Published in EMBO J on September 08, 2005
Conformational transition of Sec machinery inferred from bacterial SecYE structures. Nature (2008) 2.48
Nanodiscs unravel the interaction between the SecYEG channel and its cytosolic partner SecA. EMBO J (2007) 1.81
A role for the two-helix finger of the SecA ATPase in protein translocation. Nature (2008) 1.75
Secretion by numbers: Protein traffic in prokaryotes. Mol Microbiol (2006) 1.75
Single copies of Sec61 and TRAP associate with a nontranslating mammalian ribosome. Structure (2008) 1.68
The plug domain of yeast Sec61p is important for efficient protein translocation, but is not essential for cell viability. Mol Biol Cell (2006) 1.42
The action of cardiolipin on the bacterial translocon. Proc Natl Acad Sci U S A (2010) 1.30
The hydrophobic core of the Sec61 translocon defines the hydrophobicity threshold for membrane integration. Mol Biol Cell (2010) 1.29
Molecular dynamics studies of the archaeal translocon. Biophys J (2006) 1.27
Preserving the membrane barrier for small molecules during bacterial protein translocation. Nature (2011) 1.23
The bacterial Sec-translocase: structure and mechanism. Philos Trans R Soc Lond B Biol Sci (2012) 1.22
Mapping polypeptide interactions of the SecA ATPase during translocation. Proc Natl Acad Sci U S A (2009) 1.18
Structure of the SecY complex unlocked by a preprotein mimic. Cell Rep (2012) 1.16
Hydrophobically stabilized open state for the lateral gate of the Sec translocon. Proc Natl Acad Sci U S A (2010) 1.15
Energy transduction in protein transport and the ATP hydrolytic cycle of SecA. Proc Natl Acad Sci U S A (2009) 1.11
The roles of pore ring and plug in the SecY protein-conducting channel. J Gen Physiol (2008) 1.07
Interactions that drive Sec-dependent bacterial protein transport. Biochemistry (2007) 1.07
Translocation of proteins through the Sec61 and SecYEG channels. Curr Opin Cell Biol (2009) 1.06
Oligomeric states of the SecA and SecYEG core components of the bacterial Sec translocon. Biochim Biophys Acta (2006) 1.05
SecA, a remarkable nanomachine. Cell Mol Life Sci (2011) 1.04
Size, motion, and function of the SecY translocon revealed by molecular dynamics simulations with virtual probes. Biophys J (2006) 1.04
Two copies of the SecY channel and acidic lipids are necessary to activate the SecA translocation ATPase. Proc Natl Acad Sci U S A (2012) 1.02
Dynamics of SecY translocons with translocation-defective mutations. Structure (2010) 1.02
Emerging themes in SecA2-mediated protein export. Nat Rev Microbiol (2012) 1.02
Analysis of polypeptide movement in the SecY channel during SecA-mediated protein translocation. J Biol Chem (2008) 0.98
Conformational dynamics of the plug domain of the SecYEG protein-conducting channel. J Biol Chem (2011) 0.94
Protein export through the bacterial Sec pathway. Nat Rev Microbiol (2016) 0.93
Direct simulation of early-stage Sec-facilitated protein translocation. J Am Chem Soc (2012) 0.93
Channel crossing: how are proteins shipped across the bacterial plasma membrane? Philos Trans R Soc Lond B Biol Sci (2015) 0.92
Mobility of the SecA 2-helix-finger is not essential for polypeptide translocation via the SecYEG complex. J Cell Biol (2012) 0.91
The structure of the Sec complex and the problem of protein translocation. EMBO Rep (2006) 0.90
Immobilization of the plug domain inside the SecY channel allows unrestricted protein translocation. J Biol Chem (2010) 0.90
The SecY complex forms a channel capable of ionic discrimination. EMBO Rep (2009) 0.89
Structural studies and the assembly of the heptameric post-translational translocon complex. J Biol Chem (2010) 0.89
Crystal structure of a substrate-engaged SecY protein-translocation channel. Nature (2016) 0.88
Selective transport by SecA2: an expanding family of customized motor proteins. Biochim Biophys Acta (2013) 0.88
Constitutive, translation-independent opening of the protein-conducting channel in the endoplasmic reticulum. Pflugers Arch (2008) 0.88
Assembly of the translocase motor onto the preprotein-conducting channel. Mol Microbiol (2008) 0.82
A prl mutation in SecY suppresses secretion and virulence defects of Listeria monocytogenes secA2 mutants. J Bacteriol (2014) 0.80
Unlocking the Bacterial SecY Translocon. Structure (2016) 0.79
MifM monitors total YidC activities of Bacillus subtilis, including that of YidC2, the target of regulation. J Bacteriol (2014) 0.79
Determination of the Oligomeric State of SecYEG Protein Secretion Channel Complex Using in Vivo Photo- and Disulfide Cross-linking. J Biol Chem (2016) 0.78
Position-dependent effects of polylysine on Sec protein transport. J Biol Chem (2012) 0.78
Passenger protein determines translocation versus retention in the endoplasmic reticulum for aromatase expression. Mol Pharmacol (2013) 0.75
Blue native electrophoresis for isolation of membrane protein complexes in enzymatically active form. Anal Biochem (1991) 12.68
X-ray structure of a protein-conducting channel. Nature (2003) 9.20
Suppressor mutations that restore export of a protein with a defective signal sequence. Cell (1981) 6.33
Architecture of the protein-conducting channel associated with the translating 80S ribosome. Cell (2001) 2.84
A signal sequence is not required for protein export in prlA mutants of Escherichia coli. EMBO J (1993) 2.70
Distinct catalytic roles of the SecYE, SecG and SecDFyajC subunits of preprotein translocase holoenzyme. EMBO J (1997) 2.60
SecA protein, a peripheral protein of the Escherichia coli plasma membrane, is essential for the functional binding and translocation of proOmpA. EMBO J (1989) 2.33
Three-dimensional structure of the bacterial protein-translocation complex SecYEG. Nature (2002) 2.16
ProOmpA spontaneously folds in a membrane assembly competent state which trigger factor stabilizes. EMBO J (1988) 2.10
Membrane-protein integration and the role of the translocation channel. Trends Cell Biol (2004) 2.03
Oligomerization of G protein-coupled receptors: past, present, and future. Biochemistry (2004) 2.03
Disulfide bridge formation between SecY and a translocating polypeptide localizes the translocation pore to the center of SecY. J Cell Biol (2005) 1.93
Binding, activation and dissociation of the dimeric SecA ATPase at the dimeric SecYEG translocase. EMBO J (2003) 1.84
SecYEG and SecA are the stoichiometric components of preprotein translocase. J Biol Chem (1995) 1.81
PrlA suppressor mutations cluster in regions corresponding to three distinct topological domains. EMBO J (1993) 1.77
SecYEG assembles into a tetramer to form the active protein translocation channel. EMBO J (2000) 1.74
The protein-conducting channel SecYEG. Biochim Biophys Acta (2004) 1.72
SRP-mediated protein targeting: structure and function revisited. Biochim Biophys Acta (2004) 1.57
Projection structure and oligomeric properties of a bacterial core protein translocase. EMBO J (2001) 1.57
Quaternary structure and function of transport proteins. Trends Biochem Sci (2002) 1.52
Mapping an interface of SecY (PrlA) and SecE (PrlG) by using synthetic phenotypes and in vivo cross-linking. J Bacteriol (1999) 1.52
The bacterial SecY/E translocation complex forms channel-like structures similar to those of the eukaryotic Sec61p complex. J Mol Biol (1999) 1.50
The SecYEG preprotein translocation channel is a conformationally dynamic and dimeric structure. EMBO J (2002) 1.46
An essential amino acid residue in the protein translocation channel revealed by targeted random mutagenesis of SecY. Proc Natl Acad Sci U S A (2001) 1.42
Cysteine-directed cross-linking demonstrates that helix 3 of SecE is close to helix 2 of SecY and helix 3 of a neighboring SecE. Biochemistry (1999) 1.38
The general protein secretory pathway: phylogenetic analyses leading to evolutionary conclusions. Biochim Biophys Acta (2003) 1.34
Sec-translocase mediated membrane protein biogenesis. Biochim Biophys Acta (2004) 1.34
PrlA4 prevents the rejection of signal sequence defective preproteins by stabilizing the SecA-SecY interaction during the initiation of translocation. EMBO J (1998) 1.32
The PrlA and PrlG phenotypes are caused by a loosened association among the translocase SecYEG subunits. EMBO J (1999) 1.32
Fluorescence resonance energy transfer analysis of protein translocase. SecYE from Thermus thermophilus HB8 forms a constitutive oligomer in membranes. J Biol Chem (2003) 1.28
PrlA and PrlG suppressors reduce the requirement for signal sequence recognition. J Bacteriol (1994) 1.26
prlA suppressors in Escherichia coli relieve the proton electrochemical gradient dependency of translocation of wild-type precursors. Proc Natl Acad Sci U S A (1996) 1.21
SecY-SecY and SecY-SecG contacts revealed by site-specific crosslinking. FEBS Lett (2002) 1.20
Evaluating the oligomeric state of SecYEG in preprotein translocase. EMBO J (2000) 1.18
Targeting of signal sequenceless proteins for export in Escherichia coli with altered protein translocase. EMBO J (1996) 1.09
Structural insight into the protein translocation channel. Curr Opin Struct Biol (2004) 0.99
Nearest neighbor analysis of the SecYEG complex. 1. Identification of a SecY-SecG interface. Biochemistry (2003) 0.90
The F286Y mutation of PrlA4 tempers the signal sequence suppressor phenotype by reducing the SecA binding affinity. FEBS Lett (2002) 0.89
Nearest neighbor analysis of the SecYEG complex. 2. Identification of a SecY-SecE cytosolic interface. Biochemistry (2003) 0.85
Nanodiscs unravel the interaction between the SecYEG channel and its cytosolic partner SecA. EMBO J (2007) 1.81
The SecYEG preprotein translocation channel is a conformationally dynamic and dimeric structure. EMBO J (2002) 1.46
The action of cardiolipin on the bacterial translocon. Proc Natl Acad Sci U S A (2010) 1.30
Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling. J Biol Chem (2012) 1.20
Crystal structures of Weissella viridescens FemX and its complex with UDP-MurNAc-pentapeptide: insights into FemABX family substrates recognition. Structure (2004) 1.19
The bacterial protein-translocation complex: SecYEG dimers associate with one or two SecA molecules. J Mol Biol (2004) 1.09
Deregulation of the SecYEG translocation channel upon removal of the plug domain. J Biol Chem (2006) 1.09
Two copies of the SecY channel and acidic lipids are necessary to activate the SecA translocation ATPase. Proc Natl Acad Sci U S A (2012) 1.02
Structure, binding, and activity of Syd, a SecY-interacting protein. J Biol Chem (2009) 1.01
Reconstitution of the SecY translocon in nanodiscs. Methods Mol Biol (2010) 0.99
Idiosyncratic features in tRNAs participating in bacterial cell wall synthesis. Nucleic Acids Res (2007) 0.99
Discovery of an auto-regulation mechanism for the maltose ABC transporter MalFGK2. PLoS One (2012) 0.97
Structure and function of the bacterial Sec translocon. Mol Membr Biol (2007) 0.96
SecYEG activates GTPases to drive the completion of cotranslational protein targeting. J Cell Biol (2013) 0.95
The maltose ABC transporter: action of membrane lipids on the transporter stability, coupling and ATPase activity. Biochim Biophys Acta (2013) 0.90
The SecY complex forms a channel capable of ionic discrimination. EMBO Rep (2009) 0.89
ATP alone triggers the outward facing conformation of the maltose ATP-binding cassette transporter. J Biol Chem (2012) 0.88
Phosphatidylglycerol directs binding and inhibitory action of EIIAGlc protein on the maltose transporter. J Biol Chem (2013) 0.86
Differential stability and fusion activity of Lyssavirus glycoprotein trimers. Virus Res (2003) 0.85
Structural basis for metal sensing by CnrX. J Mol Biol (2011) 0.82
X-ray structure of the metal-sensor CnrX in both the apo- and copper-bound forms. FEBS Lett (2008) 0.82
The SecY complex: conducting the orchestra of protein translocation. Trends Cell Biol (2011) 0.82
Nanodiscs and SILAC-based mass spectrometry to identify a membrane protein interactome. J Proteome Res (2011) 0.81
Break on through to the other side--the Sec translocon. Trends Biochem Sci (2004) 0.80
Nucleotide-free MalK drives the transition of the maltose transporter to the inward-facing conformation. J Biol Chem (2014) 0.80
Cell biology: fraternal twins. Nature (2007) 0.79
A step-by-step method for the reconstitution of an ABC transporter into nanodisc lipid particles. J Vis Exp (2012) 0.78
FhuA interactions in a detergent-free nanodisc environment. Biochim Biophys Acta (2013) 0.76
Modulation of the SecY channel permeability by pore mutations and trivalent cations. Channels (Austin) (2010) 0.76
Metal sensing and signal transduction by CnrX from Cupriavidus metallidurans CH34: role of the only methionine assessed by a functional, spectroscopic, and theoretical study. Metallomics (2014) 0.76
Spectroscopic characterization of the metal-binding sites in the periplasmic metal-sensor domain of CnrX from Cupriavidus metallidurans CH34. Biochemistry (2011) 0.76
Crystallization and preliminary X-ray analysis of Weissella viridescens FemX UDP-MurNAc-pentapeptide:l-alanine ligase. Acta Crystallogr D Biol Crystallogr (2003) 0.75