Published in Development on March 01, 2010
Sox9 directs hypertrophic maturation and blocks osteoblast differentiation of growth plate chondrocytes. Dev Cell (2012) 2.28
Hypertrophic differentiation of chondrocytes in osteoarthritis: the developmental aspect of degenerative joint disorders. Arthritis Res Ther (2010) 1.48
Regulation of human chondrocyte function through direct inhibition of cartilage master regulator SOX9 by microRNA-145 (miRNA-145). J Biol Chem (2011) 1.29
A pathway to bone: signaling molecules and transcription factors involved in chondrocyte development and maturation. Development (2015) 1.19
SOX9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression. PLoS Genet (2011) 1.16
Developmental mechanisms in articular cartilage degradation in osteoarthritis. Arthritis (2010) 1.10
Dual pathways to endochondral osteoblasts: a novel chondrocyte-derived osteoprogenitor cell identified in hypertrophic cartilage. Biol Open (2015) 1.07
SOX9 gene transfer via safe, stable, replication-defective recombinant adeno-associated virus vectors as a novel, powerful tool to enhance the chondrogenic potential of human mesenchymal stem cells. Stem Cell Res Ther (2012) 1.06
SUMOylated SoxE factors recruit Grg4 and function as transcriptional repressors in the neural crest. J Cell Biol (2012) 1.03
Perlecan modulates VEGF signaling and is essential for vascularization in endochondral bone formation. Matrix Biol (2012) 1.00
Matrix metalloproteinase 13 loss associated with impaired extracellular matrix remodeling disrupts chondrocyte differentiation by concerted effects on multiple regulatory factors. Arthritis Rheum (2010) 0.99
Targeting Runx2 expression in hypertrophic chondrocytes impairs endochondral ossification during early skeletal development. J Cell Physiol (2012) 0.99
The versatile functions of Sox9 in development, stem cells, and human diseases. Genes Dis (2014) 0.98
Sox9 transcriptionally represses Spp1 to prevent matrix mineralization in maturing heart valves and chondrocytes. PLoS One (2011) 0.95
Osterix regulates calcification and degradation of chondrogenic matrices through matrix metalloproteinase 13 (MMP13) expression in association with transcription factor Runx2 during endochondral ossification. J Biol Chem (2012) 0.94
Interplay of Nkx3.2, Sox9 and Pax3 regulates chondrogenic differentiation of muscle progenitor cells. PLoS One (2012) 0.91
Generation of transgenic mice for conditional overexpression of Sox9. J Bone Miner Metab (2010) 0.91
SHP2 regulates chondrocyte terminal differentiation, growth plate architecture and skeletal cell fates. PLoS Genet (2014) 0.90
CCAAT/enhancer-binding protein β regulates the repression of type II collagen expression during the differentiation from proliferative to hypertrophic chondrocytes. J Biol Chem (2013) 0.89
Arid5a cooperates with Sox9 to stimulate chondrocyte-specific transcription. Mol Biol Cell (2011) 0.88
In vivo genome-wide analysis of multiple tissues identifies gene regulatory networks, novel functions and downstream regulatory genes for Bapx1 and its co-regulation with Sox9 in the mammalian vertebral column. BMC Genomics (2014) 0.87
Coordination of chondrogenesis and osteogenesis by hypertrophic chondrocytes in endochondral bone development. J Bone Miner Metab (2010) 0.86
E6-AP/UBE3A protein acts as a ubiquitin ligase toward SOX9 protein. J Biol Chem (2013) 0.85
Putative function of TAP63α during endochondral bone formation. Gene (2012) 0.85
Emulating native periosteum cell population and subsequent paracrine factor production to promote tissue engineered periosteum-mediated allograft healing. Biomaterials (2015) 0.84
In vitro osteogenic potential of human mesenchymal stem cells is predicted by Runx2/Sox9 ratio. Tissue Eng Part A (2014) 0.84
Distinct function of P63 isoforms during embryonic skeletal development. Gene (2013) 0.83
Achondroplasia: Development, Pathogenesis, and Therapy. Dev Dyn (2016) 0.83
Absence of endochondral ossification and craniosynostosis in posterior frontal cranial sutures of Axin2(-/-) mice. PLoS One (2013) 0.82
Notch signaling controls chondrocyte hypertrophy via indirect regulation of Sox9. Bone Res (2015) 0.82
Icariin promotes directed chondrogenic differentiation of bone marrow mesenchymal stem cells but not hypertrophy in vitro. Exp Ther Med (2014) 0.81
An immunohistochemistry study of Sox9, Runx2, and Osterix expression in the mandibular cartilages of newborn mouse. Biomed Res Int (2013) 0.81
Mutant activated FGFR3 impairs endochondral bone growth by preventing SOX9 downregulation in differentiating chondrocytes. Hum Mol Genet (2014) 0.81
Bioactive factors for tissue regeneration: state of the art. Muscles Ligaments Tendons J (2012) 0.79
rAAV-mediated overexpression of sox9, TGF-β and IGF-I in minipig bone marrow aspirates to enhance the chondrogenic processes for cartilage repair. Gene Ther (2015) 0.79
Relating the chondrocyte gene network to growth plate morphology: from genes to phenotype. PLoS One (2012) 0.79
Epimorphin alters the inhibitory effects of SOX9 on Mmp13 in activated hepatic stellate cells. PLoS One (2014) 0.78
A Track Record on SHOX: From Basic Research to Complex Models and Therapy. Endocr Rev (2016) 0.78
Endochondral ossification for enhancing bone regeneration: converging native extracellular matrix biomaterials and developmental engineering in vivo. Tissue Eng Part B Rev (2014) 0.78
β-catenin activity in late hypertrophic chondrocytes locally orchestrates osteoblastogenesis and osteoclastogenesis. Development (2016) 0.78
SOX9 and the many facets of its regulation in the chondrocyte lineage. Connect Tissue Res (2016) 0.78
CCN2 as a novel molecule supporting energy metabolism of chondrocytes. J Cell Biochem (2014) 0.77
Col10a1-Runx2 transgenic mice with delayed chondrocyte maturation are less susceptible to developing osteoarthritis. Am J Transl Res (2014) 0.77
Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development. Dev Biol (2014) 0.77
On the evolutionary relationship between chondrocytes and osteoblasts. Front Genet (2015) 0.77
Correlation Analysis of SOX9, -5, and -6 as well as COL2A1 and Aggrecan Gene Expression of Collagen I Implant-Derived and Osteoarthritic Chondrocytes. Cartilage (2016) 0.77
Sox9 reprogrammed dermal fibroblasts undergo hypertrophic differentiation in vitro and trigger endochondral ossification in vivo. Cell Reprogram (2014) 0.77
Cartilage to bone transformation during fracture healing is coordinated by the invading vasculature and induction of the core pluripotency genes. Development (2017) 0.76
Signaling Cascades Governing Cdc42-Mediated Chondrogenic Differentiation and Mensenchymal Condensation. Genetics (2016) 0.76
Increased adipogenesis in cultured embryonic chondrocytes and in adult bone marrow of dominant negative Erg transgenic mice. PLoS One (2012) 0.76
Articular cartilage tissue engineering: the role of signaling molecules. Cell Mol Life Sci (2016) 0.75
Minicircle Mediated Gene Delivery to Canine and Equine Mesenchymal Stem Cells. Int J Mol Sci (2017) 0.75
PEDF Is Associated with the Termination of Chondrocyte Phenotype and Catabolism of Cartilage Tissue. Biomed Res Int (2017) 0.75
TGF-β regulates phosphorylation and stabilization of Sox9 protein in chondrocytes through p38 and Smad dependent mechanisms. Sci Rep (2016) 0.75
The Signaling Pathways Involved in Chondrocyte Differentiation and Hypertrophic Differentiation. Stem Cells Int (2016) 0.75
Dynamic epigenetic mechanisms regulate age-dependent SOX9 expression in mouse articular cartilage. Int J Biochem Cell Biol (2016) 0.75
Downregulation of carbonic anhydrase IX promotes Col10a1 expression in chondrocytes. PLoS One (2013) 0.75
Regeneration of hyaline-like cartilage in situ with SOX9 stimulation of bone marrow-derived mesenchymal stem cells. PLoS One (2017) 0.75
SHP2 Regulates the Osteogenic Fate of Growth Plate Hypertrophic Chondrocytes. Sci Rep (2017) 0.75
Cellular reprogramming for clinical cartilage repair. Cell Biol Toxicol (2017) 0.75
Regulation of Cartilage Development and Diseases by Transcription Factors. J Bone Metab (2017) 0.75
The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell (2002) 15.20
The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev (2002) 8.19
Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories. Neuron (2006) 4.80
Interactions between Sox9 and beta-catenin control chondrocyte differentiation. Genes Dev (2004) 4.78
Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts. Nat Med (2006) 4.74
Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors. Proc Natl Acad Sci U S A (2005) 4.25
SOX9 is required for the differentiation of paneth cells in the intestinal epithelium. Gastroenterology (2007) 4.17
A simplified laminin nomenclature. Matrix Biol (2005) 3.81
NFAT and Osterix cooperatively regulate bone formation. Nat Med (2005) 2.99
Nanosize and vitality: TiO2 nanotube diameter directs cell fate. Nano Lett (2007) 2.82
Regulatory T cells protect from local and systemic bone destruction in arthritis. J Immunol (2010) 2.70
Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest. Proc Natl Acad Sci U S A (2003) 2.64
Impaired renal Na(+) retention in the sgk1-knockout mouse. J Clin Invest (2002) 2.47
Expression and function of laminins in the embryonic and mature vasculature. Physiol Rev (2005) 2.46
A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. Cell (2010) 2.37
Reversal of pathological pain through specific spinal GABAA receptor subtypes. Nature (2008) 2.30
Transcriptional mechanisms in osteoblast differentiation and bone formation. Trends Genet (2003) 2.23
Gene targeting reveals a widespread role for the high-mobility-group transcription factor Sox11 in tissue remodeling. Mol Cell Biol (2004) 2.23
Multiple functions of Osterix are required for bone growth and homeostasis in postnatal mice. Proc Natl Acad Sci U S A (2010) 2.20
Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells. J Exp Med (2009) 2.13
Glycinergic neurons expressing enhanced green fluorescent protein in bacterial artificial chromosome transgenic mice. J Comp Neurol (2005) 2.05
Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype. Genes Dev (2004) 1.88
Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development. J Exp Med (2011) 1.87
Inhibition of Wnt signaling by the osteoblast-specific transcription factor Osterix. Proc Natl Acad Sci U S A (2008) 1.86
Genetic regulation of bone mass and susceptibility to osteoporosis. Genes Dev (2006) 1.86
p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling. J Cell Biol (2005) 1.86
Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa. Proc Natl Acad Sci U S A (2004) 1.77
Requirements for FGF3 and FGF10 during inner ear formation. Development (2003) 1.76
Multiple conserved regulatory elements with overlapping functions determine Sox10 expression in mouse embryogenesis. Nucleic Acids Res (2007) 1.68
Ligand-dependent genetic recombination in fibroblasts : a potentially powerful technique for investigating gene function in fibrosis. Am J Pathol (2002) 1.68
A hypomorphic mouse model of dystrophic epidermolysis bullosa reveals mechanisms of disease and response to fibroblast therapy. J Clin Invest (2008) 1.67
PPARβ/δ governs Wnt signaling and bone turnover. Nat Med (2013) 1.66
Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis. Arthritis Rheum (2010) 1.64
The B subunit of the CCAAT box binding transcription factor complex (CBF/NF-Y) is essential for early mouse development and cell proliferation. Cancer Res (2003) 1.63
TNF-induced structural joint damage is mediated by IL-1. Proc Natl Acad Sci U S A (2007) 1.61
TiO2 nanotube surfaces: 15 nm--an optimal length scale of surface topography for cell adhesion and differentiation. Small (2009) 1.60
Articular cartilage repair by gene therapy using growth factor-producing mesenchymal cells. Arthritis Rheum (2003) 1.59
Synovial stem cells are regionally specified according to local microenvironments after implantation for cartilage regeneration. Stem Cells (2006) 1.58
Chondromodulin 1 stabilizes the chondrocyte phenotype and inhibits endochondral ossification of porcine cartilage repair tissue. Arthritis Rheum (2011) 1.57
Positive regulation of adult bone formation by osteoblast-specific transcription factor osterix. J Bone Miner Res (2009) 1.56
Regulation of the osteoblast-specific transcription factor Osterix by NO66, a Jumonji family histone demethylase. EMBO J (2009) 1.54
Postnatal induction of transforming growth factor beta signaling in fibroblasts of mice recapitulates clinical, histologic, and biochemical features of scleroderma. Arthritis Rheum (2007) 1.51
Prolonged glial expression of Sox4 in the CNS leads to architectural cerebellar defects and ataxia. J Neurosci (2007) 1.50
Regulation of bone formation and remodeling by G-protein-coupled receptor 48. Development (2009) 1.50
The LIM-only protein FHL2 interacts with beta-catenin and promotes differentiation of mouse myoblasts. J Cell Biol (2002) 1.49
Sox10 is required for Schwann cell identity and progression beyond the immature Schwann cell stage. J Cell Biol (2010) 1.48
Sox9-expressing precursors are the cellular origin of the cruciate ligament of the knee joint and the limb tendons. Genesis (2010) 1.46
Cardiac grafting of engineered heart tissue in syngenic rats. Circulation (2002) 1.43
Expression of HIF-1α in ischemia and reperfusion in human microsurgical free muscle tissue transfer. Plast Reconstr Surg (2011) 1.42
Engineering of vascularized transplantable bone tissues: induction of axial vascularization in an osteoconductive matrix using an arteriovenous loop. Tissue Eng (2006) 1.40
Active tuberculosis is characterized by an antigen specific and strictly localized expansion of effector T cells at the site of infection. Eur J Immunol (2012) 1.40
Selfish supernumerary chromosome reveals its origin as a mosaic of host genome and organellar sequences. Proc Natl Acad Sci U S A (2012) 1.37
From RNA-seq to large-scale genotyping - genomics resources for rye (Secale cereale L.). BMC Plant Biol (2011) 1.35
Sox12 deletion in the mouse reveals nonreciprocal redundancy with the related Sox4 and Sox11 transcription factors. Mol Cell Biol (2008) 1.35
Differential gene expression in pseudoexfoliation syndrome. Invest Ophthalmol Vis Sci (2005) 1.33
Intraspecific variation of recombination rate in maize. Genome Biol (2013) 1.32
In vivo magnetic resonance imaging of dendritic cell migration into the draining lymph nodes of mice. Eur J Immunol (2006) 1.31
The postnatal role of Sox9 in cartilage. J Bone Miner Res (2012) 1.31
Generation of aggrecan-CreERT2 knockin mice for inducible Cre activity in adult cartilage. Genesis (2009) 1.31
Fibroblast-specific expression of a kinase-deficient type II transforming growth factor beta (TGFbeta) receptor leads to paradoxical activation of TGFbeta signaling pathways with fibrosis in transgenic mice. J Biol Chem (2003) 1.29
Adjacent DNA sequences modulate Sox9 transcriptional activation at paired Sox sites in three chondrocyte-specific enhancer elements. Nucleic Acids Res (2003) 1.28
Constitutive activation of MKK6 in chondrocytes of transgenic mice inhibits proliferation and delays endochondral bone formation. Proc Natl Acad Sci U S A (2005) 1.26
Genetic evidence for the vital function of Osterix in cementogenesis. J Bone Miner Res (2012) 1.26
Identification of SOX9 interaction sites in the genome of chondrocytes. PLoS One (2010) 1.26
Alternative splice variants of alpha 7 beta 1 integrin selectively recognize different laminin isoforms. J Biol Chem (2001) 1.25
β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis. Ann Rheum Dis (2012) 1.25
Prolonged Sox4 expression in oligodendrocytes interferes with normal myelination in the central nervous system. Mol Cell Biol (2007) 1.24
Cthrc1 is a positive regulator of osteoblastic bone formation. PLoS One (2008) 1.24
Interferon alfa down-regulates collagen gene transcription and suppresses experimental hepatic fibrosis in mice. Hepatology (2003) 1.24
Transcriptional regulation of chondrogenesis by coactivator Tip60 via chromatin association with Sox9 and Sox5. Nucleic Acids Res (2008) 1.23
Postnatally induced inactivation of Osterix in osteoblasts results in the reduction of bone formation and maintenance. Bone (2009) 1.23
Sp1 and Sp3 transcription factors mediate interleukin-1 beta down-regulation of human type II collagen gene expression in articular chondrocytes. J Biol Chem (2003) 1.21
Hypomorphic Sox10 alleles reveal novel protein functions and unravel developmental differences in glial lineages. Development (2007) 1.20
Wif-1 is expressed at cartilage-mesenchyme interfaces and impedes Wnt3a-mediated inhibition of chondrogenesis. J Cell Sci (2009) 1.19
Superposition of horseshoe-like periodicity and linear tonotopic maps in auditory cortex of the Mongolian gerbil. Eur J Neurosci (2002) 1.19
c-Cbl binding and ubiquitin-dependent lysosomal degradation of membrane-associated Notch1. J Biol Chem (2002) 1.16
Olig2 regulates Sox10 expression in oligodendrocyte precursors through an evolutionary conserved distal enhancer. Nucleic Acids Res (2010) 1.15
The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor. J Biol Chem (2004) 1.15
The transcription factor Sox9 is degraded by the ubiquitin-proteasome system and stabilized by a mutation in a ubiquitin-target site. Matrix Biol (2004) 1.15
Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling. EMBO J (2012) 1.15
Genetic architecture of complex agronomic traits examined in two testcross populations of rye (Secale cereale L.). BMC Genomics (2012) 1.15
Size selective behavior of mesenchymal stem cells on ZrO(2) and TiO(2) nanotube arrays. Integr Biol (Camb) (2009) 1.12
Chondrocyte-specific ablation of Osterix leads to impaired endochondral ossification. Biochem Biophys Res Commun (2012) 1.11
Transgenic mice expressing a ligand-inducible cre recombinase in osteoblasts and odontoblasts: a new tool to examine physiology and disease of postnatal bone and tooth. Am J Pathol (2004) 1.11
Replacement of the Sox10 transcription factor by Sox8 reveals incomplete functional equivalence. Development (2006) 1.11
Perivascular cells expressing annexin A5 define a novel mesenchymal stem cell-like population with the capacity to differentiate into multiple mesenchymal lineages. Development (2005) 1.11
Interactions between PIAS proteins and SOX9 result in an increase in the cellular concentrations of SOX9. J Biol Chem (2006) 1.10
Low-dose cardio-respiratory phase-correlated cone-beam micro-CT of small animals. Med Phys (2011) 1.10
Murine CXCL14 is dispensable for dendritic cell function and localization within peripheral tissues. Mol Cell Biol (2006) 1.09
Narrow window in nanoscale dependent activation of endothelial cell growth and differentiation on TiO2 nanotube surfaces. Nano Lett (2009) 1.09
Osterix, a transcription factor for osteoblast differentiation, mediates antitumor activity in murine osteosarcoma. Cancer Res (2005) 1.09
Specific expression of Cre recombinase in hypertrophic cartilage under the control of a BAC-Col10a1 promoter. Matrix Biol (2008) 1.08