43 Little evidence for involvement of MLH3 in colorectal cancer predisposition. Int J Cancer 2003 0.93
44 Causes of death of mutation carriers in Finnish Lynch syndrome families. Fam Cancer 2012 0.92
45 NOD2 3020insC alone is not sufficient for colorectal cancer predisposition. Cancer Res 2004 0.92
46 Identification of candidate oncogenes in human colorectal cancers with microsatellite instability. Gastroenterology 2013 0.92
47 Compliance and Satisfaction with Long-Term Surveillance in Finnish HNPCC Families. Fam Cancer 2006 0.92
48 Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci. BMC Med Genet 2011 0.91
49 PolyA deletions in hereditary nonpolyposis colorectal cancer: mutations before a gatekeeper. Am J Pathol 2002 0.90
50 A novel functionally deficient MYH variant in individuals with colorectal adenomatous polyposis. Hum Mutat 2005 0.90
51 Mutations in Exon 1 highlight the role of MED12 in uterine leiomyomas. Hum Mutat 2014 0.89
52 Somatic mutations and germline sequence variants in patients with familial colorectal cancer. Int J Cancer 2010 0.89
53 Exome sequencing in diagnostic evaluation of colorectal cancer predisposition in young patients. Scand J Gastroenterol 2013 0.88
54 Recessively inherited right atrial isomerism caused by mutations in growth/differentiation factor 1 (GDF1). Hum Mol Genet 2010 0.87
55 Colorectal surveillance in Lynch syndrome families. Fam Cancer 2013 0.87
56 Mutations in two short noncoding mononucleotide repeats in most microsatellite-unstable colorectal cancers. Cancer Res 2005 0.85
57 Psychosocial consequences of predictive genetic testing for Lynch syndrome and associations to surveillance behaviour in a 7-year follow-up study. Fam Cancer 2013 0.84
58 Distinct molecular profiles in Lynch syndrome-associated and sporadic ovarian carcinomas. Int J Cancer 2013 0.84
59 EPHB2 germline variants in patients with colorectal cancer or hyperplastic polyposis. BMC Cancer 2006 0.83
60 History of the International Collaborative Group on Hereditary Non Polyposis Colorectal Cancer. Fam Cancer 2003 0.83
61 The impact of upper GI endoscopy referral volume on the diagnosis of gastroesophageal reflux disease and its complications: a 1-year cross-sectional study in a referral area with 260,000 inhabitants. Am J Gastroenterol 2002 0.82
62 Numbers of mutations to different types of colorectal cancer. BMC Cancer 2005 0.81
63 High frequency of TTK mutations in microsatellite-unstable colorectal cancer and evaluation of their effect on spindle assembly checkpoint. Carcinogenesis 2010 0.81
64 Genome-wide allelotyping of 104 Finnish colorectal cancers reveals an excess of allelic imbalance in chromosome 20q in familial cases. Oncogene 2003 0.80
65 Epigenetic analysis of sporadic and Lynch-associated ovarian cancers reveals histology-specific patterns of DNA methylation. Epigenetics 2014 0.80
66 ARLTS1 germline variants and the risk for breast, prostate, and colorectal cancer. Eur J Hum Genet 2008 0.79
67 No evidence for association of NOD2 R702W and G908R with colorectal cancer. Int J Cancer 2007 0.79
68 Quantitative analysis of γ-H2AX and p53 nuclear expression levels in ovarian and fallopian tube epithelium from risk-reducing salpingo-oophorectomies in BRCA1 and BRCA2 mutation carriers. Int J Gynecol Pathol 2014 0.79
69 Uroepithelial and kidney carcinoma in Lynch syndrome. Fam Cancer 2012 0.77
70 3'-UTR poly(T/U) repeat of EWSR1 is altered in microsatellite unstable colorectal cancer with nearly perfect sensitivity. Fam Cancer 2015 0.75
71 [Rectal cancer]. Duodecim 2002 0.75
72 Subtotal Colectomy for Colon Cancer Reduces the Need for Subsequent Surgery in Lynch Syndrome. Dis Colon Rectum 2017 0.75
73 Clinical and laboratory findings in the diagnosis of right lower quadrant abdominal pain: outcome analysis of the APPAC trial. Clin Chem Lab Med 2016 0.75
74 Spinopelvic Changes Based on the Simplified SRS-Schwab Adult Spinal Deformity Classification: Relationships with Disability and Health-related Quality of Life in Adult Patients with Prolonged Degenerative Spinal Disorders. Spine (Phila Pa 1976) 2017 0.75
75 [Risk factors and possibilities of prevention of bowel cancer]. Duodecim 2016 0.75
76 [Diagnosis and treatment of Lynch syndrome]. Duodecim 2016 0.75
77 Reliability and Validity Study of the Finnish Adaptation of Scoliosis Research Society Questionnaire Version SRS-30. Spine (Phila Pa 1976) 2017 0.75