Published in J Comput Biol on August 19, 2005
Multipoint linkage analysis with many multiallelic or dense diallelic markers: Markov chain-Monte Carlo provides practical approaches for genome scans on general pedigrees. Am J Hum Genet (2006) 1.95
Efficient genome ancestry inference in complex pedigrees with inbreeding. Bioinformatics (2010) 1.40
An almost linear time algorithm for a general haplotype solution on tree pedigrees with no recombination and its extensions. J Bioinform Comput Biol (2009) 1.21
Mapping a new spontaneous preterm birth susceptibility gene, IGF1R, using linkage, haplotype sharing, and association analysis. PLoS Genet (2011) 1.09
Haplotype-based quantitative trait mapping using a clustering algorithm. BMC Bioinformatics (2006) 1.07
A survey on haplotyping algorithms for tightly linked markers. J Bioinform Comput Biol (2008) 1.06
Genetic effects at pleiotropic loci are context-dependent with consequences for the maintenance of genetic variation in populations. PLoS Genet (2011) 1.05
Change in maternal environment induced by cross-fostering alters genetic and epigenetic effects on complex traits in mice. Proc Biol Sci (2009) 1.04
Polymorphisms of estrogen-biosynthesis genes CYP17 and CYP19 may influence age at menarche: a genetic association study in Caucasian females. Hum Mol Genet (2006) 1.01
Association analyses of RANKL/RANK/OPG gene polymorphisms with femoral neck compression strength index variation in Caucasians. Calcif Tissue Int (2009) 0.95
Genetic, epigenetic, and gene-by-diet interaction effects underlie variation in serum lipids in a LG/JxSM/J murine model. J Lipid Res (2010) 0.91
Detection of recombination events, haplotype reconstruction and imputation of sires using half-sib SNP genotypes. Genet Sel Evol (2014) 0.90
Detecting genome-wide haplotype polymorphism by combined use of Mendelian constraints and local population structure. Pac Symp Biocomput (2010) 0.90
Haplotyping methods for pedigrees. Hum Hered (2009) 0.90
Pronounced inter- and intrachromosomal variation in linkage disequilibrium across the zebra finch genome. Genome Res (2010) 0.88
The importance of context to the genetic architecture of diabetes-related traits is revealed in a genome-wide scan of a LG/J × SM/J murine model. Mamm Genome (2011) 0.87
Association analyses of vitamin D-binding protein gene with compression strength index variation in Caucasian nuclear families. Osteoporos Int (2009) 0.85
Comparison of haplotyping methods using families and unrelated individuals on simulated rheumatoid arthritis data. BMC Proc (2007) 0.85
Genomic imprinting and genetic effects on muscle traits in mice. BMC Genomics (2012) 0.84
Detecting maternal-effect loci by statistical cross-fostering. Genetics (2012) 0.83
HDC gene polymorphisms are associated with age at natural menopause in Caucasian women. Biochem Biophys Res Commun (2006) 0.83
Computation of haplotypes on SNPs subsets: advantage of the "global method". BMC Genet (2006) 0.83
A linear-time algorithm for reconstructing zero-recombinant haplotype configuration on a pedigree. BMC Bioinformatics (2012) 0.82
Obesity-insulin targeted genes in the 3p26-25 region in human studies and LG/J and SM/J mice. Metabolism (2012) 0.81
Efficient haplotype inference from pedigrees with missing data using linear systems with disjoint-set data structures. Comput Syst Bioinformatics Conf (2008) 0.79
Genotype-dependent responses to levels of sibling competition over maternal resources in mice. Heredity (Edinb) (2011) 0.78
Linked region detection using high-density SNP genotype data via the minimum recombinant model of pedigree haplotype inference. BMC Bioinformatics (2009) 0.77
Association analyses of CYP19 gene polymorphisms with height variation in a large sample of Caucasian nuclear families. Hum Genet (2006) 0.77
Identifying mutation regions for closely related individuals without a known pedigree. BMC Bioinformatics (2012) 0.75
Association of a missense mutation in the positional candidate gene GRIP1 with backfat thickness traits in pigs. Asian-Australas J Anim Sci (2016) 0.75
International network of cancer genome projects. Nature (2010) 20.35
Sequencing of 50 human exomes reveals adaptation to high altitude. Science (2010) 11.27
Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification. Mol Cell (2008) 11.24
Resequencing of 200 human exomes identifies an excess of low-frequency non-synonymous coding variants. Nat Genet (2010) 5.44
Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma. Nat Genet (2011) 3.66
Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response. Mol Cell (2009) 3.50
Using VAAST to identify an X-linked disorder resulting in lethality in male infants due to N-terminal acetyltransferase deficiency. Am J Hum Genet (2011) 3.43
Surgery with molecular fluorescence imaging using activatable cell-penetrating peptides decreases residual cancer and improves survival. Proc Natl Acad Sci U S A (2010) 3.41
Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases. Proc Natl Acad Sci U S A (2010) 3.03
A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62. Mol Cell Biol (2010) 2.93
Complete resequencing of 40 genomes reveals domestication events and genes in silkworm (Bombyx). Science (2009) 2.68
Integrated approach for the identification of human hepatocyte nuclear factor 4alpha target genes using protein binding microarrays. Hepatology (2010) 2.51
Efficient and robust feature extraction by maximum margin criterion. IEEE Trans Neural Netw (2006) 2.32
Roscovitine targets, protein kinases and pyridoxal kinase. J Biol Chem (2005) 2.31
Prevalence of the initiator over the TATA box in human and yeast genes and identification of DNA motifs enriched in human TATA-less core promoters. Gene (2006) 2.31
In vivo characterization of activatable cell penetrating peptides for targeting protease activity in cancer. Integr Biol (Camb) (2009) 2.30
Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Proc Natl Acad Sci U S A (2011) 2.22
Comprehensive comparison of three commercial human whole-exome capture platforms. Genome Biol (2011) 2.15
MSOAR: a high-throughput ortholog assignment system based on genome rearrangement. J Comput Biol (2007) 2.14
The Mg-chelatase H subunit of Arabidopsis antagonizes a group of WRKY transcription repressors to relieve ABA-responsive genes of inhibition. Plant Cell (2010) 2.13
Genomic segmental polymorphisms in inbred mouse strains. Nat Genet (2004) 1.93
Estimation of allele frequency and association mapping using next-generation sequencing data. BMC Bioinformatics (2011) 1.93
Efficient inference of haplotypes from genotypes on a pedigree. J Bioinform Comput Biol (2003) 1.89
Association between variants of PRDM1 and NDP52 and Crohn's disease, based on exome sequencing and functional studies. Gastroenterology (2013) 1.83
Understanding high grade glioma: molecular mechanism, therapy and comprehensive management. Cancer Lett (2013) 1.82
Systemic in vivo distribution of activatable cell penetrating peptides is superior to that of cell penetrating peptides. Integr Biol (Camb) (2009) 1.78
IsoLasso: a LASSO regression approach to RNA-Seq based transcriptome assembly. J Comput Biol (2011) 1.76
MiR-221 and miR-222 target PUMA to induce cell survival in glioblastoma. Mol Cancer (2010) 1.74
Inference of isoforms from short sequence reads. J Comput Biol (2011) 1.72
Regulation of renal lipid metabolism, lipid accumulation, and glomerulosclerosis in FVBdb/db mice with type 2 diabetes. Diabetes (2005) 1.70
Molecular classification of gliomas based on whole genome gene expression: a systematic report of 225 samples from the Chinese Glioma Cooperative Group. Neuro Oncol (2012) 1.66
Assignment of orthologous genes via genome rearrangement. IEEE/ACM Trans Comput Biol Bioinform (2006) 1.66
A small-molecule inducer of the antioxidant response element. Chem Biol (2010) 1.65
ChemmineR: a compound mining framework for R. Bioinformatics (2008) 1.64
Regulation of renal fatty acid and cholesterol metabolism, inflammation, and fibrosis in Akita and OVE26 mice with type 1 diabetes. Diabetes (2006) 1.64
Crosstalk between Aurora-A and p53: frequent deletion or downregulation of Aurora-A in tumors from p53 null mice. Cancer Cell (2007) 1.59
Natural selection affects multiple aspects of genetic variation at putatively neutral sites across the human genome. PLoS Genet (2011) 1.54
The Wilms tumor gene, Wt1, is critical for mouse spermatogenesis via regulation of sertoli cell polarity and is associated with non-obstructive azoospermia in humans. PLoS Genet (2013) 1.52
Exome sequencing and unrelated findings in the context of complex disease research: ethical and clinical implications. Discov Med (2011) 1.52
Real-time in vivo molecular detection of primary tumors and metastases with ratiometric activatable cell-penetrating peptides. Cancer Res (2012) 1.50
Circulating microRNAs in cancer: origin, function and application. J Exp Clin Cancer Res (2012) 1.50
Identifying transcription factor binding sites through Markov chain optimization. Bioinformatics (2002) 1.50
High-responsivity graphene/InAs nanowire heterojunction near-infrared photodetectors with distinct photocurrent on/off ratios. Small (2014) 1.49
HOTAIR, a cell cycle-associated long noncoding RNA and a strong predictor of survival, is preferentially expressed in classical and mesenchymal glioma. Neuro Oncol (2013) 1.47
Experimental verification of reversed Cherenkov radiation in left-handed metamaterial. Phys Rev Lett (2009) 1.47
Protective effect of nicotine on lipopolysaccharide-induced acute lung injury in mice. Respiration (2010) 1.46
The magnesium-chelatase H subunit binds abscisic acid and functions in abscisic acid signaling: new evidence in Arabidopsis. Plant Physiol (2009) 1.44
Analysis of bacterial community composition by oligonucleotide fingerprinting of rRNA genes. Appl Environ Microbiol (2002) 1.41
A maximum common substructure-based algorithm for searching and predicting drug-like compounds. Bioinformatics (2008) 1.38
A broadly flavivirus cross-neutralizing monoclonal antibody that recognizes a novel epitope within the fusion loop of E protein. PLoS One (2011) 1.36
The chemokine CXCL12 and its receptor CXCR4 promote glioma stem cell-mediated VEGF production and tumour angiogenesis via PI3K/AKT signalling. J Pathol (2011) 1.36
Expression of hypoxia-inducible factor-1 alpha and associated proteins in pancreatic ductal adenocarcinoma and their impact on prognosis. Int J Oncol (2007) 1.35
Transcriptome assembly and isoform expression level estimation from biased RNA-Seq reads. Bioinformatics (2012) 1.34
Whole-genome microRNA expression profiling identifies a 5-microRNA signature as a prognostic biomarker in Chinese patients with primary glioblastoma multiforme. Cancer (2012) 1.33
Uncover disease genes by maximizing information flow in the phenome-interactome network. Bioinformatics (2011) 1.32
Learning curve of transumbilical single incision laparoscopic cholecystectomy (SILS): a preliminary study of 80 selected patients with benign gallbladder diseases. World J Surg (2011) 1.30
MicroRNA roles in beta-catenin pathway. Mol Cancer (2010) 1.30
Crystal structure of the carnitine transporter and insights into the antiport mechanism. Nat Struct Mol Biol (2010) 1.30
miR-181d: a predictive glioblastoma biomarker that downregulates MGMT expression. Neuro Oncol (2012) 1.29
Diabetic nephropathy is accelerated by farnesoid X receptor deficiency and inhibited by farnesoid X receptor activation in a type 1 diabetes model. Diabetes (2010) 1.29
Haplotype-based linkage disequilibrium mapping via direct data mining. Bioinformatics (2005) 1.28
OligoSpawn: a software tool for the design of overgo probes from large unigene datasets. BMC Bioinformatics (2006) 1.28
MiR-181d acts as a tumor suppressor in glioma by targeting K-ras and Bcl-2. J Cancer Res Clin Oncol (2011) 1.27
Correlation of IDH1 mutation with clinicopathologic factors and prognosis in primary glioblastoma: a report of 118 patients from China. PLoS One (2012) 1.27
Short-term and medium-term clinical outcomes of laparoscopic-assisted and open surgery for colorectal cancer: a single center retrospective case-control study. BMC Gastroenterol (2011) 1.25
Induction of angiogenesis in tissue-engineered scaffolds designed for bone repair: a combined gene therapy-cell transplantation approach. Proc Natl Acad Sci U S A (2008) 1.25
IL28B genetic variation is associated with spontaneous clearance of hepatitis C virus, treatment response, serum IL-28B levels in Chinese population. PLoS One (2012) 1.25
VHL regulates the effects of miR-23b on glioma survival and invasion via suppression of HIF-1α/VEGF and β-catenin/Tcf-4 signaling. Neuro Oncol (2012) 1.24
Extensive X-linked adaptive evolution in central chimpanzees. Proc Natl Acad Sci U S A (2012) 1.23
Confirmation by exome sequencing of the pathogenic role of NCSTN mutations in acne inversa (hidradenitis suppurativa). J Invest Dermatol (2011) 1.23
Computational prediction of operons in Synechococcus sp. WH8102. Genome Inform (2004) 1.22
Manipulating electromagnetic wave polarizations by anisotropic metamaterials. Phys Rev Lett (2007) 1.22
MiR-410 regulates MET to influence the proliferation and invasion of glioma. Int J Biochem Cell Biol (2012) 1.22
Nrf2 promotes neuronal cell differentiation. Free Radic Biol Med (2009) 1.22
Plasma IGFBP-2 levels predict clinical outcomes of patients with high-grade gliomas. Neuro Oncol (2009) 1.20
Computational prediction of type III secreted proteins from gram-negative bacteria. BMC Bioinformatics (2010) 1.19
High-performance affinity monolith chromatography: development and evaluation of human serum albumin columns. Anal Chem (2004) 1.18
Inhibition of STAT3 activity with AG490 decreases the invasion of human pancreatic cancer cells in vitro. Cancer Sci (2006) 1.18
Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex. Nature (2008) 1.18
Early second-trimester serum miRNA profiling predicts gestational diabetes mellitus. PLoS One (2011) 1.18
Identification of MMP-9 specific microRNA expression profile as potential targets of anti-invasion therapy in glioblastoma multiforme. Brain Res (2011) 1.17
Profiling the DNA-binding specificities of engineered Cys2His2 zinc finger domains using a rapid cell-based method. Nucleic Acids Res (2007) 1.17
The farnesoid X receptor modulates renal lipid metabolism and diet-induced renal inflammation, fibrosis, and proteinuria. Am J Physiol Renal Physiol (2009) 1.16
Modulation of carbohydrate response element-binding protein gene expression in 3T3-L1 adipocytes and rat adipose tissue. Am J Physiol Endocrinol Metab (2004) 1.16
Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells. Nat Chem Biol (2012) 1.15
Primate-specific miR-663 functions as a tumor suppressor by targeting PIK3CD and predicts the prognosis of human glioblastoma. Clin Cancer Res (2014) 1.15
Structure and functional implications of the human rad9-hus1-rad1 cell cycle checkpoint complex. J Biol Chem (2009) 1.14
miR-137 is frequently down-regulated in glioblastoma and is a negative regulator of Cox-2. Eur J Cancer (2012) 1.14
SEED: efficient clustering of next-generation sequences. Bioinformatics (2011) 1.14
The role of microRNA in human lung squamous cell carcinoma. Cancer Genet Cytogenet (2010) 1.13
Laparoscopic and open resection for colorectal cancer: an evaluation of cellular immunity. BMC Gastroenterol (2010) 1.12
Crystal structure of brain pyridoxal kinase, a novel member of the ribokinase superfamily. J Biol Chem (2002) 1.12
Management and survival rates in patients with glioma in China (2004-2010): a retrospective study from a single-institution. J Neurooncol (2013) 1.12
Exome sequencing identifies MVK mutations in disseminated superficial actinic porokeratosis. Nat Genet (2012) 1.12
Oligonucleotide fingerprinting of rRNA genes for analysis of fungal community composition. Appl Environ Microbiol (2002) 1.12
Human endothelial cell growth and phenotypic expression on three dimensional poly(lactide-co-glycolide) sintered microsphere scaffolds for bone tissue engineering. Biotechnol Bioeng (2007) 1.12
Low-density lipoprotein in hypercholesterolemic human plasma induces vascular endothelial cell apoptosis by inhibiting fibroblast growth factor 2 transcription. Circulation (2003) 1.12
Rational design of a live attenuated dengue vaccine: 2'-o-methyltransferase mutants are highly attenuated and immunogenic in mice and macaques. PLoS Pathog (2013) 1.11