Published in EMBO J on August 25, 2005
G protein-coupled receptor kinases: more than just kinases and not only for GPCRs. Pharmacol Ther (2011) 2.13
Regulation of Smad activities. Biochim Biophys Acta (2006) 1.41
Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2. EMBO J (2006) 1.39
The complex G protein-coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targets. Br J Pharmacol (2010) 1.30
Post-translational regulation of TGF-β receptor and Smad signaling. FEBS Lett (2012) 1.21
Differential Regulation of TGF-β/Smad Signaling in Hepatic Stellate Cells between Acute and Chronic Liver Injuries. Front Physiol (2012) 1.20
GRK2: multiple roles beyond G protein-coupled receptor desensitization. Trends Pharmacol Sci (2012) 1.15
Growth differentiation factor 15 deficiency protects against atherosclerosis by attenuating CCR2-mediated macrophage chemotaxis. J Exp Med (2011) 1.10
Smad phosphoisoform signals in acute and chronic liver injury: similarities and differences between epithelial and mesenchymal cells. Cell Tissue Res (2011) 1.04
Smad phosphoisoform signaling specificity: the right place at the right time. Carcinogenesis (2011) 1.02
TGF-β/Smad signaling during hepatic fibro-carcinogenesis (review). Int J Oncol (2014) 1.00
G protein-coupled receptor kinase 2 (GRK2) modulation and cell cycle progression. Proc Natl Acad Sci U S A (2009) 0.99
G protein-coupled receptor kinase 5 phosphorylation of hip regulates internalization of the chemokine receptor CXCR4. Biochemistry (2011) 0.96
Developmental and tumoral vascularization is regulated by G protein-coupled receptor kinase 2. J Clin Invest (2013) 0.87
Link between cancer and Alzheimer disease via oxidative stress induced by nitric oxide-dependent mitochondrial DNA overproliferation and deletion. Oxid Med Cell Longev (2013) 0.84
The Dual Role of TGFβ in Human Cancer: From Tumor Suppression to Cancer Metastasis. ISRN Mol Biol (2012) 0.83
Inhibition of G-protein-coupled receptor kinase 2 (GRK2) triggers the growth-promoting mitogen-activated protein kinase (MAPK) pathway. J Biol Chem (2013) 0.81
Linker phosphorylation of Smad3 promotes fibro-carcinogenesis in chronic viral hepatitis of hepatocellular carcinoma. World J Gastroenterol (2014) 0.81
Multiple scaffolding functions of {beta}-arrestins in the degradation of G protein-coupled receptor kinase 2. J Biol Chem (2010) 0.80
Growth inhibition of human hepatocellular carcinoma cells by overexpression of G-protein-coupled receptor kinase 2. J Cell Physiol (2012) 0.80
Reversible Human TGF-β Signal Shifting between Tumor Suppression and Fibro-Carcinogenesis: Implications of Smad Phospho-Isoforms for Hepatic Epithelial-Mesenchymal Transitions. J Clin Med (2016) 0.78
Breast cancer anti-estrogen resistance 3 inhibits transforming growth factor β/Smad signaling and associates with favorable breast cancer disease outcomes. Breast Cancer Res (2014) 0.78
GRK2 in the heart: a GPCR kinase and beyond. Antioxid Redox Signal (2014) 0.78
p21-Activated kinase 2 (PAK2) inhibits TGF-β signaling in Madin-Darby canine kidney (MDCK) epithelial cells by interfering with the receptor-Smad interaction. J Biol Chem (2012) 0.78
Engulfment protein GULP is regulator of transforming growth factor-β response in ovarian cells. J Biol Chem (2012) 0.76
HS-173, a novel PI3K inhibitor suppresses EMT and metastasis in pancreatic cancer. Oncotarget (2016) 0.75
Role of G protein-coupled receptor kinase 2 in tumoral angiogenesis. Mol Cell Oncol (2014) 0.75
Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell (2003) 25.94
TGF-beta signaling in tumor suppression and cancer progression. Nat Genet (2001) 11.64
p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. Nature (1994) 10.95
Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover. Nat Cell Biol (2003) 7.74
Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling. Nature (1997) 7.69
Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation. Mol Cell (2000) 6.69
The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling. Cell (1997) 6.34
G protein-coupled receptor kinases. Annu Rev Biochem (1998) 5.53
A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras. Genes Dev (1999) 5.13
TGF-beta signaling: positive and negative effects on tumorigenesis. Curr Opin Genet Dev (2002) 4.66
Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases. J Clin Invest (2002) 4.64
Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1. Nature (1997) 4.41
Ubiquitin-dependent degradation of TGF-beta-activated smad2. Nat Cell Biol (1999) 3.25
Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects. J Clin Invest (2002) 3.24
Cyclin-dependent kinases regulate the antiproliferative function of Smads. Nature (2004) 3.05
Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor beta 1. Proc Natl Acad Sci U S A (1992) 2.54
The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2. Genes Dev (1997) 2.35
Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling. Science (2003) 2.31
Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus. Mol Cell (2002) 2.05
GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptor. J Cell Biol (2004) 1.98
Transforming growth factor beta-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element. Mol Cell Biol (2004) 1.77
Inactivation of smad-transforming growth factor beta signaling by Ca(2+)-calmodulin-dependent protein kinase II. Mol Cell Biol (2000) 1.51
Apoptosis and the liver. Semin Cancer Biol (2000) 1.37
Antitumor activity of a recombinant soluble betaglycan in human breast cancer xenograft. Cancer Res (2002) 1.31
Transforming growth factor-beta receptors interact with AP2 by direct binding to beta2 subunit. Mol Biol Cell (2002) 1.29
Activin A: an autocrine inhibitor of initiation of DNA synthesis in rat hepatocytes. J Clin Invest (1993) 1.18
Agonist-dependent modulation of G protein-coupled receptor kinase 2 by mitogen-activated protein kinases. Mol Pharmacol (2000) 1.09
Casein kinase Iepsilon plays a functional role in the transforming growth factor-beta signaling pathway. J Biol Chem (2004) 1.05
Activin induces hepatocyte cell growth arrest through induction of the cyclin-dependent kinase inhibitor p15INK4B and Sp1. Cell Signal (2004) 1.02
Phosphorylation of the platelet-derived growth factor receptor-beta and epidermal growth factor receptor by G protein-coupled receptor kinase-2. Mechanisms for selectivity of desensitization. J Biol Chem (2002) 1.00
Analysis of the human G protein-coupled receptor kinase 2 (GRK2) gene promoter: regulation by signal transduction systems in aortic smooth muscle cells. Circulation (2000) 0.98
Epidermal growth factor-induced phosphatidylinositol 3-kinase activation and DNA synthesis. Identification of Grb2-associated binder 2 as the major mediator in rat hepatocytes. J Biol Chem (2000) 0.93
A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature (2007) 35.08
Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and beta-arrestin proteins. Prog Neurobiol (2002) 2.76
Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin. Blood (2009) 2.31
A novel function for p21Cip1 and acetyltransferase p/CAF as critical transcriptional regulators of TGFβ-mediated breast cancer cell migration and invasion. Breast Cancer Res (2012) 1.70
Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex. J Cell Biol (2002) 1.40
Transcriptional regulation by insulin: from the receptor to the gene. Can J Physiol Pharmacol (2006) 1.25
Defining the role of prolactin as an invasion suppressor hormone in breast cancer cells. Cancer Res (2006) 1.23
Activin and TGFβ regulate expression of the microRNA-181 family to promote cell migration and invasion in breast cancer cells. Cell Signal (2013) 1.22
Ribavirin treatment effects on breast cancers overexpressing eIF4E, a biomarker with prognostic specificity for luminal B-type breast cancer. Clin Cancer Res (2011) 1.20
Prolactin induces SHP-2 association with Stat5, nuclear translocation, and binding to the beta-casein gene promoter in mammary cells. J Biol Chem (2002) 1.19
Activin/TGF-beta induce apoptosis through Smad-dependent expression of the lipid phosphatase SHIP. Nat Cell Biol (2002) 1.19
Unraveling G protein-coupled receptor endocytosis pathways using real-time monitoring of agonist-promoted interaction between beta-arrestins and AP-2. J Biol Chem (2007) 1.15
A novel SHP-1/Grb2-dependent mechanism of negative regulation of cytokine-receptor signaling: contribution of SHP-1 C-terminal tyrosines in cytokine signaling. Blood (2003) 1.08
Differential β-arrestin-dependent conformational signaling and cellular responses revealed by angiotensin analogs. Sci Signal (2012) 1.07
Transforming growth factor-beta inhibits telomerase through SMAD3 and E2F transcription factors. Cell Signal (2007) 1.06
An antiangiogenic urokinase-derived peptide combined with tamoxifen decreases tumor growth and metastasis in a syngeneic model of breast cancer. Cancer Res (2002) 1.05
c-Src regulates clathrin adapter protein 2 interaction with beta-arrestin and the angiotensin II type 1 receptor during clathrin- mediated internalization. Mol Endocrinol (2004) 1.04
Apparent loss-of-function mutant GPCRs revealed as constitutively desensitized receptors. Biochemistry (2002) 1.02
Activin induces hepatocyte cell growth arrest through induction of the cyclin-dependent kinase inhibitor p15INK4B and Sp1. Cell Signal (2004) 1.02
c-Src-mediated phosphorylation of AP-2 reveals a general mechanism for receptors internalizing through the clathrin pathway. Cell Signal (2008) 0.99
Dissociation of beta-arrestin from internalized bradykinin B2 receptor is necessary for receptor recycling and resensitization. Cell Signal (2005) 0.98
Real-time detection of interactions between the human oxytocin receptor and G protein-coupled receptor kinase-2. Mol Endocrinol (2004) 0.97
Smad signaling antagonizes STAT5-mediated gene transcription and mammary epithelial cell differentiation. J Biol Chem (2007) 0.94
MicroRNA-584 and the protein phosphatase and actin regulator 1 (PHACTR1), a new signaling route through which transforming growth factor-β Mediates the migration and actin dynamics of breast cancer cells. J Biol Chem (2013) 0.93
Src-dependent phosphorylation of beta2-adaptin dissociates the beta-arrestin-AP-2 complex. J Cell Sci (2007) 0.92
ARF6 regulates angiotensin II type 1 receptor endocytosis by controlling the recruitment of AP-2 and clathrin. Cell Signal (2007) 0.91
A novel biased allosteric compound inhibitor of parturition selectively impedes the prostaglandin F2alpha-mediated Rho/ROCK signaling pathway. J Biol Chem (2010) 0.91
Epidermal growth factor-induced DNA synthesis. Key role for Src phosphorylation of the docking protein Gab2. J Biol Chem (2002) 0.89
TGFbeta-induced GRK2 expression attenuates AngII-regulated vascular smooth muscle cell proliferation and migration. Cell Signal (2009) 0.89
Compartmentalization of signaling-competent epidermal growth factor receptors in endosomes. Endocrinology (2007) 0.87
Epidermal growth factor-induced vacuolar (H+)-atpase assembly: a role in signaling via mTORC1 activation. J Biol Chem (2012) 0.87
Compartmentalization of EGFR in cellular membranes: role of membrane rafts. J Cell Biochem (2010) 0.87
Role of ßarrestins in bradykinin B2 receptor-mediated signalling. Cell Signal (2010) 0.86
Gbetagamma is a negative regulator of AP-1 mediated transcription. Cell Signal (2010) 0.85
Tyrosine phosphorylation of Grb2: role in prolactin/epidermal growth factor cross talk in mammary epithelial cell growth and differentiation. Mol Cell Biol (2009) 0.85
Essential role of endocytosis of the type II transmembrane serine protease TMPRSS6 in regulating its functionality. J Biol Chem (2011) 0.83
Regulation of hepatic insulin-like growth factor-binding protein-1 gene expression by insulin: central role for mammalian target of rapamycin independent of forkhead box O proteins. Endocrinology (2006) 0.83
Biasing the prostaglandin F2α receptor responses toward EGFR-dependent transactivation of MAPK. Mol Endocrinol (2012) 0.82
Effect of inhibiting vacuolar acidification on insulin signaling in hepatocytes. J Biol Chem (2003) 0.82
Involvement of actin in agonist-induced endocytosis of the G protein-coupled receptor for thromboxane A2: overcoming of actin disruption by arrestin-3 but not arrestin-2. J Biol Chem (2005) 0.82
Resistance to cancer treatment: the role of somatic genetic events and the challenges for targeted therapies. Front Pharmacol (2011) 0.81
Activin inhibits the human Pit-1 gene promoter through the p38 kinase pathway in a Smad-independent manner. Endocrinology (2006) 0.81
Involvement of a cytoplasmic-tail serine cluster in urotensin II receptor internalization. Biochem J (2005) 0.81
Functional interactions between the oxytocin receptor and the β2-adrenergic receptor: implications for ERK1/2 activation in human myometrial cells. Cell Signal (2011) 0.80
An interaction between L-prostaglandin D synthase and arrestin increases PGD2 production. J Biol Chem (2010) 0.80
Activin inhibits pituitary prolactin expression and cell growth through Smads, Pit-1 and menin. Mol Endocrinol (2004) 0.80
Effect of insulin on caveolin-enriched membrane domains in rat liver. J Biol Chem (2004) 0.80
TGF-beta inhibits human cutaneous melanoma cell migration and invasion through regulation of the plasminogen activator system. Cell Signal (2012) 0.79
Allosteric interactions between the oxytocin receptor and the β2-adrenergic receptor in the modulation of ERK1/2 activation are mediated by heterodimerization. Cell Signal (2011) 0.79
Cell-specific optoporation with near-infrared ultrafast laser and functionalized gold nanoparticles. Nanoscale (2015) 0.79
Compartmentalization of epidermal growth factor receptor in liver plasma membrane. J Cell Biochem (2009) 0.79
Novel roles for arrestins in G protein-coupled receptor biology and drug discovery. Curr Opin Drug Discov Devel (2005) 0.79
Visible and near infrared resonance plasmonic enhanced nanosecond laser optoporation of cancer cells. Biomed Opt Express (2013) 0.79
The adaptor function of SHP-2 downstream of the prolactin receptor is required for the recruitment of p29, a substrate of SHP-2. Cell Signal (2003) 0.79
Study of G protein-coupled receptor/β-arrestin interactions within endosomes using FRAP. Methods Mol Biol (2011) 0.79
Prolactin Receptor Expression is an Independent Favorable Prognostic Marker in Human Breast Cancer. Appl Immunohistochem Mol Morphol (2016) 0.79
Cross-talk between signaling pathways can generate robust oscillations in calcium and cAMP. PLoS One (2009) 0.79
Inferring the lifetime of endosomal protein complexes by fluorescence recovery after photobleaching. Biophys J (2007) 0.78
The Development of Novel Therapies for the Treatment of Acute Myeloid Leukemia (AML). Cancers (Basel) (2012) 0.78
Monitoring Response and Resistance to the Novel Arsenical Darinaparsin in an AML Patient. Front Pharmacol (2013) 0.78
GPCR heterodimers: asymmetries in ligand binding and signalling output offer new targets for drug discovery. Br J Pharmacol (2013) 0.78
Gab2 tyrosine phosphorylation by a pleckstrin homology domain-independent mechanism: role in epidermal growth factor-induced mitogenesis. Mol Endocrinol (2003) 0.77
Targeting the prostaglandin F2α receptor for preventing preterm labor with azapeptide tocolytics. J Med Chem (2011) 0.77
A simple method to detect allostery in GPCR dimers. Methods Cell Biol (2013) 0.77
Development of buffers for fast semidry transfer of proteins. Anal Biochem (2013) 0.76
Engulfment protein GULP is regulator of transforming growth factor-β response in ovarian cells. J Biol Chem (2012) 0.76
Novel dominant negative Smad antagonists to TGFbeta signaling. Cell Signal (2007) 0.76
Quantitative analysis of a proteome by N-terminal stable-isotope labelling of tryptic peptides. Rapid Commun Mass Spectrom (2007) 0.75
Global analysis of protein phosphorylation networks in insulin signaling by sequential enrichment of phosphoproteins and phosphopeptides. Mol Biosyst (2012) 0.75
Insulin receptor kinase-associated phosphotyrosine phosphatases in hepatic endosomes: assessing the role of phosphotyrosine phosphatase-1B. Endocrinology (2005) 0.75
Investigation of the active turn geometry for the labour delaying activity of indolizidinone and azapeptide modulators of the prostaglandin F2α receptor. Org Biomol Chem (2015) 0.75