Published in Nat Genet on August 22, 2004
Bias of selection on human copy-number variants. PLoS Genet (2006) 4.44
Mouse segmental duplication and copy number variation. Nat Genet (2008) 4.24
A high-resolution map of segmental DNA copy number variation in the mouse genome. PLoS Genet (2006) 3.24
Segmental copy number variation shapes tissue transcriptomes. Nat Genet (2009) 2.95
Array-CGH detection of micro rearrangements in mentally retarded individuals: clinical significance of imbalances present both in affected children and normal parents. J Med Genet (2005) 2.60
Copy number variants and common disorders: filling the gaps and exploring complexity in genome-wide association studies. PLoS Genet (2007) 2.32
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Extensive genomic copy number variation in embryonic stem cells. Proc Natl Acad Sci U S A (2008) 1.91
The impact of copy number variation on local gene expression in mouse hematopoietic stem and progenitor cells. Nat Genet (2009) 1.89
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Genomic copy number and expression variation within the C57BL/6J inbred mouse strain. Genome Res (2007) 1.71
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Genome-wide assessments reveal extremely high levels of polymorphism of two active families of mouse endogenous retroviral elements. PLoS Genet (2008) 1.69
Dissection of a QTL hotspot on mouse distal chromosome 1 that modulates neurobehavioral phenotypes and gene expression. PLoS Genet (2008) 1.64
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Copy number variation in the bovine genome. BMC Genomics (2010) 1.45
A common and unstable copy number variant is associated with differences in Glo1 expression and anxiety-like behavior. PLoS One (2009) 1.44
Widespread duplications in the genomes of laboratory stocks of Dictyostelium discoideum. Genome Biol (2008) 1.37
A snapshot of CNVs in the pig genome. PLoS One (2008) 1.36
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Antitumor activity of the investigational proteasome inhibitor MLN9708 in mouse models of B-cell and plasma cell malignancies. Clin Cancer Res (2011) 1.32
An initial map of chromosomal segmental copy number variations in the chicken. BMC Genomics (2010) 1.24
The evolution of meiosis from mitosis. Genetics (2009) 1.05
Mouse genomic representational oligonucleotide microarray analysis: detection of copy number variations in normal and tumor specimens. Proc Natl Acad Sci U S A (2006) 1.01
The neutral coalescent process for recent gene duplications and copy-number variants. Genetics (2007) 0.96
DNA microarray and proteomic strategies for understanding alcohol action. Alcohol Clin Exp Res (2006) 0.94
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Increased de novo copy number variants in the offspring of older males. Transl Psychiatry (2011) 0.92
The evolutionary significance of copy number variation in the human genome. Cytogenet Genome Res (2009) 0.89
The drifting human genome. Proc Natl Acad Sci U S A (2007) 0.88
Analysis of molecular cytogenetic alterations in uterine leiomyosarcoma by array-based comparative genomic hybridization. J Cancer Res Clin Oncol (2012) 0.87
Construction and application of a zebrafish array comparative genomic hybridization platform. Genes Chromosomes Cancer (2009) 0.87
Gene duplication of endothelin 3 is closely correlated with the hyperpigmentation of the internal organs (Fibromelanosis) in silky chickens. Genetics (2011) 0.86
Genome-wide copy number variations in Oryza sativa L. BMC Genomics (2013) 0.86
Copy number variation in the horse genome. PLoS Genet (2014) 0.86
Copy number variation in the mouse genome: implications for the mouse as a model organism for human disease. Cytogenet Genome Res (2009) 0.85
Lgals6, a 2-million-year-old gene in mice: a case of positive Darwinian selection and presence/absence polymorphism. Genetics (2008) 0.85
Genome-wide copy number variant discovery in dogs using the CanineHD genotyping array. BMC Genomics (2014) 0.84
The landscape of inherited and de novo copy number variants in a Plasmodium falciparum genetic cross. BMC Genomics (2011) 0.82
A comprehensive profile of DNA copy number variations in a Korean population: identification of copy number invariant regions among Koreans. Exp Mol Med (2009) 0.81
Description and genetic mapping of Polypodia: an X-linked dominant mouse mutant with ectopic caudal limbs and other malformations. Mamm Genome (2006) 0.81
Molecular cloning and copy number variation of a ferritin subunit (Fth1) and its association with growth in freshwater pearl mussel Hyriopsis cumingii. PLoS One (2011) 0.76
Variation in CCL3L1 copy number in rhesus macaques (Macaca mulatta). Comp Med (2012) 0.76
Characterization of in vivo recombination activities in the mouse embryo. Mol Genet Genomics (2005) 0.76
Deletions in the genomes of fifteen inbred mouse lines and their possible implications for fat accumulation. J Zhejiang Univ Sci B (2007) 0.75
Genome Wide Distributions and Functional Characterization of Copy Number Variations between Chinese and Western Pigs. PLoS One (2015) 0.75
International network of cancer genome projects. Nature (2010) 20.35
Evolutionary and biomedical insights from the rhesus macaque genome. Science (2007) 16.21
The somatic genomic landscape of glioblastoma. Cell (2013) 11.73
Sequencing of 50 human exomes reveals adaptation to high altitude. Science (2010) 11.27
Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification. Mol Cell (2008) 11.24
Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution. Genome Res (2005) 8.38
The genome sequence of taurine cattle: a window to ruminant biology and evolution. Science (2009) 8.23
The DNA sequence of the human X chromosome. Nature (2005) 6.97
The genome of the model beetle and pest Tribolium castaneum. Nature (2008) 6.50
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature (2010) 6.48
A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis. Cell (2009) 6.03
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. N Engl J Med (2015) 5.71
Resequencing of 200 human exomes identifies an excess of low-frequency non-synonymous coding variants. Nat Genet (2010) 5.44
High-precision, whole-genome sequencing of laboratory strains facilitates genetic studies. PLoS Genet (2008) 4.86
The functional spectrum of low-frequency coding variation. Genome Biol (2011) 4.42
Deep resequencing reveals excess rare recent variants consistent with explosive population growth. Nat Commun (2010) 4.39
Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene. Nature (2004) 4.35
Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis. J Lipid Res (2008) 4.09
The genome of the ctenophore Mnemiopsis leidyi and its implications for cell type evolution. Science (2013) 4.07
FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression. Science (2008) 3.78
Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia. Proc Natl Acad Sci U S A (2008) 3.71
Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human. Nat Genet (2003) 3.70
Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma. Nat Genet (2011) 3.66
Metastasis is driven by sequential elevation of H-ras and Smad2 levels. Nat Cell Biol (2002) 3.52
Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response. Mol Cell (2009) 3.50
Using VAAST to identify an X-linked disorder resulting in lethality in male infants due to N-terminal acetyltransferase deficiency. Am J Hum Genet (2011) 3.43
Surgery with molecular fluorescence imaging using activatable cell-penetrating peptides decreases residual cancer and improves survival. Proc Natl Acad Sci U S A (2010) 3.41
Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1. Nat Med (2010) 3.27
Dyskeratosis congenita and cancer in mice deficient in ribosomal RNA modification. Science (2003) 3.18
Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases. Proc Natl Acad Sci U S A (2010) 3.03
Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency. Nature (2008) 2.95
Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer. Clin Cancer Res (2007) 2.94
Exome sequencing of ion channel genes reveals complex profiles confounding personal risk assessment in epilepsy. Cell (2011) 2.93
A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62. Mol Cell Biol (2010) 2.93
Complete resequencing of 40 genomes reveals domestication events and genes in silkworm (Bombyx). Science (2009) 2.68
Characterization of human embryonic stem cells with features of neoplastic progression. Nat Biotechnol (2009) 2.66
Whole-genome sequence-based analysis of high-density lipoprotein cholesterol. Nat Genet (2013) 2.62
Demographic histories and patterns of linkage disequilibrium in Chinese and Indian rhesus macaques. Science (2007) 2.62
Gastrointestinal microbiome signatures of pediatric patients with irritable bowel syndrome. Gastroenterology (2011) 2.60
Epigenome analyses using BAC microarrays identify evolutionary conservation of tissue-specific methylation of SHANK3. Nat Genet (2005) 2.51
Integrated approach for the identification of human hepatocyte nuclear factor 4alpha target genes using protein binding microarrays. Hepatology (2010) 2.51
RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions, cancer-associated long noncoding RNAs and aberrant alternative splicings. Cell Res (2012) 2.41
Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing. Nat Genet (2011) 2.36
Stem-cell hierarchy in skin cancer. Nat Rev Cancer (2003) 2.36
Efficient and robust feature extraction by maximum margin criterion. IEEE Trans Neural Netw (2006) 2.32
Roscovitine targets, protein kinases and pyridoxal kinase. J Biol Chem (2005) 2.31
Prevalence of the initiator over the TATA box in human and yeast genes and identification of DNA motifs enriched in human TATA-less core promoters. Gene (2006) 2.31
In vivo characterization of activatable cell penetrating peptides for targeting protease activity in cancer. Integr Biol (Camb) (2009) 2.30
The Drosophila melanogaster transcriptome by paired-end RNA sequencing. Genome Res (2010) 2.25
Dissociation of epithelial and neuroendocrine carcinoma lineages in the transgenic adenocarcinoma of mouse prostate model of prostate cancer. Am J Pathol (2007) 2.23
Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Proc Natl Acad Sci U S A (2011) 2.22
Comprehensive comparison of three commercial human whole-exome capture platforms. Genome Biol (2011) 2.15
MSOAR: a high-throughput ortholog assignment system based on genome rearrangement. J Comput Biol (2007) 2.14
The Mg-chelatase H subunit of Arabidopsis antagonizes a group of WRKY transcription repressors to relieve ABA-responsive genes of inhibition. Plant Cell (2010) 2.13
Kras regulatory elements and exon 4A determine mutation specificity in lung cancer. Nat Genet (2008) 2.05
Genome-wide detection of chromosomal imbalances in tumors using BAC microarrays. Nat Biotechnol (2002) 2.04
Single nucleotide polymorphism-mediated translational suppression of endoplasmic reticulum mannosidase I modifies the onset of end-stage liver disease in alpha1-antitrypsin deficiency. Hepatology (2009) 2.03
Overexpression of Separase induces aneuploidy and mammary tumorigenesis. Proc Natl Acad Sci U S A (2008) 1.98
Insights into bilaterian evolution from three spiralian genomes. Nature (2012) 1.97
Estimation of allele frequency and association mapping using next-generation sequencing data. BMC Bioinformatics (2011) 1.93
Recommendations of the 2006 Human Variome Project meeting. Nat Genet (2007) 1.90
Efficient inference of haplotypes from genotypes on a pedigree. J Bioinform Comput Biol (2003) 1.89
Genetic architecture of mouse skin inflammation and tumour susceptibility. Nature (2009) 1.89
Mutations in SERPINF1 cause osteogenesis imperfecta type VI. J Bone Miner Res (2011) 1.83
Association between variants of PRDM1 and NDP52 and Crohn's disease, based on exome sequencing and functional studies. Gastroenterology (2013) 1.83
Bos taurus genome assembly. BMC Genomics (2009) 1.83
Understanding high grade glioma: molecular mechanism, therapy and comprehensive management. Cancer Lett (2013) 1.82
Acid suppression therapy may not alter malignant progression in Barrett's metaplasia showing p53 protein accumulation. Am J Gastroenterol (2002) 1.81
A functional switch from lung cancer resistance to susceptibility at the Pas1 locus in Kras2LA2 mice. Nat Genet (2006) 1.79
Computing the minimum recombinant haplotype configuration from incomplete genotype data on a pedigree by integer linear programming. J Comput Biol (2005) 1.78
Systemic in vivo distribution of activatable cell penetrating peptides is superior to that of cell penetrating peptides. Integr Biol (Camb) (2009) 1.78
IsoLasso: a LASSO regression approach to RNA-Seq based transcriptome assembly. J Comput Biol (2011) 1.76
MiR-221 and miR-222 target PUMA to induce cell survival in glioblastoma. Mol Cancer (2010) 1.74
Inference of isoforms from short sequence reads. J Comput Biol (2011) 1.72
Mapping segmental and sequence variations among laboratory mice using BAC array CGH. Genome Res (2005) 1.71
Regulation of renal lipid metabolism, lipid accumulation, and glomerulosclerosis in FVBdb/db mice with type 2 diabetes. Diabetes (2005) 1.70
The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability. Proc Natl Acad Sci U S A (2003) 1.69
Overexpression of E2F-1 in lung and liver metastases of human colon cancer is associated with gene amplification. Cancer Biol Ther (2004) 1.67
Molecular classification of gliomas based on whole genome gene expression: a systematic report of 225 samples from the Chinese Glioma Cooperative Group. Neuro Oncol (2012) 1.66
Assignment of orthologous genes via genome rearrangement. IEEE/ACM Trans Comput Biol Bioinform (2006) 1.66
A small-molecule inducer of the antioxidant response element. Chem Biol (2010) 1.65
ChemmineR: a compound mining framework for R. Bioinformatics (2008) 1.64
piggyBac transposon/transposase system to generate CD19-specific T cells for the treatment of B-lineage malignancies. Hum Gene Ther (2010) 1.64
A handcuff model for the cohesin complex. J Cell Biol (2008) 1.64
Regulation of renal fatty acid and cholesterol metabolism, inflammation, and fibrosis in Akita and OVE26 mice with type 1 diabetes. Diabetes (2006) 1.64
An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations. J Clin Invest (2007) 1.64
Squamous cell carcinoma related oncogene/DCUN1D1 is highly conserved and activated by amplification in squamous cell carcinomas. Cancer Res (2006) 1.61
Aurora-A/STK15 T+91A is a general low penetrance cancer susceptibility gene: a meta-analysis of multiple cancer types. Carcinogenesis (2005) 1.61
Crosstalk between Aurora-A and p53: frequent deletion or downregulation of Aurora-A in tumors from p53 null mice. Cancer Cell (2007) 1.59
HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis. Proc Natl Acad Sci U S A (2007) 1.58