Telomere structure and shortening in telomerase-deficient Trypanosoma brucei.

RAP1 is essential for silencing telomeric variant surface glycoprotein genes in Trypanosoma brucei. Cell (2009) 1.55

Deletion of a trypanosome telomere leads to loss of silencing and progressive loss of terminal DNA in the absence of cell cycle arrest. Nucleic Acids Res (2007) 1.23

Repression of polymerase I-mediated gene expression at Trypanosoma brucei telomeres. EMBO Rep (2006) 1.23

Telomere length affects the frequency and mechanism of antigenic variation in Trypanosoma brucei. PLoS Pathog (2012) 0.98

Telomerase-independent stabilization of short telomeres in Trypanosoma brucei. Mol Cell Biol (2006) 0.92

Antigenic variation in African trypanosomes: the importance of chromosomal and nuclear context in VSG expression control. Cell Microbiol (2013) 0.89

Consequences of telomere shortening at an active VSG expression site in telomerase-deficient Trypanosoma brucei. Eukaryot Cell (2006) 0.88

Evolutionary perspectives of telomerase RNA structure and function. RNA Biol (2016) 0.83

A trans-spliced telomerase RNA dictates telomere synthesis in Trypanosoma brucei. Cell Res (2013) 0.82

Telomere length in Trypanosoma brucei. Exp Parasitol (2007) 0.81

Leishmania major telomerase TERT protein has a nuclear/mitochondrial eclipsed distribution that is affected by oxidative stress. Infect Immun (2014) 0.79

Cloning and characterization of telomerase reverse transcriptase gene in Trichinella spiralis. Parasitol Res (2011) 0.78

A newly discovered role of telomeres in an ancient organism. Nucleus (2010) 0.77

Does DNA replication direct locus-specific recombination during host immune evasion by antigenic variation in the African trypanosome? Curr Genet (2016) 0.75

The protein subunit of telomerase displays patterns of dynamic evolution and conservation across different metazoan taxa. BMC Evol Biol (2017) 0.75

Specific association of human telomerase activity with immortal cells and cancer. Science (1994) 28.20

Telomeres shorten during ageing of human fibroblasts. Nature (1990) 23.97

Telomerase catalytic subunit homologs from fission yeast and human. Science (1997) 12.35

Mammalian telomeres end in a large duplex loop. Cell (1999) 12.12

A tightly regulated inducible expression system for conditional gene knock-outs and dominant-negative genetics in Trypanosoma brucei. Mol Biochem Parasitol (1999) 11.77

TRF2 protects human telomeres from end-to-end fusions. Cell (1998) 10.13

Reverse transcriptase motifs in the catalytic subunit of telomerase. Science (1997) 10.10

Origin of concatemeric T7 DNA. Nat New Biol (1972) 9.08

TLC1: template RNA component of Saccharomyces cerevisiae telomerase. Science (1994) 9.08

hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell (1997) 8.74

A mutant with a defect in telomere elongation leads to senescence in yeast. Cell (1989) 8.69

The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity. Cell (1987) 8.32

Continuous cultivation of Trypanosoma brucei blood stream forms in a medium containing a low concentration of serum protein without feeder cell layers. J Parasitol (1989) 7.06

Regulation of telomerase by telomeric proteins. Annu Rev Biochem (2004) 5.69

Protection of mammalian telomeres. Oncogene (2002) 5.38

Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening. Cell (1997) 4.86

Saccharomyces telomeres acquire single-strand TG1-3 tails late in S phase. Cell (1993) 4.33

Senescence induced by altered telomere state, not telomere loss. Science (2002) 4.17

Telomerase activity in human ovarian carcinoma. Proc Natl Acad Sci U S A (1994) 3.86

Activation of trypanosome surface glycoprotein genes involves a duplication-transposition leading to an altered 3' end. Cell (1981) 3.65

T-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhang. EMBO J (2001) 3.28

Structure of the growing telomeres of Trypanosomes. Cell (1984) 3.24

Growth of chromosome ends in multiplying trypanosomes. Nature (1983) 3.16

Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature (2003) 2.92

Telomeres, stem cells, senescence, and cancer. J Clin Invest (2004) 2.87

Genomic environment of the expression-linked extra copies of genes for surface antigens of Trypanosoma brucei resembles the end of a chromosome. Nature (1982) 2.75

T-loops and the origin of telomeres. Nat Rev Mol Cell Biol (2004) 2.54

A novel mechanism for telomere size control in Saccharomyces cerevisiae. Genes Dev (1996) 2.49

The reverse transcriptase component of the Tetrahymena telomerase ribonucleoprotein complex. Proc Natl Acad Sci U S A (1998) 2.43

Activation of telomerase in a human tumor. Proc Natl Acad Sci U S A (1994) 2.11

The generation of proper constitutive G-tails on yeast telomeres is dependent on the MRX complex. Genes Dev (2004) 2.10

Disruption of the telomerase catalytic subunit gene from Arabidopsis inactivates telomerase and leads to a slow loss of telomeric DNA. Proc Natl Acad Sci U S A (1999) 1.99

t-loops at trypanosome telomeres. EMBO J (2001) 1.91

Differential size variations between transcriptionally active and inactive telomeres of Trypanosoma brucei. Nucleic Acids Res (1983) 1.77

Telomere shortening is proportional to the size of the G-rich telomeric 3'-overhang. J Biol Chem (2000) 1.73

Rap1 affects the length and heterogeneity of human telomeres. Mol Biol Cell (2003) 1.59

Telomeres of polytene chromosomes in a ciliated protozoan terminate in duplex DNA loops. Proc Natl Acad Sci U S A (1999) 1.57

The molecular evolution of trypanosomes. Parasitol Today (1999) 1.55

History of sleeping sickness in East Africa. Clin Microbiol Rev (1999) 1.48

Differential RNA elongation controls the variant surface glycoprotein gene expression sites of Trypanosoma brucei. Mol Microbiol (2000) 1.45

Telomere looping in P. sativum (common garden pea). Plant J (2003) 1.32

Short telomeres in yeast are highly recombinogenic. Mol Cell (2001) 1.31

Position-dependent and promoter-specific regulation of gene expression in Trypanosoma brucei. EMBO J (1997) 1.31

Analysis of Trypanosoma brucei vsg expression site switching in vitro. Mol Biochem Parasitol (1997) 1.26

Antigenic variation in clones of animal-infective Trypanosoma brucei derived and maintained in vitro. Parasitology (1980) 1.17

DNA rearrangements associated with multiple consecutive directed antigenic switches in Trypanosoma brucei. Mol Cell Biol (1996) 1.17

Analysis of the G-overhang structures on plant telomeres: evidence for two distinct telomere architectures. Plant J (2000) 1.02

Molecular cloning and characterization of AtTERT, a telomerase reverse transcriptase homolog in Arabidopsis thaliana. FEBS Lett (1999) 1.01

Telomere maintenance and length regulation in Trypanosoma brucei. EMBO J (2000) 0.98

Long telomeric C-rich 5'-tails in human replicating cells. J Biol Chem (2002) 0.84

Four histone variants mark the boundaries of polycistronic transcription units in Trypanosoma brucei. Genes Dev (2009) 3.62

Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. Nucleic Acids Res (2010) 2.38

Telomeric expression sites are highly conserved in Trypanosoma brucei. PLoS One (2008) 2.22

Developmental progression to infectivity in Trypanosoma brucei triggered by an RNA-binding protein. Science (2012) 1.94

A unified phylogeny-based nomenclature for histone variants. Epigenetics Chromatin (2012) 1.82

A histone methyltransferase modulates antigenic variation in African trypanosomes. PLoS Biol (2008) 1.72

Selective di- or trimethylation of histone H3 lysine 76 by two DOT1 homologs is important for cell cycle regulation in Trypanosoma brucei. Mol Cell (2006) 1.70

RAP1 is essential for silencing telomeric variant surface glycoprotein genes in Trypanosoma brucei. Cell (2009) 1.55

Nucleosomes are depleted at the VSG expression site transcribed by RNA polymerase I in African trypanosomes. Eukaryot Cell (2009) 1.52

A variant histone H3 is enriched at telomeres in Trypanosoma brucei. J Cell Sci (2004) 1.45

A yeast-endonuclease-generated DNA break induces antigenic switching in Trypanosoma brucei. Nature (2009) 1.44

Systematic study of sequence motifs for RNA trans splicing in Trypanosoma brucei. Mol Cell Biol (2005) 1.36

Trypanosomal TBP functions with the multisubunit transcription factor tSNAP to direct spliced-leader RNA gene expression. Mol Cell Biol (2005) 1.35

Unusual histone modifications in Trypanosoma brucei. FEBS Lett (2006) 1.28

Histone modifications in Trypanosoma brucei. Mol Biochem Parasitol (2007) 1.27

Histone H2AZ dimerizes with a novel variant H2B and is enriched at repetitive DNA in Trypanosoma brucei. J Cell Sci (2005) 1.25

A computational investigation of kinetoplastid trans-splicing. Genome Biol (2005) 1.23

Epigenetic regulation in African trypanosomes: a new kid on the block. Nat Rev Microbiol (2009) 1.20

The architecture of variant surface glycoprotein gene expression sites in Trypanosoma brucei. Mol Biochem Parasitol (2002) 1.20

Multifunctional class I transcription in Trypanosoma brucei depends on a novel protein complex. EMBO J (2007) 1.20

Trypanosome telomeres are protected by a homologue of mammalian TRF2. Mol Cell Biol (2005) 1.19

Two essential MYST-family proteins display distinct roles in histone H4K10 acetylation and telomeric silencing in trypanosomes. Mol Microbiol (2008) 1.15

Telomere structure and function in trypanosomes: a proposal. Nat Rev Microbiol (2006) 1.13

TOPO3alpha influences antigenic variation by monitoring expression-site-associated VSG switching in Trypanosoma brucei. PLoS Pathog (2010) 1.11

Analysis of the Trypanosoma brucei cell cycle by quantitative DAPI imaging. Mol Biochem Parasitol (2008) 1.11

An adenosine-to-inosine tRNA-editing enzyme that can perform C-to-U deamination of DNA. Proc Natl Acad Sci U S A (2007) 1.10

Gene expression in Trypanosoma brucei: lessons from high-throughput RNA sequencing. Trends Parasitol (2011) 1.10

Cholesterol import fails to prevent catalyst-based inhibition of ergosterol synthesis and cell proliferation of Trypanosoma brucei. J Lipid Res (2006) 1.08

Acetylation of histone H4K4 is cell cycle regulated and mediated by HAT3 in Trypanosoma brucei. Mol Microbiol (2007) 1.08

Two thymidine hydroxylases differentially regulate the formation of glucosylated DNA at regions flanking polymerase II polycistronic transcription units throughout the genome of Trypanosoma brucei. Nucleic Acids Res (2010) 1.08

CRE recombinase-based positive-negative selection systems for genetic manipulation in Trypanosoma brucei. Mol Biochem Parasitol (2007) 1.05

Mutational analysis of the variant surface glycoprotein GPI-anchor signal sequence in Trypanosoma brucei. J Cell Sci (2002) 1.05

Telomere length regulation and transcriptional silencing in KU80-deficient Trypanosoma brucei. Nucleic Acids Res (2004) 1.04

MCM-BP is required for repression of life-cycle specific genes transcribed by RNA polymerase I in the mammalian infectious form of Trypanosoma brucei. PLoS One (2013) 1.03

Structural features affecting variant surface glycoprotein expression in Trypanosoma brucei. Mol Biochem Parasitol (2003) 1.00

Histone H3 trimethylated at lysine 4 is enriched at probable transcription start sites in Trypanosoma brucei. Mol Biochem Parasitol (2010) 1.00

The essential polysome-associated RNA-binding protein RBP42 targets mRNAs involved in Trypanosoma brucei energy metabolism. RNA (2012) 0.99

Trypanosoma brucei Orc1 is essential for nuclear DNA replication and affects both VSG silencing and VSG switching. Mol Microbiol (2012) 0.98

Telomere length affects the frequency and mechanism of antigenic variation in Trypanosoma brucei. PLoS Pathog (2012) 0.98

Transposon mutagenesis of Trypanosoma brucei identifies glycosylation mutants resistant to concanavalin A. J Biol Chem (2004) 0.95

Identification of Trypanosoma brucei RMI1/BLAP75 homologue and its roles in antigenic variation. PLoS One (2011) 0.94

Trypanosoma brucei expression-site-associated-gene-8 protein interacts with a Pumilio family protein. Mol Biochem Parasitol (2002) 0.94

Trypanosome H2Bv replaces H2B in nucleosomes enriched for H3 K4 and K76 trimethylation. Biochem Biophys Res Commun (2008) 0.92

Telomerase-independent stabilization of short telomeres in Trypanosoma brucei. Mol Cell Biol (2006) 0.92

Trypanosoma brucei MRE11 is non-essential but influences growth, homologous recombination and DNA double-strand break repair. Mol Biochem Parasitol (2002) 0.92

Consequences of telomere shortening at an active VSG expression site in telomerase-deficient Trypanosoma brucei. Eukaryot Cell (2006) 0.88

Targeted deletion of the gp72 gene decreases the infectivity of Trypanosoma cruzi for mice and insect vectors. J Parasitol (2002) 0.87

Identification of selective tubulin inhibitors as potential anti-trypanosomal agents. Bioorg Med Chem Lett (2012) 0.86

Trypanosomes at the gates. Science (2005) 0.86

Strategies to construct null and conditional null Trypanosoma brucei mutants using Cre-recombinase and loxP. Mol Biochem Parasitol (2013) 0.85

An organism-specific method to rank predicted coding regions in Trypanosoma brucei. Nucleic Acids Res (2003) 0.84

Identification of biomarkers for hepatocellular carcinoma using network-based bioinformatics methods. Eur J Med Res (2013) 0.84

An mre11 mutation that promotes telomere recombination and an efficient bypass of senescence. Genetics (2010) 0.84

A trans-spliced telomerase RNA dictates telomere synthesis in Trypanosoma brucei. Cell Res (2013) 0.82

Silencing subtelomeric VSGs by Trypanosoma brucei RAP1 at the insect stage involves chromatin structure changes. Nucleic Acids Res (2013) 0.82

Telomere length in Trypanosoma brucei. Exp Parasitol (2007) 0.81

Hedgehog signaling regulates telomerase reverse transcriptase in human cancer cells. PLoS One (2013) 0.79

Examination of the telomere G-overhang structure in Trypanosoma brucei. J Vis Exp (2011) 0.77

Application of atomic force microscopy in morphological observation of antisense probe labeled with magnetism. Mol Vis (2008) 0.76

Preparation and quality test of superparamagnetic iron oxide labeled antisense oligodeoxynucleotide probe: a preliminary study. Ann Biomed Eng (2009) 0.76

Drug discovery: Fat-free proteins kill parasites. Nature (2010) 0.75

The naming of genes. Trends Parasitol (2011) 0.75