Published in Nature on October 16, 2008
Delivering proteins for export from the cytosol. Nat Rev Mol Cell Biol (2009) 2.00
Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes. Proc Natl Acad Sci U S A (2010) 1.57
The lateral gate of SecYEG opens during protein translocation. J Biol Chem (2009) 1.48
Signal peptides are allosteric activators of the protein translocase. Nature (2009) 1.28
The bacterial Sec-translocase: structure and mechanism. Philos Trans R Soc Lond B Biol Sci (2012) 1.22
Mechanism of activation of bacterial cellulose synthase by cyclic di-GMP. Nat Struct Mol Biol (2014) 1.20
Mapping polypeptide interactions of the SecA ATPase during translocation. Proc Natl Acad Sci U S A (2009) 1.18
P. aeruginosa PilT structures with and without nucleotide reveal a dynamic type IV pilus retraction motor. J Mol Biol (2010) 1.12
Conformational flexibility and peptide interaction of the translocation ATPase SecA. J Mol Biol (2009) 1.11
The oligomeric state and arrangement of the active bacterial translocon. J Biol Chem (2010) 1.09
Translocation of proteins through the Sec61 and SecYEG channels. Curr Opin Cell Biol (2009) 1.06
SecA, a remarkable nanomachine. Cell Mol Life Sci (2011) 1.04
A "push and slide" mechanism allows sequence-insensitive translocation of secretory proteins by the SecA ATPase. Cell (2014) 1.03
Emerging themes in SecA2-mediated protein export. Nat Rev Microbiol (2012) 1.02
Mapping of the SecA·SecY and SecA·SecG interfaces by site-directed in vivo photocross-linking. J Biol Chem (2011) 1.02
Characterization of Streptococcus gordonii SecA2 as a paralogue of SecA. J Bacteriol (2009) 0.98
Protein export through the bacterial Sec pathway. Nat Rev Microbiol (2016) 0.93
Direct simulation of early-stage Sec-facilitated protein translocation. J Am Chem Soc (2012) 0.93
Channel crossing: how are proteins shipped across the bacterial plasma membrane? Philos Trans R Soc Lond B Biol Sci (2015) 0.92
Energetics of SecA dimerization. J Mol Biol (2011) 0.92
Mapping of the signal peptide-binding domain of Escherichia coli SecA using Förster resonance energy transfer. Biochemistry (2010) 0.92
Mobility of the SecA 2-helix-finger is not essential for polypeptide translocation via the SecYEG complex. J Cell Biol (2012) 0.91
Structural changes in the mitochondrial Tim23 channel are coupled to the proton-motive force. Nat Struct Mol Biol (2013) 0.91
The dynamic action of SecA during the initiation of protein translocation. Biochem J (2013) 0.91
Stabilization of the E* form turns thrombin into an anticoagulant. J Biol Chem (2009) 0.91
Transport of preproteins by the accessory Sec system requires a specific domain adjacent to the signal peptide. J Bacteriol (2010) 0.90
Visualization of distinct entities of the SecYEG translocon during translocation and integration of bacterial proteins. Mol Biol Cell (2009) 0.90
Evidence of the E*-E equilibrium from rapid kinetics of Na+ binding to activated protein C and factor Xa. J Phys Chem B (2010) 0.89
Selective transport by SecA2: an expanding family of customized motor proteins. Biochim Biophys Acta (2013) 0.88
Bacterial Sec protein transport is rate-limited by precursor length: a single turnover study. Mol Biol Cell (2009) 0.88
The Sec-dependent pathway. Res Microbiol (2013) 0.87
The first low microM SecA inhibitors. Bioorg Med Chem (2010) 0.86
The membrane topography of the diphtheria toxin T domain linked to the a chain reveals a transient transmembrane hairpin and potential translocation mechanisms. Biochemistry (2009) 0.84
Two-way communication between SecY and SecA suggests a Brownian ratchet mechanism for protein translocation. Elife (2016) 0.83
Defining the Escherichia coli SecA dimer interface residues through in vivo site-specific photo-cross-linking. J Bacteriol (2013) 0.82
Cryo-electron microscopic structure of SecA protein bound to the 70S ribosome. J Biol Chem (2014) 0.80
Structural biology: Clamour for a kiss. Nature (2008) 0.79
Characterization of the Escherichia coli SecA signal peptide-binding site. J Bacteriol (2011) 0.79
The use of analytical sedimentation velocity to extract thermodynamic linkage. Biophys Chem (2011) 0.79
Using a low denaturant model to explore the conformational features of translocation-active SecA. Biochemistry (2012) 0.78
ADP-dependent conformational changes distinguish Mycobacterium tuberculosis SecA2 from SecA1. J Biol Chem (2013) 0.78
Analysis of SecA dimerization in solution. Biochemistry (2014) 0.78
Position-dependent effects of polylysine on Sec protein transport. J Biol Chem (2012) 0.78
Structural Features Reminiscent of ATP-Driven Protein Translocases Are Essential for the Function of a Type III Secretion-Associated ATPase. J Bacteriol (2015) 0.77
Conformational Changes of the Clamp of the Protein Translocation ATPase SecA. J Mol Biol (2015) 0.77
SecA cotranslationally interacts with nascent substrate proteins in vivo. J Bacteriol (2016) 0.77
Protein translocation: what's the problem? Biochem Soc Trans (2016) 0.76
Structural Similarities and Differences between Two Functionally Distinct SecA Proteins, Mycobacterium tuberculosis SecA1 and SecA2. J Bacteriol (2015) 0.75
Conserved SecA Signal Peptide-Binding Site Revealed by Engineered Protein Chimeras and Förster Resonance Energy Transfer. Biochemistry (2016) 0.75
Alignment of the protein substrate hairpin along the SecA two-helix finger primes protein transport in Escherichia coli. Proc Natl Acad Sci U S A (2017) 0.75
X-ray structure of a protein-conducting channel. Nature (2003) 9.20
Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes. Nature (2007) 4.99
The purified E. coli integral membrane protein SecY/E is sufficient for reconstitution of SecA-dependent precursor protein translocation. Cell (1990) 4.78
Central pore residues mediate the p97/VCP activity required for ERAD. Mol Cell (2006) 4.56
SecA promotes preprotein translocation by undergoing ATP-driven cycles of membrane insertion and deinsertion. Cell (1994) 3.95
Nucleotide control of interdomain interactions in the conformational reaction cycle of SecA. Science (2002) 2.72
Loops in the central channel of ClpA chaperone mediate protein binding, unfolding, and translocation. Cell (2005) 2.69
Crystal structures of the HslVU peptidase-ATPase complex reveal an ATP-dependent proteolysis mechanism. Structure (2001) 2.63
Protein translocation is mediated by oligomers of the SecY complex with one SecY copy forming the channel. Cell (2007) 2.17
Role of the processing pore of the ClpX AAA+ ATPase in the recognition and engagement of specific protein substrates. Genes Dev (2004) 2.11
Diverse pore loops of the AAA+ ClpX machine mediate unassisted and adaptor-dependent recognition of ssrA-tagged substrates. Mol Cell (2008) 1.96
Disulfide bridge formation between SecY and a translocating polypeptide localizes the translocation pore to the center of SecY. J Cell Biol (2005) 1.93
Dissociation of the dimeric SecA ATPase during protein translocation across the bacterial membrane. EMBO J (2002) 1.92
A large conformational change of the translocation ATPase SecA. Proc Natl Acad Sci U S A (2004) 1.86
Investigating the SecY plug movement at the SecYEG translocation channel. EMBO J (2005) 1.65
Conserved pore residues in the AAA protease FtsH are important for proteolysis and its coupling to ATP hydrolysis. J Biol Chem (2003) 1.61
Projection structure and oligomeric properties of a bacterial core protein translocase. EMBO J (2001) 1.57
Characterization of the accessory Sec system of Staphylococcus aureus. J Bacteriol (2008) 1.56
Role of the GYVG pore motif of HslU ATPase in protein unfolding and translocation for degradation by HslV peptidase. J Biol Chem (2005) 1.53
Mapping an interface of SecY (PrlA) and SecE (PrlG) by using synthetic phenotypes and in vivo cross-linking. J Bacteriol (1999) 1.52
A molecular switch in SecA protein couples ATP hydrolysis to protein translocation. Mol Microbiol (1999) 1.47
Complementation of two overlapping fragments of SecA, a protein translocation ATPase of Escherichia coli, allows ATP binding to its amino-terminal region. J Biol Chem (1990) 1.47
Determinants of the streptococcal surface glycoprotein GspB that facilitate export by the accessory Sec system. Mol Microbiol (2005) 1.43
Protein transport by purified yeast Sec complex and Kar2p without membranes. Science (1997) 1.30
Global co-ordination of protein translocation by the SecA IRA1 switch. J Biol Chem (2004) 1.08
Analysis of polypeptide movement in the SecY channel during SecA-mediated protein translocation. J Biol Chem (2008) 0.98
Isolation and analysis of dominant secA mutations in Escherichia coli. J Bacteriol (1991) 0.93
X-ray structure of a protein-conducting channel. Nature (2003) 9.20
A class of membrane proteins shaping the tubular endoplasmic reticulum. Cell (2006) 8.53
Crystal structure of the potassium channel KirBac1.1 in the closed state. Science (2003) 7.46
A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol. Nature (2004) 6.37
Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins. Cell (2006) 5.54
Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling. Mol Cell Biol (2003) 4.43
Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains. J Cell Biol (2003) 4.35
Retro-translocation of proteins from the endoplasmic reticulum into the cytosol. Nat Rev Mol Cell Biol (2002) 4.29
Mathematical models of protein kinase signal transduction. Mol Cell (2002) 4.08
A class of dynamin-like GTPases involved in the generation of the tubular ER network. Cell (2009) 3.88
Structure of a complex of the ATPase SecA and the protein-translocation channel. Nature (2008) 3.73
Membrane proteins of the endoplasmic reticulum induce high-curvature tubules. Science (2008) 3.60
Mechanisms determining the morphology of the peripheral ER. Cell (2010) 3.35
Structural organization of the endoplasmic reticulum. EMBO Rep (2002) 3.25
The reticulon and DP1/Yop1p proteins form immobile oligomers in the tubular endoplasmic reticulum. J Biol Chem (2008) 3.13
Protein translocation by the Sec61/SecY channel. Annu Rev Cell Dev Biol (2005) 3.09
Gangliosides are receptors for murine polyoma virus and SV40. EMBO J (2003) 2.99
Rough sheets and smooth tubules. Cell (2006) 2.97
Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane. Proc Natl Acad Sci U S A (2005) 2.81
Mechanisms shaping the membranes of cellular organelles. Annu Rev Cell Dev Biol (2009) 2.71
Mechanisms of Sec61/SecY-mediated protein translocation across membranes. Annu Rev Biophys (2011) 2.40
Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p. Cell (2010) 2.33
Structure of human O-GlcNAc transferase and its complex with a peptide substrate. Nature (2011) 2.24
The plug domain of the SecY protein stabilizes the closed state of the translocation channel and maintains a membrane seal. Mol Cell (2007) 2.18
Protein translocation is mediated by oligomers of the SecY complex with one SecY copy forming the channel. Cell (2007) 2.17
Three-dimensional structure of the bacterial protein-translocation complex SecYEG. Nature (2002) 2.16
STIM1 gates the store-operated calcium channel ORAI1 in vitro. Nat Struct Mol Biol (2009) 2.15
Crystallographic snapshot of cellulose synthesis and membrane translocation. Nature (2012) 2.10
The signal sequence coding region promotes nuclear export of mRNA. PLoS Biol (2007) 2.09
Structures of the atlastin GTPase provide insight into homotypic fusion of endoplasmic reticulum membranes. Proc Natl Acad Sci U S A (2011) 2.06
The ATPase SpoIIIE transports DNA across fused septal membranes during sporulation in Bacillus subtilis. Cell (2007) 2.03
Stacked endoplasmic reticulum sheets are connected by helicoidal membrane motifs. Cell (2013) 1.97
Targeting of rough endoplasmic reticulum membrane proteins and ribosomes in invertebrate neurons. Mol Biol Cell (2002) 1.97
Architecture of the ribosome-channel complex derived from native membranes. J Mol Biol (2005) 1.97
Disulfide bridge formation between SecY and a translocating polypeptide localizes the translocation pore to the center of SecY. J Cell Biol (2005) 1.93
Unfolded cholera toxin is transferred to the ER membrane and released from protein disulfide isomerase upon oxidation by Ero1. J Cell Biol (2002) 1.86
A large conformational change of the translocation ATPase SecA. Proc Natl Acad Sci U S A (2004) 1.86
Conformational locking upon cooperative assembly of notch transcription complexes. Structure (2012) 1.79
Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1. Mol Cell Biol (2006) 1.75
Crystal structure of the long-chain fatty acid transporter FadL. Science (2004) 1.74
Role of ubiquitination in retro-translocation of cholera toxin and escape of cytosolic degradation. EMBO Rep (2002) 1.71
Single copies of Sec61 and TRAP associate with a nontranslating mammalian ribosome. Structure (2008) 1.68
Ribosome binding of a single copy of the SecY complex: implications for protein translocation. Mol Cell (2007) 1.59
Polyubiquitin serves as a recognition signal, rather than a ratcheting molecule, during retrotranslocation of proteins across the endoplasmic reticulum membrane. J Biol Chem (2003) 1.55
Weaving the web of ER tubules. Cell (2011) 1.53
Processing and turnover of the Hedgehog protein in the endoplasmic reticulum. J Cell Biol (2011) 1.48
Lipid interaction of the C terminus and association of the transmembrane segments facilitate atlastin-mediated homotypic endoplasmic reticulum fusion. Proc Natl Acad Sci U S A (2012) 1.46
Hsp42 is required for sequestration of protein aggregates into deposition sites in Saccharomyces cerevisiae. J Cell Biol (2011) 1.45
Structure of a bacterial homologue of vitamin K epoxide reductase. Nature (2010) 1.44
Structure of the mammalian ribosome-channel complex at 17A resolution. J Mol Biol (2002) 1.43
The dynamin-like GTPase Sey1p mediates homotypic ER fusion in S. cerevisiae. J Cell Biol (2012) 1.38
Vitamin K epoxide reductase prefers ER membrane-anchored thioredoxin-like redox partners. Proc Natl Acad Sci U S A (2010) 1.34
Tertiary model of a plant cellulose synthase. Proc Natl Acad Sci U S A (2013) 1.34
Role of p97 AAA-ATPase in the retrotranslocation of the cholera toxin A1 chain, a non-ubiquitinated substrate. J Biol Chem (2005) 1.33
RecA-like motor ATPases--lessons from structures. Biochim Biophys Acta (2004) 1.33
A novel dimer interface and conformational changes revealed by an X-ray structure of B. subtilis SecA. J Mol Biol (2006) 1.27
Cooperation of transmembrane segments during the integration of a double-spanning protein into the ER membrane. EMBO J (2003) 1.27
Preserving the membrane barrier for small molecules during bacterial protein translocation. Nature (2011) 1.23
Gem1 and ERMES do not directly affect phosphatidylserine transport from ER to mitochondria or mitochondrial inheritance. Traffic (2012) 1.21
Determining the conductance of the SecY protein translocation channel for small molecules. Mol Cell (2007) 1.19
Mapping polypeptide interactions of the SecA ATPase during translocation. Proc Natl Acad Sci U S A (2009) 1.18
Generation of nonidentical compartments in vesicular transport systems. J Cell Biol (2005) 1.17
BcsA and BcsB form the catalytically active core of bacterial cellulose synthase sufficient for in vitro cellulose synthesis. Proc Natl Acad Sci U S A (2013) 1.15
Interactions between Sec complex and prepro-alpha-factor during posttranslational protein transport into the endoplasmic reticulum. Mol Biol Cell (2003) 1.12
Conformational flexibility and peptide interaction of the translocation ATPase SecA. J Mol Biol (2009) 1.11
Bacterial protein translocation requires only one copy of the SecY complex in vivo. J Cell Biol (2012) 1.08
A grid-enabled web service for low-resolution crystal structure refinement. Acta Crystallogr D Biol Crystallogr (2012) 1.06
Ribosome binding to and dissociation from translocation sites of the endoplasmic reticulum membrane. Mol Biol Cell (2006) 1.04
E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system. Proc Natl Acad Sci U S A (2006) 1.04
The hyaluronan synthase catalyzes the synthesis and membrane translocation of hyaluronan. J Mol Biol (2012) 1.01
Structural insight into the protein translocation channel. Curr Opin Struct Biol (2004) 0.99
The 2nd DBCLS BioHackathon: interoperable bioinformatics Web services for integrated applications. J Biomed Semantics (2011) 0.99
Apo- and cellopentaose-bound structures of the bacterial cellulose synthase subunit BcsZ. J Biol Chem (2011) 0.98
Analysis of polypeptide movement in the SecY channel during SecA-mediated protein translocation. J Biol Chem (2008) 0.98
A molecular description of cellulose biosynthesis. Annu Rev Biochem (2015) 0.97
Multiple mechanisms determine ER network morphology during the cell cycle in Xenopus egg extracts. J Cell Biol (2013) 0.95
Increasing the diffraction limit and internal order of a membrane protein crystal by dehydration. J Struct Biol (2003) 0.93
A conserved role for atlastin GTPases in regulating lipid droplet size. Cell Rep (2013) 0.91
The C-terminal portion of the cleaved HT motif is necessary and sufficient to mediate export of proteins from the malaria parasite into its host cell. Mol Microbiol (2013) 0.90
A novel centrosome-associated protein with affinity for microtubules. J Cell Sci (2002) 0.87
The ER-associated degradation component Der1p and its homolog Dfm1p are contained in complexes with distinct cofactors of the ATPase Cdc48p. FEBS Lett (2008) 0.87
Crystal structure of an unusual thioredoxin protein with a zinc finger domain. J Biol Chem (2007) 0.85
Notch ankyrin repeat domain variation influences leukemogenesis and Myc transactivation. PLoS One (2011) 0.75