Published in J Gene Med on January 01, 2006
Engineering cartilage tissue. Adv Drug Deliv Rev (2007) 2.08
Hypertrophy is induced during the in vitro chondrogenic differentiation of human mesenchymal stem cells by bone morphogenetic protein-2 and bone morphogenetic protein-4 gene transfer. Arthritis Res Ther (2009) 1.34
Comparative chondrogenesis of human cell sources in 3D scaffolds. J Tissue Eng Regen Med (2009) 1.31
Concise review: the periosteum: tapping into a reservoir of clinically useful progenitor cells. Stem Cells Transl Med (2012) 1.22
Deficiency in the LIM-only protein Fhl2 impairs skin wound healing. J Cell Biol (2007) 1.13
Mesenchymal stem cells in the treatment of traumatic articular cartilage defects: a comprehensive review. Arthritis Res Ther (2014) 1.09
Concepts in gene therapy for cartilage repair. Injury (2008) 1.08
Mesenchymal stem cells at the intersection of cell and gene therapy. Expert Opin Biol Ther (2010) 1.07
SOX9 gene transfer via safe, stable, replication-defective recombinant adeno-associated virus vectors as a novel, powerful tool to enhance the chondrogenic potential of human mesenchymal stem cells. Stem Cell Res Ther (2012) 1.06
Enhanced in vitro chondrogenesis of primary mesenchymal stem cells by combined gene transfer. Tissue Eng Part A (2009) 1.02
The periosteum as a cellular source for functional tissue engineering. Tissue Eng Part A (2009) 0.99
Orthopedic gene therapy in 2008. Mol Ther (2008) 0.98
Chondrogenic differentiation of mesenchymal stem cells: challenges and unfulfilled expectations. Tissue Eng Part B Rev (2014) 0.96
Preclinical studies on mesenchymal stem cell-based therapy for growth plate cartilage injury repair. Stem Cells Int (2011) 0.89
Clinical potential and challenges of using genetically modified cells for articular cartilage repair. Croat Med J (2011) 0.88
The elusive path to cartilage regeneration. Adv Mater (2009) 0.87
Bone marrow derived stem cells in joint and bone diseases: a concise review. Int Orthop (2014) 0.86
BMP-2 gene-fibronectin-apatite composite layer enhances bone formation. J Biomed Sci (2011) 0.84
Simultaneous gene transfer of bone morphogenetic protein (BMP) -2 and BMP-7 by in vivo electroporation induces rapid bone formation and BMP-4 expression. BMC Musculoskelet Disord (2006) 0.81
Analysis of OPLA scaffolds for bone engineering constructs using human jaw periosteal cells. J Mater Sci Mater Med (2007) 0.80
Gene modification of mesenchymal stem cells and articular chondrocytes to enhance chondrogenesis. Biomed Res Int (2014) 0.79
Supernatant of bone marrow mesenchymal stromal cells induces peripheral blood mononuclear cells possessing mesenchymal features. Int J Biol Sci (2011) 0.78
Magnetic resonance imaging of stem cell apoptosis in arthritic joints with a caspase activatable contrast agent. ACS Nano (2015) 0.76
Osteogenic and adipogenic cell fractions isolated from postnatal mouse calvaria. Cells Tissues Organs (2008) 0.76
Premature induction of hypertrophy during in vitro chondrogenesis of human mesenchymal stem cells correlates with calcification and vascular invasion after ectopic transplantation in SCID mice. Arthritis Rheum (2006) 4.16
A simplified laminin nomenclature. Matrix Biol (2005) 3.81
Nanosize and vitality: TiO2 nanotube diameter directs cell fate. Nano Lett (2007) 2.82
Human laminin beta2 deficiency causes congenital nephrosis with mesangial sclerosis and distinct eye abnormalities. Hum Mol Genet (2004) 2.67
Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis. Nat Commun (2012) 2.65
Histological assessment of cartilage repair: a report by the Histology Endpoint Committee of the International Cartilage Repair Society (ICRS). J Bone Joint Surg Am (2003) 2.24
Association between crystals and cartilage degeneration in the ankle. J Rheumatol (2008) 2.15
Relative messenger RNA expression profiling of collagenases and aggrecanases in human articular chondrocytes in vivo and in vitro. Arthritis Rheum (2002) 1.97
Repair of chronic osteochondral defects using predifferentiated mesenchymal stem cells in an ovine model. Am J Sports Med (2010) 1.81
SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossification. Development (2010) 1.61
TiO2 nanotube surfaces: 15 nm--an optimal length scale of surface topography for cell adhesion and differentiation. Small (2009) 1.60
Wnt inhibitory factor 1 deficiency uncouples cartilage and bone destruction in tumor necrosis factor α-mediated experimental arthritis. Arthritis Rheum (2013) 1.59
Articular cartilage repair by gene therapy using growth factor-producing mesenchymal cells. Arthritis Rheum (2003) 1.59
Synovial stem cells are regionally specified according to local microenvironments after implantation for cartilage regeneration. Stem Cells (2006) 1.58
Chondromodulin 1 stabilizes the chondrocyte phenotype and inhibits endochondral ossification of porcine cartilage repair tissue. Arthritis Rheum (2011) 1.57
NEK1 mutations cause short-rib polydactyly syndrome type majewski. Am J Hum Genet (2011) 1.56
Molecular characterization of commonly used cell lines for bone tumor research: a trans-European EuroBoNet effort. Genes Chromosomes Cancer (2010) 1.50
The LIM-only protein FHL2 interacts with beta-catenin and promotes differentiation of mouse myoblasts. J Cell Biol (2002) 1.49
Differential expression of GADD45beta in normal and osteoarthritic cartilage: potential role in homeostasis of articular chondrocytes. Arthritis Rheum (2008) 1.33
Differential gene expression in pseudoexfoliation syndrome. Invest Ophthalmol Vis Sci (2005) 1.33
Activation of interleukin-1 signaling cascades in normal and osteoarthritic articular cartilage. Am J Pathol (2007) 1.28
Alternative splice variants of alpha 7 beta 1 integrin selectively recognize different laminin isoforms. J Biol Chem (2001) 1.25
β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis. Ann Rheum Dis (2012) 1.25
Hypoxia and osteoarthritis: how chondrocytes survive hypoxic environments. Curr Opin Rheumatol (2007) 1.23
Freshly isolated osteoarthritic chondrocytes are catabolically more active than normal chondrocytes, but less responsive to catabolic stimulation with interleukin-1beta. Arthritis Rheum (2005) 1.23
Identification of markers to characterize and sort human articular chondrocytes with enhanced in vitro chondrogenic capacity. Arthritis Rheum (2007) 1.20
Negative pressure wound therapy to prevent seromas and treat surgical incisions after total hip arthroplasty. Int Orthop (2011) 1.19
Wif-1 is expressed at cartilage-mesenchyme interfaces and impedes Wnt3a-mediated inhibition of chondrogenesis. J Cell Sci (2009) 1.19
In utero gene transfer of human factor IX to fetal mice can induce postnatal tolerance of the exogenous clotting factor. Blood (2002) 1.16
c-Cbl binding and ubiquitin-dependent lysosomal degradation of membrane-associated Notch1. J Biol Chem (2002) 1.16
The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor. J Biol Chem (2004) 1.15
Stimulation of GCMa and syncytin via cAMP mediated PKA signaling in human trophoblastic cells under normoxic and hypoxic conditions. FEBS Lett (2005) 1.13
Deficiency in the LIM-only protein Fhl2 impairs skin wound healing. J Cell Biol (2007) 1.13
Size selective behavior of mesenchymal stem cells on ZrO(2) and TiO(2) nanotube arrays. Integr Biol (Camb) (2009) 1.12
Perivascular cells expressing annexin A5 define a novel mesenchymal stem cell-like population with the capacity to differentiate into multiple mesenchymal lineages. Development (2005) 1.11
Discrete integration of collagen XVI into tissue-specific collagen fibrils or beaded microfibrils. Matrix Biol (2003) 1.10
Narrow window in nanoscale dependent activation of endothelial cell growth and differentiation on TiO2 nanotube surfaces. Nano Lett (2009) 1.09
Prevalence and prevention of severe complications of hypohidrotic ectodermal dysplasia in infancy. Early Hum Dev (2010) 1.09
Neurodevelopmental deficits in Pierson (microcoria-congenital nephrosis) syndrome. Am J Med Genet A (2007) 1.09
Specific expression of Cre recombinase in hypertrophic cartilage under the control of a BAC-Col10a1 promoter. Matrix Biol (2008) 1.08
Parosteal lipoma of the thigh with cartilaginous and osseous differentiation: an osteochondrolipoma. Ann Diagn Pathol (2006) 1.07
Regulation of type II collagen synthesis during osteoarthritis by prolyl-4-hydroxylases: possible influence of low oxygen levels. Am J Pathol (2006) 1.07
Abnormal expression of Col X, PTHrP, TGF-beta, bFGF, and VEGF in cartilage with Kashin-Beck disease. J Bone Miner Metab (2006) 1.06
Annexin A5 is not essential for skeletal development. Mol Cell Biol (2003) 1.05
Role of c-fos in the regulation of type X collagen gene expression by PTH and PTHrP: localization of a PTH/PTHrP-responsive region in the human COL10A1 enhancer. J Cell Biochem (2002) 1.05
Improved attachment of mesenchymal stem cells on super-hydrophobic TiO2 nanotubes. Acta Biomater (2008) 1.04
Transforming growth factor alpha suppression of articular chondrocyte phenotype and Sox9 expression in a rat model of osteoarthritis. Arthritis Rheum (2007) 1.04
Evidence for a role of the amyloid precursor protein in thyroid carcinogenesis. J Endocrinol (2008) 1.03
Population doublings and percentage of S100-positive cells as predictors of in vitro chondrogenicity of expanded human articular chondrocytes. J Cell Physiol (2010) 1.02
Proteomic analysis of synovial fluid from the osteoarthritic knee: comparison with transcriptome analyses of joint tissues. Arthritis Rheum (2013) 1.00
IL-1beta induction of IL-6 and LIF in normal articular human chondrocytes involves the ERK, p38 and NFkappaB signaling pathways. Cytokine (2004) 1.00
Ucma, a novel secreted cartilage-specific protein with implications in osteogenesis. J Biol Chem (2007) 1.00
Matrix-associated implantation of predifferentiated mesenchymal stem cells versus articular chondrocytes: in vivo results of cartilage repair after 1 year. Am J Sports Med (2011) 0.99
Def-6, a guanine nucleotide exchange factor for Rac1, interacts with the skeletal muscle integrin chain alpha7A and influences myoblast differentiation. J Biol Chem (2007) 0.97
Quantification of expression levels of cellular differentiation markers does not support a general shift in the cellular phenotype of osteoarthritic chondrocytes. J Orthop Res (2003) 0.96
Antisense inhibition of osteogenic protein 1 disturbs human articular cartilage integrity. Arthritis Rheum (2005) 0.96
Isolated Anxa5+/Sca-1+ perivascular cells from mouse meningeal vasculature retain their perivascular phenotype in vitro and in vivo. Exp Cell Res (2007) 0.96
A highly conserved enhancer in mammalian type X collagen genes drives high levels of tissue-specific expression in hypertrophic cartilage in vitro and in vivo. Matrix Biol (2004) 0.96
Microparticles stimulate angiogenesis by inducing ELR(+) CXC-chemokines in synovial fibroblasts. J Cell Mol Med (2011) 0.95
Role of mitogen-activated protein kinases and NFkappaB on IL-1beta-induced effects on collagen type II, MMP-1 and 13 mRNA expression in normal articular human chondrocytes. Rheumatol Int (2006) 0.95
Inhibition of activator protein 1 signaling abrogates transforming growth factor β-mediated activation of fibroblasts and prevents experimental fibrosis. Arthritis Rheum (2012) 0.95
Bone morphogenetic protein and transforming growth factor beta inhibitory Smads 6 and 7 are expressed in human adult normal and osteoarthritic cartilage in vivo and are differentially regulated in vitro by interleukin-1beta. Arthritis Rheum (2004) 0.94
Aloxe3 knockout mice reveal a function of epidermal lipoxygenase-3 as hepoxilin synthase and its pivotal role in barrier formation. J Invest Dermatol (2012) 0.93
Sustained delivery of therapeutic concentrations of human clotting factor IX--a comparison of adenoviral and AAV vectors administered in utero. J Gene Med (2002) 0.93
SOX gene expression in human osteoarthritic cartilage. Pathobiology (2008) 0.93
FOXO3a: a novel player in thyroid carcinogenesis? Endocr Relat Cancer (2008) 0.92
The role of annexin A5 in the modulation of the immune response against dying and dead cells. Curr Med Chem (2007) 0.92
Osteomyelitis of the ulna caused by Porphyromonas gingivalis. J Clin Microbiol (2006) 0.92
Synergistic control of mesenchymal stem cell differentiation by nanoscale surface geometry and immobilized growth factors on TiO2 nanotubes. Small (2011) 0.92
Blockade of canonical Wnt signalling ameliorates experimental dermal fibrosis. Ann Rheum Dis (2013) 0.92
Type II collagen as specific marker for mesenchymal chondrosarcomas compared to other small cell sarcomas of the skeleton. Mod Pathol (2005) 0.91
No juvenile arterial hypertension in sheep multiples despite reduced nephron numbers. Pediatr Nephrol (2010) 0.91
Inhibition of TGF-β signaling and decreased apoptosis in IUGR-associated lung disease in rats. PLoS One (2011) 0.91
Bone morphogenetic protein-mediating receptor-associated Smads as well as common Smad are expressed in human articular chondrocytes but not up-regulated or down-regulated in osteoarthritic cartilage. J Bone Miner Res (2002) 0.91
Residual lymph node metastasis in stage 4 neuroblastoma--advantage of radio-guided surgery? Pediatr Hematol Oncol (2010) 0.90
Regulation of chondrocyte gene expression by osteogenic protein-1. Arthritis Res Ther (2011) 0.90
miR-148a promotes plasma cell differentiation and targets the germinal center transcription factors Mitf and Bach2. Eur J Immunol (2015) 0.90
Twisted gastrulation modulates bone morphogenetic protein-induced collagen II and X expression in chondrocytes in vitro and in vivo. J Biol Chem (2006) 0.89
Early respiratory and ocular involvement in X-linked hypohidrotic ectodermal dysplasia. Eur J Pediatr (2013) 0.89
Jun activation domain-binding protein 1 binds Smad5 and inhibits bone morphogenetic protein signaling. Arthritis Rheum (2006) 0.88
Modulation of the immune system by dying cells and the phosphatidylserine-ligand annexin A5. Autoimmunity (2007) 0.88
Interaction of the disintegrin and cysteine-rich domains of ADAM12 with integrin alpha7beta1. Exp Cell Res (2004) 0.88
Homeostatic effects of the metalloproteinase disintegrin ADAM15 in degenerative cartilage remodeling. Arthritis Rheum (2005) 0.88
Cell-based resurfacing of large cartilage defects: long-term evaluation of grafts from autologous transgene-activated periosteal cells in a porcine model of osteoarthritis. Arthritis Rheum (2008) 0.88
BAC constructs in transgenic reporter mouse lines control efficient and specific LacZ expression in hypertrophic chondrocytes under the complete Col10a1 promoter. Histochem Cell Biol (2006) 0.88
Novel and recurrent mutations in the laminin-5 genes causing lethal junctional epidermolysis bullosa: molecular basis and clinical course of Herlitz disease. Hum Genet (2004) 0.86
Laminin-5-deficient human keratinocytes: defective adhesion results in a saltatory and inefficient mode of migration. Exp Cell Res (2007) 0.86
Deficiency in the LIM-only protein FHL2 impairs assembly of extracellular matrix proteins. FASEB J (2008) 0.86
Uteroplacental insufficiency after bilateral uterine artery ligation in the rat: impact on postnatal glucose and lipid metabolism and evidence for metabolic programming of the offspring by sham operation. Endocrinology (2007) 0.85
Systematic evaluation of exertional hyperthermia in children and adolescents with hypohidrotic ectodermal dysplasia: an observational study. Pediatr Res (2011) 0.85
Inhibition of sumoylation prevents experimental fibrosis. Ann Rheum Dis (2012) 0.85
Down-regulation of the GTPase RhoB might be involved in the pre-apoptotic phenotype of osteoarthritic chondrocytes. Front Biosci (2004) 0.85
The Wnt antagonist Wif-1 interacts with CTGF and inhibits CTGF activity. J Cell Physiol (2012) 0.85